Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(11 produits)
- Caspase(142 produits)
- FOXO1(3 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(138 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(14 produits)
- Survivant(14 produits)
- TNF(89 produits)
- c-RET(56 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
5903 produits trouvés pour "Apoptose"
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EGFR-IN-47
EGFR-IN-47: strong oral EGFRL858R/T790M/C797S blocker, induces cell death; promising for NSCLC research. IC50: 0.01 μM.Formule :C29H35N7Couleur et forme :SolidMasse moléculaire :481.64TrxR-IN-8
CAS :TrxR-IN-8 (Compound 6f) is a selective inhibitor of TrxR with an IC50 of 10.2 μM. It induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species, reducing intracellular thiols, and lowering the glutathione/glutathione disulfide ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells.Formule :C16H16INO2Couleur et forme :SolidMasse moléculaire :381.21PIM1-IN-3
PIM1-IN-3 (HL8) selectively blocks PIM1, induces Colo320 cell apoptosis, and may be researched for cancer.Formule :C27H25BrN6OCouleur et forme :SolidMasse moléculaire :529.43GLS1 Inhibitor-6
GLS1 Inhibitor-6: IC50=68nM, 220x more selective for GLS2, has anti-tumor and pro-apoptosis effects.Formule :C37H52N6O3SCouleur et forme :SolidMasse moléculaire :660.91LSD1-IN-21
<p>LSD1-IN-21: potent LSD1 inhibitor, crosses blood-brain barrier, IC50 of 0.956 μM; lowers TNF-α, anti-cancer, anti-inflammatory.</p>Formule :C24H25N5O2SCouleur et forme :SolidMasse moléculaire :447.55EGFR/HER2-IN-6
EGFR/HER2-IN-6 is a dual inhibitor of EGFR, HER2, and DHFR with IC50s: 0.122, 0.078, and 0.585 μM, showing anticancer potential and selectivity.Formule :C18H21N5O3SCouleur et forme :SolidMasse moléculaire :387.46Lometrexol disodium
CAS :Lometrexol disodium: Inhibits hSHMT1/2 and GARFT, anticancer by blocking purine synthesis, induces apoptosis and cell cycle arrest.Formule :C21H23N5Na2O6Couleur et forme :SolidMasse moléculaire :487.424PD-1/PD-L1-IN-23
CAS :PD-1/PD-L1-IN-23: potent, oral PD-1/PD-L1 inhibitor; L7's ester prodrug; exhibits strong antitumor effects.Formule :C32H30BrCl2N3O6Couleur et forme :SolidMasse moléculaire :703.41HER2-IN-11
HER2-IN-11 is a psoralen derivative that induces apoptosis. HER2-IN-11 shows light-activated cytotoxicity and also exhibits anti-breast cancer activity [1].Formule :C17H11NO6Couleur et forme :SolidMasse moléculaire :325.27eIF4E-IN-4
CAS :<p>eIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 μM and is applicable in research on breast cancer, colon cancer, and head and neck cancer.</p>Formule :C20H19ClN5O5PCouleur et forme :SolidMasse moléculaire :475.822RIP1 kinase inhibitor 1
CAS :RIP1 kinase inhibitor 1 is an orally available and brain-penetrating inhibitor of RIP1 kinase with pKi of 9.04.Formule :C24H20ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.9LSD1/ER-IN-1
LSD1/ER-IN-1 inhibits ER & LSD1 (IC50: 1.55 μM), and fights MCF-7 breast cancer (IC50: 8.79 μM).Formule :C23H18FNO6SCouleur et forme :SolidMasse moléculaire :455.46TP-030-1
CAS :TP-030-1, RIPK1 inhibitor: K(i) hRIPK1 at 3.9nM, IC50 mRIPK1 at 4.2μM; targets inflammation, neurodegeneration research.Formule :C23H22N4O3Couleur et forme :SolidMasse moléculaire :402.45Triphen diol
CAS :Triphen diol, a phenol diol, fights pancreatic cancer & cholangiocarcinoma, inducing apoptosis via caspase-dependent & -independent paths.Formule :C22H20O4Couleur et forme :SolidMasse moléculaire :348.39FAK-IN-2
FAK-IN-2: potent oral FAK inhibitor, IC50 35 nM, reduces tumor growth, migration, and induces cell death.Formule :C28H31ClN8O3Couleur et forme :SolidMasse moléculaire :563.05Oxamic acid
CAS :<p>Oxamic acid is an inhibitor of LDH-A and exhibits antitumor activity. It demonstrates antiproliferative effects on cancer cells and can induce apoptosis.</p>Formule :C2H3NO3Couleur et forme :SolidMasse moléculaire :89.05Kahweol Acetate
