Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
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4-hydroperoxy cyclophosphamide
CAS :<p>4-hydroperoxy cyclophosphamide (4-OOH-CY) induces hepatotoxicity. It increases ghrelin levels and enhances inflammatory factors and oxidative markers.</p>Formule :C7H15Cl2N2O4PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :293.09GSK-3β inhibitor 15
<p>GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-</p>Formule :C17H16N6OSCouleur et forme :SolidMasse moléculaire :352.41Chol-CTPP
<p>Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.</p>Formule :C144H263N3O53Couleur et forme :SolidMasse moléculaire :2884.62Balstilimab
CAS :<p>Balstilimab (AGEN2034) is a fully human monoclonal IgG4 antibody against PD-1 [1] .</p>Couleur et forme :LiquidSF1126
CAS :<p>SF1126 is a first-in-class PI3K/BRD4 inhibitor and RGDS-conjugated LY294002 prodrug, enhancing solubility and targeting tumor integrins.</p>Formule :C39H48N8O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :852.84Anticancer agent 134
<p>Anticancer Agent 134 (Compound 6a), an environment-sensitive fluorescent probe, induces apoptosis and selectively differentiates between tumor and normal</p>Formule :C34H36ClN7O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :690.28TD1092
<p>TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.</p>Formule :C55H70N8O9Couleur et forme :SolidMasse moléculaire :987.19DRI-C21041 (DIEA)
<p>DRI-C21041 DIEA serves as an inhibitor of CD40/CD40L interaction, exhibiting an inhibitory concentration (IC50) of 0.31 μM.</p>Formule :C38H40N4O7SCouleur et forme :SolidMasse moléculaire :696.81DHFR-IN-23
<p>DHFR-IN-23 (compound 5) is a dual inhibitor of DNA binders/DHFR, exhibiting an IC50 value of 0.08 μM against hDHFR. It serves as an apoptosis inducer and is applicable in research on ER+ breast cancer.</p>Couleur et forme :Odour SolidEGFR T790M/L858R-IN-2
<p>EGFRT790M/L858R-IN-2: selective inhibitor, IC50: 3.5 nM (mutant), 1290 nM (WT); reduces p-EGFR/AKT/ERK1/2, triggers apoptosis, G1 arrest, anti-cancer.</p>Formule :C28H28FN7OCouleur et forme :SolidMasse moléculaire :497.57TAT-NEP1-40 acetate
<p>TAT-NEP1-40 acetate, a potential therapeutic for axonal regeneration and functional recovery post-stroke, safeguards PC12 cells from oxygen and glucose</p>Formule :C268H438N88O77·xC2H4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6124.89 (free base)Inuviscolide
CAS :<p>Inuviscolide induces apoptosis, G2/M arrest in melanoma, and has anti-cancer, anti-inflammatory effects.</p>Formule :C15H20O3Couleur et forme :SolidMasse moléculaire :248.327,3′,5′-Trihydroxyflavanone
CAS :<p>7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression.</p>Formule :C15H12O5Couleur et forme :SolidMasse moléculaire :272.25AS-99 free base
CAS :<p>AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity.</p>Formule :C27H30F3N5O3S2Couleur et forme :SolidMasse moléculaire :593.68Pegsunercept
CAS :<p>Pegsunercept (PEG sTNF-RI), a pegylated monoclonal antibody, selectively binds to TNFA, incorporating a polyethylene glycol (pegol) moiety [1].</p>Couleur et forme :LiquidPomalidomide-PEG3-CO2H
CAS :<p>Pomalidomide-PEG3-CO2H is a cereblon ligand-PEG3 linker for PROTACs.</p>Formule :C22H27N3O9Degré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :477.46cpm-1285
CAS :<p>CPM-1285 induces apoptosis by effectively inhibiting the function of intracellular Bcl-2 and associated death antagonists.</p>Formule :C153H240N44O42SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3399.88Garivulimab
CAS :<p>Garivulimab (BGB-A333), a humanized IgG1 monoclonal antibody, binds to PD-L1, blocking PD-1 interaction and exhibiting antitumor activity.</p>Couleur et forme :LiquidMechercharmycin A
CAS :<p>Mechercharmycin A, a cytotoxic compound, was isolated from Thermoactinomyces sp. YM3-251, a marine source. It demonstrates potent antitumor activity.</p>Formule :C35H32N8O7SCouleur et forme :SolidMasse moléculaire :708.75PD-1-IN-20
<p>PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.</p>Formule :C12H20N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.32PEAQX tetrasodium hydrate
<p>PEAQX tetrasodium hydrate: potent/selective oral NMDA antagonist, IC50 270 nM (1A/2A), 29600 nM (1A/2B).</p>Formule :C17H15BrN3Na4O6PDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :560.15Nrf2 activator-9
<p>Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density</p>Formule :C26H27N5O4Couleur et forme :SolidMasse moléculaire :473.52ChoKα inhibitor-5
<p>ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.</p>Formule :C54H68Br2N4S4Couleur et forme :SolidMasse moléculaire :1061.21Anti-inflammatory agent 61
<p>Compound 5b (Anti-inflammatory agent 61) is a potent anti-inflammatory agent that diminishes TNF-α expression in LPS-induced inflammation within RAW 264.7 cells</p>Couleur et forme :Odour SolidSB-1295
<p>SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 μM, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells.</p>Formule :C23H22ClNO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.88HC Toxin
CAS :<p>HC Toxin: cyclic tetrapeptide, reversible HDAC inhibitor (IC50=30 nM), upregulates 15-lipoxygenase-1, induces fetal hemoglobin, from C. carbonum.</p>Formule :C21H32N4O6Couleur et forme :SolidMasse moléculaire :436.509Tengonermin
CAS :<p>Tengonermin (ARENEGYR), a vascular agent, is TNF-α fused with CNGRCG peptide, enhancing chemo and T-cell access in tumors.</p>Couleur et forme :LiquidHDAC3-IN-2
<p>HDAC3-IN-2 (compound 4i), a pyrazinyl hydrazide-based HDAC3 inhibitor with an IC50 of 14 nM, effectively targets triple-negative breast cancer cells.</p>Formule :C16H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.37NecroIr2
<p>NecroIr2, an iridium(III) compound, induces necroptosis in Cisplatin-resistant A549R lung cancer cells and disrupts mitochondria.</p>Formule :C46H30ClIrN6O2Couleur et forme :SolidMasse moléculaire :926.44APG-1387
