Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5599 produits trouvés pour "Apoptose"
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p38 MAPK-IN-3
<p>Compound 2c is a potent p38α MAPK inhibitor with antitumor effects, enhancing apoptosis and ROS.</p>Formule :C22H17BrO2Couleur et forme :SolidMasse moléculaire :393.27Thalidomide-Piperazine-PEG1-NH2
CAS :<p>Thalidomide-Piperazine-PEG1-NH2 is a synthetic E3 ligase ligand-linker conjugate, featuring a cereblon ligand based on Thalidomide and a single linker.</p>Formule :C21H27N5O5Masse moléculaire :429.47PD-1/PD-L1-IN-16
<p>PD-1/PD-L1-IN-16 is a potent inhibitor of PD-1/PD-L1 (IC50: 53.2 nM) and has shown research potential for tumour immunotherapy.</p>Formule :C34H30N4O4Couleur et forme :SolidMasse moléculaire :558.63Topoisomerase I/II inhibitor 3
<p>Topoisomerase I/II inhibitor 3 suppresses cell growth and induces apoptosis in liver cancer by blocking PI3K/Akt/mTOR.</p>Formule :C24H24N2O4Couleur et forme :SolidMasse moléculaire :404.46HDL-16
CAS :<p>HDL-16 is a highly effective P2Y14R antagonist with anti-colitis effects, targeting P2Y14R in intestinal epithelial cells to alleviate ulcerative colitis.</p>Formule :C14H11BrN2ODegré de pureté :97.58%Couleur et forme :SolidMasse moléculaire :303.15Lepidozin G
<p>Lepidozin G blocks cancer growth (IC50=4.2-5.7μM) and triggers apoptosis in PC-3 cells via mitochondria.</p>Formule :C30H48O4Couleur et forme :SolidMasse moléculaire :472.7Thalidomide-NH-amido-C4-NH2
CAS :<p>Thalidomide-NH-amido-C4-NH2 is a synthetic E3 ligase ligand-linker conjugate composed of a Thalidomide-based cereblon ligand and a linker, which is utilized in the synthesis of PROTAC.</p>Formule :C19H23N5O5Masse moléculaire :401.42Glyphosate isopropylammonium
CAS :<p>Glyphosate isopropylammonium is a broad-spectrum, non-selective systemic biocide derived from the amino acid glycine. It inhibits the enzyme activity of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) in the shikimate pathway, blocking the synthesis of aromatic amino acids tyrosine, phenylalanine, and tryptophan. Additionally, Glyphosate isopropylammonium induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, leading to neuronal death through autophagy, necrosis, or apoptosis, resulting in behavioral and motor disturbances.</p>Formule :C6H17N2O5PMasse moléculaire :228.18MTX-216
CAS :<p>MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.</p>Formule :C22H14Cl2FN5O2SCouleur et forme :SolidMasse moléculaire :502.348CDK4/6-IN-10
<p>CDK4/6-IN-10: Oral CDK4 (IC50: 22 nM) & CDK6 (IC50: 10 nM) inhibitor with anti-cancer potential for MM research.</p>Couleur et forme :SolidMLS-0053105
CAS :<p>MLS-0053105, a chloromaleimide, functions as a selective inhibitor of BFL-1, exhibiting an IC50 of 0.4 µM against Bfl-1/F-Bid. Its inhibitory potency is over tenfold lower for Bcl-W, Bcl-2, and Bcl-XL, and it shows no activity against Bcl-B and Mcl-1.</p>Formule :C15H14Cl3N3O2Couleur et forme :SolidMasse moléculaire :374.65ERK1/2 inhibitor 11
<p>ERK1/2 inhibitor 11 (compound L6) is a dual inhibitor of ERK1/2 that promotes the accumulation of DSBs and the degradation of ERK1/2 expression. This compound decreases BCL-2 levels and induces DNA damage by inhibiting PARP and ERK1/2. Additionally, ERK1/2 inhibitor 11 activates caspase 3 to induce apoptosis.</p>Formule :C15H19N5O2SCouleur et forme :SolidMasse moléculaire :333.41SL-176
CAS :<p>SL-176, a WIP1 inhibitor, when combined with GSK-J4, can induce cell cycle arrest and apoptosis (apoptosis), thereby inhibiting tumor growth both in vitro and in vivo.</p>Formule :C24H48O4Si2Couleur et forme :SolidMasse moléculaire :456.806PAK4-IN-5
<p>PAK4-IN-5 (Compound 12i) is a potent inhibitor of PAK4 (IC50: PAK4 at 7.68 nM, PAK1 at 1872.01 nM) that forms stable interactions with the PAK4 enzyme. This compound effectively inhibits the proliferation and migration potential of MDA-MB-231 cells by hindering the phosphorylation of PAK4 and LIMK1. Additionally, PAK4-IN-5 arrests the cell cycle in the G0/G1 phase, induces apoptosis, and prompts the production of reactive oxygen species. The LD50 in mice is greater than 500 mg/kg (oral).</p>Formule :C31H28ClN5OCouleur et forme :SolidMasse moléculaire :522.04CRI9
<p>CRI9 effectively inhibits the c-MET/PI3K/Akt/mTOR axis, suppressing the proliferation of hepatocellular carcinoma (HCC) cells. This compound exhibits potent cytotoxicity against HCC cells and induces apoptosis.</p>Formule :C26H18N6O4Couleur et forme :SolidMasse moléculaire :478.46DWP-05195
CAS :<p>DWP-05195 is a TRPV1 antagonist capable of inhibiting pain signal transduction. Additionally, it induces ER stress-dependent apoptosis in human ovarian cancer cells via the ROS-p38-CHOP pathway.</p>Formule :C18H10BrF3N4Couleur et forme :SolidMasse moléculaire :419.2RIP3 activator 1
CAS :<p>RIP3 Activator 1 (compound C8) is an effective RIP3 activator that inhibits cell growth and induces necroptotic cell death (necroptosis) and autophagy through the RIP3/p62/Keap1 signaling pathway. Additionally, this compound enhances the expression of p-MLKL and promotes the accumulation of LC3-II and p62 proteins.</p>Formule :C26H50N4O3Couleur et forme :SolidMasse moléculaire :466.7Sinulatumolin E
CAS :<p>Sinulatumolin E, a terpenoid, inhibits TNF-α (IC 50: 3.6 μM); has anti-inflammatory properties.</p>Formule :C15H22O2Couleur et forme :SolidMasse moléculaire :234.33hCAIX/XII-IN-5
<p>Coumarin 9a: Selective inhibitor of hCA IX/XII (Ki 93.3/85.7 nM), blocks cancer cell growth, and induces apoptosis.</p>Formule :C18H13NO3Couleur et forme :SolidMasse moléculaire :291.3Mcl-1 inhibitor 9
CAS :<p>Mcl-1 Inhibitor 9 (Example 2) is a potent inhibitor of myeloid cell leukemia 1 (Mcl-1), demonstrating anti-tumor activity with an IC50 value of 0.21889 nM.</p>Formule :C32H39ClN2O5SCouleur et forme :SolidMasse moléculaire :599.18WF-47-JS03
<p>WF-47-JS03: RET kinase inhibitor, crosses blood-brain barrier, 500x more selective for KDR, IC50: 1.7 nM in Ba/F3 cells, 5.3 nM in LC-2/ad lung cancer cells.</p>Formule :C30H38N6O2Couleur et forme :SolidMasse moléculaire :514.66Belotecan
CAS :<p>Belotecan (CKD-602) inhibits DNA topoisomerase I, blocks cell cycle, induces apoptosis, and is a camptothecin-derived anticancer agent.</p>Formule :C25H27N3O4Couleur et forme :SolidMasse moléculaire :433.5PKM2 modulator 2
CAS :<p>PKM2 modulator 2 (compound C599) is a potent inhibitor of PKM2, displaying antiproliferative activity and inducing apoptosis. This compound holds potential for research in glioblastoma.</p>Formule :C21H13FN4O3Couleur et forme :SolidMasse moléculaire :388.351MG28
CAS :<p>MG28 exhibits significant cytotoxic effects, likely stemming from its direct and potent DNA-damaging activity. The compound is utilized in cancer research.</p>Formule :C27H25NO3SCouleur et forme :SolidMasse moléculaire :443.56PD-L1/HDAC6-IN-1
