Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(135 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6225 produits trouvés pour "Apoptose"
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NOD1-RIPK2-IN-1
NOD1-RIPK2-IN-1 (Compound 37) is an inhibitor of the NOD1-RIPK2 signaling pathway, displaying potent IC50 values of 42 nM and 1.52 nM against NOD1 and RIPK2, respectively. This compound effectively reduces the secretion of the pro-inflammatory cytokine IL-8, making it valuable for research in inflammation and immune disorders.Formule :C22H26Cl2N4O3Couleur et forme :SolidMasse moléculaire :465.37IMMH 010 maleate
CAS :IMMH 010 maleate (YPD-30 maleate) is a programmed cell death ligand 1 inhibitor used in the study of neurological disorders and advanced malignant solid tumors.Formule :C36H36BrClN2O9Couleur et forme :SoildMasse moléculaire :756.04PROTAC PD-1/PD-L1 degrader-1
CAS :PROTAC PD-1/PD-L1 degrader-1, a Cereblon-based inhibitor, blocks PD-1/PD-L1 with 39.2 nM IC50, boosting immune response and reducing PD-L1 via lysosomes.Formule :C59H58ClN7O11Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :1076.59Ac-FEID-CMK TFA
Ac-FEID-CMK TFA is a zebrafish GSDMEb-derived peptide inhibitor that acts by inhibiting the caspy2-mediated atypical inflammatory vesicle pathway.Formule :C29H38ClF3N4O11Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :711.08Mas7
CAS :Amphiphilic peptide Mas7, a structural analogue of mastoparan is a known activator of heterotrimeric Gi-proteins and its downstream effectors.Formule :C67H124N18O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1421.81RIPK2/3-IN-1
RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3.Formule :C24H16N4O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.54Enlonstobart
CAS :Enlonstobart is a humanized IgG4-κ monoclonal antibody targeting PDCD1, functioning as both an immunostimulant and antineoplastic agent [1].Couleur et forme :LiquidTelitacicept
CAS :Telitacicept (RC18), a fully human TACI-Fc fusion protein, acts as a dual inhibitor of B lymphocyte stimulator (BLyS) and APRIL (a proliferation-inducing ligandCouleur et forme :LiquidRozibafusp alfa
CAS :Rozibafusp alfa is an IgG2-κ antibody that targets ICOSLG, combined with a TNFSF13B fusion protein [1].Couleur et forme :LiquidIparomlimab
CAS :Iparomlimab: anti-PD-1 IgG4κ antibody, targets PSB103 γ4/κ-chains, forms dimers, used in cancer research.Couleur et forme :LiquidRanevetmab
CAS :Ranevetmab (NV-01), a caninized anti-NGF mAb, relieves pain in DJD research.Couleur et forme :LiquidAtorolimumab
CAS :Atorolimumab (P3x22914G4), a monoclonal antibody, is employed in immunotherapies that target the programmed death-1 (PD-1) receptor [1].Couleur et forme :LiquidCofetuzumab
CAS :Cofetuzumab (PF-06523435) is a antibody targeting protein tyrosine kinase 7 (PTK7), which can be used to synthesize ADC compounds like cofetuzumab pelidotin.Degré de pureté :>95%Couleur et forme :LiquidMasse moléculaire :146.7 kDaAnti-Mouse TNF α Antibody (TN3-19.12)
Anti-Mouse TNF alpha Antibody is a rat-derived IgG inhibitor targeting mouse TNF alpha.Degré de pureté :95%Couleur et forme :Odour LiquidMasse moléculaire :150 kDaOnfekafusp alfa
CAS :Onfekafusp alfa (L19TNF), a trimeric fusion of L19 scFv and human TNF, targets malignant glioma.Couleur et forme :LiquidLorigerlimab
CAS :Lorigerlimab (MGD019) is a bispecific IgG4 DART that blocks PD-1/CTLA-4, enhancing T-cells for mCRPC research.Couleur et forme :LiquidAnti-ETBR Antibody (DEDN6526A Naked Antibody)
DEDN6526A (RG-7636) is a humanized ADC compound targeting endothelin B receptor (ETBR), which can be used to study melanoma.Couleur et forme :LiquidMasse moléculaire :145.54 kDaAnti-PD-L1/B7-H1 Antibody (29E.2A3)
Anti-PD-L1/B7-H1 Antibody (29E.2A3) represents a chimeric antibody of mouse IgG2b, κ type, specifically targeting human PD-L1/B7-H1. The recommended isotype control for this antibody is Mouse IgG2b kappa, Isotype Control.Lipustobart
CAS :Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplasticDegré de pureté :98%Couleur et forme :LiquidAsunercept
