Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(8 produits)
- Caspase(145 produits)
- FOXO1(3 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(139 produits)
- PDK(9 produits)
- PERK(26 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(92 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6093 produits trouvés pour "Apoptose"
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MLKL-IN-6
<p>MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.</p>Formule :C20H18N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.386:2 Cl-PFAES
CAS :6:2 Cl-PFAES exhibits reproductive toxicity by elevating the levels of serum estradiol and vitellogenin in adult males, which can harm the embryonic development of offspring.Formule :C8ClF16KO4SCouleur et forme :SolidMasse moléculaire :570.67PARP10/15-IN-3
Compound 8a, a dual PARP10 & PARP15 inhibitor, has IC50s: PARP10 at 0.14μM & PARP15 at 0.40μM; it's cell-permeable & anti-apoptotic.Formule :C12H12N2O3Couleur et forme :SolidMasse moléculaire :232.24Tubulin inhibitor 14
Tubulin inhibitor 14 blocks NQO2 and microtubule formation, disrupts blood vessels, and may target tumors; IC50 of 1.0 μM.Formule :C15H9F2NOCouleur et forme :SolidMasse moléculaire :257.23UCN-01
CAS :inhibitor of Akt, protein kinase C, PDK1 and cyclin-dependent kinasesFormule :C28H26N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :482.53Minnelide free acid
CAS :Minnelide treats pancreatic cancer, hinders androgen-related prostate growth, shrinks tumors, and improves survival.Formule :C21H27O10PCouleur et forme :SolidMasse moléculaire :470.41Anti-inflammatory agent 16
Compound 14 is a peptidomimetic that significantly lowers TNFα, NO, CD40, and CD86, showcasing strong anti-inflammatory effects.Formule :C21H23N5O3Couleur et forme :SolidMasse moléculaire :393.44RIPK1-IN-19
CAS :RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.Formule :C28H25FN6O2Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :496.54Multi-kinase-IN-1
CAS :Multi-kinase-IN-1, a powerful kinase inhibitor, exhibits antitumor properties by inducing cell apoptosis.Formule :C35H36F2N6O6SCouleur et forme :SolidMasse moléculaire :706.76TLBC
CAS :TLBC, a borane-chalcone derivative, exhibits dose-dependent inhibitory effects across various glioma cell lines with IC50 values ranging from 5.5 to 25.5 μM. TLBC induces apoptosis independently of alterations in the tumor suppressor factor p53.Formule :C15H12BIO3Couleur et forme :SolidMasse moléculaire :377.97hCAIX/XII-IN-5
Coumarin 9a: Selective inhibitor of hCA IX/XII (Ki 93.3/85.7 nM), blocks cancer cell growth, and induces apoptosis.Formule :C18H13NO3Couleur et forme :SolidMasse moléculaire :291.3RIPK3-IN-6
CAS :RIPK3-IN-6 (compound 1) is a type I RIPK3 inhibitor with low selectivity within the RIPK family, particularly in relation to RIPK2 activity.Formule :C21H17N3OCouleur et forme :SolidMasse moléculaire :327.38Pan-Trk-IN-3
Pan-Trk-IN-3: potent Trk inhibitor (IC50: 2-26 nM), effective against drug-resistant mutants, induces apoptosis, anti-tumor effects.Formule :C29H31ClN8O3Couleur et forme :SolidMasse moléculaire :575.06Tubulin/NRP1-IN-1
CAS :Tubulin/NRP1-IN-1 (compound TN-2) serves as a dual inhibitor targeting both Tubulin and NRP1, exhibiting IC50 values of 0.71 μM and 0.85 μM, respectively. This compound notably reduces the viability of prostate tumor cell lines and triggers apoptosis [1].Formule :C28H37N5O8Couleur et forme :SolidMasse moléculaire :571.62HDAC1-IN-5
