Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5598 produits trouvés pour "Apoptose"
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TS-IN-5
<p>TS-IN-5 (Compound 15) is an inhibitor of thymidylate synthase (TS). It induces apoptosis by modulating the proteins Bax, BCL-2, PI3K, and STAT1. TS-IN-5 exhibits antitumor activity against liver cancer, breast cancer, and colon cancer.</p>Formule :C16H17N5OSCouleur et forme :SolidMasse moléculaire :327.404FF2049
<p>FF2049 is a selective HDAC PROTAC degrader with a DC50 of 257 nM for HDAC1. It facilitates the ubiquitination and degradation of HDAC and promotes apoptosis (Apoptosis). FF2049 is applicable in research involving hematological and solid tumors.</p>Formule :C31H38ClN7O7Couleur et forme :SolidMasse moléculaire :656.129NFh-NMe-2
<p>NFh-NMe-2 is a photosensitizer that interacts with nitroreductase (nitroreductase) to generate singlet oxygen in tumor cells, exhibiting cytotoxicity in cancer cells and inducing apoptosis (apoptosis). In mouse models, NFh-NMe-2 demonstrates antitumor activity.</p>Formule :C32H33IN2OCouleur et forme :SolidMasse moléculaire :588.522Sarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Formule :C38H44O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :692.75Antiproliferative agent-59
<p>Antiproliferative agent-59 (Compound 14u) acts as an inhibitor of tubulin polymerization. Demonstrating anticancer activity in Huh7, SGC-7901, and MCF-7 cell lines, this compound achieves IC50 values of 0.03, 0.18, and 0.13 μM, respectively. Additionally, it arrests the cell cycle at the G2/M phase and induces apoptosis in Huh7 cells. In a xenograft mouse model utilizing Huh7 cells, Antiproliferative agent-59 exhibits antitumor effects against hepatocellular carcinoma without significant toxicity.</p>Formule :C26H22N2O3Couleur et forme :SolidMasse moléculaire :410.46LSD1-IN-36
<p>LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity.</p>Formule :C22H25N3O6SCouleur et forme :SolidMasse moléculaire :459.52BCL-XL-IN-1
<p>BCL-XL-IN-1 (Compound 11) is a selective inhibitor of BCL-XL, exhibiting a Ki of less than 0.01 nM against BCL-XLTR-FERT. It is primarily used in cancer research.</p>Formule :C46H55N7O6SCouleur et forme :SolidMasse moléculaire :834.04PIM-1/CK2-IN-2
<p>PIM-1/CK2-IN-2 (compound 3aA) is an inhibitor of the PIM-1/CK2 enzymes. This compound can induce the mitochondrial apoptosis pathway in CCRF-CEM cells and is utilized in cancer research.</p>Formule :C15H8Br4N2OCouleur et forme :SolidMasse moléculaire :551.85CDK2-IN-32
<p>CDK2-IN-32 (Compound 5g) is a selective CDK2 inhibitor with an IC50 of 0.21 μM. It exhibits cytotoxicity towards Vero cells with an IC50 of 28.52 μM.</p>Formule :C18H13Cl2N5O2Couleur et forme :SolidMasse moléculaire :402.23Quercetin-d3
<p>Quercetin-d3 hydrate, a deuterated form of Quercetin hydrate, acts as a flavonoid that stimulates recombinant SIRT1 and serves as a PI3K inhibitor. The compound specifically exhibits IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM against PI3Kγ, PI3Kδ, and PI3Kβ, respectively.</p>Formule :C15H9D3O8Couleur et forme :SolidMasse moléculaire :323.27Apoptosis inducer 30
<p>Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0/G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.</p>Formule :C52H69BrNO4PCouleur et forme :SolidMasse moléculaire :882.99Tubulin polymerization-IN-70
<p>Tubulin polymerization-IN-70 (compound Q19) is an effective inhibitor of tubulin polymerization. This compound exerts antiproliferative properties by targeting the colchicine binding site on tubulin, thereby inhibiting its polymerization. Tubulin polymerization-IN-70 also induces apoptosis and cell cycle arrest at the G2/M phase. Additionally, it triggers a decrease in mitochondrial membrane potential and elevates levels of reactive oxygen species (ROS). Moreover, Tubulin polymerization-IN-70 possesses anti-angiogenic and anticancer activities.</p>Formule :C25H23N3O2Couleur et forme :SolidMasse moléculaire :397.47ECDD-S18
<p>ECDD-S18 (compound ECDD-S18) induces apoptosis in a dose-dependent manner, effectively targeting the vacuolar ATPase (V-ATPase) and impairing lysosomal acidification.</p>Formule :C35H31BrO12Couleur et forme :SolidMasse moléculaire :723.52[Au(L4)(CyJohnPhos)]SbF6
