Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5593 produits trouvés pour "Apoptose"
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Antitumor agent-113
<p>Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cell</p>Formule :C21H22ClN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.95(E/Z)-Squalene
CAS :<p>(E/Z)-Squalene modulates ROS, triggers apoptosis/necrosis, reduces liver cholesterol and triglycerides.</p>Formule :C30H50Degré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :410.72IRAK4-IN-27
<p>IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM.</p>Formule :C23H22N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.465-LOX-IN-2
CAS :<p>5-LOX-in-2: a 5-lipoxygenase inhibitor with IC50 of 0.33 μM, reduces kidney cancer cell activity, induces apoptosis.</p>Formule :C17H16O4Degré de pureté :98.74%Couleur et forme :SoildMasse moléculaire :284.31Pim-1 kinase inhibitor 4
<p>Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity and</p>Formule :C19H12ClN3ODegré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :333.77HPOB
CAS :<p>HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.</p>Formule :C17H18N2O4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :314.34Tubulysin B
CAS :<p>Tubulysin B: a potent, cytotoxic microtubule-disrupting peptide from Archangium geophyra and Angiococcus disciformis.</p>Formule :C42H63N5O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :830.04Δ8-Tetrahydrocannabinoquinone
CAS :<p>Δ8-Tetrahydrocannabinoquinone (HU-336) is a potent anti-angiogenic agent that inhibits angiogenesis by directly inducing apoptosis in vascular endothelial cells. It achieves this without altering the expression of pro-angiogenic and anti-angiogenic cytokines and receptors. Δ8-Tetrahydrocannabinoquinone also shows significant effectiveness against tumor xenografts in nude mice.</p>Formule :C21H28O3Couleur et forme :SolidMasse moléculaire :328.45BCL-XL-IN-3
CAS :<p>BCL-XL-IN-3 (Compound 11) is an inhibitor of BCL-XL, with a Ki of less than 0.01 nM. It suppresses cell viability in both normal Molt-4 cells and digitonin-permeabilized Molt-4 cells, with EC50 values of 77.8 nM and 0.07 nM, respectively. BCL-XL-IN-3 can be utilized as an ADC toxin for synthesizing Clezutoclax.</p>Formule :C46H55N7O6SCouleur et forme :SolidMasse moléculaire :834.04ARI-1
<p>ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor that binds to ROR1's extracellular Frizzled domain, effectively inhibiting aberrant</p>Couleur et forme :Odour SolidHFY-4A
CAS :<p>HFY-4A is a novel HDAC inhibitor.HFY-4A has antitumour activity and has shown antiproliferative activity in breast cancer cells.</p>Formule :C20H19N3O2Degré de pureté :98.66% - 99.22%Couleur et forme :SoildMasse moléculaire :333.38Ascochlorin
CAS :<p>Ascochlorin, an isoprenoid antibiotic, inhibits STAT3 to combat tumors, induces apoptosis, and reduces inflammation.</p>Formule :C23H29ClO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.93GPX4-IN-7
<p>GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment.</p>Formule :C25H23ClN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :478.93TNF-α-IN-11
<p>TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.</p>Formule :C24H26N2O5Couleur et forme :SolidMasse moléculaire :422.47KHKI-01215
<p>KHKI-01215 is a NUAK2 inhibitor with anticancer activity, inhibiting the proliferation of SW480 cancer cells and inducing apoptosis.</p>Formule :C24H26F3IN6ODegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :598.4Secalonic acid D
CAS :<p>Secalonic acid D, from Aspergillus aculeatus, is anti-tumor, activates GSK3-β, degrades β-catenin, inhibits c-Myc, and induces apoptosis.</p>Formule :C32H30O14Couleur et forme :SolidMasse moléculaire :638.57Thalidomide-NH-C8-NH2 hydrochloride
CAS :<p>Thalidomide-based E3 ligase ligand-linker for PROTAC, with cereblon ligand and C8-NH2 hydrochloride.</p>Formule :C21H29ClN4O4Couleur et forme :SolidMasse moléculaire :436.94SDU-071
CAS :<p>SDU-071 is a BRD4-p53 inhibitor, suppressing MDA-MB-231 cell proliferation, inducing cell cycle arrest and apoptosis.</p>Formule :C28H25N3O2Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :435.52Conglobatin
CAS :<p>Conglobatin is a natural product for research related to life sciences. The catalog number is T36494 and the CAS number is 72263-05-9.</p>Formule :C28H38N2O6Couleur et forme :SolidMasse moléculaire :498.62Z-VEID-FMK
CAS :<p>Z-VEID-FMK is a selective caspase-6 peptide inhibitor that irreversibly covalently binds to the enzyme, thereby inhibiting apoptosis and DNA breakage.</p>Formule :C31H45FN4O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :652.71PTD-p65-P1 Peptide
<p>PTD-p65-P1: a NF-kappaB inhibitor blocking activation from multiple inflammatory stimuli.</p>Formule :C168H275N57O44SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3829.5NS3694
CAS :<p>NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.</p>Formule :C15H10ClF3N2O3Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :358.7MSU-42011
CAS :<p>MSU-42011: oral RXR-like agonist, inhibits iNOS & p-ERK, antitumor in lung cancer model, effective preclinical treatment.</p>Formule :C24H34N2O2Degré de pureté :99.52%Couleur et forme :SoildMasse moléculaire :382.54MAO-B-IN-30
