Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5598 produits trouvés pour "Apoptose"
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ASCT2-IN-1
CAS :ASCT2-IN-1 (compound 20k) is an inhibitor of ASCT2, demonstrating IC50 values of 5.6 μM in A549 cells and 3.5 μM in HEK293 cells. It induces apoptosis and inhibits tumor growth.Formule :C36H32Cl2N2O4Masse moléculaire :627.56Tubulin polymerization-IN-3
<p>Tubulin polymerization-IN-3 is a potent inhibitor of microtubulin polymerization (IC50: 3.84 μM) and induces apoptosis in colon cancer cells.</p>Formule :C20H20ClN5O3Couleur et forme :SolidMasse moléculaire :413.86PI3Kα-IN-8
<p>PI3Kα-IN-8 is a selective inhibitor of PI3Kα (IC50: 0.012 μM).</p>Formule :C26H27BrN4O2Couleur et forme :SolidMasse moléculaire :507.42MTX-216
CAS :<p>MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.</p>Formule :C22H14Cl2FN5O2SCouleur et forme :SolidMasse moléculaire :502.348Topoisomerase I/II inhibitor 3
<p>Topoisomerase I/II inhibitor 3 suppresses cell growth and induces apoptosis in liver cancer by blocking PI3K/Akt/mTOR.</p>Formule :C24H24N2O4Couleur et forme :SolidMasse moléculaire :404.46Topo I-IN-1
<p>Topo I-IN-1 (14d) is a powerful Topo I inhibitor with antitumor effects and DNA intercalation, inducing apoptosis.</p>Formule :C20H14BrN3O2Couleur et forme :SolidMasse moléculaire :408.25Flonoltinib sulfate
CAS :<p>Flonoltinib maleate is an orally active dual inhibitor of JAK2/FLT3, with IC50 values of 0.7 nM for JAK2, 4 nM for FLT3, 26 nM for JAK1, and 39 nM for JAK3. It exhibits anticancer properties.</p>Formule :C25H36FN7O5SCouleur et forme :SolidMasse moléculaire :565.661PD-1/PD-L1-IN-15
<p>PD-1/PD-L1-IN-15 is a potent inhibitor of PD-1/PD-L1 (IC50: 60.1 nM) and has shown investigational potential for tumor immunotherapy.</p>Formule :C32H30N4O3Couleur et forme :SolidMasse moléculaire :518.61ASK1-IN-7
CAS :<p>ASK1-IN-7 (Compound 4c) is an ASK1 inhibitor and a derivative of the ASK1 inhibitor scaffold 5-(5-Phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-4-one. This compound is potentially applicable in research involving ASK1 signaling pathways, including studies on cellular stress response, inflammatory response, neurodegenerative diseases, and cardiovascular diseases.</p>Formule :C13H8N2O2S2Couleur et forme :SolidMasse moléculaire :288.345MLKL-IN-6
<p>MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.</p>Formule :C20H18N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.38Thalidomide-NH-amido-PEG1-C2-NH2 hydrochloride
CAS :<p>Thalidomide-NH-amido-PEG1-C2-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that includes a thalidomide-based cereblon ligand and a linker, used in the synthesis of PROTAC.</p>Formule :C19H24ClN5O6Masse moléculaire :453.88NLRP3-IN-28
CAS :<p>NLRP3-IN-28 (compound N77) serves as a potent inhibitor of NLRP3, effectively blocking Nigericin-induced pyroptosis with an EC50 of 0.07μM. Additionally, it mitigates inflammatory reactions in vivo [1].</p>Formule :C12H9F3N2O3SCouleur et forme :SolidMasse moléculaire :318.27ZSH-512
CAS :<p>ZSH-512 is a potent inhibitor of RARγ with antiproliferative properties. It induces apoptosis and reduces the expression of CD133, NANOG, SOX2, and EPCAM proteins. ZSH-512 exhibits anticancer activity and shows potential for colorectal cancer research.</p>Formule :C20H21N3O3SCouleur et forme :SolidMasse moléculaire :383.464Anticancer agent 45
<p>Anticancer agent 46, potent and selective, induces apoptosis, is cytotoxic to cancer cells, with low toxicity to human lymphocytes.</p>Formule :C22H14ClN3O6S2Couleur et forme :SolidMasse moléculaire :515.95S100A2-p53-IN-1
CAS :<p>S100A2-p53-IN-1 inhibits S100A2-p53 in pancreatic cancer, stunting MiaPaCa-2 cell growth at 1.2-3.4 μM.</p>Formule :C20H20F6N2O4SCouleur et forme :SolidMasse moléculaire :498.44HC-7366
CAS :<p>HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.</p>Formule :C20H15ClF2N6O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :508.89RIPK1-IN-24
CAS :<p>RIPK1-IN-24 is an inhibitor of receptor-interacting protein kinase 1 (RIPK1) with an IC50 of 1.3 μM. It is utilized in research on inflammatory diseases.</p>Formule :C26H21FN6O2Couleur et forme :SolidMasse moléculaire :468.48AQIM-I
CAS :<p>AQIM-I is a survivin inhibitor that reduces survivin expression and colony formation. It promotes reactive oxygen species (ROS) production, apoptosis, cell cycle arrest, DNA damage, and autophagy. Moreover, AQIM-I effectively inhibits nonsmall cell lung cancer cells A549, with an IC 50 value of 9 nM [1].</p>Formule :C17H13IN2O2Couleur et forme :SolidMasse moléculaire :404.20Sabialimon P
CAS :<p>Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.</p>Formule :C31H50O4Couleur et forme :SolidMasse moléculaire :486.73MG-B-28
<p>MG-B-28, a BTLA-HVEM inhibitor, demonstrates an IC50 value of 906 nM. It promotes T cell activation dose-dependently by inhibiting the interaction between BTLA and HVEM.</p>Formule :C28H25N5O3Couleur et forme :SolidMasse moléculaire :479.53PD-1/PD-L1-IN-16
<p>PD-1/PD-L1-IN-16 is a potent inhibitor of PD-1/PD-L1 (IC50: 53.2 nM) and has shown research potential for tumour immunotherapy.</p>Formule :C34H30N4O4Couleur et forme :SolidMasse moléculaire :558.63RET-IN-7
CAS :<p>RET-IN-7 exhibits strong inhibitory effects against RET kinase in vitro and shows significant efficacy in treating RET-driven tumor xenografts in mice through</p>Formule :C22H24ClFN6O2Couleur et forme :SolidMasse moléculaire :458.92GL0388
<p>GL0388, a Bax activator, induces apoptosis, hinders breast cancer growth, and has IC50 of 0.299-1.57 μM.</p>Formule :C21H17FN2OCouleur et forme :SolidMasse moléculaire :332.37CK156
CAS :<p>CK156 inhibits DAPK with high selectivity; IC50: 182 nM (DRAK1), 34 μM (CK2a1), 39 μM (CK2a2); key in autoimmune/inflammation research.</p>Formule :C21H25N5O3Couleur et forme :SolidMasse moléculaire :395.45Spliceostatin A
CAS :<p>Spliceostatin A is an anticancer agent and splicing inhibitor that induces apoptosis by inducing cell cycle arrest in the G1 and G2/M phases.</p>Formule :C28H43NO8Degré de pureté :94.66%Couleur et forme :SolidMasse moléculaire :521.643NDs-IN-1
CAS :NDs-IN-1 (Compound 3g) is a novel non-covalent multi-target inhibitor that inhibits the activities of key enzymes such as hBACE-1, hAChE, and hMAO-B, and is primarily used in the study of neurodegenerative diseases [1].Formule :C20H18N2O2Masse moléculaire :318.37Flizasertib
CAS :<p>Flizasertib is a serine/threonine kinase inhibitor that acts by inhibiting RIPK1, which has anti-inflammatory and therapeutic effects on immune disorders.</p>Formule :C15H14FN3ODegré de pureté :99.39% - 99.57%Couleur et forme :SolidMasse moléculaire :271.29Tubulin inhibitor 14
<p>Tubulin inhibitor 14 blocks NQO2 and microtubule formation, disrupts blood vessels, and may target tumors; IC50 of 1.0 μM.</p>Formule :C15H9F2NOCouleur et forme :SolidMasse moléculaire :257.23Topo I/COX-2-IN-1
<p>Topo I/COX-2-IN-1: potent dual inhibitor; IC50 0.24μM (COX-2), 4.42μM (Topo I); anti-cancer; induces apoptosis, halts migration.</p>Formule :C21H18ClFN2O3Couleur et forme :SolidMasse moléculaire :400.83NTU281