CAS :Asunercept (APG101/CAN008) is a CD95-Fc protein targeting CD95L, used in GBM, MDS, and GvHD research.Couleur et forme :LiquidDazodalibep
CAS :Dazodalibep (MEDI 4920; VIB 4920) is a monoclonal antibody that specifically targets CD40LG/TNFSF5 and is fused to human serum albumin (ALB/HSA) [1].Couleur et forme :LiquidBaminercept
CAS :Baminercept (BG 9924) is a lymphotoxin-β receptor-immunoglobulin fusion protein that blocks the lymphotoxin-letter/LIGHT axis.Degré de pureté :95% (SDS-PAGE); 98.3% (SEC-HPLC) - 95% (SDS-PAGE); 98.3% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :46.88 kDaPlaculumab
CAS :Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.Couleur et forme :LiquidGarivulimab
CAS :Garivulimab (BGB-A333), a humanized IgG1 monoclonal antibody, binds to PD-L1, blocking PD-1 interaction and exhibiting antitumor activity.Couleur et forme :LiquidPropylparaben-d7
CAS :Propylparaben-d7 (Propyl parahydroxybenzoate-d7) is a deuterium-labeled form of Propylparaben. This compound serves as an antimicrobial preservative and is naturally produced by plants and bacteria. Propylparaben is extensively utilized in cosmetics, pharmaceuticals, and food products. It disrupts follicular development and steroidogenesis by altering the cell cycle, apoptosis, and steroidogenic pathways. Additionally, Propylparaben reduces sperm count and motility in rats.Formule :C10H12O3Couleur et forme :SolidMasse moléculaire :187.245-Fluorouracil-15N2
CAS :5-Fluorouracil-15N2 is a nitrogen-15 labeled form of 5-Fluorouracil (5-FU), a uracil analog (nucleoside antimetabolite/analog) and potent antitumor agent. It hampers pyrimidine synthesis by inhibiting thymidylate synthase, depleting the intracellular dTTP pool, inducing apoptosis, acting as a chemotherapeutic sensitizer, inhibiting HIV, and damaging exosome-specific rRNA.Formule :C4H3FN2O2Couleur et forme :SolidMasse moléculaire :132.06JST-TfR09
JST-TfR09 (PPMX-T003) is a human monoclonal antibody (mAb) targeting CD71. It reduces ferritin levels in ATLL cell lines to induce ferroptosis, increases the production of ferrous ions and reactive oxygen species (ROS), and induces lipid peroxidation through malondialdehyde. JST-TfR09 is applicable in leukemia research. Recommended isotype control: Human IgG1 kappa, Isotype Control.Couleur et forme :Odour LiquidAdenosine-d2
CAS :Adenosine-d2 is the deuterated analog of Adenosine. Adenosine (Adenine riboside) is a widely found endogenous compound, acting through four G protein-coupled receptors (A1, A2A, A2B, and A3). It affects nearly all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.Formule :C10H13N5O4Couleur et forme :SolidMasse moléculaire :269.25Adenosine-13C10
CAS :Adenosine-13C10 (Adenine riboside-13C10; D-Adenosine-13C10) is the 13C-labeled form of adenosine. Adenosine (Adenine riboside) is a widely occurring endogenous secretion that operates through four G protein-coupled receptors (A1, A2A, A2B, and A3). It affects nearly every aspect of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.Formule :C10H13N5O4Couleur et forme :SolidMasse moléculaire :277.17Vincristine-d3 sulfate
CAS :Vincristine-d3 (sulfate) is the deuterated form of Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid that inhibits the formation of microtubules in the mitotic spindle, resulting in the arrest of dividing cells at metaphase. It binds to microtubules with a Ki of 85 nM.Formule :C46H58N4O14SCouleur et forme :SolidMasse moléculaire :926.06Quercetin-d3 hydrate
Quercetin-d3 hydrate is a deuterated form of quercetin hydrate, known as a flavonoid that stimulates recombinant SIRT1 and acts as a PI3K inhibitor. It has IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM for PI3Kγ, PI3K δ, and PI3Kβ, respectively.Couleur et forme :Odour SolidUM4118
CAS :UM4118 (N-quinolin-8-ylpyridine-2-carboxamide) is a copper ion carrier used in the study of acute myeloid leukemia.Formule :C15H11N3ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :249.27IRF1-IN-1
CAS :IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.Formule :C22H24N4O4SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :440.52Golimumab
