Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
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CK156
CAS :<p>CK156 inhibits DAPK with high selectivity; IC50: 182 nM (DRAK1), 34 μM (CK2a1), 39 μM (CK2a2); key in autoimmune/inflammation research.</p>Formule :C21H25N5O3Couleur et forme :SolidMasse moléculaire :395.45ASP9831
CAS :<p>ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.</p>Formule :C20H23N3O3Couleur et forme :SolidMasse moléculaire :353.42OICR12694
CAS :<p>OICR12694 (JNJ-65234637) is an orally active inhibitor of B cell lymphoma 6 (BCL6) .</p>Formule :C29H28ClF3N8O4Couleur et forme :SolidMasse moléculaire :645.03CDK4/6-IN-10
<p>CDK4/6-IN-10: Oral CDK4 (IC50: 22 nM) & CDK6 (IC50: 10 nM) inhibitor with anti-cancer potential for MM research.</p>Couleur et forme :SolidLA-CB1
CAS :<p>LA-CB1 is a derivative of Abemaciclib that targets CDK4/6 and promotes their degradation via the ubiquitin-proteasome pathway, thereby blocking the CDK4/6-Cyclin D1-Rb-E2F axis and inducing G0/G1 cell cycle arrest and apoptosis (Apoptosis). It demonstrates antiproliferative activity against MDA-MB-231 cells with an IC50 of 0.27 µM and effectively inhibits epithelial-mesenchymal transition, cell migration, invasion, and angiogenesis. In highly invasive models like triple-negative breast cancer (TNBC), LA-CB1 significantly suppresses tumor growth, showing robust dose-dependent antitumor activity. This compound can be utilized in breast cancer research.</p>Formule :C28H23ClFN7OCouleur et forme :SolidMasse moléculaire :527.98Mcl-1 inhibitor 22
CAS :<p>Mcl-1 inhibitor22 (Example 36) is an MCL-1 inhibitor that suppresses its anti-apoptotic function by blocking the interaction between MCL-1 and pro-apoptotic proteins. It exhibits antiproliferative activity against various cancer cell lines and can be utilized for cancer research.</p>Formule :C33H33ClFN3O4Couleur et forme :SolidMasse moléculaire :590.084MLKL-IN-6
<p>MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein.</p>Formule :C20H18N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :394.38SILA-123
CAS :<p>SILA-123, an inhibitor of FLT3 (FLT3-WT: IC50=2.1 nM; FLT3-ITD: IC50=1.0 nM), induces cell apoptosis by hindering the cell cycle progression at the G0/G1 phase through the suppression of FLT3 phosphorylation and its downstream signaling pathways. This compound is utilized in the study of acute myeloid leukemia.</p>Formule :C24H25N5O2Couleur et forme :SolidMasse moléculaire :415.49NF-κB-IN-4
<p>NF-κB-IN-4 (compound 17) is a potent inhibitor of NF-κB pathway which can cross blood brain barrier (BBB).</p>Formule :C18H15FN4OCouleur et forme :SolidMasse moléculaire :322.34Thalidomide-NH-C5-NH2
CAS :<p>Thalidomide-NH-C5-NH2 is a synthetic E3 ligase ligand-linker conjugate, consisting of a Thalidomide-based cereblon ligand and a linker, used in the synthesis of PROTACs.</p>Formule :C18H22N4O4Masse moléculaire :358.39NLRP3-IN-28
CAS :<p>NLRP3-IN-28 (compound N77) serves as a potent inhibitor of NLRP3, effectively blocking Nigericin-induced pyroptosis with an EC50 of 0.07μM. Additionally, it mitigates inflammatory reactions in vivo [1].</p>Formule :C12H9F3N2O3SCouleur et forme :SolidMasse moléculaire :318.27Top/HDAC-IN-1
<p>Top/HDAC-IN-1: Dual Top/HDAC inhibitor, potent against HDAC1-3,6,8 and HCT116 cells; blocks G2 phase, induces apoptosis.</p>Formule :C29H27N5O4Couleur et forme :SolidMasse moléculaire :509.56Autophagy-IN-1
