Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
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Anti-inflammatory agent 42
CAS :<p>Anti-inflammatory agent 42 has anti-inflammatory activity and inhibits the expression of TNF-α and IL-6 in LPS-stimulated macrophages.</p>Formule :C20H12N2OSDegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :328.39ATPase-IN-3
CAS :<p>ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.</p>Formule :C10H6N2O3S2Degré de pureté :97.76%Couleur et forme :SoildMasse moléculaire :266.3QN523
CAS :<p>QN523 has drug-like traits, kills cancer cells in vitro, effective in vivo against pancreatic cancer, works via autophagy.</p>Formule :C14H10N4ODegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :250.26Antitumor agent-61
CAS :<p>Antitumor agent-61, a potent Irinotecan derivative, exhibits IC50s of 0.92-3.23 μM in 6 cancer cells, inducing apoptosis via mitochondrial pathways.</p>Formule :C54H63FN5O10PCouleur et forme :SolidMasse moléculaire :992.08Besufetamig
CAS :<p>Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.</p>Couleur et forme :LiquidEciskafusp alfa
CAS :<p>Eciskafusp alfa, a cis-targeted IL2v immunocytokine, acts on programmed cell death 1 (PDCD1, commonly known as PD-1), preferentially targeting antigen-specific</p>Degré de pureté :98%Couleur et forme :SolidIRAK4-IN-27
<p>IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM.</p>Formule :C23H22N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.46Humulone
<p>Humulone is a natural product and has a wide range of applications in life science related research.</p>Formule :C21H30O5Couleur et forme :SolidMasse moléculaire :362.47[1,1'-Biphenyl]-3-amine
CAS :<p>[1,1'-Biphenyl]-3-amine is an inhibitor of MAO-A and MAO-B and can inhibit the cell viability of HT-29, HEK 293, and MCF-7 cells.</p>Formule :C12H11NDegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :169.22p53-HDM2-IN-1
<p>p53-HDM2-IN-1 is a potent inhibitor of the p53-HDM2 protein-protein interaction, demonstrating an inhibitory concentration (IC 50) of 0.103 μM.</p>Formule :C35H38F6N4O7SCouleur et forme :SolidMasse moléculaire :772.75Sterigmatocystine
CAS :<p>Sterigmatocystine, a G1 phase and DNA synthesis inhibitor, curbs p21 and is a mycotoxin precursor from Aspergillus versicolor.</p>Formule :C18H12O6Degré de pureté :98%Couleur et forme :Pale-Yellow Crystals Pale Yellow SolidMasse moléculaire :324.28SBP-0636457
CAS :<p>SBP-0636457: SMAC mimetic, IAP inhibitor, binds BIR-domains (Ki=0.27μM), potential in tumor/cancer research.</p>Formule :C25H36N4O4Couleur et forme :SolidMasse moléculaire :456.587Didocosahexaenoin
CAS :<p>Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.</p>Formule :C25H40O5Couleur et forme :SolidMasse moléculaire :420.58STM3006
CAS :<p>STM3006 is an orally active, selective and and potent METTL3 inhibitor with antitumor activity for the study of acute myeloid leukemia (AML).</p>Formule :C25H27BrN8Degré de pureté :97.16%Couleur et forme :SoildMasse moléculaire :519.44Ferroptosis-IN-14
<p>Ferroptosis-IN-14 (compund 36) exhibits the most potent anti-ferroptotic activity with an EC50 value of 0.58 ± 0.02 μM, demonstrating excellent anti-ferroptotic efficacy, as well as stability in microsomes and plasma.</p>Couleur et forme :Odour SolidF1324 acetate
<p>F1324 acetate is an efficient, high-affinity b-cell lymphoma inhibitor with IC50 of 1 nM.</p>Formule :C85H125N21O22SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1825.09Episilvestrol
CAS :<p>Episilvestrol is a derivative of silvestrol with eIF4A-targeted antitumor properties, found in Aglaia silvestris fruits and twigs.</p>Formule :C34H38O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :654.66mTOR inhibitor-27
<p>mTORinhibitor-27 (Compound 7e) is an inhibitor of mammalian target of rapamycin (mTOR) with an IC50 value of 5.47 μM. It can induce apoptosis in tumor cells and arrest the cell cycle in the S phase, thereby inhibiting cancer cell growth. mTORinhibitor-27 presents potential for research in cancer, including skin cancer.</p>Couleur et forme :Odour SolidDeoxynyboquinone