CAS :<p>APG-1387 inhibits IAPs, degrades cIAP1/2, XIAP, boosts chemosensitivity, and induces apoptosis in NPC.</p>Formule :C60H72N10O10S2Couleur et forme :SolidMasse moléculaire :1157.41β-Apopicropodophyllin
CAS :<p>β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage,</p>Formule :C22H20O7Couleur et forme :SolidMasse moléculaire :396.39IC 86621
CAS :<p>IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.</p>Formule :C12H15NO3Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :221.25PG-11047 2HCl
<p>PG-11047 2HCl treats genitourinary, immune, genetic, ocular, blood/lymphatic disorders, and aids lymphoma/prostate cancer research.</p>Formule :C14H34Cl2N4Degré de pureté :97.47%Couleur et forme :SolidMasse moléculaire :329.35CYP51/PD-L1-IN-4
<p>CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target inhibitor of CYP51/PD-L1, displaying IC50 values of 0.17 and 0.021 μM, respectively.</p>Formule :C27H28N4O3Couleur et forme :SolidMasse moléculaire :456.54G-Glu-Val
CAS :<p>G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".</p>Formule :C10H18N2O5Couleur et forme :SolidMasse moléculaire :246.26p38-α MAPK-IN-8
<p>p38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. It exhibits cytotoxicity toward various tumor cells, inducing cell cycle arrest and apoptosis, as well as increasing reactive oxygen species (ROS) production and causing mitochondrial membrane potential depolarization. Its antitumor activity may be related to the p38α MAPK pathway, making it a potential candidate for cancer research.</p>Formule :C49H62BrO4PCouleur et forme :SolidMasse moléculaire :825.892MAO-B-IN-30
CAS :<p>MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in organisms, and can be used to study Parkinson's-type neurological disorders.</p>Formule :C15H10BrN3O2Degré de pureté :98.31%Couleur et forme :SoildMasse moléculaire :344.168-hydroxy Efavirenz
CAS :<p>8-hydroxy Efavirenz, a main efavirenz metabolite by CYP2B6, causes apoptosis in rat neurons at 0.01 μM.</p>Formule :C14H9ClF3NO3Couleur et forme :SolidMasse moléculaire :331.68Ankaflavin
CAS :<p>Ankaflavin, from red rice fermentation, is a PPARγ agonist with anti-inflammatory properties and selectively kills cancer cells.</p>Formule :C23H30O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.48Mepacrine
CAS :<p>Mepacrine (Erion) is an acridine derivative formerly widely used as an antimalarial.</p>Formule :C23H30ClN3ODegré de pureté :98.78%Couleur et forme :Bright Yellow CrystalsMasse moléculaire :399.96PAK4-IN-3
<p>PAK4-IN-3 (compound 27e) is a PAK4 inhibitor exhibiting an IC50 of 10 nM and demonstrates antiproliferative effects on A549 cells with an IC50 of 0.61μM.</p>Degré de pureté :98%Couleur et forme :Odour SolidMSU-42011
CAS :<p>MSU-42011: oral RXR-like agonist, inhibits iNOS & p-ERK, antitumor in lung cancer model, effective preclinical treatment.</p>Formule :C24H34N2O2Degré de pureté :99.52%Couleur et forme :SoildMasse moléculaire :382.54β-Glucuronide-dPBD-PEG5-NH2
CAS :<p>β-Glucuronide-dPBD-PEG5-NH2 is a β-glucuronide-linked pyrrolobenzodiazepine dimer that functions as a proagent for the synthesis of the antibody-drug conjugate</p>Formule :C78H101N7O35Couleur et forme :SolidMasse moléculaire :1696.66XZ739
CAS :<p>XZ739: Cereblon-based PROTAC, degrades BCL-XL (DC50 2.5 nM in MOLT-4, 16hr), induces caspase apoptosis.</p>Formule :C65H76ClF3N8O12S3Couleur et forme :SolidMasse moléculaire :1349.99BM-1244
CAS :<p>BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively.</p>Formule :C54H59ClF4N6O8S4Couleur et forme :SolidMasse moléculaire :1159.78Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
CAS :<p>Thalidomide-based E3 ligase ligand with PEG2-C2 linker; used as an immunomodulatory cancer treatment.</p>Formule :C21H27ClN4O8Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :498.914Thailanstatin D
CAS :<p>Thailanstatin D blocks AR-V7 splicing, disrupts U2AF65/SAP155 binding, and induces apoptosis in CRPC xenografts.</p>Formule :C28H41NO8Couleur et forme :SolidMasse moléculaire :519.635PTD-p65-P1 Peptide
<p>PTD-p65-P1: a NF-kappaB inhibitor blocking activation from multiple inflammatory stimuli.</p>Formule :C168H275N57O44SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3829.5(±)-Enterodiol
CAS :<p>"(±)-Enterodiol, the racemate of Enterodiol, is metabolized from lignans found in whole-grain cereals, nuts, legumes, flaxseed, and vegetables by human intestinal bacteria. This compound exhibits apoptotic effects in colorectal cancer (CRC) cells and has been identified to possess anti-cancer activities [1] [2]."</p>Formule :C18H22O4Couleur et forme :SolidMasse moléculaire :302.36Ferroptosis-IN-17
<p>Ferroptosis-IN-17 (Compound 18) is an inhibitor of ferroptosis with an EC50 value of 0.57 μM. It effectively reduces the accumulation of intracellular ferrous ions and lipid peroxidation while restoring levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In rat plasma, Ferroptosis-IN-17 demonstrates good solubility and notable metabolic stability. This compound holds potential for research in tumor suppression, neurodegenerative diseases, and cardiovascular disorders.</p>Formule :C21H26N4O5SCouleur et forme :SolidMasse moléculaire :446.52RET ligand-3
<p>RETligand-3 is the ligand for PROTAC QZ2135, which targets RET.</p>Formule :C38H42N10O3Couleur et forme :SolidMasse moléculaire :686.81Anticancer agent 157
<p>Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg/mL, exhibiting both anti-inflammatory and anticancer effects.</p>Formule :C14H20O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :220.31Vonlerizumab
<p>Vonlerizumab (Anti-TNFRSF4/OX40/CD134 Antibody) is a humanized monoclonal antibody targeting OX40, used in tumor research.</p>Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :145.5 kDaDesmethyl-WEHI-345 analog
