Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6222 produits trouvés pour "Apoptose"
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DB0614
CAS :DB0614 degrades 26 kinases including AAK1 and CDK6, targeting aberrant activity in disease research.Formule :C41H42N8O7S2Couleur et forme :SolidMasse moléculaire :822.95PROTAC AR-NTD degrader 1
PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminalFormule :C41H47ClN6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.3Golimumab
CAS :Golimumab (CNTO-148), an anti-TNFα IgG1κ monoclonal antibody with anti-inflammatory and anti-cancer activity, can be used to prevent inflammation and cartilage.Couleur et forme :LiquidMasse moléculaire :146.93 kDaPF-543
CAS :PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Formule :C27H31NO4SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :465.6Ac-LEHD-AMC
CAS :Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.Formule :C33H41N7O11Couleur et forme :SolidMasse moléculaire :711.729Apoptosis inducer 26
Apoptosisinducer 26 (compound [AgCl(dap2SH)(PPh3)2]) is a mononuclear Ag(I) ligand-based autophagy inducer that exhibits antibacterial and anticancer activities against various bacterial strains and cancer cell lines. This compound facilitates the accumulation of Ag(I) ions in the periphery of bacteria, effectively inhibiting the growth of both Gram-positive (+) and Gram-negative (-) bacteria. Additionally, Apoptosisinducer 26 can intercalate between the base pairs of CT DNA, inducing apoptosis in A549 cells. It also possesses radical scavenging properties, which helps prevent oxidative stress.Formule :C40H36AgClN4P2SCouleur et forme :SolidMasse moléculaire :810.07EGFR-IN-153
EGFR-IN-153 (Compound 5l) is an EGFR inhibitor that suppresses the proliferation of MDA-MB-231 cells with an IC50 of 0.73 μM and induces apoptosis. It is applicable for research in breast cancer.Couleur et forme :Odour Solidc-Met/HDAC-IN-4
c-Met/HDAC-IN-4, a dual inhibitor of c-Met/HDAC, exhibits an IC 50 value of 28.92 nM for c-Met. This compound effectively induces G 0 /G 1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells. Additionally, c-Met/HDAC-IN-4 suppresses both the proliferation and invasion of breast cancer cell lines.Formule :C37H36N8OCouleur et forme :SolidMasse moléculaire :608.73ZX782
ZX782 acts as a GPX4 protein degrader and an inducer of ferroptosis (Ferroptosis), targeting GPX4 for destruction via both the ubiquitin-proteasome system and the autophagy-lysosome pathway. Following the degradation of GPX4 induced by ZX782, there is a significant increase in the accumulation of lipid reactive oxygen species (ROS) in HT1080 cells.Formule :C39H48ClN5O8Couleur et forme :SolidMasse moléculaire :750.28dTAGV-1-NEG
CAS :Negative control for dTAGV-1.Formule :C68H90N6O14SCouleur et forme :SolidMasse moléculaire :1247.56Bcl-xL antagonist 2
CAS :Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM.Formule :C21H16N4O3S2Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :436.51Ref: TM-T38622
1mg77,00€5mg166,00€1mL*10mM (DMSO)182,00€10mg248,00€25mg447,00€50mg622,00€100mg800,00€200mg1.071,00€A-1248767
CAS :A-1248767, a derivative of A-1210477, is an MCL-1 inhibitor (IC50=23.9 nM; Ki=0.41 nM) known for its anticancer properties. It binds to MCL-1 with high affinity, induces an increase in MCL-1 protein levels inside cells, and promotes apoptosis in tumor cells.Formule :C47H55N7O6Couleur et forme :SolidMasse moléculaire :813.98Ferroptosis-IN-13
Ferroptosis-IN-13 (compound NY-26) is an inhibitor of ferroptosis. It effectively suppresses RSL3-induced ferroptosis in 786-O cells, with an EC50 value of 62 nM.Formule :C32H30F2N4O3Couleur et forme :SolidMasse moléculaire :556.602Ch282-5
CAS :Ch282-5, an orally active inhibitor targeting the Bcl-2 protein, promotes mitochondria-dependent apoptosis (Apoptosis) by disrupting mitophagy and the mTOR pathway. It demonstrates antiproliferative effects on colorectal cancer cells, effective both in vitro and in vivo, while also inhibiting metastasis. Further, Ch282-5 augments Oxaliplatin-induced autophagy (Autophagy) by downregulating Mcl-1 protein and raising platelet count, which helps mitigate the adverse effects of Navitoclax.Formule :C34H34N2Na2O14S2Couleur et forme :SolidMasse moléculaire :804.75p53 (17-26)
CAS :Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.Formule :C60H90N12O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1251.43hMcl-1-IN-1
hMcl-1-IN-1 (Compound 9) is an hMcl-1 inhibitor based on a His224 arylsulfonyl fluoride, displaying an IC50 value of 5.8 nM.Formule :C69H113FN20O19SCouleur et forme :SolidMasse moléculaire :1577.82HDAC-IN-77
HDAC-IN-77 (HL-5s), an HDAC inhibitor, has the capability to induce ferroptosis and suppress the Nrf2/HO-1 signaling pathway. This compound is utilized in cancer research.Formule :C22H26N4O2SCouleur et forme :SolidMasse moléculaire :410.53Antagonist G
CAS :Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.Formule :C49H66N12O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :951.19Anticancer agent 268
Anticanceragent 268 (Compound 4k) is a potential antitumor agent. It exhibits antiproliferative effects on HepG2 cells, with an IC50 value of 6.08 μM. Additionally, Anticanceragent 268 induces apoptosis and inhibits colony formation and migration of HepG2 cells.Couleur et forme :Odour SolidBaceridin
CAS :Baceridin, a cyclic hexapeptide and proteasome inhibitor, can be isolated from the culture medium of Epiphytic Bacillus.Formule :C37H57N7O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :695.89
