Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
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JNK-1-IN-3
CAS :<p>JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.</p>Formule :C19H17FN4O3Degré de pureté :97.551%Couleur et forme :SolidMasse moléculaire :368.36Pimagedine
CAS :<p>Pimagedine is a prototype therapeutic agent for the prevention of formation of advanced glycation endproducts.</p>Formule :CH6N4Couleur et forme :SolidMasse moléculaire :74.09CDK9-Cyclin T1 PPI-IN-1
<p>CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC</p>Degré de pureté :98%Couleur et forme :Odour SolidPralnacasan
CAS :<p>Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).</p>Formule :C26H29N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.54Thalidomide-O-C6-NH2
CAS :<p>Thalidomide-O-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1].</p>Formule :C19H23N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :373.4Anticancer agent 137
<p>Anticancer agent 137 (8q), a potent PI3k inhibitor, exhibits broad-spectrum anticancer activity by inducing G2/M cell cycle arrest and apoptosis.</p>Formule :C26H27NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.54-Nitro-3-cresol
CAS :<p>4-Nitro-3-cresol exhibits ciliate toxicity against Tetrahymena pyriformis and is widely used in biochemical experiments and drug synthesis research.</p>Formule :C7H7NO3Degré de pureté :99.87%Couleur et forme :Beige PowderMasse moléculaire :153.14Ranevetmab
CAS :<p>Ranevetmab (NV-01), a caninized anti-NGF mAb, relieves pain in DJD research.</p>Couleur et forme :LiquidFPR1 antagonist 1
<p>Compound 24a, an FPR1 antagonist, demonstrates potent inhibition of the formyl peptide receptor 1 (FPR1) with an IC50 value of 25 nM.</p>Formule :C25H28O5Couleur et forme :SolidMasse moléculaire :408.49Retifanlimab
CAS :<p>Retifanlimab (MGA-012) is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). Retifanlimab is used in studies of Merkel cell carcinoma.</p>Degré de pureté :95% - 98.56% (SEC-HPLC)Couleur et forme :LiquidFerroptosis-IN-12
<p>Ferroptosis-IN-12 (Cpd-A1) is an inhibitor of ferroptosis. It effectively suppresses ferroptosis in mouse renal tubular epithelial cells (mTECs) treated with Erastin and improves renal function in dose-dependent manners in mouse models of acute kidney injury (AKI) induced by ischemia/reperfusion (I/R) or cecal ligation and puncture (CLP). This compound also reduces renal tubular damage and eliminates inflammation. Exhibiting good plasma stability and high distribution in renal tissues during pharmacokinetic studies in mice, Ferroptosis-IN-12 shows promising potential for research in the field of AKI.</p>Couleur et forme :Odour SolidDAPK-IN-2
CAS :<p>DAPK-IN-2: DAPK inhibitor with anticancer potential. Used in cerebral infarction and ischemia research.</p>Formule :C17H14N2O4Degré de pureté :98.26%Couleur et forme :SolidMasse moléculaire :310.3Danburstotug
CAS :<p>Danburstotug (IMC-001), an immunostimulant and antineoplastic [1], is a humanized IgG1-lambda monoclonal antibody targeting CD274 (PDL1, B7 homologue 1, B7H1).</p>Degré de pureté :98%Couleur et forme :LiquidAS-99 TFA
<p>AS-99 TFA: potent ASH1L inhibitor, IC50=0.79 μM, combats leukemia, inhibits cell growth, induces apoptosis.</p>Couleur et forme :SolidDual Galectin-3/EGFR-IN-1
<p>Dual Galectin-3/EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.</p>Formule :C32H41N7O10Couleur et forme :SolidMasse moléculaire :683.709PARP1/BRD4-IN-3
<p>PARP1/BRD4-IN-3 (compound HF4) is an effective inhibitor of BRD4 and PARP1, with IC50 values of 1210 nM and 2019 nM respectively. The compound exhibits antiproliferative activity, induces apoptosis (apoptosis) and cell cycle arrest at the G0/G1 phase. Additionally, PARP1/BRD4-IN-3 causes DNA damage and reduces the expression of the Rad51 protein, demonstrating anti-tumor activity.</p>Couleur et forme :Odour Solid(Rac)-BIO8898
CAS :<p>(Rac)-BIO8898 is a chemical compound that serves as an inhibitor of the co-stimulatory interaction between CD40 and CD154.</p>Formule :C53H64N8O6Couleur et forme :SolidMasse moléculaire :909.13Thalidomide-O-amido-PEG4-azide
