Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6223 produits trouvés pour "Apoptose"
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Euphjatrophane M
Euphjatrophane M (Compound 6) is a FOXO1 inhibitor that reduces NF-κBp65 phosphorylation and exhibits anti-inflammatory properties. It can inhibit the production of nitric oxide and also suppress the mRNA expression of IL-6, IL-1β, and TNFα in LPS-induced RAW 264.7 macrophages.Formule :C20H28O4Couleur et forme :SolidMasse moléculaire :332.43Thyrotropin
CAS :Thyrotropin (TSH), a thyroid-stimulating hormone, is synthesized by thyrotrope cells in the anterior pituitary gland and modulates the endocrine activity of theCouleur et forme :SolidKC01
CAS :KC01 selectively inhibits ABHD16A (IC50: 0.2-0.5 μM), much more potent than KC02 (>10 μM); human ABHD16A IC50: 90±20 nM.Formule :C22H39NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.558Spexin TFA
Spexin TFA: GAL2/GAL3 agonist (EC50: 45.7/112.2 nM), no activity at GAL1, reduces appetite, fatty acid uptake, and LH secretion; anxiolytic.Formule :C76H115F3N20O21SCouleur et forme :SolidMasse moléculaire :1733.9Z-Ala-Ala-Asp-CMK
CAS :Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor that blocks granzyme B protease activity, for inflammatory diseases and tumours.Formule :C19H24ClN3O7Degré de pureté :99.967%Couleur et forme :SolidMasse moléculaire :441.86RMC-9805
CAS :RMC-9805(Zoldonrasib) is a KRAS G12D inhibitor with anti-tumor and anti-proliferative activity for the study of pancreatic cancer.Formule :C63H88F3N11O7Degré de pureté :98.10% - 99.99%Couleur et forme :SolidMasse moléculaire :1168.44Ref: TM-T78212
1mg120,00€5mg295,00€10mg460,00€1mL*10mM (DMSO)650,00€25mg753,00€50mg1.099,00€100mg1.620,00€ChoKα inhibitor-4
ChoKα Inhibitor-4 is a bioisosteric agent that effectively inhibits human choline kinase α1 (HChoK α1) with an IC50 of 0.66 μM.Couleur et forme :Odour SolidS-Adenosyl-L-methionine iodide
CAS :S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].Formule :C15H23IN6O5SCouleur et forme :SolidMasse moléculaire :526.35Syringolin A
CAS :Syringolin A is a useful organic compound for research related to life sciences. The catalog number is T125354 and the CAS number is 212115-96-3.
Formule :C24H39N5O6Couleur et forme :SolidMasse moléculaire :493.605Disitertide diammonium
Disitertide (P144) is a TGF-β1 receptor blocker, PI3K inhibitor, and apoptosis inducer.Formule :C68H115N19O22S2Couleur et forme :SolidMasse moléculaire :1614.88RBN013209
CAS :RBN013209 is a potent CD38 inhibitor. RBN013209 is useful in the treatment of cancer.Formule :C19H24N6O3Degré de pureté :99.84%Couleur et forme :SoildMasse moléculaire :384.43Ref: TM-T60099
1mg58,00€5mg126,00€1mL*10mM (DMSO)138,00€10mg178,00€25mg356,00€50mg512,00€100mg713,00€AVJ16
CAS :AVJ16 as a member of the insulin growth factor 2 mRNA-binding protein family, binds to the mRNA of certain genes to regulate protein translation.Formule :C28H27N3O4Degré de pureté :98.87% - 99.72%Couleur et forme :SolidMasse moléculaire :469.53Ref: TM-T9980
1mg130,00€5mg313,00€1mL*10mM (DMSO)323,00€10mg500,00€25mg807,00€50mg1.108,00€100mg1.485,00€200mg1.998,00€DC-Y13-27
Dc-y13-27, a derivative of DC-Y13, is a potent YTHDF2 inhibitor (KD: 37.9 μM).