CAS :<p>NTU281 inhibits transglutaminase-2, lowers creatinine in diabetic rats, reduces proteinuria, and fights glomerulosclerosis.</p>Formule :C25H31N2O6SCouleur et forme :SolidMasse moléculaire :487.59CDK2/9-IN-1
CAS :<p>CDK2/9-IN-1 (compound 20a) is an orally active dual inhibitor of CDK2 and CDK9, with IC50 values of 0.004 μM and 0.009 μM for CDK2 and CDK9, respectively. It induces apoptosis by regulating G2/M cell cycle arrest and exhibits antitumor activity.</p>Formule :C14H14N6O2S2Couleur et forme :SolidMasse moléculaire :362.43NA-17
CAS :<p>NA-17 is a naphthalimide compound with antitumor activity and exhibits lower toxicity to normal cells such as HL-7702 and WI-38. It demonstrates p53-dependent inhibition selectivity in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of these cells. NA-17 causes cell cycle arrest in the G1 phase and promotes apoptosis and cell death.</p>Formule :C26H27N3O4Couleur et forme :SolidMasse moléculaire :445.51Bafilomycin C1
CAS :<p>vacuolar H+-ATPases (V-ATPases) inhibitor</p>Formule :C39H60O12Degré de pureté :98%Couleur et forme :Light Tan SolidMasse moléculaire :720.89PIM1-IN-3
<p>PIM1-IN-3 (HL8) selectively blocks PIM1, induces Colo320 cell apoptosis, and may be researched for cancer.</p>Formule :C27H25BrN6OCouleur et forme :SolidMasse moléculaire :529.43Ph-Ph+
<p>Ph-Ph+ is a dimerized phenanthroline derivative with antitumor, antibacterial, and antifungal effects.</p>Formule :C24H17N4Couleur et forme :SolidMasse moléculaire :361.42EGFR/HER2-IN-6
<p>EGFR/HER2-IN-6 is a dual inhibitor of EGFR, HER2, and DHFR with IC50s: 0.122, 0.078, and 0.585 μM, showing anticancer potential and selectivity.</p>Formule :C18H21N5O3SCouleur et forme :SolidMasse moléculaire :387.46Fosizensertib
CAS :<p>Fosizensertib is an inhibitor of RIP-1 kinase and is used in research related to ulcerative colitis.</p>Formule :C22H21F2N4O5PCouleur et forme :SolidMasse moléculaire :490.397SMIP34
CAS :<p>SMIP34 is an inhibitor of PELP1, binding to this target with a dissociation constant (Kd) of 37.4 μM. It demonstrates efficacy in inhibiting the proliferation of cancer cells and tumor progression. Specifically, SMIP34 is effective in breast cancer research, showing activity against wild-type (WT), mutant (MT) estrogen receptor-positive (ER+), and treatment-resistant (TR)-ER+ breast cancers.</p>Formule :C25H32ClN5O3Couleur et forme :SolidMasse moléculaire :486.01LSD1-IN-21
<p>LSD1-IN-21: potent LSD1 inhibitor, crosses blood-brain barrier, IC50 of 0.956 μM; lowers TNF-α, anti-cancer, anti-inflammatory.</p>Formule :C24H25N5O2SCouleur et forme :SolidMasse moléculaire :447.55PSP205
CAS :<p>PSP205 is an effective anticancer agent with cytotoxic properties. It induces apoptosis and triggers autophagy mediated by ER stress. Furthermore, PSP205 enhances the expression of LC3BII protein and increases the expression of CHOP and spliced XBP1 at both mRNA and protein levels.</p>Formule :C28H32ClN7O5S2Couleur et forme :SolidMasse moléculaire :646.181RSK-IN-2
CAS :<p>RSK-IN-2 (Compound 3e) is an inhibitor of RSK, showing IC50 values of 37.89 nM for RSK2, 30.78 nM for RSK1, 20.51 nM for RSK3, and 91.28 nM for RSK4. It suppresses tumor cell proliferation, induces apoptosis, and causes cell cycle arrest at the G2/M phase.</p>Formule :C25H30ClN7O3Couleur et forme :SolidMasse moléculaire :512.004Lysosomal P-gp targeted agent 1
CAS :<p>Lysosomal P-gp targeted agent 1 (Compound 14) is an antitumor drug that targets lysosomal P-glycoprotein (Pgp). It is selectively transported to lysosomes via overexpressed Pgp, releasing nitric oxide that generates reactive oxygen species (ROS), causing lysosomal membrane permeabilization (LMP) and inducing apoptosis. This compound can overcome resistance mediated by P-glycoprotein, leading to cell cycle arrest while maintaining relatively low toxicity to normal cells. It exhibits antitumor activity by significantly inhibiting tumor growth.</p>Formule :C39H34N2O9SCouleur et forme :SolidMasse moléculaire :706.76Topo II/HDAC-IN-2
CAS :<p>Topo II/HDAC-IN-2 (8d) demonstrates remarkable dual inhibitory effects on Topo II and HDAC, and also induces apoptosis [1].</p>Formule :C17H20N4O3SCouleur et forme :SolidMasse moléculaire :360.43XIAP degrader-1
<p>XIAP degrader-1 is a small primary amine molecule that promotes the degradation of X-linked apoptosis inhibitory protein (XIAP).</p>Formule :C34H45N5O4Couleur et forme :SolidMasse moléculaire :587.7506:0 PE
CAS :<p>06:0 PE (PE(6:0/6:0)) is a water-soluble phospholipid characterized by its short acyl chains. It possesses notable antitumor activity and can inhibit tumor progression in the body. Additionally, it exhibits antiproliferative and pro-apoptotic properties, and serves as a precursor for phosphatidylcholine and phosphatidylethanolamine.</p>Formule :C17H34NO8PCouleur et forme :SolidMasse moléculaire :411.43ER covalent antagonist-1
CAS :<p>ER covalent antagonist-1 (Compound 39D) acts as an antagonist of the estrogen receptor α (ERα). This compound inhibits the proliferation of ERα-positive MCF-7 cells with an IC50 of 0.98 μM, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis. Additionally, ER covalent antagonist-1 demonstrates antitumor activity in mouse models.</p>Formule :C33H32N2O5SCouleur et forme :SolidMasse moléculaire :568.683p38 MAPK-IN-3
<p>Compound 2c is a potent p38α MAPK inhibitor with antitumor effects, enhancing apoptosis and ROS.</p>Formule :C22H17BrO2Couleur et forme :SolidMasse moléculaire :393.27c-Myc inhibitor 16 iodide
CAS :<p>c-Myc inhibitor16 iodide (Compound W11) is a selective inhibitor of the c-MycG-quadruplex (c-MycG4). It suppresses the transcription and translation of the c-Myc gene, disrupts the tumor cell cycle by halting growth at the G0/G1 phase, and activates mitochondrial apoptotic pathways, leading to early apoptosis in cancer cells. This compound shows potential for research in breast cancer.</p>Formule :C26H24INOCouleur et forme :SolidMasse moléculaire :493.379Fluvastatin sodium monohydrate
CAS :<p>Fluvastatin (XU 62-320) sodium monohydrate, a fully synthetic competitive HMG-CoA reductase inhibitor, features an IC 50 of 8 nM. This compound also safeguards vascular smooth muscle cells from oxidative stress via the Nrf2-dependent antioxidant pathway [1] [2].</p>Formule :C24H27FNNaO5Couleur et forme :SolidMasse moléculaire :451.46HDL-16
CAS :<p>HDL-16 is a highly effective P2Y14R antagonist with anti-colitis effects, targeting P2Y14R in intestinal epithelial cells to alleviate ulcerative colitis.</p>Formule :C14H11BrN2ODegré de pureté :97.58%Couleur et forme :SolidMasse moléculaire :303.15IMB5046
CAS :<p>IMB5046 is a microtubule inhibitor that induces apoptosis (cell death) by obstructing the G2/M phase of the cell cycle. It possesses antitumor properties.</p>Formule :C19H20N2O5SCouleur et forme :SolidMasse moléculaire :388.438[D-Leu-4]-OB3
CAS :[D-Leu-4]-OB3 suppresses the expression of genes associated with inflammation, proliferation, and metastasis, as well as the expression of PD-L1.Formule :C29H50N8O12SCouleur et forme :SolidMasse moléculaire :734.82DL-Buthionine-(S,R)-sulfoximine hydrochloride
<p>DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent and specific glutamylcysteine synthetase biosynthesis inhibitor</p>Formule :C8H19ClN2O3SCouleur et forme :SolidMasse moléculaire :258.77TOPOI/PARP-1-IN-1