CAS :<p>Desmethyl-WEHI-345 analog, a protein kinase inhibitor, holds potential for colon cancer research.</p>Formule :C22H23N7OCouleur et forme :SolidMasse moléculaire :401.474Os30
<p>Os30 is a potent fourth-generation EGFR inhibitor, specifically targeting the EGFRC797S-TK mutation with IC50 values of 18 nM for EGFRDel19/T790M/C797S TK and</p>Degré de pureté :98%Couleur et forme :Odour SolidZ-VEID-FMK
CAS :<p>Z-VEID-FMK is a selective caspase-6 peptide inhibitor that irreversibly covalently binds to the enzyme, thereby inhibiting apoptosis and DNA breakage.</p>Formule :C31H45FN4O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :652.71BU 224 hydrochloride
CAS :<p>BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.</p>Formule :C12H12ClN3Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :233.7CGP 3466B maleate
CAS :<p>CGP 3466B (Omigapil) is an oral drug inhibiting GAPDH nitrosylation and apoptosis, potentially treating Alzheimer's and CMD.</p>Formule :C23H21NO5Degré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :391.42Shepherdin (79-87)
CAS :<p>Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.</p>Formule :C41H64N12O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :949.09Eriosematin
CAS :<p>Eriosematin has anti-proliferative and apoptosis-inducing properties and is a compound extracted from the root of Flemingia philippinensis in the Philippines.</p>Formule :C19H20O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.36RIPK3-IN-3
<p>RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM.</p>Formule :C16H11N5SCouleur et forme :SolidMasse moléculaire :305.36PL120131
<p>PL120131 is a PD-1/PD-L1 inhibitory peptide that disrupts the interaction between PD-1 and PD-L1 by binding to PD-1. This compound can inhibit the apoptosis signaling pathway mediated by PD-1, thereby preventing apoptosis (apoptosis) in Jurkat cells and primary lymphocytes. Additionally, PL120131 supports cytotoxic T lymphocytes (CTL) in exhibiting antitumor activity.</p>Formule :C62H105N19O18Couleur et forme :SolidMasse moléculaire :1404.61Thalidomide-O-PEG4-amine
CAS :<p>Thalidomide-O-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].</p>Formule :C23H31N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :493.51Platycoside G3
CAS :<p>Platycoside G3 is a useful organic compound for research related to life sciences. The catalog number is T124100 and the CAS number is 849758-44-7.</p>Formule :C63H102O32Couleur et forme :SolidMasse moléculaire :1371.48Polyinosinic-polycytidylic acid potassium
CAS :<p>Poly(I:C) potassium is a synthetic RNA analog, activates TLR3/RIG-I, used as a vaccine adjuvant, and induces apoptosis in cancer cells.</p>Formule :(C10H13N4O8P)x·(C9H14N3O8P)x·xKCouleur et forme :SolidGSPT1 degrader-1
<p>GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and induces</p>Formule :C28H33ClN4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :541.04PZ703b
CAS :<p>PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.</p>Formule :C80H102ClF3N10O11S4Couleur et forme :SolidMasse moléculaire :1600.44Apoptosis inducer 13
<p>Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion.</p>Formule :C59H54ClF6N8O4PRuDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1220.6Ac-VDVAD-CHO TFA
<p>Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.</p>Couleur et forme :Odour SolidPUMA BH3
<p>PUMA BH3 activates Bak, binds Bcl-2; triggers apoptosis via cytochrome C release; Kd 26 nM.</p>Formule :C128H202N42O43SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3049.3BRAFV600E/JNK-IN-1
<p>BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3, and BRAFV600E, with IC50 values of 0.51 μM, 0.53 μM, 1.02 μM, and 0.009 μM, respectively. It also inhibits the phosphorylation of MEK1/2 and ERK1/2. Additionally, BRAFV600E/JNK-IN-1 suppresses tumor cell proliferation, NO release, and PGE2 production, exhibiting both antitumor and anti-inflammatory activities.</p>Couleur et forme :Odour Solid2,5-Dimethylcyclohexa-2,5-diene-1,4-dione
CAS :<p>2,5-Dimethylcyclohexa-2,5-diene-1,4-dione inhibits the viability of HL60 and K562 cells and exhibits antibacterial and anticancer properties.</p>Formule :C8H8O2Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :136.15TAT-BH4 (Bcl-xL) (TFA)
<p>"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death.</p>Formule :C159H268N58O45·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3712.19 (free acid)Thalidomide-PEG2-C2-NH2 hydrochloride
CAS :<p>Thalidomide-based cereblon ligand with 2-unit PEG linker for PROTAC, in hydrochloride form.</p>Formule :C19H25ClN4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.88Apoptosis inducer 37
<p>Apoptosis inducer37 (Derivative 10) is an agent that induces apoptosis and exhibits anticancer properties by causing cell cycle arrest at the S-G2/M phase and promoting cell apoptosis. It significantly inhibits HCT116, SKOV3, and HepG2 cancer cells with IC50 values of 24.98 μM, 26.15 μM, and 23.09 μM, respectively. Apoptosis inducer37 demonstrates antitumor activity and can be utilized in ovarian cancer research.</p>Formule :C27H37BrN2O4SCouleur et forme :SolidMasse moléculaire :564.16574JPS014 TFA
<p>JPS014 TFA, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC</p>Formule :C48H60F3N7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :968.09RWJ-56110 dihydrochloride
CAS :<p>RWJ-56110 dihydrochloride is a potent PAR-1 inhibitor (IC50=0.44μM), blocking platelet aggregation, angiogenesis, and induces apoptosis. No PAR-2/3/4 effect.</p>Formule :C41H44Cl3F2N7O3Couleur et forme :SolidMasse moléculaire :827.2ZC0109
<p>ZC0109 inhibits IDO1 (50 nM) & TrxR1 (3.0 μM), induces ROS, arrests G1/S phase, causing cancer cell apoptosis.</p>Formule :C22H20BrFN8O4SCouleur et forme :SolidMasse moléculaire :591.41PI3Kα-IN-14
