Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(138 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(94 produits)
- c-RET(61 produits)
- p53(63 produits)
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6231 produits trouvés pour "Apoptose"
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STAT3-D11-PROTAC-VHL
STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting signal transducer and activator of transcription 3 (STAT3). It demonstrates anti-tumor activity with IC50 values of 1335 nM in HeLa cells and 1973 nM in MCF-7 cells. The compound binds to the DNA binding domain of STAT3, recruits the E3 ligase VHL to form a ternary complex, leading to ubiquitination and subsequent proteasomal degradation of STAT3. Additionally, STAT3-D11-PROTAC-VHL inhibits tumor cell growth, induces cell cycle arrest and apoptosis (apoptosis), and suppresses tumor immune evasion.Couleur et forme :Odour SolidAviculin
CAS :Aviculin, a lignan glycoside, exhibits anticancer properties by inducing apoptosis in breast cancer cells with an IC50 of 75.47 μM.Formule :C26H34O10Couleur et forme :SolidMasse moléculaire :506.54L-threo-PPMP
CAS :L-threo-PPMP blocks GlcT, curbs glycosphingolipid creation, and triggers cell death, showing anti-cancer effects.Formule :C29H50N2O3Couleur et forme :SolidMasse moléculaire :474.73p38-α MAPK-IN-8
p38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. It exhibits cytotoxicity toward various tumor cells, inducing cell cycle arrest and apoptosis, as well as increasing reactive oxygen species (ROS) production and causing mitochondrial membrane potential depolarization. Its antitumor activity may be related to the p38α MAPK pathway, making it a potential candidate for cancer research.Formule :C49H62BrO4PCouleur et forme :SolidMasse moléculaire :825.892(R)-Q-VD-OPh
(R)-Q-VD-OPh is the less active enantiomer of Q-VD-OPha. Q-VD-OPha is an irreversible inhibitor of pan-caspase, with potent antiapoptotic properties.Formule :C26H25F2N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.49Thalidomide-5-NH-PEG2-NH2 hydrochloride
CAS :Thalidomide-5-NH-PEG2-NH2 hydrochloride is a cereblon ligand based on Thalidomide, designed to recruit CRBN proteins. It has the capability to be linked with target protein ligands via a linker, facilitating the formation of PROTAC molecules, such as THAL-SNS-032.Formule :C19H25ClN4O6Couleur et forme :SolidMasse moléculaire :440.88NA-Ir
CAS :NA-Ir is a ferroptosis (Ferroptosis) inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to stimulate ferritin autophagy (). It also induces the production of reactive oxygen species (ROS) through photodynamic therapy (PDT), depletes glutathione (GSH), and downregulates glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and ferroptosis. NA-Ir exhibits enhanced anticancer activity under light exposure and selectively inhibits cancer cells with high H2S content.Formule :C49H36F6IrN8O4PCouleur et forme :SolidMasse moléculaire :1138.04KB02-SLF
KB02-SLF, a molecular glue, degrades nuclear FKBP12 by modifying E3 ligase DCAF16 and extends protein degradation.Formule :C50H65ClN4O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :949.52Fosbretabulin [free base]
CAS :Fosbretabulin is a natural cis-stilbene that interferes with cellular tubulin dynamics and selectively destroys tumor blood vessels.
Formule :C18H21O8PCouleur et forme :SolidMasse moléculaire :396.33ZC0109
ZC0109 inhibits IDO1 (50 nM) & TrxR1 (3.0 μM), induces ROS, arrests G1/S phase, causing cancer cell apoptosis.Formule :C22H20BrFN8O4SCouleur et forme :SolidMasse moléculaire :591.41Photosensitizer-6
CAS :Photosensitizer-6 (Compound 4) is a metal ion complex that inhibits TrxR. It induces apoptosis in 4T1 cells, targeting cancer cells and eliminating tumors through chemophototherapy and immunogenic cell death under illumination. Additionally, Photosensitizer-6 can be utilized for tumor imaging.Formule :C47H35AuF6N4P2SCouleur et forme :SolidMasse moléculaire :1060.78GB-223
GB-223 is a human monoclonal antibody (mAb) that targets TNFSF11/RANKL/CD254. It is applicable in the study of giant cell tumors of bone and postmenopausal osteoporosis.Couleur et forme :Odour LiquidDesmethyl-WEHI-345 analog
CAS :Desmethyl-WEHI-345 analog, a protein kinase inhibitor, holds potential for colon cancer research.Formule :C22H23N7OCouleur et forme :SolidMasse moléculaire :401.474ZS3-046
ZS3-046 is a TAF1 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of TAF1. It can activate p53 and induce apoptosis in acute myeloid leukemia (AML) cells. Additionally, ZS3-046 demonstrates anti-tumor efficacy in AML xenograft mouse models.Formule :C49H57N9O7Couleur et forme :SolidMasse moléculaire :883.4381MI-1061 TFA
CAS :MI-1061 TFA: potent MDM2 inhibitor, orally bioavailable, stable (IC50=4.4 nM, Ki=0.16 nM), activates p53, induces apoptosis in mice tumors.Formule :C32H27Cl2F4N3O6Couleur et forme :SolidMasse moléculaire :696.47Baminercept
CAS :Baminercept (BG 9924) is a lymphotoxin-β receptor-immunoglobulin fusion protein that blocks the lymphotoxin-letter/LIGHT axis.Degré de pureté :95% (SDS-PAGE); 98.3% (SEC-HPLC) - 95% (SDS-PAGE); 98.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :46.88 kDaRSM3 TFA
RSM3 TFA is a stapled peptide and an inhibitor of METTL3-METTL14, exhibiting a dissociation constant (Kd) of 3.10 μM. It inhibits tumor growth and induces cell apoptosis. RSM3 TFA is utilized in cancer research.Couleur et forme :Odour SolidOs30
Os30 is a potent fourth-generation EGFR inhibitor, specifically targeting the EGFRC797S-TK mutation with IC50 values of 18 nM for EGFRDel19/T790M/C797S TK andDegré de pureté :98%Couleur et forme :Odour Solidβ-Amyloid (1-40) (rat)
CAS :Rat form of the beta-Amyloid (1-40) peptideFormule :C190H291N51O57SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :4233.76PARP1-IN-15
PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis.Formule :C16H12N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :264.28
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