Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(7 produits)
- Caspase(147 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(137 produits)
- PDK(9 produits)
- PERK(26 produits)
- Sérine/thréonine kinase(19 produits)
- Survivant(14 produits)
- TNF(91 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6123 produits trouvés pour "Apoptose"
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(2R,3S)-Emricasan
CAS :(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.Formule :C26H27F4N3O7Couleur et forme :SolidMasse moléculaire :569.5Isoforretin A
CAS :Isoforretin A is a potent inhibitor of thioredoxin-1 (Trx1) with significant biological activity, inducing anti-tumor effects mediated by reactive oxygen species (ROS). The compound inhibits Trx1 activity by covalently binding to the activation site residues Cys32/Cys35, which triggers ROS accumulation, leading to DNA damage and apoptosis (Apoptosis) in cancer cells. Additionally, Isoforretin A has demonstrated the ability to suppress the growth of HepG2 tumors in a mouse hepatic cell carcinoma xenograft model.Formule :C28H38O10Couleur et forme :SolidMasse moléculaire :534.6SC428
CAS :SC428 acts as an inhibitor of the androgen receptor (AR), specifically targeting the N-terminal domain of AR. This compound effectively diminishes the transactivation of various AR forms, including AR-V7, ARv567es, full-length AR (AR-FL), and its LBD mutants. Additionally, SC428 significantly inhibits AR-FL nuclear translocation, chromatin binding, and AR-regulated gene transcription under androgen stimulation. In vitro, SC428 suppresses the proliferation of tumor cells. In vivo, it inhibits tumor growth in mice transplanted with 22Rv1 cells by inducing apoptosis.Formule :C15H10F3N3OSCouleur et forme :SolidMasse moléculaire :337.32NSD2-IN-1
CAS :NSD2-IN-1: potent, selective NSD2-PWWP1 inhibitor, IC50 0.11 μM, induces gene expression changes, apoptosis, cell cycle arrest.Formule :C29H31N5Couleur et forme :SolidMasse moléculaire :449.59PD-1/PD-L1-IN-17
PD-1/PD-L1-IN-17 (Compound P20) is a potent PD-1/PD-L1 inhibitor (IC50: 26.8 nM).
Formule :C23H20ClN3O4Couleur et forme :SolidMasse moléculaire :437.88Pim-1 kinase inhibitor 10
CAS :Pim-1 Kinase Inhibitor 10 (compound 13a) acts as both a competitive and non-competitive inhibitor of PIM-1/2 kinase, promoting cell apoptosis and displaying anticancer properties. Additionally, this compound triggers the activation of caspase 3/7 [1].Formule :C21H13N3O3Couleur et forme :SolidMasse moléculaire :355.35L5-DA
L5-DA, a G-quadruplex ligand, stabilizes G4s in HeLa cells, induces apoptosis, and is cytotoxic with an IC50 of 4.3 μM.Formule :C32H34N6O2Couleur et forme :SolidMasse moléculaire :534.65LSD1-IN-21
LSD1-IN-21: potent LSD1 inhibitor, crosses blood-brain barrier, IC50 of 0.956 μM; lowers TNF-α, anti-cancer, anti-inflammatory.Formule :C24H25N5O2SCouleur et forme :SolidMasse moléculaire :447.55EGFR/HER2-IN-6
EGFR/HER2-IN-6 is a dual inhibitor of EGFR, HER2, and DHFR with IC50s: 0.122, 0.078, and 0.585 μM, showing anticancer potential and selectivity.Formule :C18H21N5O3SCouleur et forme :SolidMasse moléculaire :387.46Antitumor agent-72
CAS :Antitumor agent-72 (compound 6w) is a potent anticancer agent that exhibits its anticancer activity by inducing apoptosis via caspase-3 activation and PARPFormule :C25H20ClNO6Couleur et forme :SolidMasse moléculaire :465.88sEH-IN-21
CAS :sEH-IN-21 is an orally active inhibitor of sEH, exhibiting IC50 values of 0.1 nM for both hsEH and msEH. It significantly suppresses the NF-κB signaling pathway. sEH-IN-21 demonstrates potent anti-inflammatory activity by reducing IL-6 and TNF-α release and maintaining intestinal barrier integrity. It is applicable in research on inflammatory bowel disease (IBD).Formule :C30H40N4O5SCouleur et forme :SolidMasse moléculaire :568.73HER2-IN-11
HER2-IN-11 is a psoralen derivative that induces apoptosis. HER2-IN-11 shows light-activated cytotoxicity and also exhibits anti-breast cancer activity [1].Formule :C17H11NO6Couleur et forme :SolidMasse moléculaire :325.27T0080
CAS :T0080 is an FPR-1 antagonist. It reduces apoptosis (Apoptosis) and inhibits the production of reactive oxygen species (ROS) and pro-inflammatory cytokines (TNF-α and IL-1β) in plaque macrophages within ApoE−/− mouse models, thereby slowing the progression of atherosclerosis.Formule :C24H22F3N3O3Couleur et forme :SolidMasse moléculaire :457.45DeFer-2
CAS :DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM). It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.Formule :C44H69N5O5SCouleur et forme :SolidMasse moléculaire :780.11WB436B
CAS :WB436B, a highly selective STAT3 inhibitor, effectively targets and inhibits STAT3-Tyr705 phosphorylation along with the expression of STAT3 target genes. It exhibits cytotoxic effects on pancreatic cancer cells by inducing apoptosis. Furthermore, WB436B suppresses tumor growth and metastasis in pancreatic cancer mouse models, thereby prolonging the survival of tumor-bearing mice.Formule :C21H20N6O3SCouleur et forme :SolidMasse moléculaire :436.49ER covalent antagonist-1
CAS :ER covalent antagonist-1 (Compound 39D) acts as an antagonist of the estrogen receptor α (ERα). This compound inhibits the proliferation of ERα-positive MCF-7 cells with an IC50 of 0.98 μM, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis. Additionally, ER covalent antagonist-1 demonstrates antitumor activity in mouse models.Formule :C33H32N2O5SCouleur et forme :SolidMasse moléculaire :568.683eIF4E-IN-4
CAS :eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.
