Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(137 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(94 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6231 produits trouvés pour "Apoptose"
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PROTAC Bcl2 degrader-1
CAS :PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).Formule :C45H45BrN6O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :941.84UNC10245380
UNC10245380 is a CIB1 inhibitor with an IC50 of 8 μM. It also inhibits the phosphorylation of AKT and ERK while upregulating the expression of TRAIL-R1/D5. UNC10245380 specifically kills cancer cells that are dependent on CIB1, demonstrating its potential value in the development of CIB1 probes and cancer research.Couleur et forme :Odour SolidLiensinine Perchlorate
CAS :Liensinine is the active constituent of plumula nelambinis with anti-hypertension.
Formule :C37H43ClN2O10Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :711.2Vinepidine sulfate
CAS :Vinepidine (LY-119863) sulfate, a derivative of vincristine, exhibits antitumor activity .Formule :C46H58N4O13SCouleur et forme :SolidMasse moléculaire :907.04W1131 TFA
W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.Formule :C25H20F3N5O6Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :543.45Ref: TM-T80847
1mL*10mM (DMSO)À demander1mg92,00€5mg188,00€10mg311,00€25mg628,00€50mg1.008,00€100mg1.596,00€Pyridinium bisretinoid A2E TFA
CAS :Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediatesFormule :C44H58F3NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :705.93Apoptosis inducer 11
Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase withinFormule :C27H28N2O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.522'-epi-2'-O-Acetylthevetin B
CAS :2'-Epi-2'-O-Acetylthevetin B (GHSC-74), a cardiac glycoside extractable from Cerbera manghas L.Formule :C44H68O19Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :901FR900359
CAS :FR900359 is a macrocyclic Gq protein inhibitor that inhibits melanoma cell proliferation and can be used to study asthma, inflammation and cancer.Formule :C49H75N7O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1002.16β-Glucuronide-dPBD-PEG5-NH2
CAS :β-Glucuronide-dPBD-PEG5-NH2 is a β-glucuronide-linked pyrrolobenzodiazepine dimer that functions as a proagent for the synthesis of the antibody-drug conjugateFormule :C78H101N7O35Couleur et forme :SolidMasse moléculaire :1696.66Ara-SH
Ara-SH, a derivative of Cytarabine with a mercaptopropionic acid substitution, serves as the initiator for the self-assembly of a smart, co-loaded CytarabineFormule :C12H17N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :331.34N-Stearoyltyrosine
CAS :N-Stearoyltyrosine (N-(1-Oxooctadecyl)-L-tyrosine) is an analog of Anandamide. It exhibits neuroprotective effects by safeguarding the CA1 region of the hippocampus in a gerbil ischemia-reperfusion model. Additionally, N-Stearoyltyrosine inhibits free radical generation, enhances antioxidant capacity, and reduces IR-induced apoptosis (cell apoptosis).Formule :C27H45NO4Couleur et forme :SolidMasse moléculaire :447.65Rapamycin-13C,d3
Rapamycin is a potent and specific mTOR inhibitor that suppresses mTOR in HEK293 cells with an IC50 of 0.1 nM. It binds to FKBP12, thereby inhibiting mTORC1. Additionally, Rapamycin serves as an autophagy (autophagy) activator and functions as an immunosuppressant.Couleur et forme :Odour SolidPitavastatin-d5 sodium
Pitavastatin-d5 (sodium) is the deuterated form of Pitavastatin sodium. Pitavastatin (NK-104) sodium acts as a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase. In HepG2 cells, it inhibits cholesterol synthesis from acetate with an IC50 of 5.8 nM. Pitavastatin sodium is a highly effective inducer of hepatic low-density lipoprotein cholesterol (LDL-C) receptors.Couleur et forme :Odour SolidBM-962
CAS :BM-962 (Compound 31) is a potent small-molecule inhibitor with an IC50 value of 4 nM (Ki=0.8 nM) for Bcl-2 and an IC50 of 3.9 nM (Ki<1 nM) for Bcl-xL. It inhibits H1417 and H146 cell lines with IC50 values of 9 and 13 nM, respectively, and shows potential for use in cancer research.Formule :C53H58ClF3N6O7S3Couleur et forme :SolidMasse moléculaire :1079.71Leucettamol A
CAS :Leucettamol A, from Leucetta microraphis, blocks LTB4 receptor and prevents Ubc13-Uev1A complex formation.Formule :C30H52N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :472.758Emavusertib hydrochloride
CAS :Emavusertib (CA-4948) hydrochloride, a selective and potent IRAK4/FLT3 inhibitor, is designed for oral administration. It achieves an IC 50 of 57 nM against IRAK4 in a FRET kinase assay and demonstrates anti-tumor activity [1] [2] [3].Formule :C24H26ClN7O5Couleur et forme :SolidMasse moléculaire :527.96Annonacin
CAS :Annonacin is a cytotoxic acetogenin in Graviola leaf extract; it blocks mitochondrial complex and inhibits NKA/SERCA ATPase pumps.Formule :C35H64O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :596.88Avotaciclib hydrochloride
Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, includingFormule :C13H12ClN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :317.73HKB99
CAS :HKB99 suppresses NSCLC growth, metastasis, and overcomes erlotinib resistance.Formule :C23H18N2O6SDegré de pureté :97.35% - 97.35%Couleur et forme :SolidMasse moléculaire :450.46Urelumab
CAS :"Urelumab (BMS-66513), a humanized IgG4 mAb CD137 agonist, boosts T-cell/NK cell-mediated cytotoxicity and anti-tumor activity."Degré de pureté :97.70%Couleur et forme :LiquidMasse moléculaire :145.90 kDaToremifene citrate
CAS :Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.Formule :C32H36ClNO8Degré de pureté :99.83% - >99.99%Couleur et forme :White Or Almost White PowderMasse moléculaire :598.08TV 3279
CAS :TV 3279 is a ChE-MAI inhibitor with neuroprotection via anti-apoptotic protein induction and blocks pro-apoptotic enzymes in cells.