CAS :Kahweol Acetate, a semi-synthetic coffee bean derivative, inhibits osteoclasts, cancer cells, DNA damage, and oxidative stress.Formule :C22H28O4Couleur et forme :SolidMasse moléculaire :356.464-Bromo A23187
CAS :4-Bromo A23187 is a halogenated analog of the calcium ionophore A-23187. 4-Bromo A23187 is a calcium modulator and induces apoptosis in different cells.Formule :C29H36BrN3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :602.52ABL-L
CAS :ABL-L is able to induce apoptosis in human laryngeal cancer cells using a p53-dependent pathway.Formule :C29H46O6Couleur et forme :SolidMasse moléculaire :490.67Lometrexol hydrate
CAS :Lometrexol hydrate, an antipurine antifolate, inhibits GARFT and purine synthesis, leading to cancer cell apoptosis without causing DNA breaks.Formule :C21H27N5O7Couleur et forme :SolidMasse moléculaire :461.475Neral
CAS :Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.Formule :C10H16OCouleur et forme :SolidMasse moléculaire :152.23MAO-B-IN-45
CAS :MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. It selectively inhibits MAO-B with an IC50 of 87.47 nM, demonstrating a selectivity over MAO-A by more than 229 times. In vitro, MAO-B-IN-45 exhibits significant anti-ferroptosis activity by modulating iron metabolism pathways and the GSH-GPX4 axis. Additionally, it improves cognitive and behavioral deficits in 3×Tg (APP/Tau/Ps1) Alzheimer's disease mice and significantly reduces levels of ferritin heavy chain 1 (FTH1), β-amyloid protein (APP), and Tau protein phosphorylation (p-Tau) in their brains.Formule :C17H14ClNO3Couleur et forme :SolidMasse moléculaire :315.75RET-IN-10
CAS :RET-IN-10: Potent RET inhibitor, may treat congenital megacolon and tumors (Patent WO2021135938A1, compound 18).Formule :C29H28N8OSCouleur et forme :SolidMasse moléculaire :536.65ADH-6
CAS :<p>ADH-6, a tripyridylamide, disrupts mutant p53 aggregates in cancer cells, reviving its function and inducing apoptosis.</p>Formule :C29H36N8O9Couleur et forme :SolidMasse moléculaire :640.64UCN-01
CAS :inhibitor of Akt, protein kinase C, PDK1 and cyclin-dependent kinasesFormule :C28H26N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :482.53Nenocorilant
CAS :Nenocorilant (Relacorilant) is an orally active glucocorticoid receptor (GR) antagonist (Ki: 0.15 nM). Nenocorilant can be used to study tumours.Formule :C26H21F4N7O3SCouleur et forme :SolidMasse moléculaire :587.55Antitumor agent-78
Antitumor agent-78 blocks GPx-4, raises COX2, triggers apoptosis, halts EMT, and stifles cancer cell growth and migration.Couleur et forme :SoildVEGFR-2-IN-15
VEGFR-2-IN-15 (Compound 14b) is a potent inhibitor of VEGFR-2. VEGFR-2-IN-15 inhibits the growth of HepG2 cells in the Pre-G1 phase and induces apoptosis.Formule :C23H18ClN3O4SCouleur et forme :SolidMasse moléculaire :467.92DeFer-2
CAS :DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM). It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.Formule :C44H69N5O5SCouleur et forme :SolidMasse moléculaire :780.11RMS5
CAS :RMS5: hambanine analogue, inhibits P-gp, anti-cancer with cytotoxic, anti-proliferative effects, reduces Bcl-2 proteins, cleaves PARP.Formule :C35H38N2O5SCouleur et forme :SolidMasse moléculaire :598.75Anticancer agent 68
CAS :Compound 12, an anticancer agent, halts G2/M phase, triggers cell death, and activates p53 & PTEN for tumor suppression.Formule :C20H18ClNO5Couleur et forme :SolidMasse moléculaire :387.81PD-1/PD-L1-IN-30
CAS :PD-1/PD-L1-IN-30: Cancer research inhibitor with 0.018 μM IC50.Formule :C29H28F3NO5Couleur et forme :SolidMasse moléculaire :527.53Verrucarin A
CAS :Verrucarin A, a mycotoxin from Myrothecium verrucaria, inhibits protein synthesis, leukemia growth, and triggers apoptosis.Formule :C27H34O9Couleur et forme :SolidMasse moléculaire :502.55p38 MAPK-IN-3
