Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(11 produits)
- Caspase(144 produits)
- FOXO1(3 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(139 produits)
- PDK(9 produits)
- PERK(27 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(62 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6063 produits trouvés pour "Apoptose"
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Triphen diol
CAS :Triphen diol, a phenol diol, fights pancreatic cancer & cholangiocarcinoma, inducing apoptosis via caspase-dependent & -independent paths.Formule :C22H20O4Couleur et forme :SolidMasse moléculaire :348.39Pan-Trk-IN-3
Pan-Trk-IN-3: potent Trk inhibitor (IC50: 2-26 nM), effective against drug-resistant mutants, induces apoptosis, anti-tumor effects.Formule :C29H31ClN8O3Couleur et forme :SolidMasse moléculaire :575.06TP-030-1
CAS :TP-030-1, RIPK1 inhibitor: K(i) hRIPK1 at 3.9nM, IC50 mRIPK1 at 4.2μM; targets inflammation, neurodegeneration research.Formule :C23H22N4O3Couleur et forme :SolidMasse moléculaire :402.45BMS-751324
CAS :<p>BMS-751324: p38α MAPK inhibitor with carbamyl-methyl, esters, phosphate from HPA. Reduces rat arthritis swelling and TNFα.</p>Formule :C32H35N6O10PCouleur et forme :SolidMasse moléculaire :694.63ADH-6
CAS :ADH-6, a tripyridylamide, disrupts mutant p53 aggregates in cancer cells, reviving its function and inducing apoptosis.Formule :C29H36N8O9Couleur et forme :SolidMasse moléculaire :640.64PF-07328948
CAS :PF-07328948 is a branched-chain keto-acid dehydrogenase kinase (BDK) inhibitor, useful for studying CVD metabolic disorders.Formule :C16H8F4O3SDegré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :356.29Darizmetinib
CAS :Darizmetinib (HRX215) is an MKK4 inhibitor.Formule :C21H17F2N5O3SDegré de pureté :98.03% - 99.57%Couleur et forme :SolidMasse moléculaire :457.45Nalmefene
CAS :Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study of opioid overdose and alcohol dependence.Formule :C21H25NO3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :339.43Vatalanib hydrochloride
CAS :Vatalanib hydrochloride (PTK787 hydrochloride) is an orally available and highly potent tyrosine kinase (VEGF) inhibitor that reduces the number and size of Aβ plaques in the cortex of 5xFAD mice, which may be useful in the study of Alzheimer's disease and cancer.Formule :C20H16Cl2N4Degré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :383.27Zotatifin
CAS :Zotatifin (eFT226) is a selective eIF4A inhibitor with antiviral and antitumor properties, inhibiting Sox4 translation and inducing apoptosis.Formule :C28H29N3O5Degré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :487.55Zharp1-211
CAS :Zharp1-211 is a RIPK3 inhibitor，reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.Formule :C24H25N5O4Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :447.49Milademetan
CAS :Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.Formule :C30H34Cl2FN5O4Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :618.53Lometrexol
CAS :<p>Lometrexol (LY 264618) is an antifolate that inhibits GARFT, blocks purine synthesis, induces apoptosis, and has anticancer properties.</p>Formule :C21H25N5O6Degré de pureté :97.76% - 99.56%Couleur et forme :SolidMasse moléculaire :443.45Tuvusertib
CAS :Tuvusertib (M1774), an oral ATR inhibitor (Ki<1µM), selectively blocks CHK1 phosphorylation, disrupts DNA repair, and induces tumor cell apoptosis.Formule :C16H12F2N8ODegré de pureté :98.44% - 99.66%Couleur et forme :SolidMasse moléculaire :370.32BCL6-IN-3
CAS :BCL6-IN-3: potent BCL6 inhibitor, 70 nM GI50 in SU-DHL4, affects cell functions, antitumor.Formule :C24H31ClF2N6O2Degré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :508.99HC-5404
CAS :HC-5404 is a potent and selective PERK inhibitor, blocking the activation of the PERK pathway, anti-tumor effects, advanced solid tumors and renal cell Cancer.Formule :C24H24F2N4O3Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :454.47SY-5609
CAS :SY-5609 (CDK7-IN-3) is a selective non-covalent CDK7 inhibitor, with weak inhibitory activity against CDK2, CDK9 and CDK12.Cost-effective and quality-assured.Formule :C23H26F3N6OPDegré de pureté :99.34% - >99.99%Couleur et forme :SolidMasse moléculaire :490.46UH15-38