Formule :C16H20N2O2Degré de pureté :97%Couleur et forme :SoildMasse moléculaire :272.34Hellebrin
CAS :Cytotoxic and antiproliferative effects of Hellebrin on breast and lung cancer cells.Formule :C36H52O15Couleur et forme :SolidMasse moléculaire :724.79SFI003
CAS :SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 / DHCR24 / ROS axis and driving apoptosis inFormule :C19H17N5OSDegré de pureté :99.44%Couleur et forme :SoildMasse moléculaire :363.44Ref: TM-T72068
1mg75,00€5mg164,00€1mL*10mM (DMSO)172,00€10mg255,00€25mg495,00€50mg712,00€100mg973,00€200mg1.341,00€2-Deoxy-D-glucose-d
CAS :2-Deoxy-D-glucose-d is the deuterated form of 2-Deoxy-D-glucose. This compound is a glucose analogue that acts as a glucose metabolism inhibitor by targeting hexokinase to hinder glycolysis.Formule :C6H12O5Couleur et forme :SolidMasse moléculaire :165.16Spexin
CAS :Potent GAL2/GAL3 agonist (EC50 = 45.7, 112.2 nM), inactive at GAL1. Reduces appetite, fatty acid uptake in adipocytes, and LH in goldfish; anxiolytic in vivo.Formule :C74H114N20O19SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1619.9Resveratrol-13C6
Resveratrol-13C6 is a carbon-13 labeled form of Resveratrol. Resveratrol (trans-Resveratrol; SRT501) is a natural polyphenol known for its antioxidant, anti-inflammatory, cardioprotective, and anticancer properties. It targets a variety of proteins, including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, and DNA polymerase, and acts as a specific activator of SIRT1. Additionally, Resveratrol is an effective Pregnane X Receptor (PXR) inhibitor and serves as an Nrf2 activator, capable of mitigating aging-related progressive renal injury in mouse models. It also enhances nitric oxide (NO) production in endothelial cells.Couleur et forme :Odour SolidThiamine-d4 hydrochloride
Thiamine-d4 (hydrochloride) is the deuterated form of Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient, serving as a cofactor for numerous central metabolic enzymes.Couleur et forme :Odour SolidThalidomide-O-amido-PEG4-azide
CAS :Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative serving as a linker for Proteolysis Targeting Chimeras (PROTACs) synthesis [1].Formule :C25H32N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :576.56MS78
MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP.Formule :C57H66FN9O6SCouleur et forme :SolidMasse moléculaire :1024.25Garivulimab
CAS :Garivulimab (BGB-A333), a humanized IgG1 monoclonal antibody, binds to PD-L1, blocking PD-1 interaction and exhibiting antitumor activity.Couleur et forme :LiquidCTP-347
CAS :CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.Formule :C19H20FNO3Couleur et forme :SolidMasse moléculaire :331.38CRA-026440 hydrochloride
CAS :CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor.Formule :C23H25ClN4O4Degré de pureté :99.78%Couleur et forme :SoildMasse moléculaire :456.92Ref: TM-T10883L
1mL*10mM (DMSO)47,00€1mg115,00€5mg274,00€10mg432,00€25mg735,00€50mg1.159,00€100mg1.568,00€Pim-1 kinase inhibitor 4
Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity andFormule :C19H12ClN3ODegré de pureté :97.37%Couleur et forme :SolidMasse moléculaire :333.77Ref: TM-T77526
1mg109,00€2mg160,00€5mg261,00€10mg374,00€25mg583,00€50mg803,00€100mg1.063,00€200mg1.431,00€Z-LEHD-fmk
CAS :Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor andFormule :C32H43FN6O10Degré de pureté :96.13%Couleur et forme :SolidMasse moléculaire :690.72Human membrane-bound PD-L1 polypeptide
CAS :Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].Formule :C85H140N26O36SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2134.24Sandacanol