CAS :<p>Compound B6, also known as TOPOI/PARP-1-IN-1, is a dual inhibitor targeting TOPOI and PARP, exhibiting low cytotoxicity and oral activity with a PARP1 IC 50 of 0.09 μM. This compound effectively inhibits cancer cell proliferation and migration, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis. In murine models, TOPOI/PARP-1-IN-1 demonstrated a tumor growth inhibition rate (TGI) of 75.4% [1].</p>Formule :C36H38Br2N4O2Couleur et forme :SolidMasse moléculaire :718.52JR5-26B
CAS :<p>JR5-26B is an orally active apoptosis (apoptosis) inducer. It induces cell death via copper-mediated apoptosis and necroptosis (necroptosis). JR5-26B exhibits antiproliferative activity against MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2 cells, with IC50 values of 0.6, 4.4, 8.0, 1.1, and 3.4 μM, respectively.</p>Formule :C19H17FN6OCouleur et forme :SolidMasse moléculaire :364.38FLT3-ITD-IN-3
CAS :<p>FLT3-ITD-IN-3 (13v) is an orally active inhibitor of FLT3-ITD (internal tandem duplication of FLT3), which works by blocking FLT3 signaling. This inhibition leads to cell cycle arrest in the G0/G1 phase and induces apoptosis. The compound is currently employed in studies related to acute myeloid leukemia (AML).</p>Formule :C27H21ClF2N6O5Couleur et forme :SolidMasse moléculaire :582.9432-Deoxy-L-ribose
CAS :<p>2-Deoxy-L-ribose is the stereoisomer of 2-Deoxy-D-ribose and can inhibit the anti-apoptotic effects of 2-Deoxy-D-ribose. Additionally, 2-Deoxy-L-ribose is capable of suppressing tumor cell metastasis by downregulating thymidine phosphorylase overexpression.</p>Formule :C5H10O4Couleur et forme :SolidMasse moléculaire :134.13ASK1-IN-8
CAS :<p>ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM. In a mouse liver injury model induced by Acetaminophen, ASK1-IN-8 significantly reduces plasma alanine aminotransferase (ALT) levels, offering liver protection. This compound is useful for research in liver disease-related fields.</p>Formule :C26H32N8O2Couleur et forme :SolidMasse moléculaire :488.585YCW-E11
CAS :<p>YCW-E11 is an antiapoptotic Bcl-2 family proteins inhibitor.</p>Formule :C25H21Cl2N3O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :594.49QTX125 TFA
<p>QTX125 TFA: Potent, selective HDAC6 inhibitor with antitumor effects.</p>Formule :C25H20F3N3O7Couleur et forme :SolidMasse moléculaire :531.44SphK1-IN-2
<p>SphK1-IN-2: SphK1 inhibitor, IC50: 19.81 nM; less effective on SphK2. Induces apoptosis, hinders cancer cell growth.</p>Formule :C27H30BrNO4SCouleur et forme :SolidMasse moléculaire :544.5FLT3-IN-13
<p>FLT3-IN-13 inhibits topoisomerase II/FLT3 in leukemia with IC50 of 2.26 μM, causes G2/M arrest, and promotes apoptosis.</p>Formule :C20H14N4O2Couleur et forme :SolidMasse moléculaire :342.35FKBP12 PROTAC dTAG-13
CAS :<p>FKBP12 PROTAC dTAG-13 is a PROTAC and selective degrader for target validation by splicing FKBP12 F36V with CRBN and thereby degrading FKBP12 F36V.</p>Formule :C57H68N4O15Degré de pureté :97.31%Couleur et forme :SolidMasse moléculaire :1049.17PARP1-IN-12
<p>PARP1-IN-12: potent PARP1 inhibitor, IC50 2.99 nM, triggers cell apoptosis, G2/M arrest, induces DSBs in BRCA-deficient cells.</p>Formule :C43H56FN5O5Couleur et forme :SolidMasse moléculaire :741.93Ran-IN-1
CAS :Ran-IN-1 (Compound M36) is an orally active and selective inhibitor of Ran GTPase. It binds allosterically with high specificity to the switch II pocket of GDP-bound Ran (RanGDP), stabilizing its inactive state and reducing the formation of active Ran-GTP. Ran-IN-1 induces apoptosis in epithelial ovarian cancer (EOC) cells and inhibits DNA repair pathways such as homologous recombination (HR) and non-homologous end joining (NHEJ). This compound shows potential for research in epithelial ovarian cancer, particularly in high-grade serous carcinoma.Formule :C27H26F3NO4SCouleur et forme :SolidMasse moléculaire :517.56RWJ-56110
CAS :<p>protease-activated receptor-1 (PAR1) antagonist</p>Formule :C41H43Cl2F2N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :790.73GLUT-1-IN-4
CAS :<p>GLUT-1-IN-4 (Compound 13) is an inhibitor of the GLUT-1 glucose transporter that depends on the p53 protein. It suppresses the proliferation of various cancer cells at submicromolar IC50 levels. Additionally, GLUT-1-IN-4 can halt the cell cycle, induce oxidative stress, and promote apoptosis (cell death).</p>Formule :C15H10N2O3Couleur et forme :SolidMasse moléculaire :266.251SPI-001
CAS :<p>SPI-001 is a selective inhibitor of PPM1D (IC50=0.48 µM) that exhibits anticancer activity. The compound inhibits the phosphatase activity of PPM1D in human breast cancer cells overexpressing PPM1D and enhances the phosphorylation of p53. Additionally, SPI-001 suppresses cell proliferation by inducing apoptosis.</p>Formule :C30H60O4Si2Couleur et forme :SolidMasse moléculaire :540.97KIM-161
CAS :<p>KIM-161 is a PIK3CA inhibitor. It demonstrates significant antiproliferative activity, with IC50 values of 1.428 and 1.562 µM against PI3KCA-mutant breast cancer cell lines MCF7 and T47D, respectively. KIM-161 induces apoptosis and cell cycle arrest by inhibiting the PI3K/AKT/mTOR signaling pathway, leading to ROS production. It is applicable for research on breast cancer and its PI3KCA-mutant subtypes.</p>Formule :C27H25N3O3Couleur et forme :SolidMasse moléculaire :439.51Casein kinase 1δ-IN-29
CAS :<p>Casein kinase1δ-IN-29 (Compound 18) is an inhibitor that targets p38α and casein kinase 1 (CK1), exhibiting inhibitory effects on p38α, CK1δ, and CK1ε with IC50 values of 0.041 µM, 0.005 µM, and 0.447 µM, respectively. This compound causes cell cycle arrest at the subG1 phase and induces apoptosis in AC1-M88 cells.</p>Formule :C26H23FN4O4SCouleur et forme :SolidMasse moléculaire :506.549PARP/NAMPT-IN-1
CAS :<p>PARP/NAMPT-IN-1 (Compound 13j) is a dual-target inhibitor of PARP and NAMPT, with IC50 values of 0.8 nM for PARP1 and 18 nM for NAMPT. It suppresses breast cancer cell proliferation and migration, inducing apoptosis. PARP/NAMPT-IN-1 is applicable for research on triple-negative breast cancer.</p>Formule :C34H36FN7O3Couleur et forme :SolidMasse moléculaire :609.693TrxR/EGFR-IN-1
CAS :<p>TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor with activity against both gefitinib-sensitive and -resistant lung cancer, effectively suppressing tumor proliferation and promoting apoptosis. It enhances GPX4 degradation through autophagosome-lysosome and proteasome pathways, leading to ferroptosis. Additionally, it induces endoplasmic reticulum stress and triggers immunogenic cell death, making it applicable for studies on gefitinib-resistant lung cancer.</p>Formule :C24H24AuClFN6O2PCouleur et forme :SolidMasse moléculaire :710.878Anti-inflammatory agent 16
<p>Compound 14 is a peptidomimetic that significantly lowers TNFα, NO, CD40, and CD86, showcasing strong anti-inflammatory effects.</p>Formule :C21H23N5O3Couleur et forme :SolidMasse moléculaire :393.44SSB-2548
CAS :<p>SSB-2548 is a CXCR-4 inhibitor that suppresses the proliferation and migration of acute myeloid leukemia cells and induces apoptosis (apoptosis). It is well absorbed in the gastrointestinal tract and can be used for leukemia research.</p>Formule :C18H17N5O2Couleur et forme :SolidMasse moléculaire :335.36Anticancer agent 64