HDAC1-IN-5 inhibits HDAC1 (IC50=15 nM) & HDAC6 (IC50=20 nM), promotes apoptosis, damages chromatin, and reduces tumor growth in mice.Formule :C20H21N3O2SCouleur et forme :SolidMasse moléculaire :367.46Bcl-2-IN-6
Bcl-2-IN-6 suppresses Bcl-2, upregulates p53/Bax/caspase-7, arrests cell cycle, and induces MCF-7 apoptosis; IC50s: MCF-7 20.91 μM, others <48 μM.Formule :C25H24N4O5S2Couleur et forme :SolidMasse moléculaire :524.61Murizatoclax
CAS :AMG 397 is an oral MCL1 inhibitor .Formule :C42H57ClN4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :765.44Anticancer agent 16
Anticancer agent 16 showed good cytotoxic effects on HCT-116 cell line (IC50: 8.55 μM), NCI-H460 cell line (IC50: 5.41 μM) and SKOV3 cell line (IC50: 6.4 μM).Formule :C27H33N5O6Couleur et forme :SolidMasse moléculaire :523.58TMC353121
CAS :TMC353121 is an effective inhibitor of respiratory syncytial virus fusion (pEC50: 9.9).Formule :C32H42N6O3Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :558.71KIRA9
KIRA9 inhibits IRE1 with a 4.8 μM IC50, blocking ER-stress-induced mRNA decay and apoptosis by fully binding IRE1's ATP site.Formule :C27H27F3N6O3SCouleur et forme :SolidMasse moléculaire :572.6CK156
CAS :CK156 inhibits DAPK with high selectivity; IC50: 182 nM (DRAK1), 34 μM (CK2a1), 39 μM (CK2a2); key in autoimmune/inflammation research.Formule :C21H25N5O3Couleur et forme :SolidMasse moléculaire :395.45Antiproliferative agent-63
CAS :Antiproliferative agent-63 (compound 4d) is a cyclic analog of cannabidiol that acts as an anticancer agent. It demonstrates favorable activity against breast and colorectal cancer. Moreover, this compound can arrest the cell cycle in the G1 phase and induce apoptosis through the mitochondrial pathway in breast cancer cell lines.Formule :C27H41NO2Couleur et forme :SolidMasse moléculaire :411.62FKBP51-Hsp90-IN-2
CAS :FKBP51-Hsp90-IN-2 (Compound E08) functions as a selective inhibitor for the FKBP51 - Hsp90 protein-protein interaction, exhibiting IC 50 values of 0.4 µM for FKBP51 and 5 µM for FKBP52. Beyond its inhibitory actions, FKBP51-Hsp90-IN-2 enhances cellular energy metabolism and promotes neurite growth. This compound is utilized in the study of neurodegenerative diseases and cancer [1].Formule :C25H27N3O2SMasse moléculaire :433.57MA242 free base
CAS :MA242 free base is a dual MDM2/NFAT1 inhibitor that triggers apoptosis in pancreatic cancer cells.Formule :C24H20ClN3O3SCouleur et forme :SolidMasse moléculaire :465.95Antibacterial agent 254
CAS :Antibacterialagent 254 (Compound 2) is an antimicrobial agent capable of eradicating 7-day-old P. aeruginosa biofilms at a concentration of 50 μM without affecting bacterial growth. Additionally, Antibacterialagent 254 enhances the efficacy of Ciprofloxacin against P. aeruginosa and upregulates the expression of the matrix-degrading enzyme genes pelA, pslG, and eddA.Formule :C13H15NO4Masse moléculaire :249.26GIC-20
CAS :GIC-20, a dual inducer of apoptosis and ferroptosis, exhibits antitumor efficacy against fibrosarcoma [1].Formule :C38H37ClN4O5SCouleur et forme :SolidMasse moléculaire :697.24Fosizensertib
CAS :Fosizensertib is an inhibitor of RIP-1 kinase and is used in research related to ulcerative colitis.Formule :C22H21F2N4O5PCouleur et forme :SolidMasse moléculaire :490.397Fluvastatin sodium monohydrate
CAS :Fluvastatin (XU 62-320) sodium monohydrate, a fully synthetic competitive HMG-CoA reductase inhibitor, features an IC 50 of 8 nM. This compound also safeguards vascular smooth muscle cells from oxidative stress via the Nrf2-dependent antioxidant pathway [1] [2].Formule :C24H27FNNaO5Couleur et forme :SolidMasse moléculaire :451.46c-Met/HDAC-IN-2
