Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5593 produits trouvés pour "Apoptose"
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SP3N hydrochloride
<p>SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). Its alkylamine moiety is metabolized into an active aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for the degradation of FKBP12. SP3N hydrochloride is applicable in cancer research.</p>Couleur et forme :Odour SolidSuramin
CAS :<p>Suramin is an RdRp and PTPase inhibitor with anti-parasitic, anti-tumor, and anti-angiogenic activities, inhibiting sirtuins and DNA topoisomerase II.</p>Formule :C51H40N6O23S6Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :1297.28PI3Kα-IN-14
<p>PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting in</p>Degré de pureté :98%Couleur et forme :Odour SolidFC-116
CAS :<p>FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice.FC-116 induces apoptosis and promotes protein degradation.</p>Formule :C21H20FNO4Degré de pureté :98.18%Couleur et forme :SoildMasse moléculaire :369.39PL120131
<p>PL120131 is a PD-1/PD-L1 inhibitory peptide that disrupts the interaction between PD-1 and PD-L1 by binding to PD-1. This compound can inhibit the apoptosis signaling pathway mediated by PD-1, thereby preventing apoptosis (apoptosis) in Jurkat cells and primary lymphocytes. Additionally, PL120131 supports cytotoxic T lymphocytes (CTL) in exhibiting antitumor activity.</p>Formule :C62H105N19O18Couleur et forme :SolidMasse moléculaire :1404.61RIPK3-IN-3
<p>RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM.</p>Formule :C16H11N5SCouleur et forme :SolidMasse moléculaire :305.36PTD-p65-P1 Peptide
<p>PTD-p65-P1: a NF-kappaB inhibitor blocking activation from multiple inflammatory stimuli.</p>Formule :C168H275N57O44SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3829.5p38-α MAPK-IN-8
<p>p38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. It exhibits cytotoxicity toward various tumor cells, inducing cell cycle arrest and apoptosis, as well as increasing reactive oxygen species (ROS) production and causing mitochondrial membrane potential depolarization. Its antitumor activity may be related to the p38α MAPK pathway, making it a potential candidate for cancer research.</p>Formule :C49H62BrO4PCouleur et forme :SolidMasse moléculaire :825.892CYP51/PD-L1-IN-4
<p>CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target inhibitor of CYP51/PD-L1, displaying IC50 values of 0.17 and 0.021 μM, respectively.</p>Formule :C27H28N4O3Couleur et forme :SolidMasse moléculaire :456.54β-Apopicropodophyllin
CAS :<p>β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage,</p>Formule :C22H20O7Couleur et forme :SolidMasse moléculaire :396.39DTUN
<p>DTUN: lipophilic radical initiator, starts STY-BODIPY liposome co-autoxidization at 0.2 mM, useful in FENIX assays.</p>Couleur et forme :SolidOxatomide
CAS :<p>Oxatomide: Dual H1/P2X7 antagonist, antihistamine, anti-allergic, treats immune diseases, IC50: 0.95 μM (P2X7), 0.43 μM (5-HT).</p>Formule :C27H30N4ODegré de pureté :98.82% - 99.72%Couleur et forme :White PowderMasse moléculaire :426.55Ianalumab
CAS :<p>Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R.</p>Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.44 kDaDMUP
CAS :<p>DMUP inhibits CD47-SIRPα, induces apoptosis, boosts macrophage activity in A549 cells, and has antitumor properties.</p>Formule :C24H24Cl2N2O10PtCouleur et forme :SolidMasse moléculaire :766.45R1-ICR-5
CAS :<p>R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.</p>Formule :C54H70N8O7S2Couleur et forme :SolidMasse moléculaire :1007.31(R)-JAK2/STAT3-IN-10a
CAS :<p>(R)-JAK2/STAT3-IN-10a is the R-isomer of JAK2/STAT3-IN-1.JAK2/STAT3-IN-1 is a structural domain inhibitor of GP130 D1 with antitumor activity.</p>Formule :C34H35BrF3N5O2Degré de pureté :97.99%Couleur et forme :SoildMasse moléculaire :682.57Conophylline