CAS :<p>Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative serving as a linker for Proteolysis Targeting Chimeras (PROTACs) synthesis [1].</p>Formule :C25H32N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :576.56Sanggenon G
CAS :<p>Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.</p>Formule :C40H38O11Couleur et forme :SolidMasse moléculaire :694.72Anti-Mouse PD-L1 Antibody (10F.9G2)
<p>Anti-Mouse PD-L1 Antibody (10F.9G2) is an IgG-class antibody against mouse PD-L1.</p>Degré de pureté :98.92% - >95% Determined by SDS-PAGECouleur et forme :Odour LiquidFludarabine triphosphate trisodium
<p>Fludarabine triphosphate (F-ara-ATP) trisodium inhibits DNA synthesis; IC50 2.3 μM, Ki 6.1 μM, blocks DNA primase, prompts apoptosis.</p>Formule :C10H12FN5Na3O13P3Couleur et forme :SolidMasse moléculaire :591.12MS41
CAS :<p>MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s values of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1). This compound effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest, and increases cellular apoptosis (Apoptosis). Additionally, MS41 reduces chromatin occupancy related to ENL-mediated transcription elongation mechanisms and suppresses the expression of oncogenes and the progression of leukemia.</p>Formule :C56H70N8O9SCouleur et forme :SolidMasse moléculaire :1031.27Anticancer agent 268
<p>Anticanceragent 268 (Compound 4k) is a potential antitumor agent. It exhibits antiproliferative effects on HepG2 cells, with an IC50 value of 6.08 μM. Additionally, Anticanceragent 268 induces apoptosis and inhibits colony formation and migration of HepG2 cells.</p>Couleur et forme :Odour SolidPROTAC EGFR degrader 5
CAS :<p>PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.</p>Formule :C57H72FN13O5SCouleur et forme :SolidMasse moléculaire :1070.33JC2-11
CAS :<p>JC2-11 is an anti-inflammatory agent blocking NLRC 4, AIM 2, ROS production, caspase-1 activity, and reducing GSDMD, IL-1β, and LDH in vesicles.</p>Formule :C17H15FO4Degré de pureté :98.6%Couleur et forme :SoildMasse moléculaire :302.3Feladilimab
CAS :<p>Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:98%Couleur et forme :LiquidMasse moléculaire :145.24 kDaGPX4-IN-5
CAS :<p>GPX4-IN-5 is a GPX4 inhibitor with antitumor activity.GPX4-IN-5 induces iron death and may be used for the treatment of triple negative breast cancer.</p>Formule :C18H17ClFNO5Degré de pureté :99.58%Couleur et forme :SoildMasse moléculaire :381.78p53 and MDM2 proteins-interaction-inhibitor (racemic)
CAS :<p>p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins.</p>Formule :C40H49Cl2N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :734.75Nofazinlimab
CAS :<p>Nofazinlimab (CS1003) is a human anti-PD-1 IgG4 monoclonal antibody for the study of unresectable hepatocellular carcinoma (uHCC).</p>Degré de pureté :98.6% (SDS-PAGE); 99.7% (SEC-HPLC) - 98.6% (SDS-PAGE); 99.7% (SEC-HPLC)Couleur et forme :LiquidPL120131
<p>PL120131 is a PD-1/PD-L1 inhibitory peptide that disrupts the interaction between PD-1 and PD-L1 by binding to PD-1. This compound can inhibit the apoptosis signaling pathway mediated by PD-1, thereby preventing apoptosis (apoptosis) in Jurkat cells and primary lymphocytes. Additionally, PL120131 supports cytotoxic T lymphocytes (CTL) in exhibiting antitumor activity.</p>Formule :C62H105N19O18Couleur et forme :SolidMasse moléculaire :1404.61BT44
CAS :<p>BT44, a potent second-gen GDNF mimetic, is a lead for treating neurodegeneration.</p>Formule :C28H27F4N3O4SDegré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :577.59Oxybenzone-d3
<p>Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium-labeled form of Oxybenzone. Commonly used as a UV filter in tanning and skin protection products, Oxybenzone (Benzophenone 3) acts as an endocrine-disrupting chemical (EDC) that can cross both the placental and blood-brain barriers. It impairs autophagy, alters epigenetic states, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.</p>Formule :C14H9D3O3Couleur et forme :SolidMasse moléculaire :231.26FW-1