<p>PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting in</p>Degré de pureté :98%Couleur et forme :Odour SolidAspidin BB
CAS :<p>Aspidin BB, a phloroglucinol from Dryopteris, inhibits cancer by causing cell cycle arrest and apoptosis in HO-8910 cells.</p>Formule :C25H32O8Couleur et forme :SolidMasse moléculaire :460.52Conglobatin
CAS :<p>Conglobatin is a natural product for research related to life sciences. The catalog number is T36494 and the CAS number is 72263-05-9.</p>Formule :C28H38N2O6Couleur et forme :SolidMasse moléculaire :498.62SDH-IN-26
<p>SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor with significant inhibitory activity against various plant pathogenic fungi, including solanrhizoctonia and Botrytis cinerea. It exhibits an EC50 value of 0.270 μg/mL against solanrhizoctonia. SDH-IN-26 compromises fungal cell membrane integrity, increases membrane permeability, disrupts cell structure, reduces mitochondrial count, and affects normal hyphal growth. It also decreases mitochondrial membrane potential, inducing apoptosis. SDH-IN-26 holds potential for studying plant diseases caused by fungi.</p>Couleur et forme :Odour SolidPI3K-AKT-mTOR Compound Library
<p>A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with</p>Couleur et forme :Odour SolidWEHI-3773
<p>WEHI-3773 is an inhibitor of the interaction between VDAC2 and either BAK or BAX. It prevents BAX-mediated apoptosis (Apoptosis) by blocking the recruitment of BAX to the mitochondria through VDAC2. Conversely, WEHI-3773 promotes BAK-mediated apoptosis (Apoptosis) by limiting VDAC2's inhibitory sequestration of BAK. This compound shows promise for research in the field of cancer therapy.</p>Couleur et forme :Odour Solidc-JUN peptide
CAS :<p>Peptide from c-Jun (33-57) blocks JNK binding, inhibits phosphorylation, upregulates p21, and induces HeLa cell apoptosis.</p>Formule :C121H210N36O34SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2743.55FD2157
<p>FD2157, a photosensitive PI3K inhibitor, exhibits inhibitory IC50 values of 43 nM for PI3Kα, 83 nM for PI3Kβ, 84 nM for PI3Kγ, and 14 nM for PI3Kδ.</p>Formule :C27H21ClN6O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :625.01RIP1-IN-1
<p>RIP1-IN-1 is an orally bioavailable RIP1 inhibitor with a high binding affinity (Kd: 110 nM). This compound exhibits significant activity against necroptosis and effectively suppresses necrosome formation by inhibiting the phosphorylation of RIP1, RIP3, and MLKL pathways. RIP1-IN-1 can inhibit necroptosis and is applicable in research on acute liver injury.</p>Couleur et forme :Odour SolidAnticancer agent 137
<p>Anticancer agent 137 (8q), a potent PI3k inhibitor, exhibits broad-spectrum anticancer activity by inducing G2/M cell cycle arrest and apoptosis.</p>Formule :C26H27NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.5JNK-1-IN-3
CAS :<p>JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.</p>Formule :C19H17FN4O3Degré de pureté :97.551%Couleur et forme :SolidMasse moléculaire :368.36Thalidomide-O-amido-C8-NH2 hydrochloride
<p>Thalidomide-O-amido-C8-NH2 hydrochloride, a synthetic cereblon ligand-linker for PROTAC synthesis.</p>Formule :C23H31ClN4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.97PZ703b hydrochloride
<p>PZ703b hydrochloride, a Bcl-xl PROTAC, triggers apoptosis and halts cancer growth; used in bladder cancer studies.</p>Formule :C80H103Cl2F3N10O11S4Couleur et forme :SolidMasse moléculaire :1636.9Enpp/Carbonic anhydrase-IN-2
CAS :<p>Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.</p>Formule :C23H24FNO4SDegré de pureté :99.46%Couleur et forme :SoildMasse moléculaire :429.5EGFR/BRAFV600E-IN-3
<p>EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.</p>Formule :C25H18N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :422.44CDK9-Cyclin T1 PPI-IN-1
<p>CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC</p>Degré de pureté :98%Couleur et forme :Odour SolidBRD4 Inhibitor-39
<p>BRD4 Inhibitor-39 (compound 12m) is an orally active inhibitor of BRD4 with an IC50 of 0.02 μM. It can induce apoptosis and demonstrates antitumor activity.</p>Formule :C24H19BrFN9Couleur et forme :SolidMasse moléculaire :532.37MET/PDGFRA-IN-1
<p>MET/PDGFRA-IN-1 (compound 8c) serves as an inhibitor of MET and PDGFRA proteins, displaying an IC50 of 36 μM against MET.</p>Formule :C26H23N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.51DiPT-4
<p>DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential to</p>Formule :C32H22FN5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :591.61AlbA-DCA
<p>AlbA-DCA, a compound of Albiziabioside A and dichloroacetate, boosts ROS and reduces lactic acid in tumors, killing cancer cells and triggering apoptosis.</p>Formule :C43H67Cl2NO12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :860.9Distamycin A
CAS :<p>Distamycin A (NSC-82150), oligopeptide antibiotic, binds A/T rich DNA, affects cleavage sites, enhances apoptosis.</p>Formule :C22H27N9O4Couleur et forme :SolidMasse moléculaire :481.51PH14
<p>PH14, a dual PI3K/HDAC inhibitor, demonstrates potent inhibition with IC50 values of 20.3 nM for PI3Kα and 24.5 nM for HDAC3.</p>Degré de pureté :98%Couleur et forme :Odour SolidPralnacasan
CAS :<p>Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).</p>Formule :C26H29N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.54U7D-1
<p>U7D-1: First-class USP7 PROTAC degrader, DC50 33 nM, anticancer, induces apoptosis in Jeko-1.</p>Formule :C53H65N9O7Couleur et forme :SolidMasse moléculaire :940.14Thalidomide-NH-C8-NH2 hydrochloride
CAS :<p>Thalidomide-based E3 ligase ligand-linker for PROTAC, with cereblon ligand and C8-NH2 hydrochloride.</p>Formule :C21H29ClN4O4Couleur et forme :SolidMasse moléculaire :436.94NCT-58
CAS :<p>NCT-58 is a potent HSP90 inhibitor that blocks Akt, downregulates HER family, and induces apoptosis in HER2+ breast cancer without triggering HSR.</p>Formule :C27H34N2O5Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :466.57Secalonic acid D
