Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(135 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6225 produits trouvés pour "Apoptose"
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Isomahanine
Isomahanine is a useful organic compound for research related to life sciences and the catalog number is T125848.Formule :C23H25NO2Couleur et forme :SolidMasse moléculaire :347.458Phosphocreatine dipotassium
CAS :Phosphocreatine dipotassium, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives.Formule :C4H8K2N3O5PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :287.29Lambertianic acid
CAS :Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.Formule :C20H28O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :316.441Fludioxonil
CAS :Fludioxonil (CGA 173506), a phenylpyrrole fungicide, inhibits the growth of B. cinerea from strawberry and blackberry crops.Formule :C12H6F2N2O2Degré de pureté :99.971%Couleur et forme :SolidMasse moléculaire :248.18Aspochalasin D
CAS :Aspochalasin D, isolated from A. microcysticus, shows antibacterial properties and cytotoxicity affecting Ba/F3-V12 cells, with IC50s of 0.49 and 1.9 μg/ml.Formule :C24H35NO4Couleur et forme :SolidMasse moléculaire :401.5412-HETE
CAS :12-HETE ((±)12-HETE) is a regulator of PGE2, having both antithrombotic and prothrombotic effects.Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.47Linearol
CAS :Linearol: diterpene from Sideritis L. with antioxidant, anti-inflammatory, anti-apoptotic effects.Formule :C22H34O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.50spisulosine
CAS :spisulosine is a natural product for research related to life sciences. The catalog number is T9664 and the CAS number is 196497-48-0.
Formule :C18H39NOCouleur et forme :SolidMasse moléculaire :285.5161-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
CAS :Phospholipid with stearic acid and 15(S)-HpETE boosts ferroptosis in MEFs upon GPX4 inhibition.
Formule :C43H78NO10PCouleur et forme :SolidMasse moléculaire :800.068RET-IN-28
CAS :RET-IN-28 (Compound 16) is an inhibitor of RET (a transmembrane receptor tyrosine kinase). It specifically inhibits the activity of a mutant RET enzyme (RET-V804M) and is utilized in cancer research.Formule :C26H29N9Couleur et forme :SolidMasse moléculaire :467.57HTR2A antagonist 1
HTR2A antagonist 1 (Compound 15f) is an HTR2A antagonist with an IC50 of 42.79 nM. It induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells by activating the p53/p21/caspase 3 signaling pathway. HTR2A antagonist 1 exhibits good liver microsomal stability and is useful for colorectal cancer research.Formule :C35H43Cl2F2N5O4Couleur et forme :SolidMasse moléculaire :706.65Verdinexor
CAS :Verdinexor (KPT-335) (KPT-335), a specific XPO1/CRM1 inhibitor, are orally bioavailable.Formule :C18H12F6N6ODegré de pureté :98% - 99.68%Couleur et forme :SolidMasse moléculaire :442.32Ref: TM-T6123
1mg35,00€5mg111,00€1mL*10mM (DMSO)123,00€10mg187,00€25mg341,00€50mg567,00€100mg905,00€200mg1.216,00€Conophylline
CAS :Conophylline, an alkaloid from Ervatamia microphylla, induces pancreatic cell differentiation and apoptosis, and suppresses HSC.Formule :C44H50N4O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :794.89(R)-JAK2/STAT3-IN-10a
CAS :(R)-JAK2/STAT3-IN-10a is the R-isomer of JAK2/STAT3-IN-1.JAK2/STAT3-IN-1 is a structural domain inhibitor of GP130 D1 with antitumor activity.
