Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6222 produits trouvés pour "Apoptose"
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MEDI-7352
MEDI-7352 is a human bispecific antibody targeting NGF/bNGF and TNF. It can be utilized in research focused on osteoarthritis (OA) pain.Couleur et forme :Odour LiquidCytarabine-d2
CAS :Cytarabine-d2 is the deuterated form of Cytarabine. Cytarabine is a nucleoside analog that induces cell cycle arrest at the S phase and inhibits DNA polymerase. It has an IC50 of 16 nM for inhibiting DNA synthesis and exhibits antiviral activity against HSV.Formule :C9H13N3O5Couleur et forme :SolidMasse moléculaire :245.23Ac-AAVALLPAVLLALLAP-YVAD-CHO
CAS :Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1 exhibiting antitumor activity [1].Formule :C97H160N20O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1990.43Δ8-Tetrahydrocannabinoquinone
CAS :Δ8-Tetrahydrocannabinoquinone (HU-336) is a potent anti-angiogenic agent that inhibits angiogenesis by directly inducing apoptosis in vascular endothelial cells. It achieves this without altering the expression of pro-angiogenic and anti-angiogenic cytokines and receptors. Δ8-Tetrahydrocannabinoquinone also shows significant effectiveness against tumor xenografts in nude mice.Formule :C21H28O3Couleur et forme :SolidMasse moléculaire :328.45LWY713
LWY713 is a PROTAC-based FLT3 degrader (DC50=0.64 nM) that selectively induces FLT3 degradation through a cereblon and proteasome-dependent mechanism. It inhibits cell proliferation and causes G0/G1 phase arrest and apoptosis (apoptosis) in MV4-11 cells. In MV4-11 xenograft models, LWY713 demonstrates significant in vivo antitumor activity. The E3 ligase ligand and linker consist of Lenalidomide-Glycolic acid, while the target protein ligand's active control is NaproxenGilteritinib.Formule :C43H54N10O8Masse moléculaire :838.41261BCL-XL-IN-3
CAS :BCL-XL-IN-3 (Compound 11) is an inhibitor of BCL-XL, with a Ki of less than 0.01 nM. It suppresses cell viability in both normal Molt-4 cells and digitonin-permeabilized Molt-4 cells, with EC50 values of 77.8 nM and 0.07 nM, respectively. BCL-XL-IN-3 can be utilized as an ADC toxin for synthesizing Clezutoclax.Formule :C46H55N7O6SCouleur et forme :SolidMasse moléculaire :834.04Vorsetuzumab
CAS :Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a monoclonal antibody targeting the CD70 antibody.Degré de pureté :SDS-PAGE:95% SEC-HPLC:99.29%Couleur et forme :LiquidMasse moléculaire :146.1 kDaDiethylnorspermine HCl
CAS :Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) potently induces SSAT (spermidine/spermine N1-acetyltransferase) mRNA and effectivelyFormule :C13H36Cl4N4Degré de pureté :99.79% - 99.86%Couleur et forme :SolidMasse moléculaire :390.26Thiamine-d4 hydrochloride
Thiamine-d4 (hydrochloride) is the deuterated form of Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient, serving as a cofactor for numerous central metabolic enzymes.Couleur et forme :Odour SolidResveratrol-13C6
Resveratrol-13C6 is a carbon-13 labeled form of Resveratrol. Resveratrol (trans-Resveratrol; SRT501) is a natural polyphenol known for its antioxidant, anti-inflammatory, cardioprotective, and anticancer properties. It targets a variety of proteins, including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, and DNA polymerase, and acts as a specific activator of SIRT1. Additionally, Resveratrol is an effective Pregnane X Receptor (PXR) inhibitor and serves as an Nrf2 activator, capable of mitigating aging-related progressive renal injury in mouse models. It also enhances nitric oxide (NO) production in endothelial cells.Couleur et forme :Odour SolidThevetiaflavone
CAS :Thevetiaflavone, a natural flavonoid from W. indica, blocks LDH leakage, boosting cell survival.Formule :C16H12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :284.262-Deoxy-D-glucose-d
CAS :2-Deoxy-D-glucose-d is the deuterated form of 2-Deoxy-D-glucose. This compound is a glucose analogue that acts as a glucose metabolism inhibitor by targeting hexokinase to hinder glycolysis.Formule :C6H12O5Couleur et forme :SolidMasse moléculaire :165.16TAT-BH4 (Bcl-xL) (TFA)
"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death.Formule :C159H268N58O45·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3712.19 (free acid)AM0001
AM0001 is a human monoclonal antibody (mAb) that targets PDCD1/PD-1/CD279. It is applicable in cancer research.Couleur et forme :Odour LiquidAc-AAVALLPAVLLALLAP-DEVD-CHO
CAS :Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) serves as a potent and reversible inhibitor of caspase-3 [1].Formule :C94H158N20O27Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2000.38CPT2
CAS :Carnitine palmitoyltransferase 2 (CPT2), an enzyme involved in fatty acid oxidation, serves as a prognostic biomarker for colorectal cancer (CRC).Degré de pureté :98%Couleur et forme :SolidTAT-NEP1-40