CAS :<p>Conophylline, an alkaloid from Ervatamia microphylla, induces pancreatic cell differentiation and apoptosis, and suppresses HSC.</p>Formule :C44H50N4O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :794.89Thalidomide-5-propargyne-NH2 hydrochloride
CAS :<p>Thalidomide derivative for CRBN protein recruitment, used in PROTACs production for protein degradation.</p>Formule :C16H14ClN3O4Couleur et forme :SolidMasse moléculaire :347.753Resolvin D2 n-3 DPA
CAS :<p>RvD2 n-3 DPA is an SPM made from docosapentaenoic acid in human leukocytes, inhibiting neutrophil chemotaxis and adhesion.</p>Formule :C22H34O5Couleur et forme :SolidMasse moléculaire :378.509Azadirone
CAS :<p>Azadirone, a limonoid, sensitizes cancer cells to TRAIL by modulating DR4/DR5, survival, and apoptotic proteins.</p>Formule :C9H15N3O5Couleur et forme :SolidMasse moléculaire :245.23Tripchlorolide
<p>Tripchlorolide is a useful organic compound for research related to life sciences and the catalog number is T126047.</p>Formule :C20H25ClO6Couleur et forme :SolidMasse moléculaire :396.86RET-IN-28
CAS :<p>RET-IN-28 (Compound 16) is an inhibitor of RET (a transmembrane receptor tyrosine kinase). It specifically inhibits the activity of a mutant RET enzyme (RET-V804M) and is utilized in cancer research.</p>Formule :C26H29N9Couleur et forme :SolidMasse moléculaire :467.57Ceftiofur hydrochloride
CAS :<p>Ceftiofur hydrochloride (U-67279A) is a stable, broad-spectrum 3rd-gen cephalosporin with antibacterial properties.</p>Formule :C19H17N5O7S3·HClDegré de pureté :99.51%Couleur et forme :Off-White SolidMasse moléculaire :560.02Albicanol
CAS :<p>Albicanol is a biochemical.</p>Formule :C15H26OCouleur et forme :SolidMasse moléculaire :222.372Phosphocreatine dipotassium
CAS :<p>Phosphocreatine dipotassium, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives.</p>Formule :C4H8K2N3O5PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :287.29Isorhamnetin 3-glucuronide
<p>Isorhamnetin 3-glucuronide is a useful organic compound for research related to life sciences and the catalog number is T124938.</p>Formule :C22H20O13Couleur et forme :SolidMasse moléculaire :492.389Amorfrutin A
CAS :<p>Amorfrutin A is a useful organic compound for research related to life sciences. The catalog number is T124190 and the CAS number is 80489-90-3.</p>Formule :C21H24O4Couleur et forme :SolidMasse moléculaire :340.419Fludarabine triphosphate
CAS :<p>Fludarabine triphosphate inhibits key enzymes, causing cell death.</p>Formule :C10H15FN5O13P3Couleur et forme :SolidMasse moléculaire :525.17HNPMI
CAS :<p>HNPMI is an epidermal growth factor receptor inhibitor that promotes apoptosis and is used in the study of colorectal cancer.</p>Formule :C22H20N2O3Degré de pureté :97.19%Couleur et forme :SoildMasse moléculaire :360.41Anticancer agent 157
<p>Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg/mL, exhibiting both anti-inflammatory and anticancer effects.</p>Formule :C14H20O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :220.31MBC-11 trisodium
CAS :<p>MBC-11 trisodium, a bisphosphonate-Ara-C conjugate, may treat TIBD.</p>Formule :C11H17N3Na3O14P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :577.16Lipustobart
CAS :<p>Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplastic</p>Degré de pureté :98%Couleur et forme :LiquidWF 10129
CAS :<p>WF 10129 is a new angiotensin converting enzyme inhibitor generated by a fungus, Doratomyces putredinis.</p>Formule :C20H28N2O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :424.45Anti-Mouse PD-L1 Antibody (10F.9G2)
<p>Anti-Mouse PD-L1 Antibody (10F.9G2) is an IgG-class antibody against mouse PD-L1.</p>Degré de pureté :98.92% - >95% Determined by SDS-PAGECouleur et forme :Odour LiquidRetifanlimab