CAS :<p>PD-L1/HDAC6-IN-1 (Compound HP29) is an inhibitor targeting both PD-L1 and HDAC6, effectively disrupting the PD-L1/PD-1 interaction and inhibiting HDAC6 activity, with IC50 values of 26.8 nM and 69 nM, respectively. This compound enhances the cytotoxicity of Jurkat T cells against HepG2 cells, exhibiting an IC50 of 3.4 μM. In rats, PD-L1/HDAC6-IN-1 demonstrates favorable pharmacokinetics, showing a drug exposure level of 871.62 ng·h/mL, and displays antitumor activity in a B16-F10 xenograft mouse model.</p>Formule :C27H33N3O3Couleur et forme :SolidMasse moléculaire :447.569Elocalcitol
CAS :<p>Elocalcitol is a calcitriol analog for inhibition of prostate cell growth.</p>Formule :C29H43FO2Couleur et forme :SolidMasse moléculaire :442.65HDAC6/HSP90-IN-2
<p>HDAC6/HSP90-IN-2, a cancer research chemical, inhibits HDAC6 & Hsp90 with IC50s of 105.7 & 61 nM.</p>Formule :C19H22N2O5Couleur et forme :SolidMasse moléculaire :358.39Bcl-2-IN-7
<p>Bcl-2-IN-7 inhibits Bcl-2, encourages apoptosis in cancer cells, and has anti-tumor activity with various IC50 values.</p>Formule :C24H22N4O5S2Couleur et forme :SolidMasse moléculaire :510.59WEHI-9625
CAS :<p>WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).</p>Formule :C34H27NO5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.71JH-XVII-10
<p>JH-XVII-10: potent, oral DYRK1A/B inhibitor (IC50: 3/5 nM), shows antitumor activity in HNSCC.</p>Formule :C21H16F4N8OCouleur et forme :SolidMasse moléculaire :472.4BNN27
CAS :<p>BNN27 is an agonist of the TrkA receptor (TrkAreceptor) and the p75NTR receptor (p75NTR receptor), exhibiting neurotrophic and anti-apoptotic properties. It enhances levels of glutamate, GABA, and glutamine in the hippocampus and prefrontal cortex of rats, improving glutamate turnover. In a mouse model of amyotrophic lateral sclerosis (ALS), BNN27 demonstrates neuroprotective effects, shows anti-inflammatory properties in an experimental autoimmune encephalomyelitis (EAE) model, and exhibits retinal protection in a rat diabetes model. BNN27 also possesses blood-brain barrier permeability.</p>Formule :C21H32O3Couleur et forme :SolidMasse moléculaire :332.477PI3K-IN-58
CAS :<p>PI3K-IN-58 (Compound 17f) is an inhibitor of PI3Kα with an IC50 value of 0.039 μM. It shows significant antiproliferative effects on PC-3, 22RV1, MDA-MB-231, and MDA-MB-453 cell lines with IC50 values of 3.48 μM, 1.06 μM, 2.21 μM, and 0.93 μM, respectively. PI3K-IN-58 induces apoptosis by downregulating the expression of anti-apoptotic proteins Bcl-XL and Bcl-2 while upregulating the expression of the pro-apoptotic protein BAX. This compound is applicable for research in cancer targeting through PI3K pathways.</p>Formule :C22H22N6O3SCouleur et forme :SolidMasse moléculaire :450.51Fosizensertib
CAS :<p>Fosizensertib is an inhibitor of RIP-1 kinase and is used in research related to ulcerative colitis.</p>Formule :C22H21F2N4O5PCouleur et forme :SolidMasse moléculaire :490.397YK5
CAS :<p>YK5 is an allosteric inhibitor pocket of Hsp70 and represents a previously unknown chemical tool to investigate cellular mechanisms associated with Hsp70.</p>Formule :C18H24N8O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.50Tubulin inhibitor 41
CAS :<p>Tubulin inhibitor 41 (Compd D19) is a promising lead compound for glioblastoma treatment, known for its ability to penetrate the blood-brain barrier (BBB). It functions as a tubulin inhibitor, inducing G2/M phase arrest, leading to cell apoptosis, and inhibiting the migration of U87 cells [1].</p>Formule :C20H15N3OCouleur et forme :SolidMasse moléculaire :313.35QTX125 TFA
<p>QTX125 TFA: Potent, selective HDAC6 inhibitor with antitumor effects.</p>Formule :C25H20F3N3O7Couleur et forme :SolidMasse moléculaire :531.44VEGFR-IN-3
CAS :<p>VEGFR-IN-3 inhibits cancer cell growth (OVCAR-4, MDA-MB-468) with IC50s: 0.29, 0.35μM. Used in cancer research.</p>Formule :C27H28N2O6Couleur et forme :SolidMasse moléculaire :476.52GLI1-IN-1
CAS :<p>GLI1-IN-1 (CBC-1), a GLI-1 inhibitor, exhibits superior water solubility and anticancer properties. It effectively induces apoptosis and inhibits colorectal cancer growth by targeting the Hedgehog (HH) pathway (IC 50 = 1.3 μM) [1].</p>Formule :C42H60N2O9Couleur et forme :SolidMasse moléculaire :736.93Akt/NF-κB/JNK-IN-1
<p>Akt/NF-κB/JNK-IN-1 (Compound 2i) is an inhibitor of Akt, NF-κB and JNK signalling pathways.Akt/NF-κB/JNK-IN-1 exhibits an inhibitory effect on nitric oxide</p>Formule :C22H22N2O6Couleur et forme :SolidMasse moléculaire :410.42Top/HDAC-IN-2
<p>Top/HDAC-IN-2 (45b) is a dual inhibitor of Top and HDAC that induces apoptosis and exhibits significant anti-tumour effects.</p>Formule :C30H32N8O4Couleur et forme :SolidMasse moléculaire :568.63Tubulin inhibitor 14
<p>Tubulin inhibitor 14 blocks NQO2 and microtubule formation, disrupts blood vessels, and may target tumors; IC50 of 1.0 μM.</p>Formule :C15H9F2NOCouleur et forme :SolidMasse moléculaire :257.23Anti-inflammatory agent 16
<p>Compound 14 is a peptidomimetic that significantly lowers TNFα, NO, CD40, and CD86, showcasing strong anti-inflammatory effects.</p>Formule :C21H23N5O3Couleur et forme :SolidMasse moléculaire :393.44ASCT2-IN-1
CAS :ASCT2-IN-1 (compound 20k) is an inhibitor of ASCT2, demonstrating IC50 values of 5.6 μM in A549 cells and 3.5 μM in HEK293 cells. It induces apoptosis and inhibits tumor growth.Formule :C36H32Cl2N2O4Masse moléculaire :627.56CDK2/9-IN-1
CAS :<p>CDK2/9-IN-1 (compound 20a) is an orally active dual inhibitor of CDK2 and CDK9, with IC50 values of 0.004 μM and 0.009 μM for CDK2 and CDK9, respectively. It induces apoptosis by regulating G2/M cell cycle arrest and exhibits antitumor activity.</p>Formule :C14H14N6O2S2Couleur et forme :SolidMasse moléculaire :362.43FGFR4-IN-7
<p>FGFR4-IN-7 is a covalent, reversible FGFR4 inhibitor (IC50: 0.42 μM) that blocks the FGFR4 signaling pathway, thereby inducing apoptosis.</p>Formule :C26H25Cl2N5O3Couleur et forme :SolidMasse moléculaire :526.41Casuarinin
CAS :<p>Casuarinin, an ellagitannin found in pomegranates and certain Casuarina/Stachyurus plants, is a carbonic anhydrase inhibitor and astringent.</p>Formule :C41H28O26Couleur et forme :SolidMasse moléculaire :936.65GLUT-1-IN-4
CAS :<p>GLUT-1-IN-4 (Compound 13) is an inhibitor of the GLUT-1 glucose transporter that depends on the p53 protein. It suppresses the proliferation of various cancer cells at submicromolar IC50 levels. Additionally, GLUT-1-IN-4 can halt the cell cycle, induce oxidative stress, and promote apoptosis (cell death).</p>Formule :C15H10N2O3Couleur et forme :SolidMasse moléculaire :266.251RET-IN-7
CAS :<p>RET-IN-7 exhibits strong inhibitory effects against RET kinase in vitro and shows significant efficacy in treating RET-driven tumor xenografts in mice through</p>Formule :C22H24ClFN6O2Couleur et forme :SolidMasse moléculaire :458.92HL001
CAS :<p>HL001 is an orally active small molecule inhibitor of cyclophilin A (CypA) and a receptor antagonist of lysophosphatidic acid 1 (LPA1). It induces cell cycle arrest and apoptosis in tumor cells via p53. By downregulating G3BP1, HL001 promotes reactive oxygen species production and DNA damage to stabilize p53. It disrupts the interaction between MDM2 and p53-72R in a CypA-dependent manner. HL001 exhibits antitumor activity and can also be used in research on pulmonary fibrosis.</p>Formule :C21H16N2O4Couleur et forme :SolidMasse moléculaire :360.363NA-17