Formule :C20H19ClN5O5PCouleur et forme :SolidMasse moléculaire :475.822PKM2 modulator 2
CAS :PKM2 modulator 2 (compound C599) is a potent inhibitor of PKM2, displaying antiproliferative activity and inducing apoptosis. This compound holds potential for research in glioblastoma.Formule :C21H13FN4O3Couleur et forme :SolidMasse moléculaire :388.351TNF-α-IN-12
CAS :TNF-α-IN-12, a TNF-α inhibitor with an IC50 of 0.1 μM, can reduce TNF-α blood levels [1].Formule :C21H22O6Couleur et forme :SolidMasse moléculaire :370.4MG28
CAS :MG28 exhibits significant cytotoxic effects, likely stemming from its direct and potent DNA-damaging activity. The compound is utilized in cancer research.Formule :C27H25NO3SCouleur et forme :SolidMasse moléculaire :443.56Gallium 8-Hydroxyquinolinate
CAS :Gallium 8-Hydroxyquinolinate is an inducer of apoptosis that initiates both p53-dependent and independent cell death in cancer cells through the induction of Ca2+ signaling transduction. In addition to its apoptotic properties, this compound's nanostructures exhibit excellent optical performance, making it suitable for use in tumor research.Formule :C27H18GaN3O3Couleur et forme :SolidMasse moléculaire :502.17PD-L1/HDAC6-IN-1
CAS :PD-L1/HDAC6-IN-1 (Compound HP29) is an inhibitor targeting both PD-L1 and HDAC6, effectively disrupting the PD-L1/PD-1 interaction and inhibiting HDAC6 activity, with IC50 values of 26.8 nM and 69 nM, respectively. This compound enhances the cytotoxicity of Jurkat T cells against HepG2 cells, exhibiting an IC50 of 3.4 μM. In rats, PD-L1/HDAC6-IN-1 demonstrates favorable pharmacokinetics, showing a drug exposure level of 871.62 ng·h/mL, and displays antitumor activity in a B16-F10 xenograft mouse model.Formule :C27H33N3O3Couleur et forme :SolidMasse moléculaire :447.569Topo I-IN-1
Topo I-IN-1 (14d) is a powerful Topo I inhibitor with antitumor effects and DNA intercalation, inducing apoptosis.Formule :C20H14BrN3O2Couleur et forme :SolidMasse moléculaire :408.25Topoisomerase I/II inhibitor 3
Topoisomerase I/II inhibitor 3 suppresses cell growth and induces apoptosis in liver cancer by blocking PI3K/Akt/mTOR.Formule :C24H24N2O4Couleur et forme :SolidMasse moléculaire :404.46Thalidomide-NH-amido-PEG2-C2-NH2
CAS :Thalidomide-NH-amido-PEG2-C2-NH2 is a synthetic E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker. It is utilized in the synthesis of PROTACs.Formule :C21H27N5O7Masse moléculaire :461.47Kahweol Acetate
CAS :Kahweol Acetate, a semi-synthetic coffee bean derivative, inhibits osteoclasts, cancer cells, DNA damage, and oxidative stress.Formule :C22H28O4Couleur et forme :SolidMasse moléculaire :356.46MTX-216
CAS :MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.Formule :C22H14Cl2FN5O2SCouleur et forme :SolidMasse moléculaire :502.348TfR-1-IN-1
CAS :TfR-1-IN-1 is a TfR-1 inhibitor, also a Fe(III) salivary phenol complex, inducing apoptosis and inhibiting tumor and normal cell growth.Formule :C20H12ClF2FeN2O2Degré de pureté :96.96%Couleur et forme :SolidMasse moléculaire :441.62BMI-135
CAS :BMI-135, a selective estrogen mimic, demonstrates agonist activity for the estrogen receptor and induces a rapid endoplasmic reticulum stress response (UPR) alongside apoptosis in breast cancer cells.