Formule :C14H10N2O2SDegré de pureté :99.75%Couleur et forme :SoildMasse moléculaire :270.31PDL1 degrader-2
PD-L1degrader-2 (Compound B3) is an orally effective AUTAC degrader that degrades PD-L1 via the autophagy-lysosome pathway with a DC50 of 0.5 μM. It inhibits the interaction between PD-1 and PD-L1, with an IC50 of 22.8 nM. PD-L1degrader-2 upregulates the expression of Atg9b, Lamp1, and Mitf, activating the autophagy-lysosome system. It exhibits antitumor activity in the CT26 mouse model.Formule :C45H48N8O5Couleur et forme :SolidMasse moléculaire :780.91Epoprostenol sodium
CAS :Epoprostenol sodium (Prostaglandin I2 sodium salt) is a vasodilator and a synthetic prostacyclin that can be used to study pulmonary hypertension.Formule :C20H31NaO5Degré de pureté :98%Couleur et forme :White Crystalline PowderMasse moléculaire :374.45NS3694
CAS :NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.Formule :C15H10ClF3N2O3Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :358.7Ref: TM-T22119
1mg37,00€2mg52,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg111,00€25mg227,00€50mg329,00€100mg512,00€500mg1.093,00€Oenothein B
CAS :Oenothein B inhibits PAR-glycohydrolase with antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects.Formule :C68H48O44Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :1569.08BOC-D-FMK
CAS :Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).Formule :C11H18FNO5Degré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :263.26Ref: TM-T10580
1mg50,00€5mg114,00€1mL*10mM (DMSO)132,00€10mg167,00€25mg326,00€50mg462,00€100mg640,00€200mg884,00€Ac-VDVAD-CHO TFA
Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.Couleur et forme :Odour SolidEP5-1
EP5-1 is an antimicrobial peptide with antibacterial, antifungal, antitumor, and antiviral properties, notably inducing apoptosis in cancer cells andFormule :C16H27N5O8SCouleur et forme :SolidMasse moléculaire :449.48Ecdysone
CAS :Ecdysone is a major steroid hormone in insects and herbs.Formule :C27H44O6Degré de pureté :99.22%Couleur et forme :PowderMasse moléculaire :464.63HLDA-212
CAS :HLDA-212 (Compound 43) is a bifunctional small molecule designed to target HaloTag-tagged protein (target protein, TP) and Aurora kinase A/B (AURKA/B, effector protein, EP). By binding TP and EP, it forms a stable ternary complex (TP:RIPTAC:EP) that inhibits the cell survival functions of EP, inducing apoptosis in cancer cells expressing TP. In 293_HFL cells, HLDA-212 demonstrates antiproliferative activity with a GI50 of 0.011 μM. This compound holds promise for treating cancers with high TP expression, such as prostate cancer and hematological malignancies.Formule :C70H90BrFN8O19SCouleur et forme :SolidMasse moléculaire :1478.47Emavusertib Tosylate
CAS :Emavusertib Tosylate (also known as CA-4948) is a potent inhibitor of IRAK4/FLT3 with demonstrated antitumor activity. In cell lines such as ABC DLBCL and AML, CA-4948 exhibits strong cellular efficacy. Among 329 evaluated kinases, it shows medium to high selectivity. The compound has excellent oral bioavailability and favorable pharmacokinetic properties in ADME and PK profiles. In preclinical models involving mice, rats, and dogs, CA-4948 demonstrated good oral bioavailability and displayed over 90% tumor growth inhibition in relevant tumor models, correlating well with in vivo pharmacodynamic regulation.Formule :C31H33N7O8SMasse moléculaire :663.7PZ703b
CAS :PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.Formule :C80H102ClF3N10O11S4Couleur et forme :SolidMasse moléculaire :1600.44(D)-PPA 1 TFA