CAS :<p>NA-17 is a naphthalimide compound with antitumor activity and exhibits lower toxicity to normal cells such as HL-7702 and WI-38. It demonstrates p53-dependent inhibition selectivity in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of these cells. NA-17 causes cell cycle arrest in the G1 phase and promotes apoptosis and cell death.</p>Formule :C26H27N3O4Couleur et forme :SolidMasse moléculaire :445.51Topoisomerase IIα-IN-4
<p>Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, specifically inhibiting TopoIIα with an IC50 value</p>Formule :C25H21NO2Couleur et forme :SolidMasse moléculaire :367.44RIPK1-IN-28
CAS :<p>RIPK1-IN-28 (compound 13) is an orally active inhibitor of RIPK1. It exhibits inhibitory effects on human I2.1 and Hepa1-6 cells, with IC50 values of 0.4 and 1.2 nM, respectively.</p>Formule :C27H24N4O4Couleur et forme :SolidMasse moléculaire :468.504HC-7366
CAS :<p>HC-7366 (GCN2 modulator-1) is an orally active GCN2 kinase activator with antitumor activity, inducing tumor growth inhibition.</p>Formule :C20H15ClF2N6O4SDegré de pureté :99.84%Couleur et forme :SolidMasse moléculaire :508.89YCW-E11
CAS :<p>YCW-E11 is an antiapoptotic Bcl-2 family proteins inhibitor.</p>Formule :C25H21Cl2N3O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :594.49VEGFR-2-IN-11
<p>VEGFR-2-IN-11 is a potent inhibitor of VEGFR-2 (IC50: 60.27 nM) with an IC50 value of 60.27 nM, which induces apoptosis and has anticancer activity.</p>Formule :C29H22BrN5SCouleur et forme :SolidMasse moléculaire :552.49FKBP12 PROTAC dTAG-13
CAS :<p>FKBP12 PROTAC dTAG-13 is a PROTAC and selective degrader for target validation by splicing FKBP12 F36V with CRBN and thereby degrading FKBP12 F36V.</p>Formule :C57H68N4O15Degré de pureté :97.31%Couleur et forme :SolidMasse moléculaire :1049.17Antitumor agent-184
CAS :Antitumor Agent-184 (compound 12aa) triggers apoptosis in various cell lines, exhibiting IC50 values of 2.35 μM in B16-F10 cells, 7.32 μM in 4T1 cells, and 10.31 μM in CT26 cells.Formule :C22H16N4O2SCouleur et forme :SolidMasse moléculaire :400.45HDAC-IN-27 dihydrochloride
CAS :<p>HDAC-IN-27 dihydrochloride (Compound 11h) is a potent, orally active, HDACI class-selective inhibitor, with IC50 values ranging from 0.43 to 3.01 nM for HDAC1-3. This compound exhibits both in vivo and in vitro anticancer activity. HDAC-IN-27 shows significant antiproliferative effects against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). It is useful for research on acute myeloid leukemia (AML).</p>Formule :C20H24Cl2N4O2Couleur et forme :SolidMasse moléculaire :423.336ZLWT-37
<p>ZLWT-37: Oral CDK inhibitor, CDK9 IC50=0.002 µM, CDK2 IC50=0.054 µM; halts HCT116 cells at G2/M, induces apoptosis.</p>Formule :C26H30ClN5OCouleur et forme :SolidMasse moléculaire :464[D-Leu-4]-OB3
CAS :[D-Leu-4]-OB3 suppresses the expression of genes associated with inflammation, proliferation, and metastasis, as well as the expression of PD-L1.Formule :C29H50N8O12SCouleur et forme :SolidMasse moléculaire :734.82LSD1/ER-IN-1
<p>LSD1/ER-IN-1 inhibits ER & LSD1 (IC50: 1.55 μM), and fights MCF-7 breast cancer (IC50: 8.79 μM).</p>Formule :C23H18FNO6SCouleur et forme :SolidMasse moléculaire :455.46JAK2/FLT3-IN-1 TFA
<p>JAK2/FLT3-IN-1 (TFA), an oral JAK2/FLT3 inhibitor, shows anticancer properties; IC50: JAK2 (0.7 nM), FLT3 (4 nM), JAK1 (26 nM), JAK3 (39 nM).</p>Formule :C27H35F4N7O3Couleur et forme :SolidMasse moléculaire :581.61Antitumor agent-43
<p>Antitumor agent-43 (Compound 4B) is a potent antitumor agent that induces cell cycle arrest at G2/M phase.</p>Formule :C16H8N2O3Couleur et forme :SolidMasse moléculaire :276.25ABL-L
CAS :<p>ABL-L is able to induce apoptosis in human laryngeal cancer cells using a p53-dependent pathway.</p>Formule :C29H46O6Couleur et forme :SolidMasse moléculaire :490.67Tofacitinib Prodrug-1
<p>Tofacitinib Prodrug-1: an oral prodrug reducing Tofacitinib's side effects, treats ulcerative colitis in mice effectively with low toxicity.</p>Formule :C36H39ClN10O7Couleur et forme :SolidMasse moléculaire :759.21Tubulin inhibitor 43
CAS :<p>Tubulin inhibitor 43 exhibits significant antitumor activity by impeding the proliferation and growth of cancer cells through the inhibition of β-microtubulin activity, ultimately inducing apoptosis [1].</p>Formule :C20H21NO6Couleur et forme :SolidMasse moléculaire :371.38Lometrexol disodium
CAS :<p>Lometrexol disodium: Inhibits hSHMT1/2 and GARFT, anticancer by blocking purine synthesis, induces apoptosis and cell cycle arrest.</p>Formule :C21H23N5Na2O6Couleur et forme :SolidMasse moléculaire :487.424SphK1-IN-2
<p>SphK1-IN-2: SphK1 inhibitor, IC50: 19.81 nM; less effective on SphK2. Induces apoptosis, hinders cancer cell growth.</p>Formule :C27H30BrNO4SCouleur et forme :SolidMasse moléculaire :544.5JAK-2/3-IN-3
<p>JAK-2-/3-IN-3 (ST4j) is a potent JAK2/3 inhibitor for leukemia research, with IC50s: JAK2, 13 nM; JAK3, 14.86 nM; induces apoptosis.</p>Formule :C13H10Cl2N4O2Couleur et forme :SolidMasse moléculaire :325.15Anticancer agent 45
<p>Anticancer agent 46, potent and selective, induces apoptosis, is cytotoxic to cancer cells, with low toxicity to human lymphocytes.</p>Formule :C22H14ClN3O6S2Couleur et forme :SolidMasse moléculaire :515.95RSK-IN-2
CAS :<p>RSK-IN-2 (Compound 3e) is an inhibitor of RSK, showing IC50 values of 37.89 nM for RSK2, 30.78 nM for RSK1, 20.51 nM for RSK3, and 91.28 nM for RSK4. It suppresses tumor cell proliferation, induces apoptosis, and causes cell cycle arrest at the G2/M phase.</p>Formule :C25H30ClN7O3Couleur et forme :SolidMasse moléculaire :512.004EMT inhibitor-3
CAS :<p>EMT inhibitor-3 (compound 11i) is an epithelial-mesenchymal transition (EMT) inhibitor that effectively suppresses the proliferation, migration, and invasion of SK-N-SH neuroblastoma cells, with an IC50 value of 2.5 μM. It induces mitochondrial-mediated intrinsic apoptosis in tumor cells by enhancing the Bax/Bcl-2 protein expression ratio, promoting the release of cytochrome C from mitochondria, and activating caspase 9 and caspase 3. EMT inhibitor-3 is applicable for cancer research.</p>Formule :C29H21F2N3O4SeCouleur et forme :SolidMasse moléculaire :592.45Apoptosis inducer 36
CAS :<p>Apoptosisinducer 36 (Compound 42) exhibits anti-leukemic activity by reducing leukemia stem cells (LSC) and inducing differentiation. It inhibits proliferation of AML cells by causing cell cycle arrest in the G1 phase, and induces PANoptosis, which includes apoptosis, pyroptosis, and necrosis.</p>Formule :C23H40O3SiCouleur et forme :SolidMasse moléculaire :392.647ADH-6
CAS :<p>ADH-6, a tripyridylamide, disrupts mutant p53 aggregates in cancer cells, reviving its function and inducing apoptosis.</p>Formule :C29H36N8O9Couleur et forme :SolidMasse moléculaire :640.64DDO-8958