CAS :<p>Anticancer agent 64 (5m) induces apoptosis, has IC50 2.4μM in CCRF-CEM, activates caspases, cleaves PARP, affects mitochondria.</p>Formule :C31H46N2O2SCouleur et forme :SolidMasse moléculaire :510.77Tubulin inhibitor 17
<p>Compound 3b inhibits tubulin polymerization, IC50 12.38 µM, with anticancer properties and promotes cell apoptosis.</p>Formule :C17H16N2OCouleur et forme :SolidMasse moléculaire :264.323-AP-Me
CAS :<p>3-AP-Me is the dimethyl derivative of the ribonucleotide reductase inhibitor 3-AP (SML0568). It activates the endoplasmic reticulum (ER) stress pathway by promoting eIF2α phosphorylation and upregulating gene expression of transcription factors ATF4 and ATF6, thereby inducing apoptosis. Additionally, 3-AP-Me activates cellular stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase, leading to the upregulation of spliced mRNA variant XBP1. It is applicable in cancer research.</p>Formule :C9H13N5SCouleur et forme :SolidMasse moléculaire :223.298HDAC1-IN-5
<p>HDAC1-IN-5 inhibits HDAC1 (IC50=15 nM) & HDAC6 (IC50=20 nM), promotes apoptosis, damages chromatin, and reduces tumor growth in mice.</p>Formule :C20H21N3O2SCouleur et forme :SolidMasse moléculaire :367.46Ganoderic acid R
CAS :<p>Ganoderic acid R: potent anticancer, induces apoptosis, cytotoxic to MDR and sensitive tumor cells.</p>Formule :C34H50O6Couleur et forme :SolidMasse moléculaire :554.76JH-XVII-10
<p>JH-XVII-10: potent, oral DYRK1A/B inhibitor (IC50: 3/5 nM), shows antitumor activity in HNSCC.</p>Formule :C21H16F4N8OCouleur et forme :SolidMasse moléculaire :472.4Anticancer agent 69
<p>Anticancer agent 69 targets PC3 cells (IC50=26 nM), raises ROS, lowers EGFR, and induces apoptosis.</p>Formule :C19H26N8SCouleur et forme :SolidMasse moléculaire :398.53MY-875
<p>MY-875 inhibits microtubule formation, binds like colchicine (IC50: 0.92 μM), activates Hippo pathway, and induces apoptosis with anticancer properties.</p>Formule :C21H25NO6Couleur et forme :SolidMasse moléculaire :387.43PD-L1/VISTA-IN-1
CAS :<p>PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual inhibitor targeting PD-L1 and VISTA. It effectively hinders the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), leading to the reactivation of T cells. Additionally, PD-L1/VISTA-IN-1 exhibits antitumor activity.</p>Formule :C22H24N4O4Couleur et forme :SolidMasse moléculaire :408.45MRK003
CAS :<p>MRK003, a γ-secretase inhibitor, induces apoptosis, halts cell growth in myeloma/NHL, and affects notch signaling and PI3K/Akt pathway.</p>Formule :C25H31F6N3O2SCouleur et forme :SolidMasse moléculaire :551.59Topoisomerase I/II inhibitor 8
CAS :<p>TopoisomeraseI/II inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of TopoisomeraseI/II that induces DNA damage and activates PARP-1, leading to the activation of RIPK1, RIPK3, and MLKL, ultimately causing necroptosis. It shows significant anticancer activity by effectively targeting cancer cell nuclei and inducing cell death through necroptosis, offering substantial clinical potential in overcoming resistance in cancer treatment.</p>Formule :C14H11Br2NO5S2Couleur et forme :SolidMasse moléculaire :497.179Bcl-2-IN-6
<p>Bcl-2-IN-6 suppresses Bcl-2, upregulates p53/Bax/caspase-7, arrests cell cycle, and induces MCF-7 apoptosis; IC50s: MCF-7 20.91 μM, others <48 μM.</p>Formule :C25H24N4O5S2Couleur et forme :SolidMasse moléculaire :524.61KDM1/CDK1-IN-1
<p>KDM1/CDK1-IN-1 inhibits KDM1 (IC50: 0.096 μM) & CDK1 (IC50: 0.078 μM), blocks HOP-92 G2/M phase, induces apoptosis, toxic to cancer cells.</p>Formule :C22H17N5O3SCouleur et forme :SolidMasse moléculaire :431.47Casuarinin
CAS :<p>Casuarinin, an ellagitannin found in pomegranates and certain Casuarina/Stachyurus plants, is a carbonic anhydrase inhibitor and astringent.</p>Formule :C41H28O26Couleur et forme :SolidMasse moléculaire :936.65PI4KIII β inhibitor 4
CAS :<p>PI4KIII beta inhibitor 4 (Compound 16) is a selective inhibitor of PI4KIIIβ with an IC50 of 0.005 μM. By inhibiting the PI3K/AKT pathway, PI4KIII beta inhibitor 4 induces apoptosis, causes cell cycle arrest, and triggers autophagy in tumor cells. This compound is applicable for tumor research.</p>Formule :C24H36N4O6S2Couleur et forme :SolidMasse moléculaire :540.696TNF-α-IN-14
CAS :<p>TNF-α-IN-14, a potent TNFα inhibitor, exhibits a selective inhibition profile with an IC50 of 1.1 µM and demonstrates antiinflammatory properties (WO2001072735A2; compound 12) [1].</p>Formule :C22H26O6Couleur et forme :SolidMasse moléculaire :386.44MDK-3345
CAS :<p>MDK-3345 is a reversible covalent inhibitor for Mcl-1.</p>Formule :C36H34BN3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :631.48HR-19011
CAS :<p>HR-19011 (Compound 40) is an inducer of eIF2α phosphorylation that increases expression levels of downstream proteins ATF and CHOP,antiproliferative.</p>Formule :C25H19F6N3O3Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :523.43PARP10/15-IN-2
CAS :<p>PARP10/15-IN-2 (Compound 8h) blocks PARP10/15, has IC50s: 0.15μM/0.37μM, cell-permeable, prevents apoptosis.</p>Formule :C15H11FN2O3Couleur et forme :SolidMasse moléculaire :286.26Mcl-1 inhibitor 9
CAS :<p>Mcl-1 Inhibitor 9 (Example 2) is a potent inhibitor of myeloid cell leukemia 1 (Mcl-1), demonstrating anti-tumor activity with an IC50 value of 0.21889 nM.</p>Formule :C32H39ClN2O5SCouleur et forme :SolidMasse moléculaire :599.18FGFR4-IN-7
<p>FGFR4-IN-7 is a covalent, reversible FGFR4 inhibitor (IC50: 0.42 μM) that blocks the FGFR4 signaling pathway, thereby inducing apoptosis.</p>Formule :C26H25Cl2N5O3Couleur et forme :SolidMasse moléculaire :526.41Thalidomide-NH-C5-NH2
CAS :<p>Thalidomide-NH-C5-NH2 is a synthetic E3 ligase ligand-linker conjugate, consisting of a Thalidomide-based cereblon ligand and a linker, used in the synthesis of PROTACs.</p>Formule :C18H22N4O4Masse moléculaire :358.39ZLHQ-5f
<p>ZLHQ-5f inhibits CDK2/Topo I, with IC50 of 0.145μM for CDK2/CycA2, and promotes apoptosis by arresting HCT116 cells in S phase.</p>Formule :C28H25N5O2Couleur et forme :SolidMasse moléculaire :463.53Kahweol Acetate
CAS :<p>Kahweol Acetate, a semi-synthetic coffee bean derivative, inhibits osteoclasts, cancer cells, DNA damage, and oxidative stress.</p>Formule :C22H28O4Couleur et forme :SolidMasse moléculaire :356.46Akt/NF-κB/JNK-IN-1
<p>Akt/NF-κB/JNK-IN-1 (Compound 2i) is an inhibitor of Akt, NF-κB and JNK signalling pathways.Akt/NF-κB/JNK-IN-1 exhibits an inhibitory effect on nitric oxide</p>Formule :C22H22N2O6Couleur et forme :SolidMasse moléculaire :410.42STAT3-IN-12
CAS :<p>STAT3-IN-12,STAT3 signaling inhibitor. Blocks IL-6-induced JAK/STAT3 activation. Induces apoptosis. Used in HCC and esophageal cancer research.</p>Formule :C28H30N4O2Degré de pureté :99.19%Couleur et forme :SoildMasse moléculaire :454.56(R)-SL18
CAS :<p>(R)-SL18 is a degrader of ANXA3 that facilitates its breakdown via ubiquitination. This compound can inhibit the proliferation, migration, invasion, and colony formation of breast cancer cells, while also inducing apoptosis. (R)-SL18 is applicable for research in triple-negative breast cancer.</p>Formule :C26H21ClN6O5S2Couleur et forme :SolidMasse moléculaire :597.065HAC-Y6