<p>Autophagy-IN-1 blocks autophagy in cancer cells, hinders tumor growth in mice, and aids in studying colorectal cancer.</p>Formule :C23H25NO7Couleur et forme :SolidMasse moléculaire :427.45Topo II/HDAC-IN-1
CAS :<p>Topo II/HDAC-IN-1 (7d) demonstrates potent dual inhibitory effects on Topo II and HDAC, while Topo II/HDAC-IN-1 (8d) effectively induces apoptosis [1].</p>Formule :C15H16N4O3SCouleur et forme :SolidMasse moléculaire :332.38Bim-IN-1
<p>Bim-IN-1 is a potent inhibitor of Bim expression with low toxicity, Bim-IN-1 reduces Bim expression levels with little inhibition of protein kinase A.</p>Formule :C19H20Cl2FNO2SCouleur et forme :SolidMasse moléculaire :416.34XPO1-IN-1
<p>XPO1-IN-1: an oral MM.1S cell inhibitor (IC50: 24 nM), induces apoptosis, stable metabolism, good pharmacokinetics.</p>Formule :C20H15F6N5O3SCouleur et forme :SolidMasse moléculaire :519.42pan-KRAS-IN-5
CAS :<p>Pan-KRAS-IN-5 (compound 15a) is a pan-KRAS translation inhibitor targeting 5′-UTR RNA G-quadruplexes (rG4s). It induces cell cycle arrest and promotes apoptosis in KRAS-driven cancer cells [1].</p>Formule :C31H36FIN4O2Couleur et forme :SolidMasse moléculaire :642.55FKBP12 PROTAC dTAG-13
CAS :<p>FKBP12 PROTAC dTAG-13 is a PROTAC and selective degrader for target validation by splicing FKBP12 F36V with CRBN and thereby degrading FKBP12 F36V.</p>Formule :C57H68N4O15Degré de pureté :97.31%Couleur et forme :SolidMasse moléculaire :1049.17Mcl-1 inhibitor 9
CAS :<p>Mcl-1 Inhibitor 9 (Example 2) is a potent inhibitor of myeloid cell leukemia 1 (Mcl-1), demonstrating anti-tumor activity with an IC50 value of 0.21889 nM.</p>Formule :C32H39ClN2O5SCouleur et forme :SolidMasse moléculaire :599.18VNPP433-3β
CAS :<p>VNPP433-3β acts as a molecular glue degrader, targeting the androgen receptor (AR) and its splice variants (AR-Vs) as well as MAP kinase-interacting serine/threonine protein kinase Mnk1/2. It effectively inhibits the proliferation of cancer cells LNCaP, C4-2B, and CWR22Rv1, with GI50 values of 0.2, 0.3, and 0.31 μM, respectively. Additionally, VNPP433-3β shows favorable pharmacokinetics in CD-1 mice and suppresses tumor growth in the CWR22Rv1 xenograft mouse model.</p>Formule :C29H34N4Couleur et forme :SolidMasse moléculaire :438.61LL-Z 1640-4
CAS :<p>A signal-specific JNK/p38 pathway and TAK 1 inhibitor</p>Formule :C19H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.39AQIM-I
CAS :<p>AQIM-I is a survivin inhibitor that reduces survivin expression and colony formation. It promotes reactive oxygen species (ROS) production, apoptosis, cell cycle arrest, DNA damage, and autophagy. Moreover, AQIM-I effectively inhibits nonsmall cell lung cancer cells A549, with an IC 50 value of 9 nM [1].</p>Formule :C17H13IN2O2Couleur et forme :SolidMasse moléculaire :404.20Topoisomerase II inhibitor 20 TFA
<p>TopoisomeraseII Inhibitor 20 TFA is a potent inhibitor of topoisomerase II with an IC50 of 0.98 µM. It can induce cell apoptosis and exhibits broad-spectrum anticancer activity.</p>Formule :C24H24F5N5O4SCouleur et forme :SolidMasse moléculaire :573.54Multi-kinase-IN-1
CAS :<p>Multi-kinase-IN-1, a powerful kinase inhibitor, exhibits antitumor properties by inducing cell apoptosis.</p>Formule :C35H36F2N6O6SCouleur et forme :SolidMasse moléculaire :706.76STAT3-IN-9