Formule :C34H35BrF3N5O2Degré de pureté :97.99%Couleur et forme :SoildMasse moléculaire :682.57Ianalumab
CAS :Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R.Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.44 kDaOxatomide
CAS :Oxatomide: Dual H1/P2X7 antagonist, antihistamine, anti-allergic, treats immune diseases, IC50: 0.95 μM (P2X7), 0.43 μM (5-HT).Formule :C27H30N4ODegré de pureté :99.28% - 99.72%Couleur et forme :White PowderMasse moléculaire :426.55Ref: TM-T19839
1mg35,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg114,00€25mg222,00€50mg356,00€100mg557,00€500mg1.153,00€Tralokinumab
CAS :Tralokinumab: human IgG4 monoclonal antibody, blocks IL-13, may treat atopic dermatitis.Degré de pureté :SDS-PAGE:95% SEC-HPLC:99.99%Couleur et forme :LiquidMasse moléculaire :144.14 kDa5α-dihydro Levonorgestrel
CAS :5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel .Formule :C21H30O2Couleur et forme :SolidMasse moléculaire :314.469S-Adenosyl-L-methionine iodide
CAS :S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].Formule :C15H23IN6O5SCouleur et forme :SolidMasse moléculaire :526.35Syringolin A
CAS :Syringolin A is a useful organic compound for research related to life sciences. The catalog number is T125354 and the CAS number is 212115-96-3.
Formule :C24H39N5O6Couleur et forme :SolidMasse moléculaire :493.605CTP-347
CAS :CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.Formule :C19H20FNO3Couleur et forme :SolidMasse moléculaire :331.38Pim-1 kinase inhibitor 4
Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity andFormule :C19H12ClN3ODegré de pureté :97.37%Couleur et forme :SolidMasse moléculaire :333.77Ref: TM-T77526
1mg109,00€2mg160,00€5mg261,00€10mg374,00€25mg583,00€50mg803,00€100mg1.063,00€200mg1.431,00€Z-LEHD-fmk
CAS :Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor andFormule :C32H43FN6O10Degré de pureté :96.13%Couleur et forme :SolidMasse moléculaire :690.72RIP1-IN-1
RIP1-IN-1 is an orally bioavailable RIP1 inhibitor with a high binding affinity (Kd: 110 nM). This compound exhibits significant activity against necroptosis and effectively suppresses necrosome formation by inhibiting the phosphorylation of RIP1, RIP3, and MLKL pathways. RIP1-IN-1 can inhibit necroptosis and is applicable in research on acute liver injury.Couleur et forme :Odour Solid(Iso)-Z-VAD(OMe)-FMK
CAS :(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.Formule :C22H30FN3O7Degré de pureté :97.10%Couleur et forme :SoildMasse moléculaire :467.49H-20
CAS :H-20 is a PD-1 agonist that reduces the required dosage of morphine for analgesia. It can be used in studies related to chronic pain.Formule :C44H64N10O15Couleur et forme :SolidMasse moléculaire :973.037Asudemotide
CAS :Asudemotide is a bioactive chemical.Formule :C58H80N10O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1189.31AZD5153
CAS :AZD5153 is an orally active and selective BET/BRD4 bromodomain inhibitor with an IC50 value of 1.7nM for BRD4.Formule :C25H33N7O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :479.57HX009
HX009 is a bispecific antibody that targets PD1 and CD47, though its binding to CD47 is attenuated. HX009 functions by blocking PD1/CD47 and can be utilized in research related to non-Hodgkin lymphoma (NHL).Couleur et forme :Odour LiquidIDOi-Pt(IV) prodrug-1
IDOi-Pt(IV) prodrug-1 (Compound 10) is an IDOi-Pt(IV) prodrug that suppresses IDO expression. It induces apoptosis, reduces mitochondrial membrane potential, and inhibits tumor cell migration and invasion. Additionally, IDOi-Pt(IV) prodrug-1 triggers reactive oxygen species-mediated endoplasmic reticulum stress and the secretion of damage-associated molecular patterns (DAMPs), leading to immunogenic cell death (ICD). Compared to cisplatin, IDOi-Pt(IV) prodrug-1 exhibits relatively high efficiency and low toxicity in its antitumor activity.Formule :C21H26Cl3N3O6PtSCouleur et forme :SolidMasse moléculaire :749.96ERK1/2 inhibitor 13