CAS :Potent dual c-Met/HDAC inhibitor, IC50: HDAC1 5.4 nM, c-Met 18.49 nM; anti-cancer, induces apoptosis, G2/M arrest in HCT-116.Formule :C34H33N5O7Couleur et forme :SolidMasse moléculaire :623.66CDK-IN-9
CDK-IN-9: A potent CDK inhibitor, gels to enhance CDK12/DDB1 binding, targets CDK2/E (IC50: 4 nM), induces apoptosis via dephosphorylation.Formule :C21H24N8SCouleur et forme :SolidMasse moléculaire :420.53Antitumor agent-100
CAS :Antitumor Agent-100 (compound A6) is a molecular gel and apoptosis inducer targeting PDE3A-SLFN12 with an IC50 of 0.3 μM, demonstrating potent antitumor activity. This orally available agent binds to the PDE3A enzyme pocket, recruiting and stabilizing SLFN12 which disrupts protein translation and induces apoptosis [1].Formule :C17H14ClN3OCouleur et forme :SolidMasse moléculaire :311.77Aeroplysinin 1
CAS :Aeroplysinin I is an antibacterial compound from the sponge. It has cytotoxic activity against colon cancer cells by promoting β-catenin degradation.Formule :C9H9Br2NO3Couleur et forme :SolidMasse moléculaire :338.98D18
CAS :D18: Dual agonist for TLR7/8, boosts PD-L1, aids tumor sensitivity to PD-1/PD-L1 inhibitors, and is a cytotoxin for ADC HE-S2.Formule :C21H28N6Couleur et forme :SolidMasse moléculaire :364.49HDAC-IN-37
HDAC-IN-37 inhibits HDACs 1, 3, 8, & 6, induces histone acetylation, halts G1 to S phase, and triggers early apoptosis.Formule :C23H24ClN7OCouleur et forme :SolidMasse moléculaire :449.94Soquelitinib
CAS :Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.Formule :C25H30N4O4S2Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :514.66Ref: TM-T87429
1mg170,00€5mg411,00€10mg677,00€25mg1.349,00€50mg2.023,00€100mg2.745,00€200mg3.695,00€1mL*10mM (DMSO)465,00€PF-07328948
CAS :PF-07328948 is a branched-chain keto-acid dehydrogenase kinase (BDK) inhibitor, useful for studying CVD metabolic disorders.Formule :C16H8F4O3SDegré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :356.29Milademetan
CAS :Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.Formule :C30H34Cl2FN5O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :618.53Ref: TM-T12040
1mg87,00€5mg170,00€10mg274,00€25mg518,00€50mg847,00€100mg1.454,00€1mL*10mM (DMSO)234,00€Zharp1-211
CAS :Zharp1-211 is a RIPK3 inhibitor，reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.Formule :C24H25N5O4Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :447.49Ref: TM-T87664
1mg87,00€5mg183,00€10mg283,00€25mg562,00€50mg873,00€100mg1.311,00€200mg1.768,00€1mL*10mM (DMSO)202,00€UH15-38
CAS :UH15-38 is a potent and selective RIPK3 inhibitor that blocks necroptosis in alveolar epithelial cells triggered by IAV, useful for studying lung inflammation.Formule :C26H27N5O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :441.53HC-5404
CAS :HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Formule :C24H24F2N4O3Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :454.47SY-5609
CAS :SY-5609 (CDK7-IN-3) is a selective non-covalent CDK7 inhibitor, with weak inhibitory activity against CDK2, CDK9 and CDK12.Cost-effective and quality-assured.Formule :C23H26F3N6OPDegré de pureté :99.34% - >99.99%Couleur et forme :SolidMasse moléculaire :490.46Ref: TM-T36038
1mg139,00€2mg200,00€5mg343,00€10mg553,00€25mgÀ demander50mgÀ demander1mL*10mM (DMSO)373,00€Darizmetinib
CAS :Darizmetinib (HRX215) is an MKK4 inhibitor.Formule :C21H17F2N5O3SDegré de pureté :98.03% - 99.57%Couleur et forme :SolidMasse moléculaire :457.45Ref: TM-T72956