Formule :C23H13FO2SCouleur et forme :SolidMasse moléculaire :372.41MJC13
CAS :MJC13 is an FKBP52-targeting agent with antitumor activity, suitable for prostate cancer research.
Formule :C13H15Cl2NOCouleur et forme :SolidMasse moléculaire :272.17Enpp-1-IN-25
CAS :Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and exhibits low oral bioavailability. By inhibiting cGAMP degradation, it effectively activates the intracellular STING pathway. Enpp-1-IN-25 can enhance immune cell infiltration and type I interferon response in the tumor microenvironment, thereby increasing the antitumor efficacy of anti-PD-L1 antibodies. It is applicable for research in cancer immunotherapy.Formule :C15H21N5O4SCouleur et forme :SolidMasse moléculaire :367.423Lometrexol hydrate
CAS :Lometrexol hydrate, an antipurine antifolate, inhibits GARFT and purine synthesis, leading to cancer cell apoptosis without causing DNA breaks.Formule :C21H27N5O7Couleur et forme :SolidMasse moléculaire :461.475PD-L1-IN-1
PD-L1-IN-1, potent PD-L1 inhibitor with 115 nM IC50, suppresses tumors, boosts immune response, and spares healthy cells.Formule :C21H23N5O2Couleur et forme :SolidMasse moléculaire :377.44Apoptosis inducer 25
CAS :Apoptosisinducer 25 (Compound 4H) demonstrates potent anticancer capabilities by inhibiting the proliferation of BGC-823 cancer cells with an IC50 of 0.37 μM. It induces apoptosis in BGC-823 cells, causes mitochondrial dysfunction, and arrests the cell cycle at the G2/M phase. Additionally, Apoptosisinducer 25 exhibits favorable pharmacokinetic properties in rats.Formule :C42H53NO7Couleur et forme :SolidMasse moléculaire :683.87Keap1-Nrf2-IN-4
Keap1-Nrf2-IN-4 hinders MGC-803 cell growth (IC50=2.55μM), migration, and induces apoptosis with low toxicity.Formule :C26H34N2OCouleur et forme :SolidMasse moléculaire :390.56Thalidomide-Piperazine-PEG1-NH2
CAS :Thalidomide-Piperazine-PEG1-NH2 is a synthetic E3 ligase ligand-linker conjugate, featuring a cereblon ligand based on Thalidomide and a single linker.Formule :C21H27N5O5Masse moléculaire :429.4717-Demethoxy-reblastatin
CAS :17-Demethoxy-reblastatin (17-DR) acts as an inhibitor of heat shock protein 90 (Hsp90). It suppresses the proliferation of HepG2 and SMMC7721 cancer cells, diminishes colony formation, and triggers apoptosis via a mitochondria and caspase-mediated pathway.Formule :C28H42N2O7Couleur et forme :SolidMasse moléculaire :518.64Ivaltinostat formic
Ivaltinostat (CG-200745) is an oral panHDAC inhibitor, inducing apoptosis and enhancing cancer drug sensitivity.Formule :C25H35N3O6Couleur et forme :SolidMasse moléculaire :473.56ADH-6
CAS :ADH-6, a tripyridylamide, disrupts mutant p53 aggregates in cancer cells, reviving its function and inducing apoptosis.Formule :C29H36N8O9Couleur et forme :SolidMasse moléculaire :640.64Antitumor agent-78
Antitumor agent-78 blocks GPx-4, raises COX2, triggers apoptosis, halts EMT, and stifles cancer cell growth and migration.Couleur et forme :SoildPSP205
CAS :PSP205 is an effective anticancer agent with cytotoxic properties. It induces apoptosis and triggers autophagy mediated by ER stress. Furthermore, PSP205 enhances the expression of LC3BII protein and increases the expression of CHOP and spliced XBP1 at both mRNA and protein levels.Formule :C28H32ClN7O5S2Couleur et forme :SolidMasse moléculaire :646.181MLKL-IN-6
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.
