Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
RET ligand-3
<p>RETligand-3 is the ligand for PROTAC QZ2135, which targets RET.</p>Formule :C38H42N10O3Couleur et forme :SolidMasse moléculaire :686.81PROTAC XPO1 degrader-1
<p>PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. It exhibits anti-proliferative effects, induces apoptosis, inhibits NF-κB activity, and causes cell cycle arrest at the G1 phase. PROTAC XPO1 degrader-1 is applicable to research on hematological malignancies.</p>Formule :C33H35ClF3N7O7Couleur et forme :SolidMasse moléculaire :734.122Thrombospondin-1 (1016-1023) (human, bovine, mouse)
CAS :<p>Thrombospondin-1 (1016-1023) (human, bovine, mouse) is part of Thrombospondin-1 (TSP-1), a peptide with CD47 agonism.</p>Formule :C56H81N13O10SDegré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :1128.39Thevetiaflavone
CAS :<p>Thevetiaflavone, a natural flavonoid from W. indica, blocks LDH leakage, boosting cell survival.</p>Formule :C16H12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :284.26XZ739
CAS :<p>XZ739: Cereblon-based PROTAC, degrades BCL-XL (DC50 2.5 nM in MOLT-4, 16hr), induces caspase apoptosis.</p>Formule :C65H76ClF3N8O12S3Couleur et forme :SolidMasse moléculaire :1349.99MAO-B-IN-30
CAS :<p>MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in organisms, and can be used to study Parkinson's-type neurological disorders.</p>Formule :C15H10BrN3O2Degré de pureté :98.31%Couleur et forme :SoildMasse moléculaire :344.16Chloranil
CAS :<p>Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.</p>Formule :C6Cl4O2Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :245.88G-Glu-Val
CAS :<p>G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".</p>Formule :C10H18N2O5Couleur et forme :SolidMasse moléculaire :246.26CYP51/PD-L1-IN-4
<p>CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target inhibitor of CYP51/PD-L1, displaying IC50 values of 0.17 and 0.021 μM, respectively.</p>Formule :C27H28N4O3Couleur et forme :SolidMasse moléculaire :456.54Sarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Formule :C38H44O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :692.75Liensinine Perchlorate
CAS :<p>Liensinine is the active constituent of plumula nelambinis with anti-hypertension.</p>Formule :C37H43ClN2O10Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :711.2NecroIr2
<p>NecroIr2, an iridium(III) compound, induces necroptosis in Cisplatin-resistant A549R lung cancer cells and disrupts mitochondria.</p>Formule :C46H30ClIrN6O2Couleur et forme :SolidMasse moléculaire :926.44TTQ-SA
<p>TTQ-SA is a near-infrared spiraling aggregation-induced emitter capable of converting near-infrared light (NIR) into thermal energy, resulting in thermal damage and death of tumor cells. In cancer cells MF-7, TTQ-SA shows cell uptake and targeting capabilities. TTQ-SA binds with DNAzyme to inhibit the expression of the survivin gene, enhancing the sensitivity of tumor cells to photothermal therapy.</p>Formule :C78H53N7SCouleur et forme :SolidMasse moléculaire :1120.37EM 163
CAS :<p>EM 163是一种 TIR-TIR 相互作用抑制剂，它是MyD88蛋白的TIR（Toll/白细胞介素-1受体）结构域拟态。EM 163针对IL-1受体中的TIR 结构域，阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B（SEB）引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中，EM 163阻断p38的激活和IL-1β对化学诱导的长期电位（LTP）引发的蛋白质合成的抑制作用。</p>Formule :C44H60IN5O4Degré de pureté :97.97%Couleur et forme :SolidMasse moléculaire :849.88ChoKα inhibitor-5
<p>ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.</p>Formule :C54H68Br2N4S4Couleur et forme :SolidMasse moléculaire :1061.21UM4118
CAS :<p>UM4118 (N-quinolin-8-ylpyridine-2-carboxamide) is a copper ion carrier used in the study of acute myeloid leukemia.</p>Formule :C15H11N3ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :249.27Cholesteryl Hemisuccinate Tris Salt