CAS :<p>DDO-8958 is an orally active and selective BET BD1 inhibitor, exhibiting a KD of 5.6 nM for BRD4 BD1. It shows low nanomolar inhibitory activity across all BET BD1 bromodomains except for BRDT BD1. DDO-8958 inhibits tumor cell proliferation and migration, induces apoptosis and cell cycle arrest, and demonstrates antitumor activity.</p>Formule :C22H22FN5O2Couleur et forme :SolidMasse moléculaire :407.441(R)-SL18
CAS :<p>(R)-SL18 is a degrader of ANXA3 that facilitates its breakdown via ubiquitination. This compound can inhibit the proliferation, migration, invasion, and colony formation of breast cancer cells, while also inducing apoptosis. (R)-SL18 is applicable for research in triple-negative breast cancer.</p>Formule :C26H21ClN6O5S2Couleur et forme :SolidMasse moléculaire :597.0652-Deoxy-L-ribose
CAS :<p>2-Deoxy-L-ribose is the stereoisomer of 2-Deoxy-D-ribose and can inhibit the anti-apoptotic effects of 2-Deoxy-D-ribose. Additionally, 2-Deoxy-L-ribose is capable of suppressing tumor cell metastasis by downregulating thymidine phosphorylase overexpression.</p>Formule :C5H10O4Couleur et forme :SolidMasse moléculaire :134.13MLKL-IN-6
<p>MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.</p>Formule :C20H18N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.38Tubulin inhibitor 13
CAS :<p>Tubulin inhibitor 13 (E27), IC50 16.1 μM, blocks tubulin polymerization, cancer cell migration, and invasion, induces apoptosis.</p>Formule :C25H21N3O4Couleur et forme :SolidMasse moléculaire :427.45PD-1/PD-L1-IN-17
<p>PD-1/PD-L1-IN-17 (Compound P20) is a potent PD-1/PD-L1 inhibitor (IC50: 26.8 nM).</p>Formule :C23H20ClN3O4Couleur et forme :SolidMasse moléculaire :437.88NSD2-IN-1
CAS :<p>NSD2-IN-1: potent, selective NSD2-PWWP1 inhibitor, IC50 0.11 μM, induces gene expression changes, apoptosis, cell cycle arrest.</p>Formule :C29H31N5Couleur et forme :SolidMasse moléculaire :449.59Nenocorilant
CAS :<p>Nenocorilant (Relacorilant) is an orally active glucocorticoid receptor (GR) antagonist (Ki: 0.15 nM). Nenocorilant can be used to study tumours.</p>Formule :C26H21F4N7O3SCouleur et forme :SolidMasse moléculaire :587.55PD-1/PD-L1-IN-55
CAS :<p>PD-1/PD-L1-IN-55 (compound D6) is a potent PD-1/PD-L1 inhibitor with an IC50 of 4.8 nM. It enhances IFN-γ secretion and decreases the proportion of late apoptosis due to PD-L1.</p>Formule :C25H23ClN2O3Couleur et forme :SolidMasse moléculaire :434.92EGFR-IN-134
<p>EGFR-IN-134 (compound 3f) is a triazolo[3,4-a]quinoline derivative and functions as a potent EGFR inhibitor with an IC50 of 0.023 µM. It induces apoptosis and necrosis in cells, and causes cell cycle arrest in the G2/M and pre-G1 phases. EGFR-IN-134 modulates the expression of apoptosis-regulating proteins by downregulating anti-apoptotic protein Bcl2 and upregulating pro-apoptotic proteins p53, Bax, and caspases 3, 8, and 9, demonstrating significant antiproliferative and anticancer activities.</p>Formule :C36H30N6O5Couleur et forme :SolidMasse moléculaire :626.66VEGFR-2-IN-15
<p>VEGFR-2-IN-15 (Compound 14b) is a potent inhibitor of VEGFR-2. VEGFR-2-IN-15 inhibits the growth of HepG2 cells in the Pre-G1 phase and induces apoptosis.</p>Formule :C23H18ClN3O4SCouleur et forme :SolidMasse moléculaire :467.92HDAC/PSMD14-IN-1
CAS :<p>HDAC/PSMD14-IN-1 is a derivative of gambogic acid. It serves as an orally active dual inhibitor targeting PSMD14 and HDAC1, with IC50 values of 238.7 nM and 141.2 nM, respectively. The compound exhibits significant cytotoxicity against ESCC cell lines (IC50: 30-250 nM) and effectively reverses epithelial-mesenchymal transition (EMT). Additionally, HDAC/PSMD14-IN-1 can induce apoptosis. In KYSE30 cell xenograft models in mice, it displays antitumor activity. HDAC/PSMD14-IN-1 is useful for researching esophageal cancer treatment.</p>Formule :C20H24N4O3S2Couleur et forme :SolidMasse moléculaire :432.563′-Hydroxyflavanone
CAS :<p>3′-Hydroxyflavanone is a cyclized flavonoid with anti-tumor properties that induces apoptosis in HeLa cells.</p>Formule :C15H12O3Couleur et forme :SolidMasse moléculaire :240.25BMS 310705
CAS :<p>BMS 310705, an Epothilone B analog, targets ovarian/renal/bladder/lung cancer, inducing apoptosis via mitochondria.</p>Formule :C27H42N2O6SCouleur et forme :SolidMasse moléculaire :522.70Tandutinib sulfate
CAS :<p>Tandutinib (MLN518) sulfate is an effective and selective inhibitor of FLT3, with an IC50 value of 0.22 μM. It also inhibits c-Kit and PDGFR, displaying IC50 values of 0.17 μM and 0.20 μM respectively. This compound can be utilized in the treatment of acute myeloid leukemia and has the capability to cross the blood-brain barrier.</p>Formule :C31H44N6O8SCouleur et forme :SolidMasse moléculaire :660.78SMO-IN-5
<p>SMO-IN-5 (Compound 25(B31)) is an effective inhibitor of smoothened (SMO), which suppresses the Hedgehog (Hh) signaling pathway. This compound inhibits cellular proliferation and induces apoptosis, demonstrating antitumor activity.</p>Formule :C25H24N6OCouleur et forme :SolidMasse moléculaire :424.5EGFR/VEGFR2-IN-3
CAS :<p>EGFR/VEGFR2-IN-3 (compound 9) is an effective inhibitor of EGFR and VEGFR-2, demonstrating IC50 values of 0.129 µM for EGFR, 0.142 µM for VEGFR-2, and 3.428 µM for COX-2. This compound exhibits cytotoxic properties and induces cell apoptosis (apoptosis) as well as cell cycle arrest at the G2/M phase.</p>Formule :C24H20ClN5O2S2Couleur et forme :SolidMasse moléculaire :510.03EGFR-IN-161
CAS :<p>EGFR-IN-161 (Compound DD-8) is a potent and reversible inhibitor of the L858R/T790M/C797S mutant EGFR kinase, with an IC50 value of 0.87 nM. EGFR-IN-161 effectively inhibits tumor cell apoptosis, G1 phase arrest, and migration.</p>Formule :C33H36Cl2N8O2Couleur et forme :SolidMasse moléculaire :647.597CIL-102
CAS :<p>CIL-102 is an apoptosis inducer that functions as an MMP-2/MMP-9 inhibitor, effectively reducing both the protein expression and mRNA levels of MMP-2/MMP-9. CIL-102 also demonstrates anticancer activity.</p>Formule :C19H14N2O2Couleur et forme :SolidMasse moléculaire :302.327Pan-Trk-IN-3
<p>Pan-Trk-IN-3: potent Trk inhibitor (IC50: 2-26 nM), effective against drug-resistant mutants, induces apoptosis, anti-tumor effects.</p>Formule :C29H31ClN8O3Couleur et forme :SolidMasse moléculaire :575.06Z-VAD
CAS :<p>Z-VAD is an irreversible pan-caspase inhibitor, suppressing multiple caspases including caspase-3, -6, -7, -8, and -9. Z-VAD induces autophagy in tumour cells.</p>Formule :C20H27N3O8Degré de pureté :98.961%Couleur et forme :SolidMasse moléculaire :437.44PI3K/AKT-IN-1
CAS :<p>PI3K/AKT-IN-1 is a dual inhibitor of PI3K and AKT with anti-cancer activity, inhibiting the PI3K/AKT pathway and inducing caspase 3-dependent apoptosis.</p>Formule :C23H23N5O4SDegré de pureté :99.84%Couleur et forme :SoildMasse moléculaire :465.53NLRP3-IN-26
CAS :<p>NLRP3-IN-26 (compound 15Z), with an IC50 of 0.13 μM, functions as an inhibitor of NLRP3. It is applicable in studies involving the DSS-induced colitis model [1].</p>Formule :C31H33ClN2O6SCouleur et forme :SolidMasse moléculaire :597.12Tubulin/NRP1-IN-1