Formule :C20H18N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.38Lonitoclax
CAS :Lonitoclax is an inhibitor of B-cell lymphoma 2 (Bcl-2). It demonstrates antitumor activity in B-cell and myeloid malignancy models comparable to Venetoclax. Lonitoclax holds potential for research in relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma, and certain low-grade lymphomas.Formule :C43H45ClN4O5Couleur et forme :SolidMasse moléculaire :733.294RMS5
CAS :RMS5: hambanine analogue, inhibits P-gp, anti-cancer with cytotoxic, anti-proliferative effects, reduces Bcl-2 proteins, cleaves PARP.Formule :C35H38N2O5SCouleur et forme :SolidMasse moléculaire :598.75Anticancer agent 68
CAS :Compound 12, an anticancer agent, halts G2/M phase, triggers cell death, and activates p53 & PTEN for tumor suppression.Formule :C20H18ClNO5Couleur et forme :SolidMasse moléculaire :387.81Tubulin polymerization-IN-68
CAS :Tubulin polymerization-IN-68 (compound 32) serves as a tubulin inhibitor, disrupting cellular microtubule networks by hindering tubulin polymerization. It also upregulates PARP-1 and caspase-3 expression, thereby inducing apoptosis and exhibiting anticancer properties. Notably, Tubulin polymerization-IN-68 effectively suppresses HepG2 cells with an IC50 of 93 nM and markedly reduces the growth of HepG2 xenograft tumors in nude mice through oral administration.Formule :C16H13N3OCouleur et forme :SolidMasse moléculaire :263.29p38 MAPK-IN-3
Compound 2c is a potent p38α MAPK inhibitor with antitumor effects, enhancing apoptosis and ROS.Formule :C22H17BrO2Couleur et forme :SolidMasse moléculaire :393.27Tubulin inhibitor 14
Tubulin inhibitor 14 blocks NQO2 and microtubule formation, disrupts blood vessels, and may target tumors; IC50 of 1.0 μM.Formule :C15H9F2NOCouleur et forme :SolidMasse moléculaire :257.23N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride
CAS :N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.Formule :C14H22Cl2N2O3SMasse moléculaire :369.31ST-899
CAS :ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS). The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.Formule :C22H29BrClNO6Couleur et forme :SolidMasse moléculaire :518.83DC-U4106
CAS :DC-U4106: USP8 inhibitor, Kd 4.7μM, IC50 1.2μM, degrades Erα, low-toxicity tumor suppressor for breast cancer research.Formule :C29H27N5O5Couleur et forme :SolidMasse moléculaire :525.56FAK-IN-4
FAK-IN-4 (Compound 7d) has anticancer activities that can induce cell apoptosis. FAK-IN-4 is potential inhibitor of FAK [1].Formule :C20H22N4OCouleur et forme :SolidMasse moléculaire :334.41RIPK1-IN-28
CAS :RIPK1-IN-28 (compound 13) is an orally active inhibitor of RIPK1. It exhibits inhibitory effects on human I2.1 and Hepa1-6 cells, with IC50 values of 0.4 and 1.2 nM, respectively.
Formule :C27H24N4O4Couleur et forme :SolidMasse moléculaire :468.504SphK1-IN-2
SphK1-IN-2: SphK1 inhibitor, IC50: 19.81 nM; less effective on SphK2. Induces apoptosis, hinders cancer cell growth.Formule :C27H30BrNO4SCouleur et forme :SolidMasse moléculaire :544.5YK5
CAS :YK5 is an allosteric inhibitor pocket of Hsp70 and represents a previously unknown chemical tool to investigate cellular mechanisms associated with Hsp70.Formule :C18H24N8O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.50K20
K20 selectively inhibits KRas G12C (IC50: 1.16 nM), shows anticancer activity in H358 cells (IC50: 0.78 μM), and induces apoptosis via Erk dephosphorylation.Formule :C24H20Cl2F4N4O2Couleur et forme :SolidMasse moléculaire :543.34Antitumor agent-58
Antitumor agent-58 suppresses tumor growth, colony formation, cell migration, and induces mitochondrial dysfunction in MGC-803 cells.Formule :C27H28F3N9SCouleur et forme :SolidMasse moléculaire :567.63ASK1-IN-7
CAS :ASK1-IN-7 (Compound 4c) is an ASK1 inhibitor and a derivative of the ASK1 inhibitor scaffold 5-(5-Phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-4-one. This compound is potentially applicable in research involving ASK1 signaling pathways, including studies on cellular stress response, inflammatory response, neurodegenerative diseases, and cardiovascular diseases.Formule :C13H8N2O2S2Couleur et forme :SolidMasse moléculaire :288.345Topoisomerase II inhibitor 20 TFA
TopoisomeraseII Inhibitor 20 TFA is a potent inhibitor of topoisomerase II with an IC50 of 0.98 µM. It can induce cell apoptosis and exhibits broad-spectrum anticancer activity.Formule :C24H24F5N5O4SCouleur et forme :SolidMasse moléculaire :573.54Tubulin inhibitor 13
CAS :Tubulin inhibitor 13 (E27), IC50 16.1 μM, blocks tubulin polymerization, cancer cell migration, and invasion, induces apoptosis.Formule :C25H21N3O4Couleur et forme :SolidMasse moléculaire :427.45p53 Activator 14