CAS :Sandacanol (Sandranol) is an olfactory receptor (OR10H1) agonist.Sandacanol induces cell cycle arrest and partial apoptosis in bladder cancer cells.Formule :C14H24ODegré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :208.34Cannflavin A
CAS :Cannflavin A, isolated from Cannabis sativa L., exhibits anti-cancer, neuroprotective, and anti-inflammatory activities by inhibiting Aβ1-42 aggregation andFormule :C26H28O6Couleur et forme :SolidMasse moléculaire :436.5H-20
CAS :H-20 is a PD-1 agonist that reduces the required dosage of morphine for analgesia. It can be used in studies related to chronic pain.Formule :C44H64N10O15Couleur et forme :SolidMasse moléculaire :973.037Nofazinlimab
CAS :Nofazinlimab (CS1003) is a human anti-PD-1 IgG4 monoclonal antibody for the study of unresectable hepatocellular carcinoma (uHCC).Degré de pureté :98.6% (SDS-PAGE); 99.7% (SEC-HPLC) - 98.6% (SDS-PAGE); 99.7% (SEC-HPLC)Couleur et forme :LiquidMasse moléculaire :145.07 kDaVolrustomig
CAS :Volrustomig is a bi-engineered fragment crystallizable (Fc) domain, a monovalent bispecific IgG1 monoclonal antibody targeting the key immune checkpoint receptors PD-1 and CTLA-4. It boosts T-cell activation and antitumor immunity, making it a promising immunotherapy for various cancers. Molecular weight: 146.77 kDa.Couleur et forme :LiquidGPI-1485
CAS :GPI-1485 (GM1485) (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.Formule :C12H19NO4Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :241.28Ref: TM-T9820
1mg58,00€5mg126,00€1mL*10mM (DMSO)141,00€10mg178,00€25mg340,00€50mg505,00€100mg715,00€200mg1.054,00€AZD5153
CAS :AZD5153 is an orally active and selective BET/BRD4 bromodomain inhibitor with an IC50 value of 1.7nM for BRD4.Formule :C25H33N7O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :479.57Cardanol (C15:1)
CAS :Cardanol (C15:1), found in cashew nut shell liquid, induces mitochondria-associated apoptosis in human melanoma cells.Formule :C21H34ODegré de pureté :98.48% - 99.77%Couleur et forme :SolidMasse moléculaire :302.49Ref: TM-TN3594
100mgÀ demander1mg92,00€2mg135,00€5mg259,00€1mL*10mM (DMSO)268,00€10mg371,00€25mg583,00€50mg800,00€IDOi-Pt(IV) prodrug-1
IDOi-Pt(IV) prodrug-1 (Compound 10) is an IDOi-Pt(IV) prodrug that suppresses IDO expression. It induces apoptosis, reduces mitochondrial membrane potential, and inhibits tumor cell migration and invasion. Additionally, IDOi-Pt(IV) prodrug-1 triggers reactive oxygen species-mediated endoplasmic reticulum stress and the secretion of damage-associated molecular patterns (DAMPs), leading to immunogenic cell death (ICD). Compared to cisplatin, IDOi-Pt(IV) prodrug-1 exhibits relatively high efficiency and low toxicity in its antitumor activity.Formule :C21H26Cl3N3O6PtSCouleur et forme :SolidMasse moléculaire :749.96ARB-272572 hydrochloride
CAS :ARB-272572 hydrochloride is a PD-L1 inhibitor that inhibits PD-1/PD-L1 cell signaling by inducing PD-L1 protein homology interactions.Formule :C32H36N6O4·xClHDegré de pureté :99.38%Couleur et forme :SoildMasse moléculaire :568.68(Free base）KTX-582
CAS :KTX-582: potent IRAK4/Ikaros degrader (DC50=4/5nM), induces MYD88 MT DLBCL apoptosis & tumor regression in lymphoma.Formule :C45H51F3N8O7Couleur et forme :SolidMasse moléculaire :872.93(E/Z)-Squalene
CAS :(E/Z)-Squalene modulates ROS, triggers apoptosis/necrosis, reduces liver cholesterol and triglycerides.Formule :C30H50Degré de pureté :98.15%Couleur et forme :SolidMasse moléculaire :410.72XmAb-2513
XmAb-2513 is a humanized monoclonal antibody inhibitor targeting CD30. It demonstrates significant anti-proliferative activity along with excellent antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). XmAb-2513 is applicable in research on hematological malignancies such as Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL).Couleur et forme :Odour Liquid