<p>STAT3-IN-9 hinders STAT3 at Tyr705, doesn't affect STAT1 Tyr701, induces apoptosis, and arrests cells in G2/M phase.</p>Formule :C22H21N3O4Couleur et forme :SolidMasse moléculaire :391.42BCL6-IN-9
CAS :<p>BCL6-IN-9 (compound 1) is a potent inhibitor of B-cell lymphoma 6 protein (BCL6) (IC50: 3.9 nM) and can be used to study cancer.</p>Formule :C22H18ClF2N5O2Couleur et forme :SolidMasse moléculaire :457.86Ivaltinostat formic
<p>Ivaltinostat (CG-200745) is an oral panHDAC inhibitor, inducing apoptosis and enhancing cancer drug sensitivity.</p>Formule :C25H35N3O6Couleur et forme :SolidMasse moléculaire :473.56Anticancer agent 54
<p>Anticancer agent 54 blocks cell cycle in G0/G1, induces apoptosis, and fights cancer via DNA embedding and ROS.</p>Formule :C33H36N6Couleur et forme :SolidMasse moléculaire :516.68JAK2/FLT3-IN-1 TFA
<p>JAK2/FLT3-IN-1 (TFA), an oral JAK2/FLT3 inhibitor, shows anticancer properties; IC50: JAK2 (0.7 nM), FLT3 (4 nM), JAK1 (26 nM), JAK3 (39 nM).</p>Formule :C27H35F4N7O3Couleur et forme :SolidMasse moléculaire :581.61L5-DA
<p>L5-DA, a G-quadruplex ligand, stabilizes G4s in HeLa cells, induces apoptosis, and is cytotoxic with an IC50 of 4.3 μM.</p>Formule :C32H34N6O2Couleur et forme :SolidMasse moléculaire :534.65Antitumor agent-54
<p>Compound C11 inhibits 14-3-3η protein (KD: 35 μM), targets liver cancer cells, blocks G1-S phase, and induces apoptosis.</p>Formule :C29H32N2O3Couleur et forme :SolidMasse moléculaire :456.58DNMT1-IN-5
CAS :<p>DNMT1-IN-5 (Compound 55) is an inhibitor of DNMT, specifically targeting DNMT1 and DNMT3A, with IC50 values of 2.42 μM and 14.4 μM, respectively. It demonstrates antiproliferative effects across various cancer cell lines (TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226, and HCT116) with IC50 values ranging from 0.19 to 2.37 μM. The compound induces G2/M phase cell cycle arrest and apoptosis in TMD-8 and DOHH2 cells. Additionally, DNMT1-IN-5 exhibits antitumor efficacy in a TMD-8 xenograft mouse model.</p>Formule :C24H32FN7Couleur et forme :SolidMasse moléculaire :437.556HER2-IN-11
<p>HER2-IN-11 is a psoralen derivative that induces apoptosis. HER2-IN-11 shows light-activated cytotoxicity and also exhibits anti-breast cancer activity [1].</p>Formule :C17H11NO6Couleur et forme :SolidMasse moléculaire :325.27APD-94
CAS :<p>APD-94 is a dual inhibitor targeting tubulin and Bmi-1. It disrupts the normal polymerization of tubulin and suppresses the expression of Bmi-1. This compound induces cell cycle arrest at the G2/M phase and triggers apoptosis, thereby inhibiting cancer cell proliferation. Additionally, APD-94 inhibits the growth of HT29 cell xenograft tumors in NOD/SCID mice and is applicable to colorectal cancer research.</p>Formule :C18H17N3O4Couleur et forme :SolidMasse moléculaire :339.345MDK-3345
CAS :<p>MDK-3345 is a reversible covalent inhibitor for Mcl-1.</p>Formule :C36H34BN3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :631.48M3258
CAS :<p>LMP7-IN-1 may used in the research of inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer, is an inhibitor of</p>Formule :C17H20BNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :329.1606:0 PE
CAS :<p>06:0 PE (PE(6:0/6:0)) is a water-soluble phospholipid characterized by its short acyl chains. It possesses notable antitumor activity and can inhibit tumor progression in the body. Additionally, it exhibits antiproliferative and pro-apoptotic properties, and serves as a precursor for phosphatidylcholine and phosphatidylethanolamine.</p>Formule :C17H34NO8PCouleur et forme :SolidMasse moléculaire :411.43EGFR-IN-161