CAS :<p>Secalonic acid D, from Aspergillus aculeatus, is anti-tumor, activates GSK3-β, degrades β-catenin, inhibits c-Myc, and induces apoptosis.</p>Formule :C32H30O14Couleur et forme :SolidMasse moléculaire :638.57Antitumor agent-116
<p>Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.</p>Formule :C31H23BrN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.51Suramin
CAS :<p>Suramin is an RdRp and PTPase inhibitor with anti-parasitic, anti-tumor, and anti-angiogenic activities, inhibiting sirtuins and DNA topoisomerase II.</p>Formule :C51H40N6O23S6Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :1297.28SP3N hydrochloride
<p>SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). Its alkylamine moiety is metabolized into an active aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for the degradation of FKBP12. SP3N hydrochloride is applicable in cancer research.</p>Couleur et forme :Odour SolidPsalmotoxin 1
CAS :<p>Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.</p>Formule :C200H312N62O57S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4689.41PROTAC RIPK degrader-2
CAS :<p>PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.</p>Formule :C52H65N7O11S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1060.31Ledostomig
CAS :<p>Ledostomig is an immunoglobulin (H-γ1-scFv-L-κ) dimer monoclonal antibody that targets human neurotensin receptor type 5 (NTS5) and programmed death-1 (PD-1). It shows potential for research in various cancer types.</p>Couleur et forme :Liquid(R)-MIK665
CAS :<p>(R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special inhibitor of Mcl-1(IC50 of 1.81 nM).</p>Formule :C47H44ClFN6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :875.41LY3415244
<p>LY3415244 is a human bispecific antibody (bsAb) that targets B7-H1/PD-L1/CD274 and TIM-3/HAVCR2/CD366. This compound is applicable in the study of advanced solid tumors.</p>Couleur et forme :Odour LiquidINF200
<p>INF200 (compound 5), a sulfonylurea-based inhibitor of NLRP3 and associated pyroptosis, exhibits cardiometabolic benefits in a rat model of high-fat diet (HFD)-</p>Formule :C13H13ClN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :296.71SA-VA
<p>SA-VA, an intracellular self-assembled PROTAC featuring azide and alkyne groups, selectively degrades VEGFR-2 and EphB4 proteins within U87 cells.</p>Formule :C50H53ClF3N11O7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1044.54WK499
<p>BCL6-IN-10 (Compound WK499) is an inhibitor of BCL6, disrupting its interaction with the SMRT protein and promoting apoptosis, cell cycle arrest, and DNA damage</p>Formule :C21H20BrN7O3Couleur et forme :SolidMasse moléculaire :498.33TNF-α-IN-9
CAS :<p>TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.</p>Formule :C17H14O4Degré de pureté :98.28%Couleur et forme :SoildMasse moléculaire :282.29Opamtistomig
CAS :<p>Opamtistomig is a humanized monoclonal antibody immunoglobulin (H-γ1-scFv-L-κ) dimer targeting human programmed death-ligand 1 (PD-L1), CD274, and tumor necrosis factor receptor superfamily member 9 (TNFRSF9). It is anticipated for use in research on various solid tumors and hematologic malignancies.</p>Couleur et forme :LiquidToremifene citrate
CAS :<p>Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.</p>Formule :C32H36ClNO8Degré de pureté :99.83% - >99.99%Couleur et forme :White Or Almost White PowderMasse moléculaire :598.08YF135
CAS :<p>YF135 is a reversible-covalent KRAS G12C PROTAC that degrades its target via the VHL-proteasome pathway.</p>Formule :C63H75ClN12O7SCouleur et forme :SolidMasse moléculaire :1179.86AS-99 TFA
<p>AS-99 TFA: potent ASH1L inhibitor, IC50=0.79 μM, combats leukemia, inhibits cell growth, induces apoptosis.</p>Couleur et forme :Solid4-oxo-27-TBDMS Withaferin A
CAS :<p>4-oxo-27-TBDMS Withaferin A, a withaferin A derivative, is an anticancer agent cytotoxic to A2780, not A2780/CP70.</p>Formule :C34H50O6SiCouleur et forme :SolidMasse moléculaire :582.853BRD-810
CAS :<p>BRD-810 is a highly selective MCL1 inhibitor (Kd=0.3 nM) capable of inducing tumour cell apoptosis, for haematological malignancies and solid tumours.</p>Formule :C39H44ClFN4O5Degré de pureté :97.88%Couleur et forme :SolidMasse moléculaire :703.24Reveromycin A
CAS :<p>Reveromycin A from Streptomyces sp. inhibits epidermal growth, tumors, and C. albicans; affects osteoclasts. IC50: 0.7-1.9 μg/ml; MIC: 2 μg/ml.</p>Formule :C36H52O11Couleur et forme :SolidMasse moléculaire :660.79anti-TNBC agent-9
<p>Anti-TNBC agent-9 (Compound 3as) is an anticancer agent used for treating triple-negative breast cancer (TNBC). It exhibits significant inhibitory activity against MDA-MB-453 cells, with an IC50 value of 8.5 μM. Anti-TNBC agent-9 impedes tumor cell migration by upregulating E-cadherin and downregulating N-cadherin, matrix metalloproteinase 2 (MMP2), and MMP9. Additionally, it inhibits tumor cell proliferation by inducing apoptosis, achieved through the increased expression of pro-apoptotic protein BAX and decreased expression of anti-apoptotic protein BCL-2.</p>Couleur et forme :Odour SolidDiazepinomicin
CAS :<p>Diazepinomicin, from Micromonospora, blocks EGF-Ras-ERK pathway and induces apoptosis; an anti-tumor agent for K-Ras mutants.</p>Formule :C28H34N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.58Tubulysin B
CAS :<p>Tubulysin B: a potent, cytotoxic microtubule-disrupting peptide from Archangium geophyra and Angiococcus disciformis.</p>Formule :C42H63N5O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :830.04Deoxynyboquinone
CAS :<p>Deoxynyboquinone is a potent inducer of cancer cell death with IC(50) values between 16 and 210 nM.</p>Formule :C15H12N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :284.27Thalidomide-O-amido-PEG4-azide