CAS :UH15-38 is a potent and selective RIPK3 inhibitor that blocks necroptosis in alveolar epithelial cells triggered by IAV, useful for studying lung inflammation.Formule :C26H27N5O2Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :441.53Gemcitabine elaidate hydrochloride
CAS :<p>CP-4126, a lipophilic pro-drug of Gemcitabine, converts to active form by esterases, allowing oral administration with dose-dependent effects.</p>Formule :C27H44ClF2N3O5Degré de pureté :98.50% - 99.6%Couleur et forme :SolidMasse moléculaire :564.11JAK2-IN-7
CAS :JAK2-IN-7 selectively inhibits JAK2 (IC50: 3 nM), shows 14-fold selectivity over JAK1/3, FLT3, induces G0/G1 arrest, apoptosis, and has antitumor effects.Formule :C26H33N7ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :459.59FX-11
CAS :<p>FX-11: potent LDHA inhibitor (Ki 8 μM), activates PKM2, reduces ATP, induces oxidative stress/ROS, cell death, shows antitumor effects.</p>Formule :C22H22O4Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :350.41β-Zearalanol
CAS :Beta-Zearalenol, a derivative of zearalenone (ZEA) capable of conjugating with glucuronic acid[2], is a mycotoxin produced by Fusarium spp. It induces apoptosis and oxidative stress in mammalian reproductive cells[1].Formule :C18H26O5Couleur et forme :SolidMasse moléculaire :322.4PIM-447 dihydrochloride
CAS :PIM-447 dihydrochloride is an orally available and selective inhibitor of pan-PIM kinase(Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively).Formule :C24H25Cl2F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.38OBAA
CAS :OBAA is a potent inhibitor of phospholipase A2 (PLA2) with an IC 50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC 50 of 0.4 μM [1] [2] [3].Formule :C28H44O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.65AP1867-3-(aminoethoxy)
CAS :AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.Formule :C38H50N2O9Couleur et forme :SolidMasse moléculaire :678.81(R)-Verapamil hydrochloride
CAS :(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is an inhibitor of P-Glycoprotein.Formule :C27H39ClN2O4Couleur et forme :SolidMasse moléculaire :491.06WEHI-539 hydrochloride
CAS :WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.Formule :C31H30ClN5O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :620.18PRGL493
CAS :PRGL493 blocks ACSL4, halts PC3/MDA-MB-231 cancer cell spread, and inhibits MA-10 tumor progesterone. Effective in mouse PC3 tumor model at 0.25 mg/kg.Formule :C25H21N7O2Degré de pureté :98.80% - 99.11%Couleur et forme :SolidMasse moléculaire :451.48Platinum, diammine[1,1-cyclobutanedi(carboxylato-kO)(2-)]-, (SP-4-2)-
CAS :Formule :C6H10N2O4PtDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.23265-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
CAS :Formule :C9H14N4O5Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :258.2313RRD-251
CAS :RRD-251 is an Rb-Raf-1 interaction inhibitor that induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine[1].Formule :C8H9Cl3N2SCouleur et forme :SolidMasse moléculaire :271.59Yatein
CAS :Yatein inhibits herpes simplex virus type 1 replication by interruption the immediate-early gene expression. Yatein is a lignan isolated from A. chilensis. It also has antiproliferative activity.Formule :C22H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.42DB818
CAS :DB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression.Formule :C19H16N6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :360.44Thalidomide-5-COOH
CAS :Thalidomide-5-COOH is a useful organic compound for research related to life sciences. The catalog number is T64600 and the CAS number is 1216805-11-6.Formule :C14H10N2O6Couleur et forme :SolidMasse moléculaire :302.242Thalidomide-O-C6-COOH
CAS :Thalidomide-O-C6-COOH is a synthetic conjugate that combines a Thalidomide-derived cereblon ligand with a PROTAC technology linker (E3 ligase ligand-linker).Formule :C20H22N2O7Couleur et forme :SolidMasse moléculaire :402.403Ingenol 3,20-dibenzoate