(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstratingFormule :C72H99F3N20O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1669.67Pim-1 kinase inhibitor 4
Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity andFormule :C19H12ClN3ODegré de pureté :97.37%Couleur et forme :SolidMasse moléculaire :333.77Ref: TM-T77526
1mg109,00€2mg160,00€5mg261,00€10mg374,00€25mg583,00€50mg803,00€100mg1.063,00€200mg1.431,00€MDM2 ligand 4
MDM2ligand 4 is a ligand of MDM2 and can be used in the synthesis of the PROTAC degrader [KT-253].Formule :C31H33Cl2FN2O4Couleur et forme :SolidMasse moléculaire :587.509EGFR-IN-143
EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. It induces apoptosis by arresting the cell cycle at the G2/M phase and exhibits antitumor activity.Formule :C20H21ClN6O3Couleur et forme :SolidMasse moléculaire :428.872(Iso)-Z-VAD(OMe)-FMK
CAS :(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.Formule :C22H30FN3O7Degré de pureté :97.10%Couleur et forme :SoildMasse moléculaire :467.49Thevetiaflavone
CAS :Thevetiaflavone, a natural flavonoid from W. indica, blocks LDH leakage, boosting cell survival.Formule :C16H12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :284.26Asudemotide
CAS :Asudemotide is a bioactive chemical.Formule :C58H80N10O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1189.31PL120131
PL120131 is a PD-1/PD-L1 inhibitory peptide that disrupts the interaction between PD-1 and PD-L1 by binding to PD-1. This compound can inhibit the apoptosis signaling pathway mediated by PD-1, thereby preventing apoptosis (apoptosis) in Jurkat cells and primary lymphocytes. Additionally, PL120131 supports cytotoxic T lymphocytes (CTL) in exhibiting antitumor activity.Formule :C62H105N19O18Couleur et forme :SolidMasse moléculaire :1404.61RIPK3-IN-3
RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM.Formule :C16H11N5SCouleur et forme :SolidMasse moléculaire :305.36TRK-IN-30
TRK-IN-30 (Compound C11) is an inhibitor of tropomyosin receptor kinases (TRK), effectively inhibiting TRKA, TRKB, TRKC, and the resistant mutant TRKAG595R, with IC50 values of 1.8, 0.98, 3.8, and 54 nM, respectively. It also suppresses the activation of downstream PI3K/AKT and MEK/ERK signaling pathways. TRK-IN-30 hinders colony formation and cell migration of Km-12, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis in Km-12 cells.Formule :C24H21N5O3Couleur et forme :SolidMasse moléculaire :427.455GPI-1485
CAS :GPI-1485 (GM1485) (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.Formule :C12H19NO4Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :241.28Ref: TM-T9820
1mg58,00€5mg126,00€1mL*10mM (DMSO)141,00€10mg178,00€25mg340,00€50mg505,00€100mg715,00€200mg1.054,00€AZD5153
CAS :AZD5153 is an orally active and selective BET/BRD4 bromodomain inhibitor with an IC50 value of 1.7nM for BRD4.Formule :C25H33N7O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :479.57Cardanol (C15:1)
CAS :Cardanol (C15:1), found in cashew nut shell liquid, induces mitochondria-associated apoptosis in human melanoma cells.Formule :C21H34ODegré de pureté :98.48% - 99.77%Couleur et forme :SolidMasse moléculaire :302.49Ref: TM-TN3594
100mgÀ demander1mg92,00€2mg135,00€5mg259,00€1mL*10mM (DMSO)268,00€10mg371,00€25mg583,00€50mg800,00€IDOi-Pt(IV) prodrug-1