CAS :<p>Retifanlimab (MGA-012) is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). Retifanlimab is used in studies of Merkel cell carcinoma.</p>Degré de pureté :95% - 98.56% (SEC-HPLC)Couleur et forme :LiquidBeclin1-Bcl-2 interaction inhibitor 1
<p>Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].</p>Couleur et forme :Odour SolidPacmilimab
CAS :<p>Pacmilimab (CX-072) is a Probody immune checkpoint inhibitor targeting programmed death ligand 1 (PD-L1) with anti-tumor activity for the study of solid tumors.</p>Degré de pureté :98.8% (SDS-PAGE); 96.3% (SEC-HPLC) - 98.8% (SDS-PAGE); 96.3% (SEC-HPLC)Couleur et forme :LiquidEriosematin
CAS :<p>Eriosematin has anti-proliferative and apoptosis-inducing properties and is a compound extracted from the root of Flemingia philippinensis in the Philippines.</p>Formule :C19H20O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :312.36DefNEtTrp
<p>DefNEtTrp is an iron bis-chelating ligand composed of Def and Trp groups. It demonstrates potent broad-spectrum antiproliferative and cytotoxic effects in cancer cell lines. DefNEtTrp induces apoptosis and ferroptosis, exhibiting cytotoxicity with an IC50 value of 0.77 μM.</p>Formule :C30H27N9O3SCouleur et forme :SolidMasse moléculaire :593.659BC13
<p>BC13 is a CDK6/BRD4 inhibitor with IC50 values of 234 nM for CDK6 and 36 nM for BRD4. It exhibits antiproliferative properties, induces apoptosis (cell death) and DNA damage, and elevates ROS levels.</p>Formule :C37H39N7O5Couleur et forme :SolidMasse moléculaire :661.75Antitumor photosensitizer-3
<p>Antitumor Photosensitizer-3 (Compound I), a chlorin derivative, effectively induces apoptosis and necrosis in tumor cells upon exposure to 650 nm laser</p>Formule :C48H34N4O4Couleur et forme :SolidMasse moléculaire :730.81VEGFR-2-IN-61
<p>VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.</p>Formule :C27H25N5OCouleur et forme :SolidMasse moléculaire :435.52Bursehernin
CAS :<p>Bursehernin is a useful organic compound for research related to life sciences and the catalog number is T124894.</p>Formule :C21H22O6Couleur et forme :SolidMasse moléculaire :370.401AMPK-IN-6
<p>AMPK-IN-6 (compound 13a) is a potent AMPK inhibitor with an IC50 value of 0.093 µM. It induces apoptosis and suppresses autophagy. Additionally, AMPK-IN-6 exhibits antiproliferative activity and holds potential for research into pulmonary arterial hypertension.</p>Formule :C18H20FN5OCouleur et forme :SolidMasse moléculaire :341.383Dual Galectin-3/EGFR-IN-1
<p>Dual Galectin-3/EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.</p>Formule :C32H41N7O10Couleur et forme :SolidMasse moléculaire :683.709WR-S-462
<p>WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 μM, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC).</p>Formule :C24H22N4O4SCouleur et forme :SolidMasse moléculaire :462.52YTHDF2-IN-1
<p>YTHDF2-IN-1 (Compound CK-75) is an inhibitor of YT521-B homology domain family 2 (YTHDF2) with a dissociation constant (Kd) of 26.2 μM, and it effectively blocks the interaction between YTHDF2 and m6A RNA. It suppresses colony formation in JAR cells and exhibits antiproliferative activity in various cancer cell lines, with an IC50 in the micromolar range. Additionally, YTHDF2-IN-1 induces apoptosis in K562 cells and causes cell cycle arrest at the G0/G1 phase.</p>Formule :C21H14N2O4Couleur et forme :SolidMasse moléculaire :358.35Pim-1 kinase inhibitor 4
<p>Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity and</p>Formule :C19H12ClN3ODegré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :333.77HPOB
CAS :<p>HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.</p>Formule :C17H18N2O4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :314.34Ecdysone
CAS :<p>Ecdysone is a major steroid hormone in insects and herbs.</p>Formule :C27H44O6Degré de pureté :99.22%Couleur et forme :PowderMasse moléculaire :464.63
