Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(127 produits)
- FOXO1(3 produits)
- IAP(65 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(126 produits)
- PDK(9 produits)
- PERK(24 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(91 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5622 produits trouvés pour "Apoptose"
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PROTAC XPO1 degrader-1
<p>PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. It exhibits anti-proliferative effects, induces apoptosis, inhibits NF-κB activity, and causes cell cycle arrest at the G1 phase. PROTAC XPO1 degrader-1 is applicable to research on hematological malignancies.</p>Formule :C33H35ClF3N7O7Couleur et forme :SolidMasse moléculaire :734.122Biotin-PEG6-Thalidomide
CAS :<p>Biotin-PEG6-Thalidomide is a PROTAC linker based on PEG.</p>Formule :C37H53N5O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :791.91RET-IN-26
<p>RET-IN-26 (compound D5) is a kinase inhibitor that selectively targets the RET protein with an IC50 value of 0.33 μM [1].</p>Couleur et forme :Odour SolidPamlectabart
<p>Pamlectabart is a humanised antibody targeting TNFRSF17/BCMA, (ADC) Pamlectabart tismanitin multiple myeloma.</p>Degré de pureté :95%Couleur et forme :Odour LiquidSTEP-IN-1
<p>STEP-IN-1 (Compound 14b) is a potent and selective inhibitor of STEP, with an IC50 of 5.27 μM. It offers neuroprotective effects by safeguarding neuronal cells from glutamate-induced toxicity, reducing intracellular reactive oxygen species (ROS) accumulation, and inhibiting apoptosis. STEP-IN-1 is applicable in research related to neurodegenerative diseases.</p>Formule :C21H10ClNO7Couleur et forme :SolidMasse moléculaire :423.76DB0614
CAS :DB0614 degrades 26 kinases including AAK1 and CDK6, targeting aberrant activity in disease research.Formule :C41H42N8O7S2Couleur et forme :SolidMasse moléculaire :822.95XY221
XY221 (Compound 16o) selectively inhibits BRD4 BD2 with an IC50 of 5.8 nM. It demonstrates high selectivity for pan-BD2 and BRD4 BD2 domains, being 667 times more selective than for BRD4 BD1, and 9-32 times more selective than for BRD2/3/T BD2. XY221 can induce apoptosis in MV4-11 cells and exhibits anti-cancer activity.Formule :C32H34FN3O5Couleur et forme :SolidMasse moléculaire :559.628PROTAC ROR1 degrader-1
<p>PROTACROR1degrader-1 (Compound 11d) serves as a PROTAC degrader targeting the pseudokinase ROR1, with the capability of degrading ROR1 in NSCLC cells at a DC50 of 40-80 nM. It induces PARP cleavage and apoptosis in NCI-H23 cells. [Pink: ligand for target protein ROR1 ligand-1; Black: linker; Blue: ligand for VHL E3 ligase (S,R,S)-AHPC]</p>Formule :C55H74BrN11O5SCouleur et forme :SolidMasse moléculaire :1081.22Dual Galectin-3/EGFR-IN-1
<p>Dual Galectin-3/EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.</p>Formule :C32H41N7O10Couleur et forme :SolidMasse moléculaire :683.709Chaetoglobosin A
CAS :Chaetoglobosin A, the active compound extracted of Penicillium aquamarinium, is a member of the cytochalasan family. It preferentially induces apoptosis.Formule :C32H36N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.649Waltonitone
CAS :<p>Waltonitone is a natural ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill.</p>Formule :C30H48O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.7Ferroptosis-IN-13
<p>Ferroptosis-IN-13 (compound NY-26) is an inhibitor of ferroptosis. It effectively suppresses RSL3-induced ferroptosis in 786-O cells, with an EC50 value of 62 nM.</p>Formule :C32H30F2N4O3Couleur et forme :SolidMasse moléculaire :556.602STAT3-IN-40
CAS :<p>STAT3-IN-40 (Compound 8b) is an anticancer agent. It initiates immune responses in CD4+ and CD8+ T lymphocytes by inhibiting the expression and phosphorylation of STAT3, and induces ferroptosis and apoptosis in tumor cells. STAT3-IN-40 is valuable for research into cancer chemoimmunotherapy drugs.</p>Formule :C34H40ClN3O10PtCouleur et forme :SolidMasse moléculaire :881.232WAY-118959-A
CAS :<p>WAY-118959-A is a potential microtubule acetylation inhibitor.</p>Formule :C16H14N4OS2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :342.44Sorafenib-d4
CAS :<p>Sorafenib D4 is deuterium-labeled Sorafenib, a multi-kinase inhibitor (Raf-1, B-Raf, VEGFR-3) with IC50s: 6, 20, 22 nM.</p>Formule :C21H16ClF3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.85Thalidomide-PEG2-NH2
CAS :<p>Thalidomide-PEG2-NH2: synthetic E3 ligase ligand-linker, combines Thalidomide-based cereblon and PROTAC linker.</p>Formule :C17H19N3O6Couleur et forme :SolidMasse moléculaire :361.354MTX-23
CAS :MTX-23, an AR-targeted Proteolysis Targeting Chimera (PROTAC), effectively degrades both AR-V7 and AR-FL, inhibiting the proliferation of CaP cells and inducingFormule :C43H53F2N7O7S2Couleur et forme :SolidMasse moléculaire :882.05Cholesteryl Hemisuccinate Tris Salt
CAS :<p>Cholesteryl Hemisuccinate Tris Salt is a cholesteryl ester with anticancer activity.Cholesteryl hemisuccinate has antitumor activity and inhibits tumor growth.</p>Formule :C35H61NO7Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :607.86HX009
HX009 is a bispecific antibody that targets PD1 and CD47, though its binding to CD47 is attenuated. HX009 functions by blocking PD1/CD47 and can be utilized in research related to non-Hodgkin lymphoma (NHL).Couleur et forme :Odour LiquidDiethylnorspermine HCl
CAS :Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) potently induces SSAT (spermidine/spermine N1-acetyltransferase) mRNA and effectivelyFormule :C13H36Cl4N4Degré de pureté :99.79% - 99.86%Couleur et forme :SolidMasse moléculaire :390.26