CAS :<p>Tubulin/NRP1-IN-1 (compound TN-2) serves as a dual inhibitor targeting both Tubulin and NRP1, exhibiting IC50 values of 0.71 μM and 0.85 μM, respectively. This compound notably reduces the viability of prostate tumor cell lines and triggers apoptosis [1].</p>Formule :C28H37N5O8Couleur et forme :SolidMasse moléculaire :571.62L5-DA
<p>L5-DA, a G-quadruplex ligand, stabilizes G4s in HeLa cells, induces apoptosis, and is cytotoxic with an IC50 of 4.3 μM.</p>Formule :C32H34N6O2Couleur et forme :SolidMasse moléculaire :534.65HDAC1-IN-5
<p>HDAC1-IN-5 inhibits HDAC1 (IC50=15 nM) & HDAC6 (IC50=20 nM), promotes apoptosis, damages chromatin, and reduces tumor growth in mice.</p>Formule :C20H21N3O2SCouleur et forme :SolidMasse moléculaire :367.46Bcl-2-IN-6
<p>Bcl-2-IN-6 suppresses Bcl-2, upregulates p53/Bax/caspase-7, arrests cell cycle, and induces MCF-7 apoptosis; IC50s: MCF-7 20.91 μM, others <48 μM.</p>Formule :C25H24N4O5S2Couleur et forme :SolidMasse moléculaire :524.61FLT3-IN-13
<p>FLT3-IN-13 inhibits topoisomerase II/FLT3 in leukemia with IC50 of 2.26 μM, causes G2/M arrest, and promotes apoptosis.</p>Formule :C20H14N4O2Couleur et forme :SolidMasse moléculaire :342.35eIF4A3-IN-4
<p>eIF4A3-IN-4 is a novel inhibitor of eIF4A (IC50: 8.6 μM).</p>Formule :C24H20N2O5Couleur et forme :SolidMasse moléculaire :416.43ER covalent antagonist-1
CAS :<p>ER covalent antagonist-1 (Compound 39D) acts as an antagonist of the estrogen receptor α (ERα). This compound inhibits the proliferation of ERα-positive MCF-7 cells with an IC50 of 0.98 μM, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis. Additionally, ER covalent antagonist-1 demonstrates antitumor activity in mouse models.</p>Formule :C33H32N2O5SCouleur et forme :SolidMasse moléculaire :568.683LA-CB1
CAS :<p>LA-CB1 is a derivative of Abemaciclib that targets CDK4/6 and promotes their degradation via the ubiquitin-proteasome pathway, thereby blocking the CDK4/6-Cyclin D1-Rb-E2F axis and inducing G0/G1 cell cycle arrest and apoptosis (Apoptosis). It demonstrates antiproliferative activity against MDA-MB-231 cells with an IC50 of 0.27 µM and effectively inhibits epithelial-mesenchymal transition, cell migration, invasion, and angiogenesis. In highly invasive models like triple-negative breast cancer (TNBC), LA-CB1 significantly suppresses tumor growth, showing robust dose-dependent antitumor activity. This compound can be utilized in breast cancer research.</p>Formule :C28H23ClFN7OCouleur et forme :SolidMasse moléculaire :527.98STAT3-IN-12
CAS :<p>STAT3-IN-12,STAT3 signaling inhibitor. Blocks IL-6-induced JAK/STAT3 activation. Induces apoptosis. Used in HCC and esophageal cancer research.</p>Formule :C28H30N4O2Degré de pureté :99.19%Couleur et forme :SoildMasse moléculaire :454.56Topo I-IN-1
<p>Topo I-IN-1 (14d) is a powerful Topo I inhibitor with antitumor effects and DNA intercalation, inducing apoptosis.</p>Formule :C20H14BrN3O2Couleur et forme :SolidMasse moléculaire :408.25Antitumor agent-58
<p>Antitumor agent-58 suppresses tumor growth, colony formation, cell migration, and induces mitochondrial dysfunction in MGC-803 cells.</p>Formule :C27H28F3N9SCouleur et forme :SolidMasse moléculaire :567.63GPX4-IN-3
CAS :<p>GPX4-IN-3 (26a) is a potent GPX4 inhibitor, inducing selective ferroptosis with 71.7% inhibition at 1 μM.</p>Formule :C29H24ClN3O3SCouleur et forme :SolidMasse moléculaire :530.04Spicamycin
CAS :<p>Spicamycin can be used as a potent inducer of differentiation of human myeloid leukemia cells (HL-60) and murine myeloid leukemia cells (M1).</p>Formule :C30H51N7O7Couleur et forme :SolidMasse moléculaire :621.77Thalidomide-NH-amido-PEG2-C2-NH2 hydrochloride
CAS :<p>Thalidomide-NH-amido-PEG2-C2-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, comprised of a cereblon ligand based on Thalidomide and a linker, utilized in the synthesis of PROTACs.</p>Formule :C21H28ClN5O7Masse moléculaire :497.93T0080
CAS :<p>T0080 is an FPR-1 antagonist. It reduces apoptosis (Apoptosis) and inhibits the production of reactive oxygen species (ROS) and pro-inflammatory cytokines (TNF-α and IL-1β) in plaque macrophages within ApoE−/− mouse models, thereby slowing the progression of atherosclerosis.</p>Formule :C24H22F3N3O3Couleur et forme :SolidMasse moléculaire :457.45Samuraciclib
CAS :<p>Samuraciclib (CT7001) is an oral CDK7 inhibitor with 41 nM IC50, notable for its high selectivity and potency against breast cancer cells.</p>Formule :C22H30N6OCouleur et forme :SolidMasse moléculaire :394.51BRD-K56819078
CAS :<p>BRD-K56819078, a Bcl-2 inhibitor, significantly reduces the burden of senescent cells and the mRNA expression of aging-related genes in the kidneys. It exerts its anti-aging effects by inhibiting cell apoptosis (apoptosis).</p>Formule :C24H20FN3O4S2Couleur et forme :SolidMasse moléculaire :497.56Bcl-2-IN-3
CAS :<p>Bcl-2-IN-3 (Compound 10) is an inhibitor of Bcl-2, utilized in cancer research.</p>Formule :C16H16N2O4Couleur et forme :SolidMasse moléculaire :300.31Autophagy-IN-1
<p>Autophagy-IN-1 blocks autophagy in cancer cells, hinders tumor growth in mice, and aids in studying colorectal cancer.</p>Formule :C23H25NO7Couleur et forme :SolidMasse moléculaire :427.45Etalocib sodium
CAS :Etalocib (LY293111) sodium is an orally active leukotriene B4 (LTB4) receptor antagonist with a Ki value of 25 nM for inhibiting [3H]LTB4 binding. It exhibits an IC50 of 20 nM against LTB4-induced calcium mobilization. Additionally, Etalocib sodium can induce apoptosis.Formule :C33H32FNaO6Couleur et forme :SolidMasse moléculaire :566.59Antitumor agent-72
CAS :<p>Antitumor agent-72 (compound 6w) is a potent anticancer agent that exhibits its anticancer activity by inducing apoptosis via caspase-3 activation and PARP</p>Formule :C25H20ClNO6Couleur et forme :SolidMasse moléculaire :465.88Lysosomal P-gp targeted agent 1
CAS :<p>Lysosomal P-gp targeted agent 1 (Compound 14) is an antitumor drug that targets lysosomal P-glycoprotein (Pgp). It is selectively transported to lysosomes via overexpressed Pgp, releasing nitric oxide that generates reactive oxygen species (ROS), causing lysosomal membrane permeabilization (LMP) and inducing apoptosis. This compound can overcome resistance mediated by P-glycoprotein, leading to cell cycle arrest while maintaining relatively low toxicity to normal cells. It exhibits antitumor activity by significantly inhibiting tumor growth.</p>Formule :C39H34N2O9SCouleur et forme :SolidMasse moléculaire :706.76Ganoderic acid R
CAS :<p>Ganoderic acid R: potent anticancer, induces apoptosis, cytotoxic to MDR and sensitive tumor cells.</p>Formule :C34H50O6Couleur et forme :SolidMasse moléculaire :554.76Anticancer agent 65
CAS :<p>Anticancer agent 65: Effective on A549 cells, IC50 1.07 μM, halts S phase, triggers apoptosis, elevates p53/p21, causes ROS and MMP collapse.</p>Formule :C36H63NO5Couleur et forme :SolidMasse moléculaire :589.89MG-B-28