1mg72,00€2mgÀ demander5mg156,00€10mg235,00€25mg343,00€50mg423,00€100mg620,00€1mL*10mM (DMSO)157,00€Lometrexol
CAS :<p>Lometrexol (LY 264618) is an antifolate that inhibits GARFT, blocks purine synthesis, induces apoptosis, and has anticancer properties.</p>Formule :C21H25N5O6Degré de pureté :97.76% - 99.56%Couleur et forme :SolidMasse moléculaire :443.45Nalmefene
CAS :Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study of opioid overdose and alcohol dependence.Formule :C21H25NO3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :339.43Tuvusertib
CAS :Tuvusertib (M1774), an oral ATR inhibitor (Ki<1µM), selectively blocks CHK1 phosphorylation, disrupts DNA repair, and induces tumor cell apoptosis.Formule :C16H12F2N8ODegré de pureté :98.44% - 99.66%Couleur et forme :SolidMasse moléculaire :370.32Ref: TM-T10406
1mg62,00€5mg131,00€10mg197,00€25mg383,00€50mg533,00€100mg757,00€1mL*10mM (DMSO)150,00€Vatalanib hydrochloride
CAS :Vatalanib hydrochloride (PTK787 hydrochloride) is an orally available and highly potent tyrosine kinase (VEGF) inhibitor that reduces the number and size of Aβ plaques in the cortex of 5xFAD mice, which may be useful in the study of Alzheimer's disease and cancer.Formule :C20H16Cl2N4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :383.27BCL6-IN-3
CAS :BCL6-IN-3: potent BCL6 inhibitor, 70 nM GI50 in SU-DHL4, affects cell functions, antitumor.Formule :C24H31ClF2N6O2Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :508.99Ref: TM-T10487
1mg109,00€5mg241,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€500mgÀ demander1mL*10mM (DMSO)370,00€Zotatifin
CAS :Zotatifin (eFT226) is a selective eIF4A inhibitor with antiviral and antitumor properties, inhibiting Sox4 translation and inducing apoptosis.Formule :C28H29N3O5Degré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :487.55Enbezotinib
CAS :Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.Formule :C21H21FN6O3Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :424.43Ref: TM-T62285
1mg77,00€5mg166,00€10mg253,00€25mg414,00€50mg567,00€100mg745,00€1mL*10mM (DMSO)182,00€Gemcitabine elaidate hydrochloride
CAS :<p>CP-4126, a lipophilic pro-drug of Gemcitabine, converts to active form by esterases, allowing oral administration with dose-dependent effects.</p>Formule :C27H44ClF2N3O5Degré de pureté :98.50% - 99.6%Couleur et forme :SolidMasse moléculaire :564.11JAK2-IN-7
CAS :JAK2-IN-7 selectively inhibits JAK2 (IC50: 3 nM), shows 14-fold selectivity over JAK1/3, FLT3, induces G0/G1 arrest, apoptosis, and has antitumor effects.Formule :C26H33N7ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :459.59Ref: TM-T35900
1mg145,00€5mg354,00€10mg630,00€25mg1.301,00€50mg1.738,00€100mg2.357,00€1mL*10mM (DMSO)358,00€FX-11
CAS :<p>FX-11: potent LDHA inhibitor (Ki 8 μM), activates PKM2, reduces ATP, induces oxidative stress/ROS, cell death, shows antitumor effects.</p>Formule :C22H22O4Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :350.41(R)-Verapamil hydrochloride
CAS :(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is an inhibitor of P-Glycoprotein.Formule :C27H39ClN2O4Couleur et forme :SolidMasse moléculaire :491.06OBAA
CAS :OBAA is a potent inhibitor of phospholipase A2 (PLA2) with an IC 50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC 50 of 0.4 μM [1] [2] [3].Formule :C28H44O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.65PIM-447 dihydrochloride
CAS :PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively).Formule :C24H25Cl2F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.38β-Zearalanol