CAS :<p>Deoxynyboquinone is a potent inducer of cancer cell death with IC(50) values between 16 and 210 nM.</p>Formule :C15H12N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :284.27STAT3-D11-PROTAC-VHL
<p>STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting signal transducer and activator of transcription 3 (STAT3). It demonstrates anti-tumor activity with IC50 values of 1335 nM in HeLa cells and 1973 nM in MCF-7 cells. The compound binds to the DNA binding domain of STAT3, recruits the E3 ligase VHL to form a ternary complex, leading to ubiquitination and subsequent proteasomal degradation of STAT3. Additionally, STAT3-D11-PROTAC-VHL inhibits tumor cell growth, induces cell cycle arrest and apoptosis (apoptosis), and suppresses tumor immune evasion.</p>Couleur et forme :Odour SolidDiazepinomicin
CAS :<p>Diazepinomicin, from Micromonospora, blocks EGF-Ras-ERK pathway and induces apoptosis; an anti-tumor agent for K-Ras mutants.</p>Formule :C28H34N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.58anti-TNBC agent-9
<p>Anti-TNBC agent-9 (Compound 3as) is an anticancer agent used for treating triple-negative breast cancer (TNBC). It exhibits significant inhibitory activity against MDA-MB-453 cells, with an IC50 value of 8.5 μM. Anti-TNBC agent-9 impedes tumor cell migration by upregulating E-cadherin and downregulating N-cadherin, matrix metalloproteinase 2 (MMP2), and MMP9. Additionally, it inhibits tumor cell proliferation by inducing apoptosis, achieved through the increased expression of pro-apoptotic protein BAX and decreased expression of anti-apoptotic protein BCL-2.</p>Couleur et forme :Odour SolidZigakibart
CAS :<p>Zigakibart (BION-1301) is a humanized monoclonal antibody targeting TNFSF13 with anti-inflammatory activity for the study of immunoglobulin A nephropathy (IgAN)</p>Degré de pureté :95.8% (SDS-PAGE); 99.8% (SEC-HPLC) - 95.8% (SDS-PAGE); 99.8% (SEC-HPLC)Couleur et forme :LiquidEGFR/HER2/DHFR-IN-3
<p>EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.</p>Degré de pureté :98%Couleur et forme :Odour SolidReACp53
<p>ReACp53 inhibits amyloid formation, restores p53 in cancer cells and HGSOC-derived organoids.</p>Formule :C108H206N52O24Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2617.13BRD-810
CAS :<p>BRD-810 is a highly selective MCL1 inhibitor (Kd=0.3 nM) capable of inducing tumour cell apoptosis, for haematological malignancies and solid tumours.</p>Formule :C39H44ClFN4O5Degré de pureté :97.88%Couleur et forme :SolidMasse moléculaire :703.24BM-1197
CAS :<p>BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 and</p>Formule :C53H59ClF4N6O7S4Couleur et forme :SolidMasse moléculaire :1131.77CPTH2 (hydrochloride) (357649-93-5 free base)
CAS :<p>CPTH2 is an inhibitor of the HAT activity of Gcn5.</p>Formule :C14H15Cl2N3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :328.26LY3415244
<p>LY3415244 is a human bispecific antibody (bsAb) that targets B7-H1/PD-L1/CD274 and TIM-3/HAVCR2/CD366. This compound is applicable in the study of advanced solid tumors.</p>Couleur et forme :Odour LiquidBcl-2-IN-2
CAS :<p>Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL.</p>Formule :C48H57N7O7SCouleur et forme :SolidMasse moléculaire :876.09Thalidomide-Piperazine-PEG2-NH2
CAS :<p>Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand with a PEG2 linker.</p>Formule :C23H31N5O6Couleur et forme :SolidMasse moléculaire :473.53PROTAC EGFR degrader 5
CAS :<p>PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.</p>Formule :C57H72FN13O5SCouleur et forme :SolidMasse moléculaire :1070.33(R)-MIK665
CAS :<p>(R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special inhibitor of Mcl-1(IC50 of 1.81 nM).</p>Formule :C47H44ClFN6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :875.41HJC0416 hydrochloride
CAS :<p>HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.</p>Formule :C18H18Cl2N2O4SCouleur et forme :SolidMasse moléculaire :429.31rac-CCT-250863 HCl