<p>Compound 2c is a potent p38α MAPK inhibitor with antitumor effects, enhancing apoptosis and ROS.</p>Formule :C22H17BrO2Couleur et forme :SolidMasse moléculaire :393.27Pan-Trk-IN-3
<p>Pan-Trk-IN-3: potent Trk inhibitor (IC50: 2-26 nM), effective against drug-resistant mutants, induces apoptosis, anti-tumor effects.</p>Formule :C29H31ClN8O3Couleur et forme :SolidMasse moléculaire :575.06VEGFR-2-IN-14
VEGFR-2-IN-14 (Compound 5) is a potent inhibitor of VEGFR-2, which inhibits the growth of HepG2 cells in the Pre-G1 phase and induces apoptosis.Formule :C24H23N3O3SCouleur et forme :SolidMasse moléculaire :433.52PD-1/PD-L1-IN-16
PD-1/PD-L1-IN-16 is a potent inhibitor of PD-1/PD-L1 (IC50: 53.2 nM) and has shown research potential for tumour immunotherapy.Formule :C34H30N4O4Couleur et forme :SolidMasse moléculaire :558.63YL-1-9
CAS :YL-1-9 is an inhibitor that prevents the degradation of p53 by MDM2 through tight binding to the crucial hydrophobic pocket of MDM2. It can induce cell cycle arrest and apoptosis in breast cancer cells [1].Formule :C22H23F3N2O3Couleur et forme :SolidMasse moléculaire :420.425HDL-16
CAS :HDL-16 is a highly effective P2Y14R antagonist with anti-colitis effects, targeting P2Y14R in intestinal epithelial cells to alleviate ulcerative colitis.Formule :C14H11BrN2ODegré de pureté :97.58%Couleur et forme :SolidMasse moléculaire :303.15Bomedemstat hydrochloride
Bomedemstat (IMG-7289) hydrochloride, an oral LSD1 inhibitor, has anticancer properties, blocking cell growth and triggering apoptosis.Formule :C28H35ClFN7O2Couleur et forme :SolidMasse moléculaire :556.08Lepidozin G
Lepidozin G blocks cancer growth (IC50=4.2-5.7μM) and triggers apoptosis in PC-3 cells via mitochondria.Formule :C30H48O4Couleur et forme :SolidMasse moléculaire :472.7HDAC1-IN-5
HDAC1-IN-5 inhibits HDAC1 (IC50=15 nM) & HDAC6 (IC50=20 nM), promotes apoptosis, damages chromatin, and reduces tumor growth in mice.Formule :C20H21N3O2SCouleur et forme :SolidMasse moléculaire :367.46Bcl-2-IN-6
<p>Bcl-2-IN-6 suppresses Bcl-2, upregulates p53/Bax/caspase-7, arrests cell cycle, and induces MCF-7 apoptosis; IC50s: MCF-7 20.91 μM, others <48 μM.</p>Formule :C25H24N4O5S2Couleur et forme :SolidMasse moléculaire :524.61Nitrovin
CAS :Nitrovin is an antimicrobial growth promoter that induces ROS-mediated non-apoptotic and quasi-apoptotic cell death by targeting TrxR1. It exhibits anticancer activity with IC50 values ranging from 1.31 to 6.60 μM for both tumor and normal cells.Formule :C14H12N6O6Couleur et forme :SolidMasse moléculaire :360.28eIF4A-IN-1
CAS :eIF4A-IN-1 is an eIF4A inhibitor used in tumor research.Formule :C31H33N3O5Couleur et forme :SolidMasse moléculaire :527.61PI3K-IN-35
CAS :<p>PI3K-IN-35 (6l) selectively inhibits PI3K-α, β, δ (IC50: 13.98, 7.22, 10.94 μM), blocks G2/M phase, induces apoptosis, and is useful in leukemia research.</p>Formule :C25H23N7O2Couleur et forme :SolidMasse moléculaire :453.5Milademetan
CAS :Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.Formule :C30H34Cl2FN5O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :618.53Tuvusertib
CAS :Tuvusertib (M1774), an oral ATR inhibitor (Ki<1µM), selectively blocks CHK1 phosphorylation, disrupts DNA repair, and induces tumor cell apoptosis.Formule :C16H12F2N8ODegré de pureté :98.44% - 99.66%Couleur et forme :SolidMasse moléculaire :370.32SY-5609
CAS :SY-5609 (CDK7-IN-3) is a selective non-covalent CDK7 inhibitor, with weak inhibitory activity against CDK2, CDK9 and CDK12.Cost-effective and quality-assured.Formule :C23H26F3N6OPDegré de pureté :99.34% - >99.99%Couleur et forme :SolidMasse moléculaire :490.46PF-07328948
CAS :<p>PF-07328948 is a branched-chain keto-acid dehydrogenase kinase (BDK) inhibitor, useful for studying CVD metabolic disorders.</p>Formule :C16H8F4O3SDegré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :356.29