CAS :Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms that effectively induces the translocation of nPKC-delta, -epsilon, and -theta, as well as PKC-mu, from the cytosolic fraction to the particulate fraction. Through de novo synthesis of macromolecules, it triggers apoptosis with characteristic morphology. Moreover, Ingenol 3,20-dibenzoate enhances IFN-γ production and degranulation in NK cells, particularly when stimulated by NSCLC cells[1][2].Formule :C34H36O7Couleur et forme :SolidMasse moléculaire :556.65A-192621
CAS :A-192621 is a potent, nonpeptide, orally active, and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. A-192621 promotes apoptosis in PASMCs and elevates both arterial blood pressure and plasma ET-1 levels[1][2][3]. Its selectivity is 636-fold higher for ETB than ETA (IC50 of 4280 nM and Ki of 5600 nM).Formule :C33H38N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.66XMU-MP-3
CAS :XMU-MP-3 is a robust, non-covalent inhibitor of BTK, exhibiting exceptional potency with IC50 values of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation, respectively, in the presence of 10 μM ATP. Moreover, XMU-MP-3 elicits apoptosis.Formule :C27H27F3N8OCouleur et forme :SolidMasse moléculaire :536.563ENMD-2076 tartrate
CAS :ENMD-2076 is an orally active kinase inhibitor. It also has antiangiogenic and antiproliferative mechanisms of action.Formule :C25H31N7O6Couleur et forme :SolidMasse moléculaire :525.56Thalidomide-O-C5-NH2 hydrochloride
CAS :Thalidomide-O-C5-NH2 hydrochloride is a synthetic compound consisting of a ligand-linker conjugate with E3 ligase activity. It combines a cereblon ligand based on Thalidomide and a linker commonly utilized in PROTAC technology.Formule :C18H22ClN3O5Couleur et forme :SolidMasse moléculaire :395.84MI-773
CAS :MI-773 is a potent inhibitor of the MDM2-p53 protein interaction (PPI) with a high affinity for MDM2 and a Kd value of 8.2 nM. MI-773 exhibits antitumour effects.Formule :C29H34Cl2FN3O3Couleur et forme :SolidMasse moléculaire :562.5Vatiquinone
CAS :Vatiquinone, also known as EPI 743, is an orally bioavailable para-benzoquinone being developed for inherited mitochondrial diseases. The mechanism of action of EPI-743 involves augmenting the synthesis of glutathione, optimizing metabolic control, enhancFormule :C29H44O3Couleur et forme :SolidMasse moléculaire :440.66Ciprofloxacin lactate
CAS :Ciprofloxacin lactate is a useful organic compound for research related to life sciences. The catalog number is T66299 and the CAS number is 97867-33-9.Formule :C20H24FN3O6Couleur et forme :SolidMasse moléculaire :421.43Prostaglandin A2
CAS :PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]Formule :C20H30O4Couleur et forme :SolidMasse moléculaire :334.45Carubicin hydrochloride
CAS :Carubicin HCl is an anthracycline antineoplastic antibiotic. Through intercalates into DNA and interacts with topoisomerase II, Carubicin inhibits DNA replication and repair and RNA and protein synthesis.Formule :C26H28ClNO10Couleur et forme :SolidMasse moléculaire :549.95Mcl-1 inhibitor 6
CAS :Mcl-1 inhibitor 6 binds Mcl-1 with KD 0.23 nM and Ki 0.02 μM, shows strong selectivity over Bcl-2 family, and demonstrates antitumor efficacy.Formule :C26H28ClNO6SCouleur et forme :SolidMasse moléculaire :518.02SCH79797
CAS :SCH79797 is a potent and specific protease-activated receptor 1 (PAR1) antagonistwith antimicrobial, anticancer, anti-inflammatory, and neuroprotective effects.Formule :C23H25N5Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :371.48Imifoplatin
CAS :Imifoplatin (PT-112) is a platinum compound with antitumor activity and may be used to study prostate cancer and immune system disorders.Formule :C6H16N2O7P2PtDegré de pureté :≥95.0%Couleur et forme :SolidMasse moléculaire :485.23Dihydroartemisinin (mixture of α and β isomers)
CAS :Dihydroartemisinin (mixture of α and β isomers) is a useful organic compound for research related to life sciences. The catalog number is T64399 and the CAS number is 131175-87-6.Formule :C15H24O5Couleur et forme :SolidMasse moléculaire :284.352Swainsonine
CAS :Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arrest in the G2/M phase.Formule :C8H15NO3Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :173.21
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