<p>FW-1 is a type I inhibitor of FLT3, with an IC50 of approximately 1 μM. It exhibits cytotoxic effects in FLT3-mutant AML cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis in MV4-11 and MOLM-13 cells.</p>Formule :C24H27N7OCouleur et forme :SolidMasse moléculaire :429.517Opnurasib
CAS :<p>Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with antitumor activity for the study of advanced non-small</p>Formule :C29H28ClN7ODegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :526.03D-CopA3
CAS :<p>D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.</p>Formule :C96H184N30O18S2Couleur et forme :SolidMasse moléculaire :2110.81Acrixolimab
CAS :<p>Acrixolimab is a humanized IgG4-κ monoclonal antibody that selectively targets PD-1 [1] [2].</p>Degré de pureté :98%Couleur et forme :Liquid1,2-Naphthoquinone
CAS :<p>1,2-Naphthoquinone inhibits urease, induces apoptosis in PBMC cells, inhibitory activity against hiCE, hCE1, hAChE, and hBChE.</p>Formule :C10H6O2Degré de pureté :98.01%Couleur et forme :Golden Yellow Needles Color On Standing (Ntp 1992)Masse moléculaire :158.15GGTI298 Trifluoroacetate
CAS :<p>GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.</p>Formule :C27H33N3O3S·C2HF3O2Degré de pureté :98.07% - >99.99%Couleur et forme :SolidMasse moléculaire :593.66Kinamycin C
CAS :<p>Kinamycin C is a bacterial metabolite used as an anticancer agent.</p>Formule :C24H20N2O10Couleur et forme :SolidMasse moléculaire :496.428EGFR/COX-2-IN-1
<p>EGFR/COX-2-IN-1 is an EGFR/COX-2 inhibitor that effectively targets EGFRWT, EGFRT790M, COX-1, and COX-2 with IC50 values of 0.12, 0.076, 20.1, and 1.52 μM, respectively. It inhibits MCF-7, HT-29, and A-549 cells with IC50 values of 1.20, 5.14, and 14.81 μM, respectively. The compound induces apoptosis by upregulating Bax protein and downregulating Bcl-2 protein levels. Additionally, EGFR/COX-2-IN-1 significantly increases the proportion of cells in the G2/M phase in MCF-7 cells, demonstrating a broad-spectrum antitumor effect.</p>Formule :C20H17FN6O2S2Couleur et forme :SolidMasse moléculaire :456.52cis-Clovamide
CAS :<p>cis-Clovamide is a naturally occurring phenolic compound with noteworthy antioxidant, anti-inflammatory, and antiapoptotic properties.</p>Formule :C18H17NO7Couleur et forme :SolidMasse moléculaire :359.334JGB1741
CAS :<p>JGB1741, a SIRT1 inhibitor (IC50=15µM), modulates apoptosis markers and p53 acetylation in breast cancer research.</p>Formule :C27H24N2O2SDegré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :440.56Fosbretabulin [free base]
CAS :<p>Fosbretabulin is a natural cis-stilbene that interferes with cellular tubulin dynamics and selectively destroys tumor blood vessels.</p>Formule :C18H21O8PCouleur et forme :SolidMasse moléculaire :396.33A011
<p>A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle</p>Formule :C27H28N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.55PI3Kα-IN-14
<p>PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting in</p>Degré de pureté :98%Couleur et forme :Odour SolidRosamultic acid
<p>Rosamultic acid is a useful organic compound for research related to life sciences and the catalog number is T125342.</p>Formule :C30H46O5Couleur et forme :SolidMasse moléculaire :486.693CAY10726
CAS :<p>CAY10726, an arylurea fatty acid, cuts ATP by 28% and promotes apoptosis in breast cancer cells by depleting mitochondrial lipids.</p>Formule :C24H36ClF3N2O3Couleur et forme :SolidMasse moléculaire :493Lisaftoclax
CAS :<p>Lisaftoclax, an oral Bcl-2/Bcl-xl inhibitor (IC50: 2 nM & 5.9 nM), treats CLL by promoting leukemia cell death.</p>Formule :C45H48ClN7O8SDegré de pureté :97.14% - 99.66%Couleur et forme :SolidMasse moléculaire :882.42Enpp/Carbonic anhydrase-IN-1
CAS :<p>Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase.</p>Formule :C23H25NO4SDegré de pureté :99.96%Couleur et forme :SoildMasse moléculaire :411.51Reproxalap
CAS :<p>Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.</p>Formule :C12H13ClN2ODegré de pureté :99.4% - 99.97%Couleur et forme :SolidMasse moléculaire :236.7
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