TAT-NEP1-40, a blood-brain barrier (BBB) permeable peptide, confers protection to PC12 cells against oxygen and glucose deprivation (OGD) while promotingFormule :C268H438N88O77Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :6124.89BTK ligand 12
CAS :BTK ligand 12 is a PROTAC target protein ligand serving as an active control for NRX-0492 (a BTK degradator).Formule :C25H34N8O2Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :478.59Flaccidoside II
CAS :Flaccidoside II, an active triterpenoid saponin from Anemone flaccida rhizome, both inhibits proliferation and induces apoptosis in Malignant Peripheral NerveFormule :C59H96O25Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1205.38NEP162
CAS :NEP162 is a BRD4 PROTAC degrader with DC50 values of 1.2 μM in SW480 cells and 1.6 μM in U2OS cells. NEP162 exhibits antiproliferative activity, effectively inhibiting tumor growth and inducing apoptosis. It is applicable in research on cancers such as osteosarcoma, colorectal cancer, and non-small cell lung cancer.Formule :C50H56ClN11O3SCouleur et forme :SolidMasse moléculaire :926.57Antitumor agent-96
"Antitumor agent-96 (Compound D34) is a potent MRE11 inhibitor that down-regulates the homologous recombination (HR) pathway by binding to and suppressing theFormule :C27H32N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :416.56Anticancer agent 146
Anticancer Agent 146 (Compound 1.19) acts as a necroptosis inducer and demonstrates anti-tumor efficacy in the MDA-MB-231 mouse xenograft model [1].Formule :C19H16Cl2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :375.25Pitavastatin-d5 sodium
Pitavastatin-d5 (sodium) is the deuterated form of Pitavastatin sodium. Pitavastatin (NK-104) sodium acts as a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase. In HepG2 cells, it inhibits cholesterol synthesis from acetate with an IC50 of 5.8 nM. Pitavastatin sodium is a highly effective inducer of hepatic low-density lipoprotein cholesterol (LDL-C) receptors.Couleur et forme :Odour SolidKB03-SLF
CAS :KB03-SLF is a protease with the capability to target specific proteins and regulate intracellular protein levels by inducing protein degradation. This mechanism renders KB03-SLF potentially valuable in the suppression of related diseases.Formule :C50H63ClF3N5O12Couleur et forme :SolidMasse moléculaire :1018.51Rapamycin-13C,d3
Rapamycin is a potent and specific mTOR inhibitor that suppresses mTOR in HEK293 cells with an IC50 of 0.1 nM. It binds to FKBP12, thereby inhibiting mTORC1. Additionally, Rapamycin serves as an autophagy (autophagy) activator and functions as an immunosuppressant.Couleur et forme :Odour SolidAnticancer agent 136
Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM), exhibits an IC50 value of 3.38 μM against human dermal fibroblasts (HDF) andFormule :C40H50N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :742.86RK-10
CAS :RK-10 is a peptide that binds to PD-L1. After being conjugated with Cy5 or Biotin, RK-10 can be used to identify PD-L1-expressing tumors through flow cytometry or immunohistochemistry. It is applicable for research in detecting cancers such as non-small cell lung cancer (NSCLC), breast cancer, squamous cell carcinoma, and melanoma.Formule :C105H176N28O36SCouleur et forme :SolidMasse moléculaire :2438.75TRF2-IN-1
TRF2-IN-1 (compound F2) is a potent inhibitor of telomere repeat-binding factor 2 (TRF2). It exhibits antiproliferative activity and induces apoptosis. TRF2-IN-1 binds directly to the TRF2TRFH domain, selectively inhibiting TRF2 protein expression and telomere localization. Additionally, TRF2-IN-1 possesses anticancer properties and shows potential for osteosarcoma research.Formule :C18H17BrO4Couleur et forme :SolidMasse moléculaire :377.229KC01
CAS :KC01 selectively inhibits ABHD16A (IC50: 0.2-0.5 μM), much more potent than KC02 (>10 μM); human ABHD16A IC50: 90±20 nM.Formule :C22H39NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.558HX009
HX009 is a bispecific antibody that targets PD1 and CD47, though its binding to CD47 is attenuated. HX009 functions by blocking PD1/CD47 and can be utilized in research related to non-Hodgkin lymphoma (NHL).Couleur et forme :Odour Liquid22-SLF
22-SLF is a PROTAC degrader that operates by FBXO22-dependent degradation of FK506 Binding Protein 12 (FKBP12) with a DC50 of 0.5 µM. Additionally, 22-SLF can degrade other endogenous proteins, such as BRD4 and the EML4-ALK fusion protein (EML4-ALK fusion protein).Sandacanol
CAS :Sandacanol (Sandranol) is an olfactory receptor (OR10H1) agonist.Sandacanol induces cell cycle arrest and partial apoptosis in bladder cancer cells.Formule :C14H24ODegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :208.34Fluorene
CAS :Compound PDK0379, with CAS No. 86-73-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0379 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C13H10Masse moléculaire :166.21spisulosine
CAS :spisulosine is a natural product for research related to life sciences. The catalog number is T9664 and the CAS number is 196497-48-0.