CAS :<p>Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative serving as a linker for Proteolysis Targeting Chimeras (PROTACs) synthesis [1].</p>Formule :C25H32N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :576.56Bifenthrin
CAS :<p>Bifenthrin is a synthetic pyrethroid insecticide.Bifenthrin induces cell death in bovine mammary epithelial cells through ROS generation, disruption of calcium homeostasis, and alteration of the MAPK signaling cascade.Bifenthrin induces apoptosis by inducing cell-cycle arrest.</p>Formule :C23H22ClF3O2Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :422.87CRA-026440 hydrochloride
CAS :<p>CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor.</p>Formule :C23H25ClN4O4Degré de pureté :99.78%Couleur et forme :SoildMasse moléculaire :456.92mTOR inhibitor-27
<p>mTORinhibitor-27 (Compound 7e) is an inhibitor of mammalian target of rapamycin (mTOR) with an IC50 value of 5.47 μM. It can induce apoptosis in tumor cells and arrest the cell cycle in the S phase, thereby inhibiting cancer cell growth. mTORinhibitor-27 presents potential for research in cancer, including skin cancer.</p>Couleur et forme :Odour SolidPD1-PDL1-IN 1 TFA
<p>PD1-PDL1-IN 1 TFA (compound 16) is a potent inhibitor of programmed cell death 1 (PD-1), functioning as an immune modulator [1].</p>Formule :C16H24F3N7O8Couleur et forme :SolidMasse moléculaire :499.4Dehydroaltenusin
CAS :<p>Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM).</p>Formule :C15H12O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :288.255Episilvestrol
CAS :<p>Episilvestrol is a derivative of silvestrol with eIF4A-targeted antitumor properties, found in Aglaia silvestris fruits and twigs.</p>Formule :C34H38O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.66A947
CAS :<p>A947 is a potent and selective SMARCA2 PROTAC that induces the degradation of SMARCA2, with significant antitumor activity in SMARCA4-mutant NSCLC cells.</p>Formule :C61H76N12O7SDegré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :1121.4VEGFR/PARP-IN-1
<p>VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively.</p>Formule :C29H27N9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.58F1324 acetate
<p>F1324 acetate is an efficient, high-affinity b-cell lymphoma inhibitor with IC50 of 1 nM.</p>Formule :C85H125N21O22SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1825.093MB-PP1
CAS :<p>3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.</p>Formule :C17H21N5Degré de pureté :99.96%Couleur et forme :White SolidMasse moléculaire :295.38VEGFR-2-IN-36
<p>VEGFR-2-IN-36 (compound 15) serves as a potent VEGFR-2 inhibitor, exhibiting an IC50 value of 0.067 μM, and acts as an apoptosis inducer with demonstrated</p>Formule :C24H23N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :489.48ICy-OH
CAS :<p>ICy-OH, an iodinated anticancer photosensitizer, excels in deep tissue imaging (640 nm excitation) and triggers pyroptosis in pancreatic cancer cells.</p>Formule :C26H25I2NO2Couleur et forme :SolidMasse moléculaire :637.29PZ703b TFA
<p>PZ703b TFA, a Bcl-xl PROTAC degradation agent, promotes apoptosis and halts bladder cancer cell proliferation, making it a pertinent investigative compound for</p>Formule :C82H103ClF6N10O13S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1714.46dFKBP-1
CAS :<p>dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].</p>Formule :C53H64N6O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1009.11[1,1'-Biphenyl]-3-amine
CAS :<p>[1,1'-Biphenyl]-3-amine is an inhibitor of MAO-A and MAO-B and can inhibit the cell viability of HT-29, HEK 293, and MCF-7 cells.</p>Formule :C12H11NDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :169.22Cannflavin A
CAS :<p>Cannflavin A, isolated from Cannabis sativa L., exhibits anti-cancer, neuroprotective, and anti-inflammatory activities by inhibiting Aβ1-42 aggregation and</p>Formule :C26H28O6Couleur et forme :SolidMasse moléculaire :436.5SL-01
CAS :<p>SL-01, an oral gemcitabine derivative, potently induces apoptosis to hinder breast cancer more effectively than gemcitabine.</p>Formule :C18H18ClNO3Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :331.79Hexapeptide-11
CAS :<p>Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.</p>Formule :C36H48N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :676.8Monensin
CAS :<p>Monensin, from Streptomyces cinnamonensis, inhibits Wnt/β-catenin. Potential anticancer agent.</p>Formule :C36H62O11Degré de pureté :98%Couleur et forme :Crystals White Or Off-White CrystalsMasse moléculaire :670.87KTX-582
CAS :<p>KTX-582: potent IRAK4/Ikaros degrader (DC50=4/5nM), induces MYD88 MT DLBCL apoptosis & tumor regression in lymphoma.</p>Formule :C45H51F3N8O7Couleur et forme :SolidMasse moléculaire :872.93GLP-2(rat)
CAS :<p>intestinal epithelium-specific growth factor</p>Formule :C166H256N44O56SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3796.17Indinavir
CAS :<p>Indinavir is an HIV protease inhibitor,HAART. inhibits the activation of MMP-2 in endothelial cells and exhibits affinity for α7-nAchR and SARS-CoV-2 Mpro.</p>Formule :C36H47N5O4Couleur et forme :SolidMasse moléculaire :613.79GPX4-IN-5
CAS :<p>GPX4-IN-5 is a GPX4 inhibitor with antitumor activity.GPX4-IN-5 induces iron death and may be used for the treatment of triple negative breast cancer.</p>Formule :C18H17ClFNO5Degré de pureté :99.58%Couleur et forme :SoildMasse moléculaire :381.78FKBP12 PROTAC dTAG-7
CAS :<p>dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.</p>Formule :C63H79N5O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1210.32BT44
CAS :<p>BT44, a potent second-gen GDNF mimetic, is a lead for treating neurodegeneration.</p>Formule :C28H27F4N3O4SDegré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :577.59RIPK1-IN-30