CAS :Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].Formule :C18H26O5Couleur et forme :SolidMasse moléculaire :322.4AP1867-3-(aminoethoxy)
CAS :AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.Formule :C38H50N2O9Couleur et forme :SolidMasse moléculaire :678.81WEHI-539 hydrochloride
CAS :WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.Formule :C31H30ClN5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :620.18PRGL493
CAS :PRGL493 blocks ACSL4, halts PC3/MDA-MB-231 cancer cell spread, and inhibits MA-10 tumor progesterone. Effective in mouse PC3 tumor model at 0.25 mg/kg.Formule :C25H21N7O2Degré de pureté :98.80% - 99.11%Couleur et forme :SolidMasse moléculaire :451.48Platinum, diammine[1,1-cyclobutanedi(carboxylato-kO)(2-)]-, (SP-4-2)-
CAS :Formule :C6H10N2O4PtDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.23265-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
CAS :Formule :C9H14N4O5Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :258.2313Thalidomide-O-C6-COOH
CAS :Thalidomide-O-C6-COOH is a synthetic conjugate that combines a Thalidomide-derived cereblon ligand with a PROTAC technology linker (E3 ligase ligand-linker).Formule :C20H22N2O7Couleur et forme :SolidMasse moléculaire :402.403A-192621
CAS :A-192621 is a potent, nonpeptide, orally active, and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and elevates both arterial blood pressure and plasma ET-1 levels[1][2][3]. Its selectivity is 636-fold higher for ETB than ETA (IC50 of 4280 nM and Ki of 5600 nM).Formule :C33H38N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.66Prostaglandin A2
CAS :PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]Formule :C20H30O4Couleur et forme :SolidMasse moléculaire :334.45Yatein
CAS :Yatein inhibits herpes simplex virus type 1 replication by interruption the immediate-early gene expression. Yatein is a lignan isolated from A. chilensis. It also has antiproliferative activity.Formule :C22H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.42Thalidomide-5-COOH
CAS :Thalidomide-5-COOH is a useful organic compound for research related to life sciences. The catalog number is T64600 and the CAS number is 1216805-11-6.Formule :C14H10N2O6Couleur et forme :SolidMasse moléculaire :302.242Imifoplatin
CAS :Imifoplatin (PT-112) is a platinum compound with antitumor activity and may be used to study prostate cancer and immune system disorders.Formule :C6H16N2O7P2PtDegré de pureté :≥95.0%Couleur et forme :SolidMasse moléculaire :485.23Ciprofloxacin lactate
CAS :Ciprofloxacin lactate is a useful organic compound for research related to life sciences. The catalog number is T66299 and the CAS number is 97867-33-9.Formule :C20H24FN3O6Couleur et forme :SolidMasse moléculaire :421.43SCH79797
CAS :SCH79797 is a potent and specific protease-activated receptor 1 (PAR1) antagonistwith antimicrobial, anticancer, anti-inflammatory, and neuroprotective effects.Formule :C23H25N5Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :371.48Carubicin hydrochloride
CAS :Carubicin HCl is an anthracycline antineoplastic antibiotic. Through intercalates into DNA and interacts with topoisomerase II, Carubicin inhibits DNA replication and repair and RNA and protein synthesis.Formule :C26H28ClNO10Couleur et forme :SolidMasse moléculaire :549.95MI-773
CAS :MI-773 is a potent inhibitor of the MDM2-p53 protein interaction (PPI) with a high affinity for MDM2 and a Kd value of 8.2 nM. MI-773 exhibits antitumour effects.Formule :C29H34Cl2FN3O3Couleur et forme :SolidMasse moléculaire :562.5Thalidomide-O-C5-NH2 hydrochloride