<p>MG-B-28, a BTLA-HVEM inhibitor, demonstrates an IC50 value of 906 nM. It promotes T cell activation dose-dependently by inhibiting the interaction between BTLA and HVEM.</p>Formule :C28H25N5O3Couleur et forme :SolidMasse moléculaire :479.53TP-030-2
CAS :<p>TP-030-2 is a RIPK1 inhibitor (human K i =0.43 nM ; mouse IC 50 =100 nM) .</p>Formule :C23H21BrN4O3Couleur et forme :SolidMasse moléculaire :481.34CCT369260
CAS :<p>CCT369260 (compound 1), an orally active inhibitor targeting B-cell lymphoma 6 (BCL6), demonstrates anti-tumor efficacy with an IC50 value of 520 nM [1].</p>Formule :C24H31ClF2N6O2Couleur et forme :SolidMasse moléculaire :508.99RET-IN-11
<p>RET-IN-11 selectively inhibits RET (IC50: 6.20 nM), promotes apoptosis, and hinders cell proliferation and migration.</p>Formule :C27H30FN9OCouleur et forme :SolidMasse moléculaire :515.59AZD0424
CAS :<p>AZD0424: oral Src/Abl kinase inhibitor; potential anticancer; induces apoptosis, cell cycle arrest in lymphoma.</p>Formule :C25H29ClN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.99ASK1-IN-8
CAS :<p>ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM. In a mouse liver injury model induced by Acetaminophen, ASK1-IN-8 significantly reduces plasma alanine aminotransferase (ALT) levels, offering liver protection. This compound is useful for research in liver disease-related fields.</p>Formule :C26H32N8O2Couleur et forme :SolidMasse moléculaire :488.585Ph-Ph+
<p>Ph-Ph+ is a dimerized phenanthroline derivative with antitumor, antibacterial, and antifungal effects.</p>Formule :C24H17N4Couleur et forme :SolidMasse moléculaire :361.42Fluvastatin sodium monohydrate
CAS :<p>Fluvastatin (XU 62-320) sodium monohydrate, a fully synthetic competitive HMG-CoA reductase inhibitor, features an IC 50 of 8 nM. This compound also safeguards vascular smooth muscle cells from oxidative stress via the Nrf2-dependent antioxidant pathway [1] [2].</p>Formule :C24H27FNNaO5Couleur et forme :SolidMasse moléculaire :451.46VEGFR-2-IN-18
<p>VEGFR-2-IN-18 is a potent VEGFR-2 inhibitor with a 60 nM IC50, promoting cell apoptosis and anticancer effects.</p>Formule :C20H13ClN4O2Couleur et forme :SolidMasse moléculaire :376.8MA242
CAS :<p>MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).</p>Formule :C26H21ClF3N3O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :579.98PD-1/PD-L1-IN-23
CAS :<p>PD-1/PD-L1-IN-23: potent, oral PD-1/PD-L1 inhibitor; L7's ester prodrug; exhibits strong antitumor effects.</p>Formule :C32H30BrCl2N3O6Couleur et forme :SolidMasse moléculaire :703.41Anticancer agent 14
<p>Anticancer agent 14: a potent breast cancer inhibitor; induces cell death, disrupts mito. membrane potential (IC50: 0.20-0.65 μM).</p>Formule :C29H34N2O3Couleur et forme :SolidMasse moléculaire :458.59Multi-kinase-IN-1
CAS :<p>Multi-kinase-IN-1, a powerful kinase inhibitor, exhibits antitumor properties by inducing cell apoptosis.</p>Formule :C35H36F2N6O6SCouleur et forme :SolidMasse moléculaire :706.76Enpp-1-IN-25
CAS :<p>Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and exhibits low oral bioavailability. By inhibiting cGAMP degradation, it effectively activates the intracellular STING pathway. Enpp-1-IN-25 can enhance immune cell infiltration and type I interferon response in the tumor microenvironment, thereby increasing the antitumor efficacy of anti-PD-L1 antibodies. It is applicable for research in cancer immunotherapy.</p>Formule :C15H21N5O4SCouleur et forme :SolidMasse moléculaire :367.423NDs-IN-1
CAS :NDs-IN-1 (Compound 3g) is a novel non-covalent multi-target inhibitor that inhibits the activities of key enzymes such as hBACE-1, hAChE, and hMAO-B, and is primarily used in the study of neurodegenerative diseases [1].Formule :C20H18N2O2Masse moléculaire :318.37RIPK1-IN-14
CAS :<p>RIPK1-IN-14 inhibits RIPK1 with 92 nM IC50 and reduces necrotic apoptosis in U937 cells.</p>Couleur et forme :SoildMJC13
CAS :<p>MJC13 is an FKBP52-targeting agent with antitumor activity, suitable for prostate cancer research.</p>Formule :C13H15Cl2NOCouleur et forme :SolidMasse moléculaire :272.17ASTX295
CAS :<p>ASTX295 is a selective mouse double minute 2 (MDM2) antagonist with an IC50 value of less than 1 nM. It specifically inhibits the interaction between MDM2 and p53, reactivating wild-type (WT) TP53, which subsequently induces the expression of related transcriptional targets, leading to cell death and cell cycle arrest. ASTX295 holds potential for research in lymphoid malignancies such as diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and T-cell lymphoma.</p>Formule :C33H34Cl2FNO6Couleur et forme :SolidMasse moléculaire :630.531ZLMT-12
<p>ZLMT-12: tacrine derivative, inhibits CDK2/CDK9, weak on AChE/BuChE, anti-proliferative, low toxicity, blocks S/G2/M phase, induces apoptosis.</p>Formule :C26H31ClN6OCouleur et forme :SolidMasse moléculaire :479.02ZLHQ-5f
<p>ZLHQ-5f inhibits CDK2/Topo I, with IC50 of 0.145μM for CDK2/CycA2, and promotes apoptosis by arresting HCT116 cells in S phase.</p>Formule :C28H25N5O2Couleur et forme :SolidMasse moléculaire :463.53Flizasertib
CAS :<p>Flizasertib is a serine/threonine kinase inhibitor that acts by inhibiting RIPK1, which has anti-inflammatory and therapeutic effects on immune disorders.</p>Formule :C15H14FN3ODegré de pureté :99.39% - 99.57%Couleur et forme :SolidMasse moléculaire :271.29PARP1/BRD4-IN-2
<p>PARP1/BRD4-IN-2, a potent inhibitor of PARP1 and BRD4, halts cell cycle, triggers apoptosis, and has antitumor effects on TNBC.</p>Formule :C25H20N4O4Couleur et forme :SolidMasse moléculaire :440.45Antiproliferative agent-8
<p>Compound 5a, an anticancer agent, enhances P53 and has antiproliferative effects.</p>Formule :C22H16ClN3O3Couleur et forme :SolidMasse moléculaire :405.83BTK-IN-7
<p>BTK-IN-7 is a potent inhibitor for BTK with 4.0 nM IC50, highly selective over ITK and EGFR, showing strong antitumor activity.</p>Formule :C30H32N6O4Couleur et forme :SolidMasse moléculaire :540.61RWJ-56110
CAS :<p>protease-activated receptor-1 (PAR1) antagonist</p>Formule :C41H43Cl2F2N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :790.73PF-07328948
CAS :<p>PF-07328948 is a branched-chain keto-acid dehydrogenase kinase (BDK) inhibitor, useful for studying CVD metabolic disorders.</p>Formule :C16H8F4O3SDegré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :356.29Zotatifin
CAS :<p>Zotatifin (eFT226) is a selective eIF4A inhibitor with antiviral and antitumor properties, inhibiting Sox4 translation and inducing apoptosis.</p>Formule :C28H29N3O5Degré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :487.55Vatalanib hydrochloride
CAS :<p>Vatalanib hydrochloride (PTK787 hydrochloride) is an orally available and highly potent tyrosine kinase (VEGF) inhibitor that reduces the number and size of Aβ plaques in the cortex of 5xFAD mice, which may be useful in the study of Alzheimer's disease and cancer.</p>Formule :C20H16Cl2N4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :383.27BCL6-IN-3