CAS :<p>HAC-Y6 exerts its anticancer effects by inducing cell cycle arrest. It prompts apoptosis in COLO 205 cells with an IC50 of 0.52 µM.</p>Formule :C23H22N2O4Couleur et forme :SolidMasse moléculaire :390.43Scytonemin
CAS :<p>Scytonemin, a cyanobacterial pigment, inhibits cancer cell growth by decreasing Plk1 activity, especially effective on U266 myeloma cells.</p>Formule :C36H20N2O4Couleur et forme :SolidMasse moléculaire :544.55EGFR/VEGFR2-IN-3
CAS :<p>EGFR/VEGFR2-IN-3 (compound 9) is an effective inhibitor of EGFR and VEGFR-2, demonstrating IC50 values of 0.129 µM for EGFR, 0.142 µM for VEGFR-2, and 3.428 µM for COX-2. This compound exhibits cytotoxic properties and induces cell apoptosis (apoptosis) as well as cell cycle arrest at the G2/M phase.</p>Formule :C24H20ClN5O2S2Couleur et forme :SolidMasse moléculaire :510.03pan-KRAS-IN-5
CAS :<p>Pan-KRAS-IN-5 (compound 15a) is a pan-KRAS translation inhibitor targeting 5′-UTR RNA G-quadruplexes (rG4s). It induces cell cycle arrest and promotes apoptosis in KRAS-driven cancer cells [1].</p>Formule :C31H36FIN4O2Couleur et forme :SolidMasse moléculaire :642.55CAR-2
CAS :<p>CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LD). It exhibits phototoxicity against breast cancer cells with an IC50 of 0.01-0.02 μM and demonstrates antitumor efficacy in a 4T1 xenograft mouse model.</p>Formule :C27H23BF2I2N4O2Couleur et forme :SolidMasse moléculaire :738.114VEGFR-2-IN-11
<p>VEGFR-2-IN-11 is a potent inhibitor of VEGFR-2 (IC50: 60.27 nM) with an IC50 value of 60.27 nM, which induces apoptosis and has anticancer activity.</p>Formule :C29H22BrN5SCouleur et forme :SolidMasse moléculaire :552.49VDR agonist 1
CAS :<p>Compound 28 is a nonsteroidal VDR agonist with 690 nM potency, inducing cell cycle arrest and apoptosis in MCF-7 cells.</p>Formule :C32H51N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.774-Hydroxyresveratrol
CAS :<p>4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene) is a resveratrol analog that variably induces the expression of pro-apoptotic genes such as p53 and Bax. It triggers apoptosis in SV40 virus-transformed WI38 cells (WI38VA), but not in WI38 cells. Additionally, 4-Hydroxyresveratrol significantly increases the expression of p53, GADD45, and Bax genes in WI38VA cells, while suppressing the expression of the bcl-2 gene.</p>Formule :C14H12O4Couleur et forme :SolidMasse moléculaire :244.243PLK1-IN-13
CAS :<p>PLK1-IN-13 is a selective, orally active PLK1 inhibitor with an IC50 of 0.27 nM. It also inhibits PLK2 (IC50: 12.72 nM) and PLK3 (IC50: 4.12 nM). PLK1-IN-13 induces cell cycle arrest at the G2 phase, promotes apoptosis, and downregulates the transcription of the cancer-associated oncogene c-MYC. This compound inhibits tumor growth and is applicable for research in acute myeloid leukemia (AML).</p>Formule :C29H39N9O2SCouleur et forme :SolidMasse moléculaire :577.744LSD1/ER-IN-1
<p>LSD1/ER-IN-1 inhibits ER & LSD1 (IC50: 1.55 μM), and fights MCF-7 breast cancer (IC50: 8.79 μM).</p>Formule :C23H18FNO6SCouleur et forme :SolidMasse moléculaire :455.46BNN27
CAS :<p>BNN27 is an agonist of the TrkA receptor (TrkAreceptor) and the p75NTR receptor (p75NTR receptor), exhibiting neurotrophic and anti-apoptotic properties. It enhances levels of glutamate, GABA, and glutamine in the hippocampus and prefrontal cortex of rats, improving glutamate turnover. In a mouse model of amyotrophic lateral sclerosis (ALS), BNN27 demonstrates neuroprotective effects, shows anti-inflammatory properties in an experimental autoimmune encephalomyelitis (EAE) model, and exhibits retinal protection in a rat diabetes model. BNN27 also possesses blood-brain barrier permeability.</p>Formule :C21H32O3Couleur et forme :SolidMasse moléculaire :332.477BCL6-IN-9
CAS :<p>BCL6-IN-9 (compound 1) is a potent inhibitor of B-cell lymphoma 6 protein (BCL6) (IC50: 3.9 nM) and can be used to study cancer.</p>Formule :C22H18ClF2N5O2Couleur et forme :SolidMasse moléculaire :457.86ASTX295
CAS :<p>ASTX295 is a selective mouse double minute 2 (MDM2) antagonist with an IC50 value of less than 1 nM. It specifically inhibits the interaction between MDM2 and p53, reactivating wild-type (WT) TP53, which subsequently induces the expression of related transcriptional targets, leading to cell death and cell cycle arrest. ASTX295 holds potential for research in lymphoid malignancies such as diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and T-cell lymphoma.</p>Formule :C33H34Cl2FNO6Couleur et forme :SolidMasse moléculaire :630.531SIRT-IN-7
CAS :<p>SIRT-IN-7 (Compound 7ba) is a SIRT inhibitor. It effectively suppresses the expression of SIRT1, SIRT2, and SIRT3, leading to increased acetylation and activation of p53. Additionally, SIRT-IN-7 inhibits the proliferation of breast cancer cells and induces apoptosis and autophagy, demonstrating antitumor activity.</p>Formule :C24H16BrClN2OSCouleur et forme :SolidMasse moléculaire :495.819VEGFR-2-IN-18
<p>VEGFR-2-IN-18 is a potent VEGFR-2 inhibitor with a 60 nM IC50, promoting cell apoptosis and anticancer effects.</p>Formule :C20H13ClN4O2Couleur et forme :SolidMasse moléculaire :376.8CB-184
CAS :<p>CB-184 is a selective ligand for sigma-2 (σ2) receptors, with Ki values of 7436 nM for sigma-1 (σ1) and 13.4 nM for sigma-2 (σ2), and it promotes apoptosis with antitumor activity.</p>Formule :C22H21Cl2NO2Couleur et forme :SolidMasse moléculaire :402.31PAK4-IN-5
<p>PAK4-IN-5 (Compound 12i) is a potent inhibitor of PAK4 (IC50: PAK4 at 7.68 nM, PAK1 at 1872.01 nM) that forms stable interactions with the PAK4 enzyme. This compound effectively inhibits the proliferation and migration potential of MDA-MB-231 cells by hindering the phosphorylation of PAK4 and LIMK1. Additionally, PAK4-IN-5 arrests the cell cycle in the G0/G1 phase, induces apoptosis, and prompts the production of reactive oxygen species. The LD50 in mice is greater than 500 mg/kg (oral).</p>Formule :C31H28ClN5OCouleur et forme :SolidMasse moléculaire :522.04PD-1-IN-17 TFA
<p>PD-1-IN-17 TFA is a potent PD-1 inhibitor, blocking 92% of splenocyte growth at 100 nM.</p>Formule :C15H23F3N6O9Couleur et forme :SolidMasse moléculaire :488.37NSC308848
CAS :<p>NSC308848 is an effective apoptosis (cell death) inducer that operates in a Myc-dependent manner. It acts by inhibiting Myc transactivation and disrupting the DNA binding activity of Myc family proteins.</p>Formule :C18H21N3O2Couleur et forme :SolidMasse moléculaire :311.378Autophagy inducer 7
CAS :<p>Autophagyinducer 7 (Compound SSA) serves as an inducer of autophagy (Autophagy) and apoptosis (Apoptosis). It stimulates autophagy by inhibiting Akt/mTOR signaling and the expression of downstream proteins. Additionally, Autophagyinducer 7 suppresses DNA synthesis and causes G0-G1 cell cycle arrest, ultimately inhibiting the growth of tumor cells.</p>Formule :C24H27FN2OSCouleur et forme :SolidMasse moléculaire :410.547Decarbamoylmitomycin C
CAS :<p>Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.</p>Formule :C14H17N3O4Couleur et forme :SolidMasse moléculaire :291.302Antiangiogenic agent 7
