Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(137 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(94 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6231 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
HFY-4A
CAS :HFY-4A is a novel HDAC inhibitor.HFY-4A has antitumour activity and has shown antiproliferative activity in breast cancer cells.Formule :C20H19N3O2Degré de pureté :98.66% - 99.22%Couleur et forme :SoildMasse moléculaire :333.38H-20
CAS :H-20 is a PD-1 agonist that reduces the required dosage of morphine for analgesia. It can be used in studies related to chronic pain.Formule :C44H64N10O15Couleur et forme :SolidMasse moléculaire :973.037Asudemotide
CAS :Asudemotide is a bioactive chemical.Formule :C58H80N10O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1189.31Tebentafusp
CAS :Tebentafusp (IMCgp100) is a protein that targets gp100 with potential anti-tumor activity.Degré de pureté :97.2% (SDS-PAGE); 100% (SEC-HPLC) - 97.2% (SDS-PAGE); 100% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :76.14 kDaTNF-α (46-65), human
CAS :Human TNF alpha (46-65) peptide.Formule :C110H172N24O30Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2310.69GPI-1485
CAS :GPI-1485 (GM1485) (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.Formule :C12H19NO4Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :241.28Ref: TM-T9820
1mg58,00€5mg126,00€1mL*10mM (DMSO)141,00€10mg178,00€25mg340,00€50mg505,00€100mg715,00€200mg1.054,00€CAY10678
CAS :CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPSFormule :C23H34N4ODegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :382.54Chol-CTPP
Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.Formule :C144H263N3O53Couleur et forme :SolidMasse moléculaire :2884.62AZD5153
CAS :AZD5153 is an orally active and selective BET/BRD4 bromodomain inhibitor with an IC50 value of 1.7nM for BRD4.Formule :C25H33N7O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :479.57HX009
HX009 is a bispecific antibody that targets PD1 and CD47, though its binding to CD47 is attenuated. HX009 functions by blocking PD1/CD47 and can be utilized in research related to non-Hodgkin lymphoma (NHL).Couleur et forme :Odour LiquidBCMA72-80
CAS :BCMA72-80: HLA-A2-specific peptide with high affinity; used in multiple myeloma and other BCMA+ tumor research.Formule :C59H97N13O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1196.55POV-PC
CAS :POV-PC is an oxidized phospholipid that inhibits VSMC growth under high serum conditions and induces cell apoptosis under low serum conditions.Formule :C29H56NO9PCouleur et forme :SolidMasse moléculaire :593.739(E),11(E),13(E)-Octadecatrienoic Acid
CAS :β-ESA, a polyunsaturated fatty acid in seed oils, inhibits Caco-2 cell growth dose- and time-dependently.Formule :C18H30O2Couleur et forme :SolidMasse moléculaire :278.436Thalidomide-O-amido-C3-COOH
CAS :Thalidomide-O-amido-C3-COOH is a cereblon ligand-linker for PROTACs, melding Thalidomide with a standard linker.Formule :C19H19N3O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.37BC011
BC011 is a human monoclonal antibody (mAb) targeting TNFRSF1B. It enhances the proliferation of CD8+ T cells and depletes Treg cells, resulting in an increased proportion of effector T cells within the tumor microenvironment. BC011 is applicable in the study of tumor immunology.Couleur et forme :Odour LiquidGB-223
GB-223 is a human monoclonal antibody (mAb) that targets TNFSF11/RANKL/CD254. It is applicable in the study of giant cell tumors of bone and postmenopausal osteoporosis.Couleur et forme :Odour LiquidSTAT3/NF-κB-IN-1
STAT3/NF-κB-IN-1 is a potent inhibitor of STAT3 and NF-κB, exhibiting IC50 values of 5.86 μM for STAT3 and 4.22 μM for NF-κB in 4 T1 cells. It induces apoptosis by upregulating key apoptotic regulators (caspases-3, 9, Bax) and downregulating Bcl-2 expression. STAT3/NF-κB-IN-1 shows significant anticancer activity against breast cancer cell lines and can reduce tumor volume in vivo. It is applicable for research in breast cancer.Couleur et forme :Odour SolidGamgertamig