CAS :<p>BCL6-IN-3: potent BCL6 inhibitor, 70 nM GI50 in SU-DHL4, affects cell functions, antitumor.</p>Formule :C24H31ClF2N6O2Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :508.99HC-5404
CAS :<p>HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.</p>Formule :C24H24F2N4O3Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :454.47Tuvusertib
CAS :<p>Tuvusertib (M1774), an oral ATR inhibitor (Ki<1µM), selectively blocks CHK1 phosphorylation, disrupts DNA repair, and induces tumor cell apoptosis.</p>Formule :C16H12F2N8ODegré de pureté :98.44% - 99.66%Couleur et forme :SolidMasse moléculaire :370.32Lometrexol
CAS :<p>Lometrexol (LY 264618) is an antifolate that inhibits GARFT, blocks purine synthesis, induces apoptosis, and has anticancer properties.</p>Formule :C21H25N5O6Degré de pureté :97.76% - 99.56%Couleur et forme :SolidMasse moléculaire :443.45UH15-38
CAS :<p>UH15-38 is a potent and selective RIPK3 inhibitor that blocks necroptosis in alveolar epithelial cells triggered by IAV, useful for studying lung inflammation.</p>Formule :C26H27N5O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :441.53Milademetan
CAS :<p>Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.</p>Formule :C30H34Cl2FN5O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :618.53SY-5609
CAS :<p>SY-5609 (CDK7-IN-3) is a selective non-covalent CDK7 inhibitor, with weak inhibitory activity against CDK2, CDK9 and CDK12.Cost-effective and quality-assured.</p>Formule :C23H26F3N6OPDegré de pureté :99.34% - >99.99%Couleur et forme :SolidMasse moléculaire :490.46JAK2-IN-7
CAS :<p>JAK2-IN-7 selectively inhibits JAK2 (IC50: 3 nM), shows 14-fold selectivity over JAK1/3, FLT3, induces G0/G1 arrest, apoptosis, and has antitumor effects.</p>Formule :C26H33N7ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :459.59Gemcitabine elaidate hydrochloride
CAS :<p>CP-4126, a lipophilic pro-drug of Gemcitabine, converts to active form by esterases, allowing oral administration with dose-dependent effects.</p>Formule :C27H44ClF2N3O5Degré de pureté :98.50% - 99.6%Couleur et forme :SolidMasse moléculaire :564.11FX-11
CAS :<p>FX-11: potent LDHA inhibitor (Ki 8 μM), activates PKM2, reduces ATP, induces oxidative stress/ROS, cell death, shows antitumor effects.</p>Formule :C22H22O4Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :350.41OBAA
CAS :<p>OBAA is a potent inhibitor of phospholipase A2 (PLA2) with an IC 50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC 50 of 0.4 μM [1] [2] [3].</p>Formule :C28H44O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.65Actinonin
CAS :<p>Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. It also induces apoptosis and inhibits aminopeptidase M, aminopeptidase N, and leucine aminopeptidase, as well as MMP-1, MMP-3, MMP-8, MMP-9, and meprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin exhibits antiproliferative and antitumor activities [1][2][3][4][5].</p>Formule :C19H35N3O5Couleur et forme :SolidMasse moléculaire :385.5WEHI-539 hydrochloride
CAS :<p>WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.</p>Formule :C31H30ClN5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :620.18β-Zearalanol
CAS :Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].Formule :C18H26O5Couleur et forme :SolidMasse moléculaire :322.4PIM-447 dihydrochloride
CAS :<p>PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively).</p>Formule :C24H25Cl2F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.38AP1867-3-(aminoethoxy)
CAS :<p>AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.</p>Formule :C38H50N2O9Couleur et forme :SolidMasse moléculaire :678.81(R)-Verapamil hydrochloride
CAS :<p>(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is an inhibitor of P-Glycoprotein.</p>Formule :C27H39ClN2O4Couleur et forme :SolidMasse moléculaire :491.065-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
CAS :Formule :C9H14N4O5Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :258.2313Platinum, diammine[1,1-cyclobutanedi(carboxylato-kO)(2-)]-, (SP-4-2)-
CAS :Formule :C6H10N2O4PtDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.2326Yatein
CAS :<p>Yatein inhibits herpes simplex virus type 1 replication by interruption the immediate-early gene expression. Yatein is a lignan isolated from A. chilensis. It also has antiproliferative activity.</p>Formule :C22H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.42Ingenol 3,20-dibenzoate
CAS :<p>Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms that effectively induces the translocation of nPKC-delta, -epsilon, and -theta, as well as PKC-mu, from the cytosolic fraction to the particulate fraction. Through de novo synthesis of macromolecules, it triggers apoptosis with characteristic morphology. Moreover, Ingenol 3,20-dibenzoate enhances IFN-γ production and degranulation in NK cells, particularly when stimulated by NSCLC cells[1][2].</p>Formule :C34H36O7Couleur et forme :SolidMasse moléculaire :556.65Prostaglandin A2
CAS :<p>PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]</p>Formule :C20H30O4Couleur et forme :SolidMasse moléculaire :334.45DB818
CAS :<p>DB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression.</p>Formule :C19H16N6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.44Vatiquinone
CAS :<p>Vatiquinone, also known as EPI 743, is an orally bioavailable para-benzoquinone being developed for inherited mitochondrial diseases. The mechanism of action of EPI-743 involves augmenting the synthesis of glutathione, optimizing metabolic control, enhanc</p>Formule :C29H44O3Couleur et forme :SolidMasse moléculaire :440.66ENMD-2076 tartrate
CAS :<p>ENMD-2076 is an orally active kinase inhibitor. It also has antiangiogenic and antiproliferative mechanisms of action.</p>Formule :C25H31N7O6Couleur et forme :SolidMasse moléculaire :525.56RRD-251
CAS :<p>RRD-251 is an Rb-Raf-1 interaction inhibitor that induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine[1].</p>Formule :C8H9Cl3N2SCouleur et forme :SolidMasse moléculaire :271.59XMU-MP-3
CAS :<p>XMU-MP-3 is a robust, non-covalent inhibitor of BTK, exhibiting exceptional potency with IC50 values of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation, respectively, in the presence of 10 μM ATP. Moreover, XMU-MP-3 elicits apoptosis.</p>Formule :C27H27F3N8OCouleur et forme :SolidMasse moléculaire :536.563Carubicin hydrochloride
CAS :<p>Carubicin HCl is an anthracycline antineoplastic antibiotic. Through intercalates into DNA and interacts with topoisomerase II, Carubicin inhibits DNA replication and repair and RNA and protein synthesis.</p>Formule :C26H28ClNO10Couleur et forme :SolidMasse moléculaire :549.95Thalidomide-5-COOH
CAS :<p>Thalidomide-5-COOH is a useful organic compound for research related to life sciences. The catalog number is T64600 and the CAS number is 1216805-11-6.</p>Formule :C14H10N2O6Couleur et forme :SolidMasse moléculaire :302.242MI-773