CAS :p53 Activator 14 (Compound 7A) is a derivative of Neratinib that can induce DNA damage and activate p53, thereby inhibiting the proliferation of various cancer cells, with an IC50 of 7.21 μM for HCT116 cells. This compound hinders adhesion, migration, and invasion of HCT116 cells, disrupts the cell cycle, and triggers apoptosis. In addition, p53 Activator 14 exhibits anti-tumor properties and inhibits angiogenesis in the chick embryo chorioallantoic membrane (CAM) model.Formule :C28H29ClN4O3Couleur et forme :SolidMasse moléculaire :505.008ZLMT-12
ZLMT-12: tacrine derivative, inhibits CDK2/CDK9, weak on AChE/BuChE, anti-proliferative, low toxicity, blocks S/G2/M phase, induces apoptosis.Formule :C26H31ClN6OCouleur et forme :SolidMasse moléculaire :479.02DAPK1-IN-1
CAS :DAPK1-IN-1 (compound 10) is an inhibitor of Death-associated protein kinase 1 (DAPK1), with a dissociation constant (Kd) of 0.63 μM. It is utilized in the study of Alzheimer's disease.Formule :C15H11BrO4Couleur et forme :SolidMasse moléculaire :335.15BRD4/CK2-IN-1
CAS :BRD4/CK2-IN-1 is a small-molecule inhibitor targeting BRD4 and CK2, inducing apoptosis and autophagy-related cell death.Formule :C29H30ClN5O5Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :564.03Hdm2 E3 ligase inhibitor 1
CAS :Hdm2 E3ligaseinhibitor 1 (Compound 1) is a reversible inhibitor of Hdm2-mediated p53 protein ubiquitination, with an IC50 of 12.7 μM. It binds to Hdm2, blocking the transfer of ubiquitin catalyzed by Hdm2 from pre-linked Ub-Ubc4 to p53, thereby inhibiting p53 ubiquitination, stabilizing p53 protein in tumor cells, and exerting antitumor activity.Formule :C10H8F6N2O3SMasse moléculaire :350.24Enbezotinib
CAS :Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.Formule :C21H21FN6O3Degré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :424.43Ref: TM-T62285
1mg77,00€5mg166,00€10mg253,00€25mg414,00€50mg567,00€100mg745,00€1mL*10mM (DMSO)182,00€Tuvusertib
CAS :Tuvusertib (M1774), an oral ATR inhibitor (Ki<1µM), selectively blocks CHK1 phosphorylation, disrupts DNA repair, and induces tumor cell apoptosis.Formule :C16H12F2N8ODegré de pureté :98.44% - 99.66%Couleur et forme :SolidMasse moléculaire :370.32Ref: TM-T10406
1mg62,00€5mg131,00€10mg197,00€25mg383,00€50mg533,00€100mg757,00€1mL*10mM (DMSO)150,00€Zharp1-211
CAS :Zharp1-211 is a RIPK3 inhibitor，reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.Formule :C24H25N5O4Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :447.49Ref: TM-T87664
1mg87,00€5mg183,00€10mg283,00€25mg562,00€50mg873,00€100mg1.311,00€200mg1.768,00€1mL*10mM (DMSO)202,00€PF-07328948
CAS :PF-07328948 is a branched-chain keto-acid dehydrogenase kinase (BDK) inhibitor, useful for studying CVD metabolic disorders.Formule :C16H8F4O3SDegré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :356.29Nalmefene
CAS :Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study of opioid overdose and alcohol dependence.Formule :C21H25NO3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :339.43HC-5404
CAS :HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Formule :C24H24F2N4O3Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :454.47Zotatifin
CAS :Zotatifin (eFT226) is a selective eIF4A inhibitor with antiviral and antitumor properties, inhibiting Sox4 translation and inducing apoptosis.Formule :C28H29N3O5Degré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :487.55Vatalanib hydrochloride
CAS :Vatalanib hydrochloride (PTK787 hydrochloride) is an orally available and highly potent tyrosine kinase (VEGF) inhibitor that reduces the number and size of Aβ plaques in the cortex of 5xFAD mice, which may be useful in the study of Alzheimer's disease and cancer.Formule :C20H16Cl2N4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :383.27SY-5609
CAS :SY-5609 (CDK7-IN-3) is a selective non-covalent CDK7 inhibitor, with weak inhibitory activity against CDK2, CDK9 and CDK12.Cost-effective and quality-assured.Formule :C23H26F3N6OPDegré de pureté :99.34% - >99.99%Couleur et forme :SolidMasse moléculaire :490.46Ref: TM-T36038
1mg139,00€2mg200,00€5mg343,00€10mg553,00€25mgÀ demander50mgÀ demander1mL*10mM (DMSO)373,00€Darizmetinib
CAS :Darizmetinib (HRX215) is an MKK4 inhibitor.Formule :C21H17F2N5O3SDegré de pureté :98.03% - 99.57%Couleur et forme :SolidMasse moléculaire :457.45Ref: TM-T72956
1mg69,00€2mg89,00€5mg147,00€10mg224,00€25mg324,00€50mg400,00€100mg587,00€1mL*10mM (DMSO)148,00€Milademetan
CAS :Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.Formule :C30H34Cl2FN5O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :618.53Ref: TM-T12040
1mg93,00€5mg167,00€10mg260,00€25mg492,00€50mg802,00€100mg1.378,00€1mL*10mM (DMSO)221,00€UH15-38