CAS :<p>MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in organisms, and can be used to study Parkinson's-type neurological disorders.</p>Formule :C15H10BrN3O2Degré de pureté :98.31%Couleur et forme :SoildMasse moléculaire :344.16Halenaquinone
CAS :<p>Halenaquinone: PI3K inhibitor, stops RAD51 DNA binding & osteoclastogenesis, induces PC12 cell apoptosis.</p>Formule :C20H12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :332.31Oenothein B
CAS :<p>Oenothein B inhibits PAR-glycohydrolase with antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects.</p>Formule :C68H48O44Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :1569.08HTR2A antagonist 1
<p>HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.</p>Formule :C35H43Cl2F2N5O4Couleur et forme :SolidMasse moléculaire :706.65MS105
CAS :<p>MS105 is an orally active, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. It recruits the VHL E3 ligase through a VHL ligand fragment, facilitating ubiquitination and proteasomal degradation of PTK6, thereby inhibiting the proliferation and migration of breast cancer cells and inducing apoptosis (apoptosis). MS105 is a promising compound for breast cancer research.</p>Formule :C56H70FN13O6SCouleur et forme :SolidMasse moléculaire :1072.30Cytostatin
CAS :<p>Cytostatin: Natural antitumor, inhibits cell adhesion, blocks B16 melanoma, induces apoptosis, selectively targets PP2A (IC50 = 29 nM).</p>Formule :C21H33O7PCouleur et forme :SolidMasse moléculaire :428.462EGFR/BRAFV600E-IN-3
<p>EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.</p>Formule :C25H18N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :422.44PEAQX tetrasodium hydrate
<p>PEAQX tetrasodium hydrate: potent/selective oral NMDA antagonist, IC50 270 nM (1A/2A), 29600 nM (1A/2B).</p>Formule :C17H15BrN3Na4O6PDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :560.15PD-1-IN-20
<p>PD-1-IN-20 is the less active enantiomer of PD-1-IN-1.</p>Formule :C12H20N6O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.32Pralnacasan
CAS :<p>Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).</p>Formule :C26H29N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.54EGFR T790M/L858R-IN-2
<p>EGFRT790M/L858R-IN-2: selective inhibitor, IC50: 3.5 nM (mutant), 1290 nM (WT); reduces p-EGFR/AKT/ERK1/2, triggers apoptosis, G1 arrest, anti-cancer.</p>Formule :C28H28FN7OCouleur et forme :SolidMasse moléculaire :497.57Z-DQMD-FMK
CAS :<p>Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.</p>Formule :C29H40FN5O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :685.72Chloranil
CAS :<p>Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.</p>Formule :C6Cl4O2Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :245.88Chol-CTPP
<p>Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.</p>Formule :C144H263N3O53Couleur et forme :SolidMasse moléculaire :2884.62Iparomlimab
CAS :<p>Iparomlimab: anti-PD-1 IgG4κ antibody, targets PSB103 γ4/κ-chains, forms dimers, used in cancer research.</p>Couleur et forme :LiquidAntitumor agent-116
<p>Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.</p>Formule :C31H23BrN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.51FC-116
CAS :<p>FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice.FC-116 induces apoptosis and promotes protein degradation.</p>Formule :C21H20FNO4Degré de pureté :98.18%Couleur et forme :SoildMasse moléculaire :369.39CALP1
CAS :<p>Cell-permeable CaM agonist; activates phosphodiesterase, binds to Ca2+ channels, inhibits cytotoxicity (IC50=52μM), protects cells, reduces inflammation.</p>Formule :C40H75N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :842.09Echitamine chloride
CAS :<p>Echitamine chloride, an alkaloid in Alstonia scholaris, has anti-cancer properties and inhibits pancreatic lipase (IC50: 10.92 µM).</p>Formule :C22H29ClN2O4Couleur et forme :SolidMasse moléculaire :420.933MB-PP1
CAS :<p>3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.</p>Formule :C17H21N5Degré de pureté :99.96%Couleur et forme :White SolidMasse moléculaire :295.38Beclin1-Bcl-2 interaction inhibitor 1
<p>Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].</p>Couleur et forme :Odour SolidThalidomide-NH-PEG8-Ts
CAS :<p>Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.</p>Formule :C36H49N3O14SCouleur et forme :SolidMasse moléculaire :779.86Ganoderic acid Mf
CAS :<p>Ganoderic acid Mf: antitumor triterpenoid, arrests G1 cell cycle, selective for cancer cells, triggers apoptosis via mitochondria.</p>Formule :C32H48O5Couleur et forme :SolidMasse moléculaire :512.72Malformin A
CAS :<p>Malformin A, from A. niger, is a plant growth regulator and has anti-TMV and cancer cell cytotoxic properties. Intraperitoneal LD50 in mice is 3.1 mg/kg.</p>Formule :C23H39N5O5S2Couleur et forme :SolidMasse moléculaire :529.72Tyroserleutide hydrochloride
CAS :<p>Tyroserleutide HCl, a tripeptide from pig spleen, inhibits tumor growth in vivo/vitro.</p>Formule :C18H28ClN3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.88Ac-LEVD-CHO
CAS :<p>Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].</p>Formule :C22H36N4O9Couleur et forme :SolidMasse moléculaire :500.54BM 957
CAS :<p>BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).</p>Formule :C52H56ClF3N6O7S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1065.68