CAS :Gamgertamig is a humanized bispecific antibody of the IgG4 type that targets TNFRSF17 and CD3E.Couleur et forme :LiquidGSK2800528
GSK2800528 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa, utilized for research related to inflammation and psoriasis.Couleur et forme :Odour LiquidMoflerafusp alfa
CAS :Moflerafusp alfa is a fusion protein that targets the human signal-regulatory protein alpha (SIRPα) variant V2 D1 domain and human programmed death-ligand 1 (PD-L1). It shows potential for research in various cancer treatments.Couleur et forme :LiquidC199
C199 is a PROTAC degrader targeting PRMT4 with a DC50 of 106 nM. It demonstrates high selectivity for PRMT4 compared to other protein arginine methyltransferases. C199 exhibits strong cellular degradation capacity and induces apoptosis in multiple myeloma cell lines. It efficiently eliminates PRMT4 protein through the VHL-proteasome pathway. C199 has a relatively long half-life and shows potent anti-multiple myeloma (MM) activity.Couleur et forme :Odour SolidPROTAC c-Met degrader-6
PROTACc-Met degrader-6 is a potent and orally active c-Met PROTAC degrader. It effectively promotes the degradation of c-Met protein, with DC50 values of 0.52 nM in EBC-1 cells and 0.45 nM in Hs746T cells. This compound almost completely abolishes the migration and invasion capabilities of tumor cells, significantly induces apoptosis (apoptosis), and arrests the cell cycle at the G0/G1 phase. PROTACc-Met degrader-6 is useful for studying various cancers, including non-small cell lung cancer and gastric cancer.Couleur et forme :Odour SolidBesufetamig
CAS :Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.Couleur et forme :LiquidWR-S-462
WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 μM, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC).Formule :C24H22N4O4SCouleur et forme :SolidMasse moléculaire :462.52E3 ligase Ligand 36
CAS :E3 ligase Ligand 36 is an E3 ligase ligand that can be utilized for synthesizing PROTACs, such as PROTAC BRM/BRG1 degrader-1.Formule :C25H30N4O5SCouleur et forme :SolidMasse moléculaire :498.6Lodapolimab
CAS :Lodapolimab (LY3300054) is an IgGλ anti- PD-1 monoclonal antibody [1] .Couleur et forme :LiquidThalidomide-NH-PEG8-Ts
CAS :Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.Formule :C36H49N3O14SCouleur et forme :SolidMasse moléculaire :779.86Apoptosis inducer 31
Apoptosisinducer 31 (compound 19) triggers caspase-dependent apoptosis (cell death). It plays a crucial role in cancer research.Formule :C14H10N4O3Couleur et forme :SolidMasse moléculaire :282.254RIPK1 ligand-Linker Conjugate-1
RIPK1ligand-Linker Conjugate-1 is a Target Protein Ligand-Linker Conjugate that consists of a RIPK1 ligand and a PROTAC linker, designed to recruit E3 ligase. It is utilized in the synthesis of PROTACRIPK1Degrader-1.Couleur et forme :Odour SolidAntitumor agent-196
CAS :Antitumor agent-196 (Compound 6a (β, β, β)) is an artemisinin-based oligomer with anticancer properties, exhibiting an IC50 of 90 nM against MCF-7 breast cancer cells. This compound induces apoptosis by modulating the Bax-caspase 3 signaling pathway and triggers ferroptosis by regulating key signaling molecules (including GPX4). Antitumor agent-196 shows potential for cancer research applications.Formule :C51H81NO15Couleur et forme :SolidMasse moléculaire :948.187Asunercept
CAS :Asunercept (APG101/CAN008) is a CD95-Fc protein targeting CD95L, used in GBM, MDS, and GvHD research.Couleur et forme :LiquidGanoderic acid Mf
CAS :Ganoderic acid Mf: antitumor triterpenoid, arrests G1 cell cycle, selective for cancer cells, triggers apoptosis via mitochondria.Formule :C32H48O5Couleur et forme :SolidMasse moléculaire :512.72(GalNAc)3-CPT
(GalNAc)3-CPT is a glycan-conjugated prodrug that targets the asialoglycoprotein receptor (ASGR) overexpressed on liver cells. It demonstrates significant antitumor activity by activating the cGAS-STING pathway and promoting CD8+ T cell infiltration into tumor sites, leading to apoptosis of tumor cells. In HepG2 cells, it shows an IC50 value of 3.07 μM.Couleur et forme :Odour SolidMalformin A
