Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
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6222 produits trouvés pour "Apoptose"
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PROTAC FGFR2 degrader 1
PROTAC FGFR2 degrader 1 (compound N5) is a potent PROTAC that efficiently targets FGFR2, boasting a DC 50 value of 6.46 nM and an FGFR2 IC 50 of 0.08 nM. This compound exhibits significant anti-proliferative effects and high selectivity. It induces G0/G1 arrest in the cell cycles of KATOIII and SNU16 and inhibits apoptosis by diminishing the activation of p-ERK and p-PLCγ, the downstream proteins of FGFR2. Additionally, PROTAC FGFR2 degrader 1 maintains over 50% inhibition of gastric cancer cells at a concentration of 0.17 nM and effectively suppresses the growth of SNU16 xenograft tumors in a mouse model.Couleur et forme :Odour Solid(+)-Mcl-1 inhibitor 22
CAS :(+)-Mcl-1 inhibitor 22 (Example 37) is an MCL-1 inhibitor that impedes the anti-apoptotic function of MCL-1 by blocking its interaction with pro-apoptotic proteins. It demonstrates antiproliferative activity against various cancer cell lines and is applicable for cancer research.Formule :C33H33ClFN3O4Couleur et forme :SolidMasse moléculaire :590.084PZ703b
CAS :PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.Formule :C80H102ClF3N10O11S4Couleur et forme :SolidMasse moléculaire :1600.44PZ703b hydrochloride
PZ703b hydrochloride, a Bcl-xl PROTAC, triggers apoptosis and halts cancer growth; used in bladder cancer studies.Formule :C80H103Cl2F3N10O11S4Couleur et forme :SolidMasse moléculaire :1636.9Bcl-2-IN-2
CAS :Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL.Formule :C48H57N7O7SCouleur et forme :SolidMasse moléculaire :876.09Thalidomide-O-amido-C8-NH2 hydrochloride
Thalidomide-O-amido-C8-NH2 hydrochloride, a synthetic cereblon ligand-linker for PROTAC synthesis.Formule :C23H31ClN4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.97Biotin-PEG6-Thalidomide
CAS :Biotin-PEG6-Thalidomide is a PROTAC linker based on PEG.Formule :C37H53N5O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :791.91QZ2135
QZ2135 (compound 20) is a PROTAC degrader that specifically targets RET and exhibits antitumor activity in vivo within a Ba/F3-KIF5B-RET-G810C xenograft mouse model. The compound demonstrates degradation activity with DC50 values of 4.7 nM (WT), 17.2 nM (V804M), and 73.8 nM (G810C) when targeting KIF5B-RET. QZ2135 is composed of the target protein ligand (red part) RETligand-3, the E3 ligase ligand (blue part) Lenalidomide-F, and the PROTAC Linker (black part) 7-Iodohept-1-yne, wherein the target protein ligand combined with the linker forms the conjugate RETLigand-Linker Conjugate-1.Formule :C53H54N12O4Couleur et forme :SolidMasse moléculaire :923.07HDAC3-IN-2
HDAC3-IN-2 (compound 4i), a pyrazinyl hydrazide-based HDAC3 inhibitor with an IC50 of 14 nM, effectively targets triple-negative breast cancer cells.Formule :C16H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.37DAPK Substrate Peptide
CAS :DAPK Substrate Peptide is a synthetic peptide substrate for death-associated protein kinase (DAPK) (Km = 9 μM).Formule :C70H115N25O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1578.82Ub4ix
CAS :Ub4ix, a DUB/26S proteasome inhibitor, safeguards K48-linked Ub chains against cleavage by deubiquitinating enzymes (DUBs) and inhibits the proteasomal degradation of Ub-tagged proteins. Additionally, it diminishes the viability of Hela cells and triggers apoptosis, exhibiting an IC 50 value of 1.6 μM.Formule :C84H106N18O23SCouleur et forme :SolidMasse moléculaire :1767.91Nrf2 activator-11
Nrf2 activator-11 (compound M11) is a Nrf2 activator that possesses blood-brain barrier permeability and offers anti-oxidation, anti-inflammation, anti-ferroptosis, and anti-apoptosis properties. It is applicable for use in studying cerebral ischemia-reperfusion (CI/R) injury models.Formule :C20H23N3O2Couleur et forme :SolidMasse moléculaire :337.42(E)-C-HDMAPP (ammonium salt)
CAS :Alkyl phosphates like (E)-C-HDMAPP activate γδ-T cells, resist hydrolysis, and boost TNF-α synthesis and γδ-T cell count in vivo.
Formule :C6H23N3O7P2Couleur et forme :SolidMasse moléculaire :311.21RET-IN-26
RET-IN-26 (compound D5) is a kinase inhibitor that selectively targets the RET protein with an IC50 value of 0.33 μM [1].Couleur et forme :Odour SolidApoptosis inducer 24
CAS :Apoptosisinducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with an IC50 range of 1.2-4.8 μM. It arrests the cell cycle at the G2/M phase, induces apoptosis in BGC-823 cells, and causes mitochondrial dysfunction. In mice, Apoptosisinducer 24 exhibits antitumor activity without significant toxicity, having an LD50 of 91.2 mg/kg.Formule :C55H70BNO9Couleur et forme :SolidMasse moléculaire :899.96EGCG-4″-sulfate
CAS :EGCG-4″-sulfate, a predominant polyphenol in green tea, demonstrates notable anticancer, antioxidant, and anti-inflammatory effects, particularly againstFormule :C22H18O14SCouleur et forme :SolidMasse moléculaire :538.43Osajin
CAS :Osajin is the major bioactive iso avone present in the fruit of Maclura pomifera. It has antitumor, antioxidant, and anti-inflammatory activities.Formule :C25H24O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.46DB0614
CAS :DB0614 degrades 26 kinases including AAK1 and CDK6, targeting aberrant activity in disease research.Formule :C41H42N8O7S2Couleur et forme :SolidMasse moléculaire :822.95SB-1295
SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 μM, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells.Formule :C23H22ClNO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.88Thalidomide-O-C7-acid
CAS :Thalidomide-O-C7-acid: A cereblon ligand from Thalidomide linked via a PROTAC-used linker.Formule :C21H24N2O7Couleur et forme :SolidMasse moléculaire :416.43