CAS :Thalidomide-O-C5-NH2 hydrochloride is a synthetic compound consisting of a ligand-linker conjugate with E3 ligase activity. It combines a cereblon ligand based on Thalidomide and a linker commonly utilized in PROTAC technology.Formule :C18H22ClN3O5Couleur et forme :SolidMasse moléculaire :395.84DB818
CAS :DB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression.Formule :C19H16N6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.44Ingenol 3,20-dibenzoate
CAS :Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms that effectively induces the translocation of nPKC-delta, -epsilon, and -theta, as well as PKC-mu, from the cytosolic fraction to the particulate fraction. Through de novo synthesis of macromolecules, it triggers apoptosis with characteristic morphology. Moreover, Ingenol 3,20-dibenzoate enhances IFN-γ production and degranulation in NK cells, particularly when stimulated by NSCLC cells[1][2].Formule :C34H36O7Couleur et forme :SolidMasse moléculaire :556.65Swainsonine
CAS :Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arrest in the G2/M phase.Formule :C8H15NO3Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :173.21Vatiquinone
CAS :Vatiquinone, also known as EPI 743, is an orally bioavailable para-benzoquinone being developed for inherited mitochondrial diseases. The mechanism of action of EPI-743 involves augmenting the synthesis of glutathione, optimizing metabolic control, enhancFormule :C29H44O3Couleur et forme :SolidMasse moléculaire :440.66Thalidomide-O-amido-C4-NH2 hydrochloride
CAS :Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon ligand derived from Thalidomide with a linker and is commonly used in the synthesis of PROTACs[1].Formule :C19H23ClN4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.86BPH-675
CAS :BPH-675 is a bioactive chemical.Formule :C24H23NO9P2SCouleur et forme :SolidMasse moléculaire :563.45RRD-251
CAS :RRD-251 is an Rb-Raf-1 interaction inhibitor that induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine[1].Formule :C8H9Cl3N2SCouleur et forme :SolidMasse moléculaire :271.59XMU-MP-3
CAS :XMU-MP-3 is a robust, non-covalent inhibitor of BTK, exhibiting exceptional potency with IC50 values of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation, respectively, in the presence of 10 μM ATP. Moreover, XMU-MP-3 elicits apoptosis.Formule :C27H27F3N8OCouleur et forme :SolidMasse moléculaire :536.563Ac-IETD-CHO TFA
Ac-IETD-CHO TFA is a granzyme B and caspase-8 inhibitor that inhibits caspase8 activity by blocking caspase3 precursor cleavage.Ac-IETD-CHO TFA inhibits Fas-mediated apoptosis.Formule :C23H35F3N4O12Couleur et forme :SoildMasse moléculaire :616.54Dihydroartemisinin (mixture of α and β isomers)
CAS :Dihydroartemisinin (mixture of α and β isomers) is a useful organic compound for research related to life sciences. The catalog number is T64399 and the CAS number is 131175-87-6.Formule :C15H24O5Couleur et forme :SolidMasse moléculaire :284.352ENMD-2076 tartrate
CAS :ENMD-2076 is an orally active kinase inhibitor. It also has antiangiogenic and antiproliferative mechanisms of action.Formule :C25H31N7O6Couleur et forme :SolidMasse moléculaire :525.56Mcl-1 inhibitor 6
CAS :Mcl-1 inhibitor 6 binds Mcl-1 with KD 0.23 nM and Ki 0.02 μM, shows strong selectivity over Bcl-2 family, and demonstrates antitumor efficacy.Formule :C26H28ClNO6SCouleur et forme :SolidMasse moléculaire :518.02CTB
CAS :<p>CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.</p>Formule :C16H13ClF3NO2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :343.73Faradiol 3-Myristate