CAS :<p>Antiangiogenic agent 7 (Compound 1) induces apoptosis, elevates Reactive Oxygen Species (Reactive Oxygen Species), and inhibits the intracellular enzyme thioredoxin reductase. It exhibits anticancer activity with IC50 values ranging from 0.08 to 3.5 μM against cervical cancer cells (HeLa), prostate cancer cells (PC-3), and non-small cell lung cancer cells (A549). Additionally, Antiangiogenic agent 7 suppresses tumor growth in a mouse xenograft model.</p>Formule :C24H26AuN3P2SCouleur et forme :SolidMasse moléculaire :647.46EGFR-IN-44
<p>EGFR-IN-44: potent EGFR kinase inhibitor, orally active, IC50 4.11 nM, 33.57% bioavailability, induces apoptosis, for lung cancer study.</p>Formule :C27H29ClN6O2SCouleur et forme :SolidMasse moléculaire :537.08Oxamic acid
CAS :<p>Oxamic acid is an inhibitor of LDH-A and exhibits antitumor activity. It demonstrates antiproliferative effects on cancer cells and can induce apoptosis.</p>Formule :C2H3NO3Couleur et forme :SolidMasse moléculaire :89.05PD-L1/HDAC-IN-1
CAS :<p>PD-L1/HDAC-IN-1 (Compound 14) is an inhibitor of PD-L1 and HDAC, effectively blocking PD-1/PD-L1 interaction as well as HDAC2 and HDAC3 with IC50 values of 88.10, 27.98, and 14.47 nM, respectively. It exhibits mild cytotoxicity in MCF-7 cells (IC50=19.34 μM) and enhances the expression of PD-L1 and CXCL10, promoting antitumor immune responses by recruiting T cell infiltration into the tumor microenvironment (TME).</p>Formule :C42H46ClN3O7Couleur et forme :SolidMasse moléculaire :740.284TZEP7
CAS :<p>TZEP7 functions as an EGFR kinase inhibitor in cancer cells. It exhibits cytotoxicity and induces apoptosis within these cells. TZEP7 downregulates the anti-apoptotic protein Bcl-2, upregulates the pro-apoptotic protein Bax, and increases caspase levels. This compound holds potential for research in anticancer drug development.</p>Formule :C27H19ClFNSCouleur et forme :SolidMasse moléculaire :443.9633′-Hydroxyflavanone
CAS :<p>3′-Hydroxyflavanone is a cyclized flavonoid with anti-tumor properties that induces apoptosis in HeLa cells.</p>Formule :C15H12O3Couleur et forme :SolidMasse moléculaire :240.25AQX-435
CAS :<p>AQX-435 activates SHIP1, inhibits PI3K in BCR signaling, induces apoptosis in B cells, and slows lymphoma growth.</p>Formule :C27H34N2O4Couleur et forme :SolidMasse moléculaire :450.57WF-47-JS03
<p>WF-47-JS03: RET kinase inhibitor, crosses blood-brain barrier, 500x more selective for KDR, IC50: 1.7 nM in Ba/F3 cells, 5.3 nM in LC-2/ad lung cancer cells.</p>Formule :C30H38N6O2Couleur et forme :SolidMasse moléculaire :514.66WEHI-539
CAS :<p>WEHI-539 is a selective Bcl-XL inhibitor (IC50: 1.1 nM).</p>Formule :C31H29N5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :583.72ADH-6
CAS :<p>ADH-6, a tripyridylamide, disrupts mutant p53 aggregates in cancer cells, reviving its function and inducing apoptosis.</p>Formule :C29H36N8O9Couleur et forme :SolidMasse moléculaire :640.64Nenocorilant
CAS :<p>Nenocorilant (Relacorilant) is an orally active glucocorticoid receptor (GR) antagonist (Ki: 0.15 nM). Nenocorilant can be used to study tumours.</p>Formule :C26H21F4N7O3SCouleur et forme :SolidMasse moléculaire :587.55BRD-K56819078
CAS :<p>BRD-K56819078, a Bcl-2 inhibitor, significantly reduces the burden of senescent cells and the mRNA expression of aging-related genes in the kidneys. It exerts its anti-aging effects by inhibiting cell apoptosis (apoptosis).</p>Formule :C24H20FN3O4S2Couleur et forme :SolidMasse moléculaire :497.56MP-010
CAS :<p>MP-010 is an FKBP12 ligand that regulates cytosolic calcium by stabilizing RyR channel activity. It facilitates functional improvement in SOD1G93A mice with amyotrophic lateral sclerosis (ALS), evidenced by enhanced motor coordination, increased integrity of neuromuscular junctions, and significantly higher spinal motor neuron survival rates. MP-010 is applicable for research in the field of neurological disorders.</p>Formule :C14H20N4O2SCouleur et forme :SolidMasse moléculaire :308.399EGFR-IN-134
<p>EGFR-IN-134 (compound 3f) is a triazolo[3,4-a]quinoline derivative and functions as a potent EGFR inhibitor with an IC50 of 0.023 µM. It induces apoptosis and necrosis in cells, and causes cell cycle arrest in the G2/M and pre-G1 phases. EGFR-IN-134 modulates the expression of apoptosis-regulating proteins by downregulating anti-apoptotic protein Bcl2 and upregulating pro-apoptotic proteins p53, Bax, and caspases 3, 8, and 9, demonstrating significant antiproliferative and anticancer activities.</p>Formule :C36H30N6O5Couleur et forme :SolidMasse moléculaire :626.66Antitumor agent-78
<p>Antitumor agent-78 blocks GPx-4, raises COX2, triggers apoptosis, halts EMT, and stifles cancer cell growth and migration.</p>Couleur et forme :SoildFerroptosis-IN-6
CAS :<p>Ferroptosis-IN-6 is an efficient ferroptosis inhibitor, protecting cells from cell death induced by ferroptosis inducers, and inhibiting STY-BODIPY oxidation.</p>Formule :C15H17NODegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :227.3VEGFR-2-IN-15
<p>VEGFR-2-IN-15 (Compound 14b) is a potent inhibitor of VEGFR-2. VEGFR-2-IN-15 inhibits the growth of HepG2 cells in the Pre-G1 phase and induces apoptosis.</p>Formule :C23H18ClN3O4SCouleur et forme :SolidMasse moléculaire :467.92HL001
CAS :<p>HL001 is an orally active small molecule inhibitor of cyclophilin A (CypA) and a receptor antagonist of lysophosphatidic acid 1 (LPA1). It induces cell cycle arrest and apoptosis in tumor cells via p53. By downregulating G3BP1, HL001 promotes reactive oxygen species production and DNA damage to stabilize p53. It disrupts the interaction between MDM2 and p53-72R in a CypA-dependent manner. HL001 exhibits antitumor activity and can also be used in research on pulmonary fibrosis.</p>Formule :C21H16N2O4Couleur et forme :SolidMasse moléculaire :360.363NiCur
CAS :<p>NiCur is an effective and selective inhibitor of CBP histone acetyltransferase (HAT), with an IC50 of 0.35 μM.</p>Formule :C22H16N2ODegré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :324.38DWP-05195
CAS :<p>DWP-05195 is a TRPV1 antagonist capable of inhibiting pain signal transduction. Additionally, it induces ER stress-dependent apoptosis in human ovarian cancer cells via the ROS-p38-CHOP pathway.</p>Formule :C18H10BrF3N4Couleur et forme :SolidMasse moléculaire :419.2Anticancer agent 54
<p>Anticancer agent 54 blocks cell cycle in G0/G1, induces apoptosis, and fights cancer via DNA embedding and ROS.</p>Formule :C33H36N6Couleur et forme :SolidMasse moléculaire :516.68Spicamycin
CAS :<p>Spicamycin can be used as a potent inducer of differentiation of human myeloid leukemia cells (HL-60) and murine myeloid leukemia cells (M1).</p>Formule :C30H51N7O7Couleur et forme :SolidMasse moléculaire :621.77Bcl-2-IN-3
CAS :<p>Bcl-2-IN-3 (Compound 10) is an inhibitor of Bcl-2, utilized in cancer research.</p>Formule :C16H16N2O4Couleur et forme :SolidMasse moléculaire :300.31Lometrexol
CAS :<p>Lometrexol (LY 264618) is an antifolate that inhibits GARFT, blocks purine synthesis, induces apoptosis, and has anticancer properties.</p>Formule :C21H25N5O6Degré de pureté :97.76% - 99.56%Couleur et forme :SolidMasse moléculaire :443.45Milademetan
CAS :<p>Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.</p>Formule :C30H34Cl2FN5O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :618.53SY-5609