CAS :UH15-38 is a potent and selective RIPK3 inhibitor that blocks necroptosis in alveolar epithelial cells triggered by IAV, useful for studying lung inflammation.Formule :C26H27N5O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :441.53BCL6-IN-3
CAS :BCL6-IN-3: potent BCL6 inhibitor, 70 nM GI50 in SU-DHL4, affects cell functions, antitumor.Formule :C24H31ClF2N6O2Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :508.99Ref: TM-T10487
1mg109,00€5mg241,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€500mgÀ demander1mL*10mM (DMSO)370,00€Lometrexol
CAS :Lometrexol (LY 264618) is an antifolate that inhibits GARFT, blocks purine synthesis, induces apoptosis, and has anticancer properties.
Formule :C21H25N5O6Degré de pureté :97.76% - 99.56%Couleur et forme :SolidMasse moléculaire :443.45Gemcitabine elaidate hydrochloride
CAS :CP-4126, a lipophilic pro-drug of Gemcitabine, converts to active form by esterases, allowing oral administration with dose-dependent effects.
Formule :C27H44ClF2N3O5Degré de pureté :98.50% - 99.6%Couleur et forme :SolidMasse moléculaire :564.11JAK2-IN-7
CAS :JAK2-IN-7 selectively inhibits JAK2 (IC50: 3 nM), shows 14-fold selectivity over JAK1/3, FLT3, induces G0/G1 arrest, apoptosis, and has antitumor effects.Formule :C26H33N7ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :459.59Ref: TM-T35900
1mg145,00€5mg354,00€10mg630,00€25mg1.301,00€50mg1.738,00€100mg2.357,00€1mL*10mM (DMSO)358,00€FX-11
CAS :FX-11: potent LDHA inhibitor (Ki 8 μM), activates PKM2, reduces ATP, induces oxidative stress/ROS, cell death, shows antitumor effects.
Formule :C22H22O4Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :350.41OBAA
CAS :OBAA is a potent inhibitor of phospholipase A2 (PLA2) with an IC 50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC 50 of 0.4 μM [1] [2] [3].Formule :C28H44O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.65(R)-Verapamil hydrochloride
CAS :(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is an inhibitor of P-Glycoprotein.Formule :C27H39ClN2O4Couleur et forme :SolidMasse moléculaire :491.06WEHI-539 hydrochloride
CAS :WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.Formule :C31H30ClN5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :620.18AP1867-3-(aminoethoxy)
CAS :AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.Formule :C38H50N2O9Couleur et forme :SolidMasse moléculaire :678.81β-Zearalanol
CAS :Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].Formule :C18H26O5Couleur et forme :SolidMasse moléculaire :322.4PIM-447 dihydrochloride
CAS :PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively).Formule :C24H25Cl2F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.38PRGL493
CAS :PRGL493 blocks ACSL4, halts PC3/MDA-MB-231 cancer cell spread, and inhibits MA-10 tumor progesterone. Effective in mouse PC3 tumor model at 0.25 mg/kg.Formule :C25H21N7O2Degré de pureté :98.80% - 99.11%Couleur et forme :SolidMasse moléculaire :451.48Platinum, diammine[1,1-cyclobutanedi(carboxylato-kO)(2-)]-, (SP-4-2)-
CAS :Formule :C6H10N2O4PtDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.23265-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
CAS :Formule :C9H14N4O5Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :258.2313MI-773
CAS :MI-773 is a potent inhibitor of the MDM2-p53 protein interaction (PPI) with a high affinity for MDM2 and a Kd value of 8.2 nM. MI-773 exhibits antitumour effects.Formule :C29H34Cl2FN3O3Couleur et forme :SolidMasse moléculaire :562.5Vatiquinone
CAS :Vatiquinone, also known as EPI 743, is an orally bioavailable para-benzoquinone being developed for inherited mitochondrial diseases. The mechanism of action of EPI-743 involves augmenting the synthesis of glutathione, optimizing metabolic control, enhancFormule :C29H44O3Couleur et forme :SolidMasse moléculaire :440.66Dihydroartemisinin (mixture of α and β isomers)
CAS :Dihydroartemisinin (mixture of α and β isomers) is a useful organic compound for research related to life sciences. The catalog number is T64399 and the CAS number is 131175-87-6.Formule :C15H24O5Couleur et forme :SolidMasse moléculaire :284.352BPH-675
CAS :BPH-675 is a bioactive chemical.Formule :C24H23NO9P2SCouleur et forme :SolidMasse moléculaire :563.45RRD-251
CAS :RRD-251 is an Rb-Raf-1 interaction inhibitor that induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine[1].Formule :C8H9Cl3N2SCouleur et forme :SolidMasse moléculaire :271.59Ac-IETD-CHO TFA
Ac-IETD-CHO TFA is a granzyme B and caspase-8 inhibitor that inhibits caspase8 activity by blocking caspase3 precursor cleavage.Ac-IETD-CHO TFA inhibits Fas-mediated apoptosis.Formule :C23H35F3N4O12Couleur et forme :SoildMasse moléculaire :616.54Thalidomide-O-amido-C4-NH2 hydrochloride