CAS :Produit contrôléFormule :C44H76O3Couleur et forme :NeatMasse moléculaire :653.072anti-TNBC agent-2
CAS :<p>Anti-TNBC agent-2 (3j), a purine derivative, acts as an anti-triple negative breast cancer (TNBC) therapeutic.</p>Formule :C28H37ClFN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :542.09Cyy-272
CAS :<p>Cyy-272 is an orally active JNK inhibitor with IC50 values of 1.25, 1.07, and 1.24 μM against JNK1, JNK2, and JNK3, respectively. It exerts anti-inflammatory effects by inhibiting the phosphorylation of JNK, thereby alleviating acute lung injury (ALI) induced by lipopolysaccharide (LPS). Moreover, Cyy-272 significantly reduces inflammation in cardiomyocytes and cardiac tissues caused by high lipid concentrations, further mitigating resultant cardiac hypertrophy, fibrosis, and apoptosis. Cyy-272 is utilized in the study of obesity-related myocarditis.</p>Formule :C23H23F2N7Couleur et forme :SolidMasse moléculaire :435.47DETD-35
CAS :<p>DETD-35 is a promising chemical compound in anti-melanoma therapy, functioning as an inhibitor of the MEK-ERK, Akt, and STAT3 signaling pathways. It enhances cancer cell apoptosis (Apoptosis) and diminishes resistance to Vemurafenib in cancer cells. The compound exhibits IC 50 values of 2.7, 6.0, 3.9, 3.1, and 2.5 μM against melanoma cell lines B16-F10, MeWo, SK-MEL-2, A2058c, and A375c, respectively. DETD-35 offers significant potential for advancing research in melanoma treatment strategies.</p>Formule :C27H24O6Couleur et forme :SolidMasse moléculaire :444.48IHMT-MST1-39
CAS :<p>IHMT-MST1-39 is an orally effective MST kinase inhibitor with IC50 values of 42 nM for MST1 and 109 nM for MST2. It activates the AMPK signaling pathway in hepatocytes and inhibits apoptosis in pancreatic β cells. Additionally, IHMT-MST1-39 improves type 1 diabetes in mice induced by Streptozotocin.</p>Formule :C20H18F2N6O3SCouleur et forme :SolidMasse moléculaire :460.46ZSQ836
CAS :<p>ZSQ836 is a dual covalent inhibitor of CDK12/CDK13 with oral bioactivity, displaying an EC50 value of 32 nM against CDK12. This compound can induce cell apoptosis (apoptosis) and demonstrates in vivo anticancer properties. ZSQ836 is applicable for research in ovarian cancer.</p>Formule :C27H28AsClN6OS2Couleur et forme :SolidMasse moléculaire :627.05SMIP34
CAS :<p>SMIP34 is an inhibitor of PELP1 that demonstrates the capability to reduce cell viability and colony formation. Additionally, SMIP34 induces cell apoptosis (apoptosis) and causes cell cycle arrest in the S phase. It reduces the expression of PELP1 and exhibits anti-tumor activity. SMIP34 also has potential for research in triple-negative breast cancer (TNBC).</p>Formule :C20H15ClFN5O2SCouleur et forme :LiquidMasse moléculaire :443.88CHMFL-48
CAS :<p>CHMFL-48, an orally active inhibitor of BCR-ABL kinase, demonstrates efficacy against both the wild-type (wt) and various imatinib-resistant mutants. It exhibits potent inhibitory activity, with IC 50 values of 1 nM for the ABL wild-type and 0.8 nM for the ABL T315I mutant. CHMFL-48 operates by inhibiting the autophosphorylation of both wild-type and mutant BCR-ABL, affecting downstream signaling mediators including STAT5 and CRKL. This disruption leads to cell cycle arrest and triggers apoptosis. Given its properties, CHMFL-48 is a promising candidate for research on chronic myeloid leukemia (CML).</p>Formule :C31H30F3N7OCouleur et forme :SolidMasse moléculaire :573.61
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