<p>rac-CCT-250863 HCl: NEK 2 inhibitor, halts cell cycle, anti-cancer growth, boosts Pomalidomide-induced apoptosis.</p>Formule :C24H26ClF3N4O2SDegré de pureté :98.21%Couleur et forme :SoildMasse moléculaire :527ZS3-046
<p>ZS3-046 is a TAF1 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of TAF1. It can activate p53 and induce apoptosis in acute myeloid leukemia (AML) cells. Additionally, ZS3-046 demonstrates anti-tumor efficacy in AML xenograft mouse models.</p>Formule :C49H57N9O7Couleur et forme :SolidMasse moléculaire :883.4381ZYH-23
<p>ZYH-23 is a potent inhibitor of necroptosis. It targets HSP90 to inhibit the phosphorylation of RIPK1, RIPK3, and MLKL, effectively blocking programmed cell necrosis.</p>Formule :C41H50N4O3Couleur et forme :SolidMasse moléculaire :646.38829AM-8553
CAS :<p>AM-8553 is potent and selective piperidine the MDM2-p53 interaction inhibitor.</p>Formule :C25H29Cl2NO4Couleur et forme :SolidMasse moléculaire :478.41Psalmotoxin 1
CAS :<p>Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.</p>Formule :C200H312N62O57S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4689.41SP3N hydrochloride
<p>SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). Its alkylamine moiety is metabolized into an active aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for the degradation of FKBP12. SP3N hydrochloride is applicable in cancer research.</p>Couleur et forme :Odour SolidSuramin
CAS :<p>Suramin is an RdRp and PTPase inhibitor with anti-parasitic, anti-tumor, and anti-angiogenic activities, inhibiting sirtuins and DNA topoisomerase II.</p>Formule :C51H40N6O23S6Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :1297.28EAD1
CAS :<p>EAD1 is a useful organic compound for research related to life sciences. The catalog number is T35329 and the CAS number is 1644388-26-0.</p>Formule :C24H27Cl2N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.42eIF4A3-IN-5
CAS :<p>eIF4A3-IN-5 potently inhibits eIF4AI/II, promising for cancer research.</p>Formule :C26H22N2O7Couleur et forme :SolidMasse moléculaire :474.469AlbA-DCA
<p>AlbA-DCA, a compound of Albiziabioside A and dichloroacetate, boosts ROS and reduces lactic acid in tumors, killing cancer cells and triggering apoptosis.</p>Formule :C43H67Cl2NO12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :860.9RIP1-IN-1
<p>RIP1-IN-1 is an orally bioavailable RIP1 inhibitor with a high binding affinity (Kd: 110 nM). This compound exhibits significant activity against necroptosis and effectively suppresses necrosome formation by inhibiting the phosphorylation of RIP1, RIP3, and MLKL pathways. RIP1-IN-1 can inhibit necroptosis and is applicable in research on acute liver injury.</p>Couleur et forme :Odour SolidMDM2/4-p53-IN-2
<p>MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.</p>Formule :C25H17Cl3FN3O3Couleur et forme :SolidMasse moléculaire :532.789,11-Dehydroergosterol peroxide
CAS :<p>9,11-Dehydroergosterol peroxide is a useful organic compound for research related to life sciences.</p>Formule :C28H42O3Couleur et forme :SolidMasse moléculaire :426.641Ac-YVAD-CHO acetate
<p>Ac-YVAD-CHO acetate, potent reversible ICE and caspase-1 inhibitor; K_i: 3.0 nM (mouse), 0.76 nM (human); blocks IL-lβ production.</p>Formule :C25H36N4O10Couleur et forme :SolidMasse moléculaire :552.57SDH-IN-26
<p>SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor with significant inhibitory activity against various plant pathogenic fungi, including solanrhizoctonia and Botrytis cinerea. It exhibits an EC50 value of 0.270 μg/mL against solanrhizoctonia. SDH-IN-26 compromises fungal cell membrane integrity, increases membrane permeability, disrupts cell structure, reduces mitochondrial count, and affects normal hyphal growth. It also decreases mitochondrial membrane potential, inducing apoptosis. SDH-IN-26 holds potential for studying plant diseases caused by fungi.</p>Couleur et forme :Odour SolidABBV-167
CAS :<p>ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.</p>Formule :C46H53ClN7O11PSCouleur et forme :SolidMasse moléculaire :978.45
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