CAS :<p>SY-5609 (CDK7-IN-3) is a selective non-covalent CDK7 inhibitor, with weak inhibitory activity against CDK2, CDK9 and CDK12.Cost-effective and quality-assured.</p>Formule :C23H26F3N6OPDegré de pureté :99.34% - >99.99%Couleur et forme :SolidMasse moléculaire :490.46HC-5404
CAS :<p>HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.</p>Formule :C24H24F2N4O3Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :454.47PF-07328948
CAS :<p>PF-07328948 is a branched-chain keto-acid dehydrogenase kinase (BDK) inhibitor, useful for studying CVD metabolic disorders.</p>Formule :C16H8F4O3SDegré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :356.29Zotatifin
CAS :<p>Zotatifin (eFT226) is a selective eIF4A inhibitor with antiviral and antitumor properties, inhibiting Sox4 translation and inducing apoptosis.</p>Formule :C28H29N3O5Degré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :487.55BCL6-IN-3
CAS :<p>BCL6-IN-3: potent BCL6 inhibitor, 70 nM GI50 in SU-DHL4, affects cell functions, antitumor.</p>Formule :C24H31ClF2N6O2Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :508.99Tuvusertib
CAS :<p>Tuvusertib (M1774), an oral ATR inhibitor (Ki<1µM), selectively blocks CHK1 phosphorylation, disrupts DNA repair, and induces tumor cell apoptosis.</p>Formule :C16H12F2N8ODegré de pureté :98.44% - 99.66%Couleur et forme :SolidMasse moléculaire :370.32Vatalanib hydrochloride
CAS :<p>Vatalanib hydrochloride (PTK787 hydrochloride) is an orally available and highly potent tyrosine kinase (VEGF) inhibitor that reduces the number and size of Aβ plaques in the cortex of 5xFAD mice, which may be useful in the study of Alzheimer's disease and cancer.</p>Formule :C20H16Cl2N4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :383.27UH15-38
CAS :<p>UH15-38 is a potent and selective RIPK3 inhibitor that blocks necroptosis in alveolar epithelial cells triggered by IAV, useful for studying lung inflammation.</p>Formule :C26H27N5O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :441.53JAK2-IN-7
CAS :<p>JAK2-IN-7 selectively inhibits JAK2 (IC50: 3 nM), shows 14-fold selectivity over JAK1/3, FLT3, induces G0/G1 arrest, apoptosis, and has antitumor effects.</p>Formule :C26H33N7ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :459.59Gemcitabine elaidate hydrochloride
CAS :<p>CP-4126, a lipophilic pro-drug of Gemcitabine, converts to active form by esterases, allowing oral administration with dose-dependent effects.</p>Formule :C27H44ClF2N3O5Degré de pureté :98.50% - 99.6%Couleur et forme :SolidMasse moléculaire :564.11FX-11
CAS :<p>FX-11: potent LDHA inhibitor (Ki 8 μM), activates PKM2, reduces ATP, induces oxidative stress/ROS, cell death, shows antitumor effects.</p>Formule :C22H22O4Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :350.41β-Zearalanol
CAS :Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].Formule :C18H26O5Couleur et forme :SolidMasse moléculaire :322.4WEHI-539 hydrochloride
CAS :<p>WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.</p>Formule :C31H30ClN5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :620.18(R)-Verapamil hydrochloride
CAS :<p>(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is an inhibitor of P-Glycoprotein.</p>Formule :C27H39ClN2O4Couleur et forme :SolidMasse moléculaire :491.06OBAA
CAS :<p>OBAA is a potent inhibitor of phospholipase A2 (PLA2) with an IC 50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC 50 of 0.4 μM [1] [2] [3].</p>Formule :C28H44O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.65Actinonin
CAS :<p>Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. It also induces apoptosis and inhibits aminopeptidase M, aminopeptidase N, and leucine aminopeptidase, as well as MMP-1, MMP-3, MMP-8, MMP-9, and meprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin exhibits antiproliferative and antitumor activities [1][2][3][4][5].</p>Formule :C19H35N3O5Couleur et forme :SolidMasse moléculaire :385.5AP1867-3-(aminoethoxy)
CAS :<p>AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.</p>Formule :C38H50N2O9Couleur et forme :SolidMasse moléculaire :678.81PIM-447 dihydrochloride
CAS :<p>PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively).</p>Formule :C24H25Cl2F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.385-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
CAS :Formule :C9H14N4O5Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :258.2313Platinum, diammine[1,1-cyclobutanedi(carboxylato-kO)(2-)]-, (SP-4-2)-
CAS :Formule :C6H10N2O4PtDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.2326Thalidomide-O-amido-C4-NH2 hydrochloride
CAS :<p>Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon ligand derived from Thalidomide with a linker and is commonly used in the synthesis of PROTACs[1].</p>Formule :C19H23ClN4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.86Imifoplatin
CAS :<p>Imifoplatin (PT-112) is a platinum compound with antitumor activity and may be used to study prostate cancer and immune system disorders.</p>Formule :C6H16N2O7P2PtDegré de pureté :≥95.0%Couleur et forme :SolidMasse moléculaire :485.23ENMD-2076 tartrate
CAS :<p>ENMD-2076 is an orally active kinase inhibitor. It also has antiangiogenic and antiproliferative mechanisms of action.</p>Formule :C25H31N7O6Couleur et forme :SolidMasse moléculaire :525.56Swainsonine
CAS :<p>Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arrest in the G2/M phase.</p>Formule :C8H15NO3Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :173.21Ac-IETD-CHO TFA
<p>Ac-IETD-CHO TFA is a granzyme B and caspase-8 inhibitor that inhibits caspase8 activity by blocking caspase3 precursor cleavage.Ac-IETD-CHO TFA inhibits Fas-mediated apoptosis.</p>Formule :C23H35F3N4O12Couleur et forme :SoildMasse moléculaire :616.54Mcl-1 inhibitor 6
CAS :<p>Mcl-1 inhibitor 6 binds Mcl-1 with KD 0.23 nM and Ki 0.02 μM, shows strong selectivity over Bcl-2 family, and demonstrates antitumor efficacy.</p>Formule :C26H28ClNO6SCouleur et forme :SolidMasse moléculaire :518.02Ciprofloxacin lactate
CAS :<p>Ciprofloxacin lactate is a useful organic compound for research related to life sciences. The catalog number is T66299 and the CAS number is 97867-33-9.</p>Formule :C20H24FN3O6Couleur et forme :SolidMasse moléculaire :421.43Thalidomide-O-C6-COOH
CAS :<p>Thalidomide-O-C6-COOH is a synthetic conjugate that combines a Thalidomide-derived cereblon ligand with a PROTAC technology linker (E3 ligase ligand-linker).</p>Formule :C20H22N2O7Couleur et forme :SolidMasse moléculaire :402.403Thalidomide-5-COOH
CAS :<p>Thalidomide-5-COOH is a useful organic compound for research related to life sciences. The catalog number is T64600 and the CAS number is 1216805-11-6.</p>Formule :C14H10N2O6Couleur et forme :SolidMasse moléculaire :302.242SCH79797
CAS :<p>SCH79797 is a potent and specific protease-activated receptor 1 (PAR1) antagonistwith antimicrobial, anticancer, anti-inflammatory, and neuroprotective effects.</p>Formule :C23H25N5Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :371.48Thalidomide-O-C5-NH2 hydrochloride