CAS :<p>Cholesteryl Hemisuccinate Tris Salt is a cholesteryl ester with anticancer activity.Cholesteryl hemisuccinate has antitumor activity and inhibits tumor growth.</p>Formule :C35H61NO7Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :607.86S-Adenosyl-L-methionine
CAS :<p>S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.</p>Formule :C15H22N6O5SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :398.44Pegsunercept
CAS :<p>Pegsunercept (PEG sTNF-RI), a pegylated monoclonal antibody, selectively binds to TNFA, incorporating a polyethylene glycol (pegol) moiety [1].</p>Couleur et forme :LiquidOenothein B
CAS :<p>Oenothein B inhibits PAR-glycohydrolase with antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects.</p>Formule :C68H48O44Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :1569.08Bfl-1-IN-6
<p>Bfl-1-IN-6 (Compound 20) is an orally active inhibitor of Bcl-2-related protein A1 (BFL1) with an IC50 of 19 nM. This compound can stabilize BFL1 protein, activate cleaved caspase 3, and demonstrates antitumor activity in mouse models.</p>Formule :C22H24ClFN2O2Couleur et forme :SolidMasse moléculaire :402.89FKBP12 ligand-1
CAS :<p>FKBP12 ligand-1 is the target protein ligand for MC-25B, which is a PROTAC targeting FKBP12.</p>Formule :C32H41NO9Couleur et forme :SolidMasse moléculaire :583.669Ceftiofur hydrochloride
CAS :<p>Ceftiofur hydrochloride (U-67279A) is a stable, broad-spectrum 3rd-gen cephalosporin with antibacterial properties.</p>Formule :C19H17N5O7S3·HClDegré de pureté :99.51%Couleur et forme :Off-White SolidMasse moléculaire :560.02DD0-2363
<p>DD0-2363 (Compound 32d) is a dual-target inhibitor of WDR5-MLL1/HDAC. It can suppress the proliferation of acute myeloid leukemia cells and induce apoptosis. With its antitumor properties, DD0-2363 is applicable for research on acute myeloid leukemia.</p>Formule :C36H36ClFN6O4Couleur et forme :SolidMasse moléculaire :671.16Topo I/II-IN-2
<p>Topo I/II-IN-2 (Compound 3g) is an inhibitor of both Topo I and Topo II. It exhibits inhibitory activity against NCI-H446 and NCI-H1048 cells with IC50 values of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial apoptosis, disrupts mitochondrial function, and stimulates activity generation. Additionally, it inhibits the PI3K/Akt/mTOR pathway, effectively preventing the proliferation, invasion, and migration of small cell lung cancer (SCLC) cells in vitro.</p>Formule :C25H26N2O4Couleur et forme :SolidMasse moléculaire :418.48PKM2 modulator 1
<p>PKM2 modulator 1 (compound C998) is an effective PKM2 inhibitor with antiproliferative activity. It induces apoptosis and holds potential for research in glioblastoma studies.</p>Formule :C26H25N3O3Couleur et forme :SolidMasse moléculaire :427.5TD1092
<p>TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.</p>Formule :C55H70N8O9Couleur et forme :SolidMasse moléculaire :987.19BAG3/HSP70-IN-1
<p>USP1-IN-11 (compound 38-P2) is a selective, reversible, and non-competitive inhibitor of USP1 (Ubiquitin-specific protease 1). It activates the DDR (DNA damage repair) pathway, leading to cell cycle arrest and apoptosis, thereby inhibiting cell survival. USP1-IN-11 increases sensitivity to Olaparib in drug-resistant cells and works synergistically with Andrographolide in cancer cells with functional BRCA. In the MDA-MB-436 xenograft model, USP1-IN-11 demonstrates significant dose-dependent antitumor activity.</p>Formule :C28H39N7O4Couleur et forme :SolidMasse moléculaire :537.65CDK4/6/HDAC-IN-1
<p>CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.</p>Formule :C35H39N9O5Couleur et forme :SolidMasse moléculaire :665.742Thalidomide-PEG3-NH2
CAS :<p>Thalidomide-PEG3-NH2: a cereblon-based E3 ligase ligand-linker for PROTAC tech.</p>Formule :C19H23N3O7Couleur et forme :SolidMasse moléculaire :405.407HEMTAC CDK4/6 degrader 1