CAS :Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon ligand derived from Thalidomide with a linker and is commonly used in the synthesis of PROTACs[1].Formule :C19H23ClN4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.86Yatein
CAS :Yatein inhibits herpes simplex virus type 1 replication by interruption the immediate-early gene expression. Yatein is a lignan isolated from A. chilensis. It also has antiproliferative activity.Formule :C22H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.42XMU-MP-3
CAS :XMU-MP-3 is a robust, non-covalent inhibitor of BTK, exhibiting exceptional potency with IC50 values of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation, respectively, in the presence of 10 μM ATP. Moreover, XMU-MP-3 elicits apoptosis.Formule :C27H27F3N8OCouleur et forme :SolidMasse moléculaire :536.563Mcl-1 inhibitor 6
CAS :Mcl-1 inhibitor 6 binds Mcl-1 with KD 0.23 nM and Ki 0.02 μM, shows strong selectivity over Bcl-2 family, and demonstrates antitumor efficacy.Formule :C26H28ClNO6SCouleur et forme :SolidMasse moléculaire :518.02Swainsonine
CAS :Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arrest in the G2/M phase.Formule :C8H15NO3Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :173.21A-192621
CAS :A-192621 is a potent, nonpeptide, orally active, and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and elevates both arterial blood pressure and plasma ET-1 levels[1][2][3]. Its selectivity is 636-fold higher for ETB than ETA (IC50 of 4280 nM and Ki of 5600 nM).Formule :C33H38N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.66Imifoplatin
CAS :Imifoplatin (PT-112) is a platinum compound with antitumor activity and may be used to study prostate cancer and immune system disorders.Formule :C6H16N2O7P2PtDegré de pureté :≥95.0%Couleur et forme :SolidMasse moléculaire :485.23DB818
CAS :DB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression.Formule :C19H16N6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.44Carubicin hydrochloride
CAS :Carubicin HCl is an anthracycline antineoplastic antibiotic. Through intercalates into DNA and interacts with topoisomerase II, Carubicin inhibits DNA replication and repair and RNA and protein synthesis.Formule :C26H28ClNO10Couleur et forme :SolidMasse moléculaire :549.95Thalidomide-O-C5-NH2 hydrochloride
CAS :Thalidomide-O-C5-NH2 hydrochloride is a synthetic compound consisting of a ligand-linker conjugate with E3 ligase activity. It combines a cereblon ligand based on Thalidomide and a linker commonly utilized in PROTAC technology.Formule :C18H22ClN3O5Couleur et forme :SolidMasse moléculaire :395.84SCH79797
CAS :SCH79797 is a potent and specific protease-activated receptor 1 (PAR1) antagonistwith antimicrobial, anticancer, anti-inflammatory, and neuroprotective effects.Formule :C23H25N5Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :371.48ENMD-2076 tartrate
CAS :ENMD-2076 is an orally active kinase inhibitor. It also has antiangiogenic and antiproliferative mechanisms of action.Formule :C25H31N7O6Couleur et forme :SolidMasse moléculaire :525.56Ciprofloxacin lactate
CAS :Ciprofloxacin lactate is a useful organic compound for research related to life sciences. The catalog number is T66299 and the CAS number is 97867-33-9.Formule :C20H24FN3O6Couleur et forme :SolidMasse moléculaire :421.43Prostaglandin A2
CAS :PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]Formule :C20H30O4Couleur et forme :SolidMasse moléculaire :334.45Thalidomide-O-C6-COOH
CAS :Thalidomide-O-C6-COOH is a synthetic conjugate that combines a Thalidomide-derived cereblon ligand with a PROTAC technology linker (E3 ligase ligand-linker).Formule :C20H22N2O7Couleur et forme :SolidMasse moléculaire :402.403Thalidomide-5-COOH
CAS :Thalidomide-5-COOH is a useful organic compound for research related to life sciences. The catalog number is T64600 and the CAS number is 1216805-11-6.Formule :C14H10N2O6Couleur et forme :SolidMasse moléculaire :302.242Ingenol 3,20-dibenzoate
CAS :Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms that effectively induces the translocation of nPKC-delta, -epsilon, and -theta, as well as PKC-mu, from the cytosolic fraction to the particulate fraction. Through de novo synthesis of macromolecules, it triggers apoptosis with characteristic morphology. Moreover, Ingenol 3,20-dibenzoate enhances IFN-γ production and degranulation in NK cells, particularly when stimulated by NSCLC cells[1][2].Formule :C34H36O7Couleur et forme :SolidMasse moléculaire :556.65CTB
CAS :CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.