IDOi-Pt(IV) prodrug-1 (Compound 10) is an IDOi-Pt(IV) prodrug that suppresses IDO expression. It induces apoptosis, reduces mitochondrial membrane potential, and inhibits tumor cell migration and invasion. Additionally, IDOi-Pt(IV) prodrug-1 triggers reactive oxygen species-mediated endoplasmic reticulum stress and the secretion of damage-associated molecular patterns (DAMPs), leading to immunogenic cell death (ICD). Compared to cisplatin, IDOi-Pt(IV) prodrug-1 exhibits relatively high efficiency and low toxicity in its antitumor activity.Formule :C21H26Cl3N3O6PtSCouleur et forme :SolidMasse moléculaire :749.96ERK1/2 inhibitor 13
ERK1/2 inhibitor 13 (Compound 21y) is an orally bioavailable ERK inhibitor that targets ERK1 and ERK2, with IC50 values of 91.71 nM and 97.87 nM, respectively. It effectively suppresses the proliferation of cancer cell lines MCF-7, 4T1, MDA-MB-468, and HCC1970 with IC50 values of 0.67 μM, 2.76 μM, 2.15 μM, and 1.68 μM, respectively. Additionally, it inhibits cancer cell migration, induces apoptosis and autophagy in MCF-7 cells, and demonstrates anti-tumor and anti-metastatic effects in a 4T1 xenograft mouse model.Formule :C36H29BrF6N4OCouleur et forme :SolidMasse moléculaire :727.54Shepherdin (79-87)
CAS :Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.Formule :C41H64N12O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :949.09NSD-IN-4
NSD-IN-4 (Compound A8) is a potent and orally active inhibitor of NSD3, inducing apoptosis in a dose-dependent manner. It demonstrates significant antitumor activity against lung squamous cell carcinoma.Formule :C17H12ClFN2O2Couleur et forme :SolidMasse moléculaire :330.741RK-10
CAS :RK-10 is a peptide that binds to PD-L1. After being conjugated with Cy5 or Biotin, RK-10 can be used to identify PD-L1-expressing tumors through flow cytometry or immunohistochemistry. It is applicable for research in detecting cancers such as non-small cell lung cancer (NSCLC), breast cancer, squamous cell carcinoma, and melanoma.Formule :C105H176N28O36SCouleur et forme :SolidMasse moléculaire :2438.75NSC243928 mesylate
CAS :NSC243928 mesylate binds to human lymphocyte antigen 6 (LY6), a cell growth inhibitor with anticancer activity.Formule :C23H25N3O6S2Degré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :503.59Aromatase-IN-5
Aromatase-IN-5 (Compound 10) is a potent inhibitor of aromatase with an IC50 value of 0.06 μM. It effectively blocks estrogen production and inhibits the proliferation of breast cancer cell lines such as MCF-7, arresting the cell cycle in the G1 phase and inducing apoptosis. Aromatase-IN-5 shows promise for breast cancer research.Couleur et forme :Odour SolidBRD4/FKBP12 degrader-1
BRD4/FKBP12 degrader-1 (a1d) is an anticancer agent that functions as a BRD4/FKBP12 degrader.Couleur et forme :Odour SolidNogo-B-IN-1
Nogo-B-IN-1 ((S,R)-4v) is a covalent inhibitor targeting Nogo-B. It suppresses osteosarcoma (OS) progression by inhibiting Nogo-B activity and the PI3K/AKT/NF-κB/Bcl-2 signaling pathways. Nogo-B-IN-1 hinders proliferation of OS 143B cells (IC50= 0.28 µM) and induces apoptosis. This compound is applicable for targeted OS research.Couleur et forme :Odour SolidLY 219703
CAS :LY 219703 is a photoactivatable diarylsulfonylurea.Formule :C13H10ClN5O3SCouleur et forme :SolidMasse moléculaire :351.77RTX-002
RTX-002 is a human monoclonal antibody (mAb) targeting PDCD1/PD-1/CD279. This compound is applicable in the research of autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis.Couleur et forme :Odour LiquidBim BH3
CAS :Bim BH3 is a bioactive peptide that belongs to the pro-apoptotic Bcl-2 family of proteins.Formule :C108H170N32O31SCouleur et forme :SolidMasse moléculaire :2444.77Dual Galectin-3/EGFR-IN-1
Dual Galectin-3/EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.Formule :C32H41N7O10Couleur et forme :SolidMasse moléculaire :683.709