Formule :C18H39NOCouleur et forme :SolidMasse moléculaire :285.516eIF4E-IN-6
eIF4E-IN-6 (Compound 4b), a GMP analog, is designed to inhibit the eIF4E protein's ability to bind to cap mRNA.Couleur et forme :Odour SolidEnlonstobart
CAS :Enlonstobart is a humanized IgG4-κ monoclonal antibody targeting PDCD1, functioning as both an immunostimulant and antineoplastic agent [1].Couleur et forme :LiquidPROTAC ATR degrader-2
CAS :PROTAC ATR degrader-2 (Compound 8i) serves as a PROTAC degrader targeting ATR, effectively degrading it in acute myeloid leukemia (AML) cell lines MV-4-11 and MOLM-13, with DC50 values of 22.9 and 34.5 nM, respectively. This compound induces apoptosis and inhibits the proliferation of AML cells. Additionally, PROTAC ATR degrader-2 demonstrates favorable pharmacokinetic properties and potent antitumor activity in a mouse model of AML.Formule :C40H41N9O6Couleur et forme :SolidMasse moléculaire :743.81Thiocolchicine
CAS :Thiocolchicine inhibits tubulin polymerization (IC50: 2.5 µM, Ki: 0.7 µM), induces apoptosis, and serves as an ADC cytotoxin.Formule :C22H25NO5SDegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :415.5Telitacicept
CAS :Telitacicept (RC18), a fully human TACI-Fc fusion protein, acts as a dual inhibitor of B lymphocyte stimulator (BLyS) and APRIL (a proliferation-inducing ligandCouleur et forme :LiquidAntitumor photosensitizer-7
Antitumor photosensitizer-7 (compound 15), a photosensitizer possessing anti-cancer properties, demonstrates substantial cytotoxic effects on the G361 melanoma cell line when exposed to 414 nm blue light irradiation.Formule :C23H20N2O3Couleur et forme :SolidMasse moléculaire :372.42Borrelidin
CAS :Borrelidin (Treponemycin) is an inhibitor of trehalose-6-phosphate synthase, a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei.Formule :C28H43NO6Degré de pureté :98%Couleur et forme :White To Off-White PowderMasse moléculaire :489.64C199
C199 is a PROTAC degrader targeting PRMT4 with a DC50 of 106 nM. It demonstrates high selectivity for PRMT4 compared to other protein arginine methyltransferases. C199 exhibits strong cellular degradation capacity and induces apoptosis in multiple myeloma cell lines. It efficiently eliminates PRMT4 protein through the VHL-proteasome pathway. C199 has a relatively long half-life and shows potent anti-multiple myeloma (MM) activity.Couleur et forme :Odour SolidWR-S-462
WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 μM, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC).Formule :C24H22N4O4SCouleur et forme :SolidMasse moléculaire :462.52Nogo-B-IN-1
Nogo-B-IN-1 ((S,R)-4v) is a covalent inhibitor targeting Nogo-B. It suppresses osteosarcoma (OS) progression by inhibiting Nogo-B activity and the PI3K/AKT/NF-κB/Bcl-2 signaling pathways. Nogo-B-IN-1 hinders proliferation of OS 143B cells (IC50= 0.28 µM) and induces apoptosis. This compound is applicable for targeted OS research.Couleur et forme :Odour SolidLinsidomine hydrochloride
CAS :SIN-1 chloride is a moxidomine metabolite with vasodilatory, anti-platelet, and antianginal effects, reducing myocardial ischemia-related damage.Formule :C6H11ClN4O2Degré de pureté :99.27% - 99.67%Couleur et forme :White Solid CrystallineMasse moléculaire :206.63Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
CAS :Iron(III) compound induces ferroptosis in NB1 cells at 3μM, not apoptosis/necroptosis; inhibits various cancers, effective against drug-resistant NALM-6.Formule :C20H14ClFeN2O2Couleur et forme :SolidMasse moléculaire :405.64Azadirone
CAS :Azadirone, a limonoid, sensitizes cancer cells to TRAIL by modulating DR4/DR5, survival, and apoptotic proteins.
Formule :C9H15N3O5Couleur et forme :SolidMasse moléculaire :245.23Liensinine Perchlorate
CAS :Liensinine is the active constituent of plumula nelambinis with anti-hypertension.
Formule :C37H43ClN2O10Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :711.2Apoptosis inducer 31
Apoptosisinducer 31 (compound 19) triggers caspase-dependent apoptosis (cell death). It plays a crucial role in cancer research.Formule :C14H10N4O3Couleur et forme :SolidMasse moléculaire :282.254Iturin A
CAS :Iturin A: antifungal compound targeting cell membranes, forms ion pores in yeast/fungi.Couleur et forme :Solid
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