ERK1/2 inhibitor 13 (Compound 21y) is an orally bioavailable ERK inhibitor that targets ERK1 and ERK2, with IC50 values of 91.71 nM and 97.87 nM, respectively. It effectively suppresses the proliferation of cancer cell lines MCF-7, 4T1, MDA-MB-468, and HCC1970 with IC50 values of 0.67 μM, 2.76 μM, 2.15 μM, and 1.68 μM, respectively. Additionally, it inhibits cancer cell migration, induces apoptosis and autophagy in MCF-7 cells, and demonstrates anti-tumor and anti-metastatic effects in a 4T1 xenograft mouse model.Formule :C36H29BrF6N4OCouleur et forme :SolidMasse moléculaire :727.54EGFR-IN-169
EGFR-IN-169 is an epidermal growth factor receptor (EGFR) inhibitor derived from ginsenoside, with an IC50 of 5.19 μM. It disrupts colorectal cancer cell migration and growth by inhibiting the EGFR-mediated RalA/EMT pathway. With an IC50 of 4.46 μM against HCT-116 cells and a selectivity index (SI) of 16.92, EGFR-IN-169 also inhibits CDKs, induces G0/G1 cell cycle arrest, and suppresses cell migration and invasion. Additionally, EGFR-IN-169 reduces mitochondrial membrane potential, induces apoptosis and reactive oxygen species (ROS) production. It is applicable in cancer research, particularly for colorectal cancer.Couleur et forme :Odour SolidTNF-α/IL-1β-IN-1
TNF-α/IL-1β-IN-1 (compound 11a) is an anti-inflammatory agent that effectively reduces the expression of TNF-α and IL-1β, inhibits oxidative stress and myocardial cell apoptosis, and demonstrates significant activity against septic myocardial injury. Additionally, it improves myocardial blood flow in vivo.Formule :C41H58N2O7Couleur et forme :SolidMasse moléculaire :690.91PROTAC c-Met degrader-6
PROTACc-Met degrader-6 is a potent and orally active c-Met PROTAC degrader. It effectively promotes the degradation of c-Met protein, with DC50 values of 0.52 nM in EBC-1 cells and 0.45 nM in Hs746T cells. This compound almost completely abolishes the migration and invasion capabilities of tumor cells, significantly induces apoptosis (apoptosis), and arrests the cell cycle at the G0/G1 phase. PROTACc-Met degrader-6 is useful for studying various cancers, including non-small cell lung cancer and gastric cancer.Couleur et forme :Odour SolidWR-S-462
WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 μM, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC).Formule :C24H22N4O4SCouleur et forme :SolidMasse moléculaire :462.52Nogo-B-IN-1
Nogo-B-IN-1 ((S,R)-4v) is a covalent inhibitor targeting Nogo-B. It suppresses osteosarcoma (OS) progression by inhibiting Nogo-B activity and the PI3K/AKT/NF-κB/Bcl-2 signaling pathways. Nogo-B-IN-1 hinders proliferation of OS 143B cells (IC50= 0.28 µM) and induces apoptosis. This compound is applicable for targeted OS research.Couleur et forme :Odour SolidDual Galectin-3/EGFR-IN-1
Dual Galectin-3/EGFR-IN-1 (Compound 29) is a dual inhibitor targeting Galectin-3 and EGFR, with dissociation constants (KD) of 52.29 μM and 3.31 μM, respectively. It inhibits TGF-β-induced hepatic stellate cell (HSC) activation, induces apoptosis in LX-2 cells, and shows antifibrotic activity in the liver.Formule :C32H41N7O10Couleur et forme :SolidMasse moléculaire :683.709Zaptuzumab
CAS :Zaptuzumab (AD5-10) is a humanized monoclonal antibody targeting death receptor 5 (DR5) with high selective binding affinity. It specifically induces cancer cell death through caspase-mediated apoptosis and autophagic cell death (ACD). Zaptuzumab can activate antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Additionally, it induces reactive oxygen species (ROS) production and reduces glutathione (GSH) levels. In various xenograft mouse tumor models, Zaptuzumab has demonstrated significant tumor growth inhibition and favorable safety profiles.Couleur et forme :LiquidGLPG4970