<p>[Au(L4)(CyJohnPhos)]SbF6 is a gold-containing compound that exhibits inhibitory effects on cyclooxygenase-1/2 (COX-1/2), suppresses the proliferation of colon cancer cells Caco2-/TC7 with an IC50 of 0.98 μM, and induces cell apoptosis (apoptosis). Additionally, [Au(L4)(CyJohnPhos)]SbF6 acts as an inhibitor of thioredoxin reductase (TrxR) and demonstrates antioxidative activity by modulating ROS levels.</p>Formule :C44H56AuF6NO4PSSbCouleur et forme :SolidMasse moléculaire :1158.68Rasagiline
CAS :<p>Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons</p>Formule :C12H13NDegré de pureté :98% - 99.87%Couleur et forme :SolidMasse moléculaire :171.24CAY10678
CAS :<p>CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPS</p>Formule :C23H34N4ODegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :382.54KH16
<p>KH16 is an HDAC inhibitor.KH16 stimulates apoptosis and is able to inhibit gene expression patterns in a variety of tumor cells.</p>Formule :C18H20N6O2Degré de pureté :98.15%Couleur et forme :SolidMasse moléculaire :352.39Dapirolizumab
<p>Dapirolizumab is an anti-CD40 monoclonal antibody used in research on systemic lupus erythematosus (SLE) and other autoimmune diseases.</p>Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :145.5 kDaUM4118
CAS :<p>UM4118 (N-quinolin-8-ylpyridine-2-carboxamide) is a copper ion carrier used in the study of acute myeloid leukemia.</p>Formule :C15H11N3ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :249.27Flavopiridol
CAS :<p>Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.</p>Formule :C21H20ClNO5Degré de pureté :97.74% - 99.86%Couleur et forme :SolidMasse moléculaire :401.84Dynorphin A
CAS :<p>Dynorphin A is a endogenous opioid peptide and a κ-opioid receptor (KOR) agonist,a neurotransmitter and regulator in the central and peripheral nervous systems</p>Formule :C99H155N31O23Degré de pureté :95.93%Couleur et forme :SolidMasse moléculaire :2147.48Etanercept
CAS :<p>Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.</p>Degré de pureté :98%Couleur et forme :LiquidSM-164 Hydrochloride (957135-43-2 free base)
<p>SM-164 Hydrochloride: cell-permeable, binds to XIAP (BIR2/3 domains), IC50 of 1.39 nM, potent XIAP antagonist.</p>Formule :C62H85ClN14O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1157.8812-HETE
CAS :<p>12-HETE ((±)12-HETE) is a regulator of PGE2, having both antithrombotic and prothrombotic effects.</p>Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.47NDI-Lyso
CAS :<p>NDI-Lyso is an anticancer agent targeting lysosomes, functioning through an enzyme-induced self-assembly (EISA) mechanism catalyzed by Cathepsin B. In cancer cell lysosomes, it forms rigid long fibers, promoting lysosomal swelling, lysosomal membrane permeabilization (LMP), and membrane disruption. This leads to non-classical caspase-independent apoptosis (Apoptosis). NDI-Lyso demonstrates significant selective anticancer activity across various cancer cell lines and drug-resistant cancer cells (IC50 approximately 10 μM), while exhibiting low toxicity to normal cells (IC50 > 60 μM).</p>Formule :C71H100N22O13Couleur et forme :SolidMasse moléculaire :1469.69PROTAC HIF-1α degrader-1
<p>PROTAC HIF-1α degrader-1 (compound V2) is an effective proteolysis-targeting chimeric (PROTAC) degrader of hypoxia-inducible factor-1α (HIF-1α), with an IC50 value of 7.54 µM. This compound exhibits anti-proliferative activity, reduces HIF-1α protein expression, and induces apoptosis.</p>Formule :C51H72N6O7SCouleur et forme :SolidMasse moléculaire :913.22hMcl-1-IN-1
<p>hMcl-1-IN-1 (Compound 9) is an hMcl-1 inhibitor based on a His224 arylsulfonyl fluoride, displaying an IC50 value of 5.8 nM.</p>Formule :C69H113FN20O19SCouleur et forme :SolidMasse moléculaire :1577.82EJMC-1
CAS :<p>EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.</p>Formule :C17H11ClN2O4SDegré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :374.8P53R3
CAS :<p>P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53</p>Formule :C32H35Cl2N5O2Degré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :592.56BM 957
CAS :<p>BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).</p>Formule :C52H56ClF3N6O7S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1065.68Voreloxin