CAS :<p>Thalidomide-O-C5-NH2 hydrochloride is a synthetic compound consisting of a ligand-linker conjugate with E3 ligase activity. It combines a cereblon ligand based on Thalidomide and a linker commonly utilized in PROTAC technology.</p>Formule :C18H22ClN3O5Couleur et forme :SolidMasse moléculaire :395.84DB818
CAS :<p>DB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression.</p>Formule :C19H16N6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.44Ingenol 3,20-dibenzoate
CAS :<p>Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms that effectively induces the translocation of nPKC-delta, -epsilon, and -theta, as well as PKC-mu, from the cytosolic fraction to the particulate fraction. Through de novo synthesis of macromolecules, it triggers apoptosis with characteristic morphology. Moreover, Ingenol 3,20-dibenzoate enhances IFN-γ production and degranulation in NK cells, particularly when stimulated by NSCLC cells[1][2].</p>Formule :C34H36O7Couleur et forme :SolidMasse moléculaire :556.65Yatein
CAS :<p>Yatein inhibits herpes simplex virus type 1 replication by interruption the immediate-early gene expression. Yatein is a lignan isolated from A. chilensis. It also has antiproliferative activity.</p>Formule :C22H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.42Prostaglandin A2
CAS :<p>PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]</p>Formule :C20H30O4Couleur et forme :SolidMasse moléculaire :334.45XMU-MP-3
CAS :<p>XMU-MP-3 is a robust, non-covalent inhibitor of BTK, exhibiting exceptional potency with IC50 values of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation, respectively, in the presence of 10 μM ATP. Moreover, XMU-MP-3 elicits apoptosis.</p>Formule :C27H27F3N8OCouleur et forme :SolidMasse moléculaire :536.563MI-773
CAS :<p>MI-773 is a potent inhibitor of the MDM2-p53 protein interaction (PPI) with a high affinity for MDM2 and a Kd value of 8.2 nM. MI-773 exhibits antitumour effects.</p>Formule :C29H34Cl2FN3O3Couleur et forme :SolidMasse moléculaire :562.5RRD-251
CAS :<p>RRD-251 is an Rb-Raf-1 interaction inhibitor that induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine[1].</p>Formule :C8H9Cl3N2SCouleur et forme :SolidMasse moléculaire :271.59Carubicin hydrochloride
CAS :<p>Carubicin HCl is an anthracycline antineoplastic antibiotic. Through intercalates into DNA and interacts with topoisomerase II, Carubicin inhibits DNA replication and repair and RNA and protein synthesis.</p>Formule :C26H28ClNO10Couleur et forme :SolidMasse moléculaire :549.95Vatiquinone
CAS :<p>Vatiquinone, also known as EPI 743, is an orally bioavailable para-benzoquinone being developed for inherited mitochondrial diseases. The mechanism of action of EPI-743 involves augmenting the synthesis of glutathione, optimizing metabolic control, enhanc</p>Formule :C29H44O3Couleur et forme :SolidMasse moléculaire :440.66A-192621
CAS :<p>A-192621 is a potent, nonpeptide, orally active, and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and elevates both arterial blood pressure and plasma ET-1 levels[1][2][3]. Its selectivity is 636-fold higher for ETB than ETA (IC50 of 4280 nM and Ki of 5600 nM).</p>Formule :C33H38N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.66CTB
CAS :<p>CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.</p>Formule :C16H13ClF3NO2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :343.73Faradiol 3-Myristate
CAS :Produit contrôléFormule :C44H76O3Couleur et forme :NeatMasse moléculaire :653.072anti-TNBC agent-2
CAS :<p>Anti-TNBC agent-2 (3j), a purine derivative, acts as an anti-triple negative breast cancer (TNBC) therapeutic.</p>Formule :C28H37ClFN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :542.09DETD-35
CAS :<p>DETD-35 is a promising chemical compound in anti-melanoma therapy, functioning as an inhibitor of the MEK-ERK, Akt, and STAT3 signaling pathways. It enhances cancer cell apoptosis (Apoptosis) and diminishes resistance to Vemurafenib in cancer cells. The compound exhibits IC 50 values of 2.7, 6.0, 3.9, 3.1, and 2.5 μM against melanoma cell lines B16-F10, MeWo, SK-MEL-2, A2058c, and A375c, respectively. DETD-35 offers significant potential for advancing research in melanoma treatment strategies.</p>Formule :C27H24O6Couleur et forme :SolidMasse moléculaire :444.48ZSQ836
CAS :<p>ZSQ836 is a dual covalent inhibitor of CDK12/CDK13 with oral bioactivity, displaying an EC50 value of 32 nM against CDK12. This compound can induce cell apoptosis (apoptosis) and demonstrates in vivo anticancer properties. ZSQ836 is applicable for research in ovarian cancer.</p>Formule :C27H28AsClN6OS2Couleur et forme :SolidMasse moléculaire :627.05SMIP34
CAS :<p>SMIP34 is an inhibitor of PELP1 that demonstrates the capability to reduce cell viability and colony formation. Additionally, SMIP34 induces cell apoptosis (apoptosis) and causes cell cycle arrest in the S phase. It reduces the expression of PELP1 and exhibits anti-tumor activity. SMIP34 also has potential for research in triple-negative breast cancer (TNBC).</p>Formule :C20H15ClFN5O2SCouleur et forme :LiquidMasse moléculaire :443.88CHMFL-48
CAS :<p>CHMFL-48, an orally active inhibitor of BCR-ABL kinase, demonstrates efficacy against both the wild-type (wt) and various imatinib-resistant mutants. It exhibits potent inhibitory activity, with IC 50 values of 1 nM for the ABL wild-type and 0.8 nM for the ABL T315I mutant. CHMFL-48 operates by inhibiting the autophosphorylation of both wild-type and mutant BCR-ABL, affecting downstream signaling mediators including STAT5 and CRKL. This disruption leads to cell cycle arrest and triggers apoptosis. Given its properties, CHMFL-48 is a promising candidate for research on chronic myeloid leukemia (CML).</p>Formule :C31H30F3N7OCouleur et forme :SolidMasse moléculaire :573.61Cyy-272
CAS :<p>Cyy-272 is an orally active JNK inhibitor with IC50 values of 1.25, 1.07, and 1.24 μM against JNK1, JNK2, and JNK3, respectively. It exerts anti-inflammatory effects by inhibiting the phosphorylation of JNK, thereby alleviating acute lung injury (ALI) induced by lipopolysaccharide (LPS). Moreover, Cyy-272 significantly reduces inflammation in cardiomyocytes and cardiac tissues caused by high lipid concentrations, further mitigating resultant cardiac hypertrophy, fibrosis, and apoptosis. Cyy-272 is utilized in the study of obesity-related myocarditis.</p>Formule :C23H23F2N7Couleur et forme :SolidMasse moléculaire :435.47IHMT-MST1-39
CAS :<p>IHMT-MST1-39 is an orally effective MST kinase inhibitor with IC50 values of 42 nM for MST1 and 109 nM for MST2. It activates the AMPK signaling pathway in hepatocytes and inhibits apoptosis in pancreatic β cells. Additionally, IHMT-MST1-39 improves type 1 diabetes in mice induced by Streptozotocin.</p>Formule :C20H18F2N6O3SCouleur et forme :SolidMasse moléculaire :460.46Taltobulin
CAS :<p>Taltobulin (HTI-286) is a synthetic analog of the tripeptide cysteine, a microtubule protein inhibitor that inhibits liver tumor cell proliferation in vitro and tumor growth in vivo.Taltobulin is cytotoxic, induces mitotic arrest and apoptosis, and may be used in the study of breast cancer and microtubule tissue-related diseases.</p>Formule :C27H43N3O4Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :473.65
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