CAS :<p>MI-773 is a potent inhibitor of the MDM2-p53 protein interaction (PPI) with a high affinity for MDM2 and a Kd value of 8.2 nM. MI-773 exhibits antitumour effects.</p>Formule :C29H34Cl2FN3O3Couleur et forme :SolidMasse moléculaire :562.5Thalidomide-O-amido-C4-NH2 hydrochloride
CAS :<p>Thalidomide-O-amido-C4-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon ligand derived from Thalidomide with a linker and is commonly used in the synthesis of PROTACs[1].</p>Formule :C19H23ClN4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :438.86Thalidomide-O-C6-COOH
CAS :<p>Thalidomide-O-C6-COOH is a synthetic conjugate that combines a Thalidomide-derived cereblon ligand with a PROTAC technology linker (E3 ligase ligand-linker).</p>Formule :C20H22N2O7Couleur et forme :SolidMasse moléculaire :402.403Ciprofloxacin lactate
CAS :<p>Ciprofloxacin lactate is a useful organic compound for research related to life sciences. The catalog number is T66299 and the CAS number is 97867-33-9.</p>Formule :C20H24FN3O6Couleur et forme :SolidMasse moléculaire :421.43Mcl-1 inhibitor 6
CAS :<p>Mcl-1 inhibitor 6 binds Mcl-1 with KD 0.23 nM and Ki 0.02 μM, shows strong selectivity over Bcl-2 family, and demonstrates antitumor efficacy.</p>Formule :C26H28ClNO6SCouleur et forme :SolidMasse moléculaire :518.02Ac-IETD-CHO TFA
<p>Ac-IETD-CHO TFA is a granzyme B and caspase-8 inhibitor that inhibits caspase8 activity by blocking caspase3 precursor cleavage.Ac-IETD-CHO TFA inhibits Fas-mediated apoptosis.</p>Formule :C23H35F3N4O12Couleur et forme :SoildMasse moléculaire :616.54Swainsonine
CAS :<p>Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arrest in the G2/M phase.</p>Formule :C8H15NO3Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :173.21Imifoplatin
CAS :<p>Imifoplatin (PT-112) is a platinum compound with antitumor activity and may be used to study prostate cancer and immune system disorders.</p>Formule :C6H16N2O7P2PtDegré de pureté :≥95.0%Couleur et forme :SolidMasse moléculaire :485.23SCH79797
CAS :<p>SCH79797 is a potent and specific protease-activated receptor 1 (PAR1) antagonistwith antimicrobial, anticancer, anti-inflammatory, and neuroprotective effects.</p>Formule :C23H25N5Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :371.48Thalidomide-O-C5-NH2 hydrochloride
CAS :<p>Thalidomide-O-C5-NH2 hydrochloride is a synthetic compound consisting of a ligand-linker conjugate with E3 ligase activity. It combines a cereblon ligand based on Thalidomide and a linker commonly utilized in PROTAC technology.</p>Formule :C18H22ClN3O5Couleur et forme :SolidMasse moléculaire :395.84A-192621
CAS :<p>A-192621 is a potent, nonpeptide, orally active, and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and elevates both arterial blood pressure and plasma ET-1 levels[1][2][3]. Its selectivity is 636-fold higher for ETB than ETA (IC50 of 4280 nM and Ki of 5600 nM).</p>Formule :C33H38N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.66CTB
CAS :<p>CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase and induces apoptosis in MCF-7 cells.</p>Formule :C16H13ClF3NO2Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :343.73Faradiol 3-Myristate
CAS :Produit contrôléFormule :C44H76O3Couleur et forme :NeatMasse moléculaire :653.072anti-TNBC agent-2
CAS :<p>Anti-TNBC agent-2 (3j), a purine derivative, acts as an anti-triple negative breast cancer (TNBC) therapeutic.</p>Formule :C28H37ClFN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :542.09Taltobulin
CAS :<p>Taltobulin (HTI-286) is a synthetic analog of the tripeptide cysteine, a microtubule protein inhibitor that inhibits liver tumor cell proliferation in vitro and tumor growth in vivo.Taltobulin is cytotoxic, induces mitotic arrest and apoptosis, and may be used in the study of breast cancer and microtubule tissue-related diseases.</p>Formule :C27H43N3O4Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :473.65CHMFL-48
CAS :<p>CHMFL-48, an orally active inhibitor of BCR-ABL kinase, demonstrates efficacy against both the wild-type (wt) and various imatinib-resistant mutants. It exhibits potent inhibitory activity, with IC 50 values of 1 nM for the ABL wild-type and 0.8 nM for the ABL T315I mutant. CHMFL-48 operates by inhibiting the autophosphorylation of both wild-type and mutant BCR-ABL, affecting downstream signaling mediators including STAT5 and CRKL. This disruption leads to cell cycle arrest and triggers apoptosis. Given its properties, CHMFL-48 is a promising candidate for research on chronic myeloid leukemia (CML).</p>Formule :C31H30F3N7OCouleur et forme :SolidMasse moléculaire :573.61ZSQ836
CAS :<p>ZSQ836 is a dual covalent inhibitor of CDK12/CDK13 with oral bioactivity, displaying an EC50 value of 32 nM against CDK12. This compound can induce cell apoptosis (apoptosis) and demonstrates in vivo anticancer properties. ZSQ836 is applicable for research in ovarian cancer.</p>Formule :C27H28AsClN6OS2Couleur et forme :SolidMasse moléculaire :627.05DETD-35
CAS :<p>DETD-35 is a promising chemical compound in anti-melanoma therapy, functioning as an inhibitor of the MEK-ERK, Akt, and STAT3 signaling pathways. It enhances cancer cell apoptosis (Apoptosis) and diminishes resistance to Vemurafenib in cancer cells. The compound exhibits IC 50 values of 2.7, 6.0, 3.9, 3.1, and 2.5 μM against melanoma cell lines B16-F10, MeWo, SK-MEL-2, A2058c, and A375c, respectively. DETD-35 offers significant potential for advancing research in melanoma treatment strategies.</p>Formule :C27H24O6Couleur et forme :SolidMasse moléculaire :444.48IHMT-MST1-39
CAS :<p>IHMT-MST1-39 is an orally effective MST kinase inhibitor with IC50 values of 42 nM for MST1 and 109 nM for MST2. It activates the AMPK signaling pathway in hepatocytes and inhibits apoptosis in pancreatic β cells. Additionally, IHMT-MST1-39 improves type 1 diabetes in mice induced by Streptozotocin.</p>Formule :C20H18F2N6O3SCouleur et forme :SolidMasse moléculaire :460.46Cyy-272
CAS :<p>Cyy-272 is an orally active JNK inhibitor with IC50 values of 1.25, 1.07, and 1.24 μM against JNK1, JNK2, and JNK3, respectively. It exerts anti-inflammatory effects by inhibiting the phosphorylation of JNK, thereby alleviating acute lung injury (ALI) induced by lipopolysaccharide (LPS). Moreover, Cyy-272 significantly reduces inflammation in cardiomyocytes and cardiac tissues caused by high lipid concentrations, further mitigating resultant cardiac hypertrophy, fibrosis, and apoptosis. Cyy-272 is utilized in the study of obesity-related myocarditis.</p>Formule :C23H23F2N7Couleur et forme :SolidMasse moléculaire :435.47SMIP34
CAS :<p>SMIP34 is an inhibitor of PELP1 that demonstrates the capability to reduce cell viability and colony formation. Additionally, SMIP34 induces cell apoptosis (apoptosis) and causes cell cycle arrest in the S phase. It reduces the expression of PELP1 and exhibits anti-tumor activity. SMIP34 also has potential for research in triple-negative breast cancer (TNBC).</p>Formule :C20H15ClFN5O2SCouleur et forme :LiquidMasse moléculaire :443.88
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