CAS :<p>Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.</p>Formule :C18H19N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.44PERK-IN-4
CAS :<p>PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.</p>Formule :C24H19F4N5ODegré de pureté :98.07% - 98.95%Couleur et forme :SolidMasse moléculaire :469.43Mcl1-IN-12
CAS :<p>Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.</p>Formule :C45H46N4O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :803Oenothein B
CAS :<p>Oenothein B inhibits PAR-glycohydrolase with antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects.</p>Formule :C68H48O44Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :1569.08NS3694
CAS :<p>NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.</p>Formule :C15H10ClF3N2O3Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :358.7PI3Kδ-IN-16
CAS :<p>PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis.</p>Formule :C22H26N6O2Degré de pureté :99.68%Couleur et forme :SoildMasse moléculaire :406.48POV-PC
CAS :<p>POV-PC is an oxidized phospholipid that inhibits VSMC growth under high serum conditions and induces cell apoptosis under low serum conditions.</p>Formule :C29H56NO9PCouleur et forme :SolidMasse moléculaire :593.73BM-962
CAS :<p>BM-962 (Compound 31) is a potent small-molecule inhibitor with an IC50 value of 4 nM (Ki=0.8 nM) for Bcl-2 and an IC50 of 3.9 nM (Ki<1 nM) for Bcl-xL. It inhibits H1417 and H146 cell lines with IC50 values of 9 and 13 nM, respectively, and shows potential for use in cancer research.</p>Formule :C53H58ClF3N6O7S3Couleur et forme :SolidMasse moléculaire :1079.715-LOX-IN-2
CAS :<p>5-LOX-in-2: a 5-lipoxygenase inhibitor with IC50 of 0.33 μM, reduces kidney cancer cell activity, induces apoptosis.</p>Formule :C17H16O4Degré de pureté :98.74%Couleur et forme :SoildMasse moléculaire :284.31Anticancer agent 130
<p>Anticancer agent 130 (compound 8d) significantly induces apoptosis in A549 cells [1].</p>Formule :C38H46FN5O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :671.8Asparanin A
CAS :<p>Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways.</p>Formule :C39H64O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :740.92Caerin 1.1 TFA
<p>Caerin 1.1 TFA, a host defense peptide derived from the Australian tree frog Litoria's glandular secretions, exhibits anti-proliferative effects on HeLa cells</p>Degré de pureté :98%Couleur et forme :Odour SolidFerroptosis-IN-3
<p>Ferroptosis-IN-3 (Compound 25), a ferroptosis inhibitor, demonstrates potent activity by inhibiting RSL3-induced ferroptosis in HT-1080 cells (EC50: 8.6 nM).</p>Degré de pureté :98%Couleur et forme :Odour SolidTAT-BH4 (Bcl-xL)
<p>TAT-BH4 (Bcl-xL), primarily localized at the mitochondria, inhibits apoptotic cell death.</p>Formule :C159H268N58O45Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3712.19Pyridinium bisretinoid A2E TFA
CAS :<p>Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediates</p>Formule :C44H58F3NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :705.93Antitumor agent-112
<p>Antitumor agent-112 (compound 3a) is a potent antitumor agent that induces apoptosis and exhibits cytotoxic activity on A549 cells, with an IC50 value of 91.35</p>Formule :C18H17ClN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.87TAT-NEP1-40 TFA
<p>TAT-NEP1-40 TFA, a blood-brain barrier-permeable peptide, safeguards PC12 cells against oxygen and glucose deprivation (OGD) and fosters neurite outgrowth.</p>Formule :C268H438N88O77·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6124.89 (free base)TP4 (Nile tilapia piscidin)
CAS :<p>TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide that exhibits inhibition of various gram-positive and negative bacterial</p>Formule :C135H226N50O27Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2981.56Antitumor agent-113
<p>Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cell</p>Formule :C21H22ClN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.95Pamrevlumab
CAS :<p>FG-3019 (Pamrevlumab), a human antibody, targets CTGF, potentially treating idiopathic pulmonary fibrosis.</p>Degré de pureté :100% (SEC-HPLC) - 95%Couleur et forme :Liquid