CAS :<p>HEMTAC CDK4/6 degrader 1, a PROTAC targeting HSP90/CDK4/6, Kd of 35.7 μM, disrupts B16F10 melanoma cell cycle, and induces apoptosis.</p>Formule :C48H53ClN16O4Couleur et forme :SolidMasse moléculaire :953.49Mcl1-IN-12
CAS :<p>Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.</p>Formule :C45H46N4O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :803Delmitide
CAS :<p>Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis.</p>Formule :C59H105N17O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1228.57AZD-4877
CAS :<p>AZD-4877: Potent Eg5 inhibitor, IC50 = 2 nM, alters mitosis, induces apoptosis, has antitumor effects.</p>Formule :C28H33N5O2SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :503.66Hydrocinchonine
CAS :<p>Hydrocinchonine is an Alkaloid from Olea europaea and is found in fruits.</p>Formule :C19H24N2OCouleur et forme :SolidMasse moléculaire :296.41AZT triphosphate TEA
<p>AZT triphosphate TFA, a Zidovudine metabolite, inhibits HIV & HBV replication and triggers mitochondrial apoptosis.</p>Couleur et forme :SolidMofarotene
CAS :<p>Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of</p>Formule :C29H39NO2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :433.63Mcl-1 inhibitor 12
CAS :<p>Mcl-1 Inhibitor 12 (Example 10), with a K i of 0.22 nM, functions as an MCL-1 inhibitor. It is utilized in cancer research [1].</p>Formule :C47H45ClFN7O6Couleur et forme :SolidMasse moléculaire :858.35Amino-PEG6-Thalidomide
<p>Amino-PEG6-Thalidomide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>Formule :C27H39N3O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.612-aminobenzo[d]thiazol-6-ol
CAS :<p>2-aminobenzo[d]thiazol-6-ol: antimicrobial, antioxidant, anticancer; may trigger cancer cell apoptosis.</p>Formule :C7H6N2OSDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :166.2Thalidomide-NH-PEG8-Ts
CAS :<p>Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.</p>Formule :C36H49N3O14SCouleur et forme :SolidMasse moléculaire :779.86Ganoderic acid Mf
CAS :<p>Ganoderic acid Mf: antitumor triterpenoid, arrests G1 cell cycle, selective for cancer cells, triggers apoptosis via mitochondria.</p>Formule :C32H48O5Couleur et forme :SolidMasse moléculaire :512.72Malformin A
CAS :<p>Malformin A, from A. niger, is a plant growth regulator and has anti-TMV and cancer cell cytotoxic properties. Intraperitoneal LD50 in mice is 3.1 mg/kg.</p>Formule :C23H39N5O5S2Couleur et forme :SolidMasse moléculaire :529.72PROTAC-O4I2
CAS :<p>PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM.</p>Formule :C29H29ClN6O5SDegré de pureté :97.45%Couleur et forme :SolidMasse moléculaire :609.16-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
CAS :<p>6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to study</p>Formule :C9H6BrN3ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :252.07SZUH280
CAS :<p>SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells.</p>Formule :C36H34N8O8Couleur et forme :SolidMasse moléculaire :706.7MDM2/4-p53-IN-2
<p>MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.</p>Formule :C25H17Cl3FN3O3Couleur et forme :SolidMasse moléculaire :532.78Albicanol
CAS :<p>Albicanol is a biochemical.</p>Formule :C15H26OCouleur et forme :SolidMasse moléculaire :222.372F1324 TFA
<p>F1324 TFA is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM.</p>Formule :C85H122N21F3O22SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1879.06Finotonlimab
<p>Finotonlimab (SCT-I10A), a humanized IgG PD-1 monoclonal antibody, shows potential in the research of solid tumors or lymphomas [1].</p>Couleur et forme :Odour Liquid
![2-aminobenzo[d]thiazol-6-ol](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT77346.webp&w=3840&q=75)
![6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT77685.webp&w=3840&q=75)