<p>RIPK1-IN-30 (compound 24) is a potent RIPK1 inhibitor with an IC50 of 2.01 μM. It demonstrates a protective effect in the HT-29 cell model of TSZ-induced necroptosis, with an EC50 of 6.77 μM.</p>Formule :C27H25FN2O4Couleur et forme :SolidMasse moléculaire :460.17984Thalidomide-5,6-Cl
CAS :<p>Thalidomide-5,6-Cl is a cereblon ligand derivative that recruits CRBN protein and forms PROTACs with a linker.</p>Formule :C13H8Cl2N2O4Couleur et forme :SolidMasse moléculaire :327.12Humulone
<p>Humulone is a natural product and has a wide range of applications in life science related research.</p>Formule :C21H30O5Couleur et forme :SolidMasse moléculaire :362.47Halenaquinone
CAS :<p>Halenaquinone: PI3K inhibitor, stops RAD51 DNA binding & osteoclastogenesis, induces PC12 cell apoptosis.</p>Formule :C20H12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.31P1D-34
<p>P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. It downregulates Pin1 substrate proteins, including Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. Additionally, P1D-34 exhibits antiproliferative activity across various acute myeloid leukemia (AML) cell lines and induces DNA damage and apoptosis by generating reactive oxygen species (ROS).</p>Couleur et forme :Odour SolidMEK/PI3K-IN-2
CAS :<p>MEK/PI3K-IN-2 is a potent dual inhibitor (MEK1 IC50: 352 nM, PI3Kα: 107 nM, PI3Kδ: 137 nM) that reduces pAKT, pERK1/2, and hinders tumor cell growth.</p>Formule :C38H41F5IN9O7Couleur et forme :SolidMasse moléculaire :957.68ADPM06
CAS :<p>ADPM06: nonporphyrin PDT agent; leads in apoptosis, strong IC50 in µM against human tumors.</p>Formule :C34H24BBr2F2N3O2Couleur et forme :SolidMasse moléculaire :715.19Nemorosone
CAS :<p>Nemorosone, a PPAP from C. rosea, inhibits neuroblastoma and pancreatic cancer cell growth, induces apoptosis, and reduces mouse xenograft tumors.</p>Formule :C33H42O4Couleur et forme :SolidMasse moléculaire :502.695CALP1
CAS :<p>Cell-permeable CaM agonist; activates phosphodiesterase, binds to Ca2+ channels, inhibits cytotoxicity (IC50=52μM), protects cells, reduces inflammation.</p>Formule :C40H75N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :842.09AP1867-2-(carboxymethoxy)
CAS :<p>AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG</p>Formule :C38H47NO11Couleur et forme :SolidMasse moléculaire :693.78PARP1-IN-15
<p>PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis.</p>Formule :C16H12N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :264.28Thalidomide-O-C8-COOH
CAS :<p>Thalidomide-O-C8-COOH, also known as Cereblon ligand 3, is a Thalidomide-derived compound that serves as a Cereblon (CRBN) ligand for the targeted recruitment</p>Formule :C22H26N2O7Couleur et forme :SolidMasse moléculaire :430.45Besufetamig
CAS :<p>Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.</p>Couleur et forme :LiquidMDM2-IN-21
CAS :<p>MDM2-IN-21 is a potent MDM2 inhibitor. MDM2-IN-21 can be used for the research of cancer.</p>Formule :C34H40Cl2N4O2Couleur et forme :SolidMasse moléculaire :607.62Lacto-N-fucopentaose I
CAS :<p>Lacto-N-fucopentaose I is a milk oligosaccharide.</p>Formule :C32H55NO25Couleur et forme :SolidMasse moléculaire :853.774JGB1741
CAS :<p>JGB1741, a SIRT1 inhibitor (IC50=15µM), modulates apoptosis markers and p53 acetylation in breast cancer research.</p>Formule :C27H24N2O2SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :440.56Galloflavin Potassium
CAS :<p>Galloflavin Potassium is an inhibitor of lactate dehydrogenase.</p>Formule :C12H5KO8Couleur et forme :SolidMasse moléculaire :316.26RET ligand-1
CAS :<p>RETligand-1 is a target protein ligand that specifically interacts with RET and can be utilized in the synthesis of the PROTAC LDD39.</p>Formule :C28H24F2N6O3Couleur et forme :SolidMasse moléculaire :530.525Antitumor agent-100 hydrochloride
CAS :<p>Antitumor agent-100 hydrochloride (compound A6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1].</p>Formule :C17H15Cl2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.23HNPMI
CAS :<p>HNPMI is an epidermal growth factor receptor inhibitor that promotes apoptosis and is used in the study of colorectal cancer.</p>Formule :C22H20N2O3Degré de pureté :97.19%Couleur et forme :SoildMasse moléculaire :360.41MEK/PI3K-IN-1
CAS :<p>MEK/PI3K-IN-1 (6r) is a dual MEK/PI3K inhibitor; IC50: 124 nM (MEK1), 130 nM (PI3Kα), 236 nM (PI3Kδ). It reduces pAKT, pERK1/2, and hinders tumor growth.</p>Formule :C36H37F5IN9O6Couleur et forme :SolidMasse moléculaire :913.63Dimethachlor
CAS :<p>Dimethachlor is a pesticide and herbicide used in wetland areas.</p>Formule :C13H18ClNO2Couleur et forme :SolidMasse moléculaire :255.74MDM2/4-p53-IN-3
<p>MDM2/4-p53-IN-3 inhibits MDM2/4-p53 PPIs (IC50: 18.5nM MDM2, 14.8nM MDM4), used in cancer research.</p>Formule :C25H24Cl2FN3O3Couleur et forme :SolidMasse moléculaire :504.38Satratoxin G
CAS :<p>Satratoxin G, from Stachybotrys chartarum, triggers apoptosis in nasal and brain OSNs.</p>Formule :C29H36O10Couleur et forme :SolidMasse moléculaire :544.597Relfovetmab
CAS :<p>Relfovetmab is an anti- NGF monoclonal antibody (mAb) [1] .</p>Couleur et forme :LiquidHydrocinchonine
CAS :<p>Hydrocinchonine is an Alkaloid from Olea europaea and is found in fruits.</p>Formule :C19H24N2OCouleur et forme :SolidMasse moléculaire :296.41Thalidomide-O-C8-NH2 hydrochloride
CAS :<p>Thalidomide-derived cereblon ligand with PROTAC linker as an E3 ligase ligand-linker conjugate, in hydrochloride form.</p>Formule :C21H28ClN3O5Couleur et forme :SolidMasse moléculaire :437.92dTAGV-1-NEG
CAS :<p>Negative control for dTAGV-1.</p>Formule :C68H90N6O14SCouleur et forme :SolidMasse moléculaire :1247.56Thalidomide-PEG4-NH2 hydrochloride
CAS :<p>Thalidomide-PEG4-NH2 HCl, a cereblon ligand-linker for PROTAC.</p>Formule :C21H28ClN3O8Couleur et forme :SolidMasse moléculaire :485.92Nargenicin