CAS :Golimumab (CNTO-148), an anti-TNFα IgG1κ monoclonal antibody with anti-inflammatory and anti-cancer activity, can be used to prevent inflammation and cartilage.Couleur et forme :LiquidMasse moléculaire :146.93 kDaPantoprazole Sodium Hydrate
CAS :Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagusFormule :C16H14F2N3NaO4SH2ODegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :432.37SCR7
CAS :SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).Formule :C18H14N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :334.4TPP-resveratrol
TPP-resveratrol is a conjugate of Resveratrol and triphenylphosphine (TPP), noted for its anticancer activity. This compound enhances the efficacy of Resveratrol by facilitating its targeted delivery to mitochondria, thus inducing mitochondrial-mediated cell apoptosis (apoptosis).Formule :C36H32BrO4PCouleur et forme :SolidMasse moléculaire :639.51CQ-Mito
CQ-Mito, a derivative of CQ, demonstrates excellent phototherapeutic efficacy with a PI value of 167. This compound induces cell death through mechanisms such as apoptosis and ferroptosis. It mediates mitochondrial dysfunction, characterized by alterations in mitochondrial morphology and loss of MMP. Additionally, CQ-Mito effectively inhibits tumor growth in 3D multicellular tumor spheroid models.Formule :C45H42BrN6O4PCouleur et forme :SolidMasse moléculaire :841.73PROTAC TRIB2 degrader-1
PROTAC TRIB2 degrader-1 (Compound 5k) is a potent TRIB2 degrader that selectively induces TRIB2 degradation via the CRBN-dependent ubiquitin-proteasome pathway. It effectively inhibits cell proliferation and induces cell apoptosis (apoptosis), making it useful in cancer research.Formule :C45H45FN8O6Couleur et forme :SolidMasse moléculaire :812.89EJMC-1
CAS :EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.Formule :C17H11ClN2O4SDegré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :374.8BIM-46174 HCl
BIM-46174 HCl is a G-protein inhibitor with anticancer activity that induces cysteine 3-dependent apoptosis.
Formule :C22H31ClN4OSDegré de pureté :99.77% - 99.77%Couleur et forme :SolidMasse moléculaire :435.03PCC0208017
CAS :PCC0208017 is an inhibitor of MARK3 and MARK4 with IC50s of 1.8 and 2.01 nM. PCC0208017 disrupts microtubule dynamics and displays potent antitumor activity.
Formule :C19H20F3N7Degré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :403.4rac-CCT-250863 HCl
rac-CCT-250863 HCl: NEK 2 inhibitor, halts cell cycle, anti-cancer growth, boosts Pomalidomide-induced apoptosis.Formule :C24H26ClF3N4O2SDegré de pureté :98.21%Couleur et forme :SoildMasse moléculaire :527Mcl1-IN-12
CAS :Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.Formule :C45H46N4O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :803Oenothein B
CAS :Oenothein B inhibits PAR-glycohydrolase with antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects.Formule :C68H48O44Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :1569.08NS3694
CAS :NS3694 is an inhibitor of apoptosis and inhibits apoptosome formation and caspase activation.Formule :C15H10ClF3N2O3Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :358.7Ref: TM-T22119
1mg37,00€2mg52,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg111,00€25mg227,00€50mg329,00€100mg512,00€500mg1.093,00€Borrelidin
CAS :Borrelidin (Treponemycin) is an inhibitor of trehalose-6-phosphate synthase, a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei.Formule :C28H43NO6Degré de pureté :98%Couleur et forme :White To Off-White PowderMasse moléculaire :489.64Sandacanol
CAS :Sandacanol (Sandranol) is an olfactory receptor (OR10H1) agonist.Sandacanol induces cell cycle arrest and partial apoptosis in bladder cancer cells.Formule :C14H24ODegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :208.34BM-962
CAS :BM-962 (Compound 31) is a potent small-molecule inhibitor with an IC50 value of 4 nM (Ki=0.8 nM) for Bcl-2 and an IC50 of 3.9 nM (Ki<1 nM) for Bcl-xL. It inhibits H1417 and H146 cell lines with IC50 values of 9 and 13 nM, respectively, and shows potential for use in cancer research.Formule :C53H58ClF3N6O7S3Couleur et forme :SolidMasse moléculaire :1079.71