CAS :Malformin A, from A. niger, is a plant growth regulator and has anti-TMV and cancer cell cytotoxic properties. Intraperitoneal LD50 in mice is 3.1 mg/kg.Formule :C23H39N5O5S2Couleur et forme :SolidMasse moléculaire :529.72OBHSA
CAS :OBHSA（Oxabicycloheptane sulfonamide） is a novel selective estrogen receptor depressant (SERD) that can be used to study breast cancer.Formule :C27H24F3NO6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :547.54Diethanolamine hydrochloride
CAS :Diethanolamine hydrochloride is HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) and pregnane X receptor (PXR), p53 Estrogen receptor.Formule :C4H12ClNO2Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :141.6GLPG4970
GLPG4970 is a potent, selective, orally active dual inhibitor of salt-inducible kinases 2 and 3 (SIK2/SIK3), with IC50 values of 0.3 nM and 0.7 nM, respectively. It exhibits weak inhibition of the hERG channel, with an IC50 value of 29 μM. GLPG4970 reduces the release of tumor necrosis factor α (TNFα) and increases the release of interleukin 10 (IL-10). This compound is applicable for research in inflammation and immunology, such as studies on colitis.Couleur et forme :Odour SolidMDM2/4-p53-IN-2
MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.Formule :C25H17Cl3FN3O3Couleur et forme :SolidMasse moléculaire :532.78dASK1
CAS :dASK1 is a selective CRBN-based PROTAC degrader targeting apoptosis signal-regulating kinase 1 (ASK1). It forms a stable ternary complex with ASK1, facilitating its rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 exhibits strong ASK1 degradation capabilities and is applicable for hepatitis research.Formule :C38H38F2N10O8Couleur et forme :SolidMasse moléculaire :800.77Thymocartin Acetate
CAS :Thymocartin Acetate, a thymopoietin fragment (32-35), inhibits enzyme breakdown; potential for immunodeficiency treatment.Formule :C23H44N8O9Couleur et forme :SoildMasse moléculaire :576.64Anti-Mouse PD-1 Antibody (RMP1-14)
Anti-Mouse PD-1 Antibody (RMP1-14) is an IgG2a antibody inhibitor against mouse PD-1 and can block PD-1/PD-L1 signaling. High-Quality, Low-Cost!Degré de pureté :14.68mg/ml - >95%Couleur et forme :LiquidMasse moléculaire :147.57 kDaAc-IEPD-AFC
CAS :Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.Formule :C32H38F3N5O11Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :725.67Thalidomide-PEG2-C2-NH2 hydrochloride
CAS :Thalidomide-based cereblon ligand with 2-unit PEG linker for PROTAC, in hydrochloride form.Formule :C19H25ClN4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.88Antitumor agent-112
Antitumor agent-112 (compound 3a) is a potent antitumor agent that induces apoptosis and exhibits cytotoxic activity on A549 cells, with an IC50 value of 91.35Formule :C18H17ClN4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :388.87Pyridinium bisretinoid A2E TFA
CAS :Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediatesFormule :C44H58F3NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :705.93Acetyl coenzyme A
CAS :Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways in the tricarboxylic acid cycle, fatty acid synthesisFormule :C23H38N7O17P3SDegré de pureté :91.68%Couleur et forme :SolidMasse moléculaire :809.57Macrophage-activating lipopeptide 2 TFA
Macrophage-activating lipopeptide 2 TFA (MALP-2 TFA) is a diacylglycerol lipopeptide and TLR-2/TLR-6 agonist activates immune cell responses macrophages,Formule :C99H167N19O30S·xC2HF3O2Degré de pureté :97.56%Couleur et forme :SolidMasse moléculaire :2135.56 (free base)UM4118
CAS :UM4118 (N-quinolin-8-ylpyridine-2-carboxamide) is a copper ion carrier used in the study of acute myeloid leukemia.Formule :C15H11N3ODegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :249.272-Acetamidophenol
CAS :2-Acetamidophenol (Orthocetamol) has analgesic and antipyretic effects. 2-Acetamidophenol is an isomer of Paracetamol (4-acetamidophenol).
Formule :C8H9NO2Degré de pureté :>99.99%Couleur et forme :Light Brown PowderMasse moléculaire :151.16KC01
CAS :KC01 selectively inhibits ABHD16A (IC50: 0.2-0.5 μM), much more potent than KC02 (>10 μM); human ABHD16A IC50: 90±20 nM.Formule :C22H39NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.558