GLPG4970 is a potent, selective, orally active dual inhibitor of salt-inducible kinases 2 and 3 (SIK2/SIK3), with IC50 values of 0.3 nM and 0.7 nM, respectively. It exhibits weak inhibition of the hERG channel, with an IC50 value of 29 μM. GLPG4970 reduces the release of tumor necrosis factor α (TNFα) and increases the release of interleukin 10 (IL-10). This compound is applicable for research in inflammation and immunology, such as studies on colitis.Couleur et forme :Odour SoliddPDL1-4
dPDL1-4 is a potent and selective eHSPTAC eHSP90PD-L1 degrader, with DC50 values of 7.77 μM (HeLa) and 6.52 μM (B16F10). It links eHSP90 to target proteins, inducing lysosomal degradation. dPDL1-4 effectively degrades PD-L1 and inhibits tumor growth, making it useful for research in cervical cancer and melanoma.Couleur et forme :Odour SolidPI3Kδ-IN-25
PI3Kδ-IN-25 is an orally active and selective PI3Kδ inhibitor with an IC50 of 2.1 nM. It exhibits IC50 values of 272, 285, and 1171 nM for PI3Kα, PI3Kγ, and PI3Kβ, respectively. In B16F10 cells, PI3Kδ-IN-25 inhibits the phosphorylation of AKTSer473, suppresses Treg cell proliferation, and downregulates the expression of PD-L1. In mouse models of B16F10 melanoma and Lewis lung cancer, PI3Kδ-IN-25 demonstrates anticancer activity by reducing tumor-infiltrating Treg cells and enhancing immune responses. This compound is applicable for research on cancers such as melanoma and lung cancer.Couleur et forme :Odour SolidVTX-0811
VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-α/NF-κB and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.Couleur et forme :Odour LiquidKdo2-Lipid A ammonium
CAS :Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.Formule :C110H214N6O39P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2306.84VEGFR-2-IN-61
VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.Formule :C27H25N5OCouleur et forme :SolidMasse moléculaire :435.52DP-15
CAS :DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]Formule :C42H44ClN9O5SCouleur et forme :SolidMasse moléculaire :822.374CGP-74514
CAS :CGP-74514,CDK1 inhibitor (IC50=25 nM). Induces G2/M arrest, apoptosis. Used in bladder cancer research.Formule :C19H24ClN7Degré de pureté :98.54%Couleur et forme :SoildMasse moléculaire :385.89PDE4-IN-28
PDE4-IN-28 (Compound G1) is an inhibitor of PDE4D, with an IC50 of 29 nM. It suppresses the production of TNF-α and NO, with IC50 values of 13.32 μM and 2.32 μM, respectively. In a rat pressure ulcer (PU) model, PDE4-IN-28 exhibits anti-inflammatory, antibacterial, and analgesic properties, while promoting HUVEC cell migration to enhance wound healing.Couleur et forme :Odour SolidFTI 277 TFA
CAS :FTI 277, a FTI 276 prodrug, blocks farnesyltransferase (IC50 = 0.5 nM), H-Ras/K-Ras processing, and fights tumor cell growth.Formule :C24H30F3N3O5S2Couleur et forme :SolidMasse moléculaire :561.64DefNEtTrp
DefNEtTrp is an iron bis-chelating ligand composed of Def and Trp groups. It demonstrates potent broad-spectrum antiproliferative and cytotoxic effects in cancer cell lines. DefNEtTrp induces apoptosis and ferroptosis, exhibiting cytotoxicity with an IC50 value of 0.77 μM.Formule :C30H27N9O3SCouleur et forme :SolidMasse moléculaire :593.659Ferroptosis-IN-20
Ferroptosis-IN-20 (Compound 34a) is an inhibitor of ferroptosis targeting voltage-dependent anion channels (VDAC) with an EC50 of 24.2 nM. It prevents VDAC oligomerization and lipid peroxidation. Additionally, Ferroptosis-IN-20 reduces ROS levels, diminishes TFR1-mediated iron uptake, inhibits Fe2+ levels, and restores glutathione (GSH) levels. It also alleviates acute kidney injury (AKI) caused by folic acid.Couleur et forme :Odour Solid