CAS :<p>Nargenicin: a macrolide antibiotic effective against S. aureus, MRSA, M. luteus; inhibits bacterial DnaE and reduces inflammation and leukemia cell growth.</p>Formule :C28H37NO8Couleur et forme :SolidMasse moléculaire :515.6Thalidomide-O-amide-C5-NH2
CAS :<p>Thalidomide-O-amide-C5-NH2 is a synthetic E3 ligase linker combining cereblon ligand and PROTAC linker.</p>Formule :C20H24N4O6Couleur et forme :SolidMasse moléculaire :416.43Sanggenon G
CAS :<p>Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.</p>Formule :C40H38O11Couleur et forme :SolidMasse moléculaire :694.72Chalcones A-N-5
CAS :<p>Chalcones A-N-5, a non-cytotoxic trihydroxy chalcone, aids cell growth & neuroprotection, inhibits ferroptosis, and targets AD research.</p>Formule :C21H20N4O4Couleur et forme :SolidMasse moléculaire :392.413-Hydroxykynurenine
CAS :<p>3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.</p>Formule :C10H12N2O4Degré de pureté :98.83% - 99.69%Couleur et forme :SolidMasse moléculaire :224.21Kinamycin C
CAS :<p>Kinamycin C is a bacterial metabolite used as an anticancer agent.</p>Formule :C24H20N2O10Couleur et forme :SolidMasse moléculaire :496.428QN523
CAS :<p>QN523 has drug-like traits, kills cancer cells in vitro, effective in vivo against pancreatic cancer, works via autophagy.</p>Formule :C14H10N4ODegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :250.26Opnurasib
CAS :<p>Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small</p>Formule :C29H28ClN7ODegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :526.03PARP1-IN-16
<p>PARP1-IN-16 (compound 12a) serves as a potent PARP1 inhibitor, exhibiting an IC50 value of 1.89 nM.</p>Degré de pureté :98%Couleur et forme :Odour SolidNF-κB-IN-19
<p>NF-κB-IN-19 (Compound 8) is an NF-κB inhibitor. It effectively induces DNA damage in tumor cells through the NF-κB signaling pathway and promotes the production of reactive oxygen species (ROS), as well as induces autophagy and apoptosis. Additionally, NF-κB-IN-19 inhibits levels of VEGF and HIF-1α, exerting antiproliferative effects in tumor cells through the PI3K/AKT and STAT-3 pathways. It is also effective in overcoming cisplatin resistance and exhibits antitumor activity.</p>Formule :C24H26Cl3F2N3O4PtCouleur et forme :SolidMasse moléculaire :759.92ROCK/HDAC-IN-2
<p>ROCK/HDAC-IN-2 (Compound C-9) is a dual inhibitor of ROCK/HDAC, characterized by IC50 values of 0.185 µM for HDAC6, 0.8 µM for ROCK1, and 0.7 µM for ROCK2. It effectively induces apoptosis and mitochondrial membrane potential alterations in cancer cells and demonstrates notable antitumor activity, making it useful for research in pancreatic ductal adenocarcinoma (PDAC) and triple-negative breast cancer (TNBC).</p>Formule :C22H32N4O4SCouleur et forme :SolidMasse moléculaire :448.58Rosomidnar
CAS :<p>PNT100: 24-base DNA oligo targeting BCL-2 regulatory region; halts tumor cell growth, induces death.</p>Formule :C227H291O141P23Couleur et forme :SolidMasse moléculaire :7220.63PROTAC CARM1/IKZF3 degrader-1
<p>PROTAC CARM1/IKZF3 degrader-1 (Compound 074) inhibits CARM1, reducing the methylation level of its substrate BAF155. This PROTAC degrader works by degrading IKZF 1/3 via a CRBN-dependent mechanism. It suppresses MYC protein expression, thereby inhibiting the proliferation of various multiple myeloma cells. Additionally, PROTAC CARM1/IKZF3 degrader-1 can induce apoptosis in H929 cells and overcomes resistance to immunomodulatory drugs (IMiDs, such as pomalidomide). It is applicable for cancer and immunology research. (Pink: ligand for target protein CARM1/IKZF3 ligand 1; Active form of target protein ligand: EZM 2302; Black: linker; Blue: ligand for E3 ligase Cereblon Thalidomide 4-fluoride)</p>Formule :C46H54ClN9O8Couleur et forme :SolidMasse moléculaire :896.43SHP1 activator 1
<p>SHP1 activator 1 (Compound 3n) is an activator of protein tyrosine phosphatase 1 containing the src homology-2 domain (SHP1), with an EC50 of 17.66 μM. It inhibits the proliferation of ABC-DLBCL cells and induces apoptosis by suppressing the STAT3 signaling pathway. In MDA-MB-231 cells, SHP1 activator 1 emits blue and green fluorescent signals, making it suitable as a cellular imaging agent.</p>Formule :C27H34N4O4Couleur et forme :SolidMasse moléculaire :478.58HDAC-IN-88
<p>HDAC-IN-88 (Compound HJ-9) is a potent inhibitor of HDAC, effectively targeting HDAC6, HDAC1, HDAC2, HDAC8, and HDAC3 with IC50 values of 0.226, 1.103, 2.308, 3.255, and 3.864 μM, respectively. This compound suppresses the proliferation of cancer cells HepG2, HCT116, and MV4-11 with IC50 values of 5.47, 9.78, and 0.38 μM, respectively. Additionally, it inhibits the migration of HCT116 cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis and autophagy in MV4-11 cells. HDAC-IN-88 reduces ROS levels and mitochondrial membrane potential and demonstrates antimalarial activity by inhibiting Plasmodium falciparum 3D7 with an EC50 of 165 nM. Furthermore, HDAC-IN-88 exhibits anti-angiogenic properties.</p>Formule :C23H36N4O4Couleur et forme :SolidMasse moléculaire :432.56UAMC-4821
<p>UAMC-4821 is a ferroptosis inhibitor with an IC50 of 5.2 nM. It effectively scavenges free radicals, inhibits lipid peroxidation, and prevents ML162-induced ferroptosis, providing protective effects on HT-1080 cells. With favorable pharmacokinetic properties in mice, UAMC-4821 presents an oral bioavailability of 63% and demonstrates blood-brain barrier permeability.</p>Formule :C15H19N3OCouleur et forme :SolidMasse moléculaire :257.33OA-Br-1
<p>OA-Br-1 is an orally active, selective inhibitor of PTP1B with an IC50 value of 7.08 μM. It induces apoptosis and exhibits broad-spectrum anti-cancer cell proliferation activity. OA-Br-1 exerts anti-breast cancer effects both in vitro and in vivo through the PTP1B/PI3K/AKT signaling pathway.</p>Formule :C43H70BrNO8Couleur et forme :SolidMasse moléculaire :808.92
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