CAS :<p>EGFR-IN-161 (Compound DD-8) is a potent and reversible inhibitor of the L858R/T790M/C797S mutant EGFR kinase, with an IC50 value of 0.87 nM. EGFR-IN-161 effectively inhibits tumor cell apoptosis, G1 phase arrest, and migration.</p>Formule :C33H36Cl2N8O2Couleur et forme :SolidMasse moléculaire :647.597Bcl-2-IN-7
<p>Bcl-2-IN-7 inhibits Bcl-2, encourages apoptosis in cancer cells, and has anti-tumor activity with various IC50 values.</p>Formule :C24H22N4O5S2Couleur et forme :SolidMasse moléculaire :510.59GPX4-IN-3
CAS :<p>GPX4-IN-3 (26a) is a potent GPX4 inhibitor, inducing selective ferroptosis with 71.7% inhibition at 1 μM.</p>Formule :C29H24ClN3O3SCouleur et forme :SolidMasse moléculaire :530.04LSD1-IN-21
<p>LSD1-IN-21: potent LSD1 inhibitor, crosses blood-brain barrier, IC50 of 0.956 μM; lowers TNF-α, anti-cancer, anti-inflammatory.</p>Formule :C24H25N5O2SCouleur et forme :SolidMasse moléculaire :447.55GPD-1116
CAS :<p>GPD-1116 is an orally active inhibitor of phosphodiesterase (PDE)4 and PDE1. The compound effectively reduces smoke-induced apoptosis in lung cells. Additionally, GPD-1116 has shown efficacy in various animal disease models, including emphysema, acute lung injury, chronic obstructive pulmonary disease (COPD), asthma, and pulmonary arterial hypertension.</p>Formule :C22H16N4OCouleur et forme :SolidMasse moléculaire :352.39Mcl-1 inhibitor 21
CAS :<p>Mcl-1 inhibitor21 (Example 1-36) is an Mcl-1 inhibitor with an IC50 of 328 nM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it applicable for cancer research.</p>Formule :C32H33N3O4Couleur et forme :SolidMasse moléculaire :523.622CP-31398
CAS :<p>CP-31398 stabilizes the active conformation of p53 in cancer cells with either mutated or wild-type p53, enhancing its activity. Additionally, CP-31398 upregulates target genes of p53 such as p21WAF1/Cip1 and KILLER/DR5. This compound possesses tumor-suppressive properties.</p>Formule :C22H26N4OCouleur et forme :SolidMasse moléculaire :362.47PARP1-IN-12
<p>PARP1-IN-12: potent PARP1 inhibitor, IC50 2.99 nM, triggers cell apoptosis, G2/M arrest, induces DSBs in BRCA-deficient cells.</p>Formule :C43H56FN5O5Couleur et forme :SolidMasse moléculaire :741.93eIF4A3-IN-4
<p>eIF4A3-IN-4 is a novel inhibitor of eIF4A (IC50: 8.6 μM).</p>Formule :C24H20N2O5Couleur et forme :SolidMasse moléculaire :416.43GNE684
CAS :<p>GNE684 inhibits RIP1; Ki app: 21 nM (human), 189 nM (mouse), 691 nM (rat).</p>Formule :C23H24N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.48RIP1 kinase inhibitor 1
CAS :<p>RIP1 kinase inhibitor 1 is an orally available and brain-penetrating inhibitor of RIP1 kinase with pKi of 9.04.</p>Formule :C24H20ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.9Tubulin polymerization-IN-6
<p>Compound 5f, a potent tubulin polymerization inhibitor (IC50 = 1.09 μM), blocks cell migration, tube formation, and has anti-angiogenic effects.</p>Formule :C19H21NO7Couleur et forme :SolidMasse moléculaire :375.37ASCT2-IN-1
CAS :<p>ASCT2-IN-1 (compound 20k) is an inhibitor of ASCT2, demonstrating IC50 values of 5.6 μM in A549 cells and 3.5 μM in HEK293 cells. It induces apoptosis and inhibits tumor growth.</p>Formule :C36H32Cl2N2O4Masse moléculaire :627.56