Formule :C16H13ClF3NO2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :343.73Faradiol 3-Myristate
CAS :Produit contrôléFormule :C44H76O3Couleur et forme :NeatMasse moléculaire :653.072anti-TNBC agent-2
CAS :Anti-TNBC agent-2 (3j), a purine derivative, acts as an anti-triple negative breast cancer (TNBC) therapeutic.
Formule :C28H37ClFN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :542.09SMIP34
CAS :SMIP34 is an inhibitor of PELP1 that demonstrates the capability to reduce cell viability and colony formation. Additionally, SMIP34 induces cell apoptosis (apoptosis) and causes cell cycle arrest in the S phase. It reduces the expression of PELP1 and exhibits anti-tumor activity. SMIP34 also has potential for research in triple-negative breast cancer (TNBC).
Formule :C20H15ClFN5O2SCouleur et forme :LiquidMasse moléculaire :443.88DETD-35
CAS :DETD-35 is a promising chemical compound in anti-melanoma therapy, functioning as an inhibitor of the MEK-ERK, Akt, and STAT3 signaling pathways. It enhances cancer cell apoptosis (Apoptosis) and diminishes resistance to Vemurafenib in cancer cells. The compound exhibits IC 50 values of 2.7, 6.0, 3.9, 3.1, and 2.5 μM against melanoma cell lines B16-F10, MeWo, SK-MEL-2, A2058c, and A375c, respectively. DETD-35 offers significant potential for advancing research in melanoma treatment strategies.
Formule :C27H24O6Couleur et forme :SolidMasse moléculaire :444.48CHMFL-48
CAS :CHMFL-48, an orally active inhibitor of BCR-ABL kinase, demonstrates efficacy against both the wild-type (wt) and various imatinib-resistant mutants. It exhibits potent inhibitory activity, with IC 50 values of 1 nM for the ABL wild-type and 0.8 nM for the ABL T315I mutant. CHMFL-48 operates by inhibiting the autophosphorylation of both wild-type and mutant BCR-ABL, affecting downstream signaling mediators including STAT5 and CRKL. This disruption leads to cell cycle arrest and triggers apoptosis. Given its properties, CHMFL-48 is a promising candidate for research on chronic myeloid leukemia (CML).
Formule :C31H30F3N7OCouleur et forme :SolidMasse moléculaire :573.61ZSQ836
CAS :ZSQ836 is a dual covalent inhibitor of CDK12/CDK13 with oral bioactivity, displaying an EC50 value of 32 nM against CDK12. This compound can induce cell apoptosis (apoptosis) and demonstrates in vivo anticancer properties. ZSQ836 is applicable for research in ovarian cancer.
Formule :C27H28AsClN6OS2Couleur et forme :SolidMasse moléculaire :627.05Cyy-272
CAS :Cyy-272 is an orally active JNK inhibitor with IC50 values of 1.25, 1.07, and 1.24 μM against JNK1, JNK2, and JNK3, respectively. It exerts anti-inflammatory effects by inhibiting the phosphorylation of JNK, thereby alleviating acute lung injury (ALI) induced by lipopolysaccharide (LPS). Moreover, Cyy-272 significantly reduces inflammation in cardiomyocytes and cardiac tissues caused by high lipid concentrations, further mitigating resultant cardiac hypertrophy, fibrosis, and apoptosis. Cyy-272 is utilized in the study of obesity-related myocarditis.
Formule :C23H23F2N7Couleur et forme :SolidMasse moléculaire :435.47IHMT-MST1-39
CAS :IHMT-MST1-39 is an orally effective MST kinase inhibitor with IC50 values of 42 nM for MST1 and 109 nM for MST2. It activates the AMPK signaling pathway in hepatocytes and inhibits apoptosis in pancreatic β cells. Additionally, IHMT-MST1-39 improves type 1 diabetes in mice induced by Streptozotocin.
Formule :C20H18F2N6O3SCouleur et forme :SolidMasse moléculaire :460.46
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