Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5592 produits trouvés pour "Apoptose"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
NC-R17
<p>NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-</p>Formule :C53H67N7O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :914.14Diphenhydramine hydrochloride
CAS :<p>DPH: antihistamine for cough, nausea, itching, allergy, Parkinson's, sleep aid, cold remedy.</p>Formule :C17H22ClNODegré de pureté :99.84%Couleur et forme :Taste Ph (5% Aqueous Solution) 4-6 (Ntp 1992)Masse moléculaire :291.82EGFR/BRAFV600E-IN-4
<p>EGFR/BRAFV600E-IN-4 (Compound 10f) is a dual inhibitor of EGFR and BRAFV600E, with IC50 values of 61 nM and 43 nM, respectively. It halts the cell cycle, induces apoptosis in both early and late stages, and inhibits cancer cell growth in vitro, showing broad-spectrum anticancer activity.</p>Formule :C22H16N4OSCouleur et forme :SolidMasse moléculaire :384.45Thalidomide-O-amido-C4-N3
CAS :<p>Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and</p>Formule :C19H20N6O6Degré de pureté :97.01%Couleur et forme :SolidMasse moléculaire :428.4Solanidine
CAS :<p>Solanidine is a cholestane alkaloid isolated from potato species with antitumor effects. Solanidine inhibits proliferation.</p>Formule :C27H43NODegré de pureté :96.83%Couleur et forme :SolidMasse moléculaire :397.64PROTAC RIPK degrader-2
CAS :<p>PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.</p>Formule :C52H65N7O11S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1060.31(R)-MIK665
CAS :<p>(R)-MIK665 is the less active enantiomer of MIK665. MIK665 is a special inhibitor of Mcl-1(IC50 of 1.81 nM).</p>Formule :C47H44ClFN6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :875.419,11-Dehydroergosterol peroxide
CAS :<p>9,11-Dehydroergosterol peroxide is a useful organic compound for research related to life sciences.</p>Formule :C28H42O3Couleur et forme :SolidMasse moléculaire :426.641S65487 sulfate
CAS :<p>S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y.</p>Formule :C41H43ClN6O8SCouleur et forme :SolidMasse moléculaire :815.34Bcl-2-IN-5
CAS :<p>Bcl-2-IN-5: BCL-2 inhibitor, IC50: 0.12 nM (wt), 0.14 nM (D103Y), 0.22 nM (G101V); Cell growth IC50: 0.2 nM, 0.44 nM (RS4;11).</p>Formule :C55H63FN8O8SCouleur et forme :SolidMasse moléculaire :1015.2(E/Z)-LAQ824
CAS :<p>(E/Z)-LAQ824 is an inhibitor of histone deacetylase.</p>Formule :C22H25N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :379.46INF200
<p>INF200 (compound 5), a sulfonylurea-based inhibitor of NLRP3 and associated pyroptosis, exhibits cardiometabolic benefits in a rat model of high-fat diet (HFD)-</p>Formule :C13H13ClN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :296.71Ac-Trp-Glu-His-Asp-Aldehyde
CAS :<p>Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].</p>Formule :C28H33N7O9Couleur et forme :SolidMasse moléculaire :611.6MBC-11 trisodium
CAS :<p>MBC-11 trisodium, a bisphosphonate-Ara-C conjugate, may treat TIBD.</p>Formule :C11H17N3Na3O14P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :577.16α-Tubulin polymerization-IN-1
<p>α-Tubulin polymerization-IN-1 (Compound 8l) functions as an inhibitor of α-tubulin polymerization. This compound modulates the NRF2/KEAP-1 signaling pathway and induces ROS production in PC-3 cells, leading to apoptosis. It inhibits the proliferation of PC-3 cells with a GI50 of 0.17 µM, causing cell cycle arrest in the G2/M phase. Additionally, α-Tubulin polymerization-IN-1 demonstrates antitumor activity in mouse models.</p>Couleur et forme :Odour SolidLipustobart
CAS :<p>Lipustobart is an IgG4-kappa humanized monoclonal antibody targeting PDCD1 (programmed cell death 1, PD1, PD-1, CD279), with immunostimulant and antineoplastic</p>Degré de pureté :98%Couleur et forme :LiquidNSC 295642
CAS :<p>NSC 295642: phosphatase inhibitor, boosts phospho-Erk in cells, aids cancer research.</p>Formule :C15H14ClCuN3S2Couleur et forme :SolidMasse moléculaire :399.42Bcl-B inhibitor 1
CAS :<p>Bcl-B inhibitor 1 is a Bcl-B inhibitor with antitumor activity that binds to and inactivates pro-apoptotic proteins in the BH3 structural domain.</p>Formule :C17H15N3OSDegré de pureté :97.77%Couleur et forme :SoildMasse moléculaire :309.39Sasanlimab
CAS :<p>Sasanlimab (PF-06801591), a humanized IgG4-κ antibody, selectively targets PD-1 and is primarily produced in Chinese Hamster Ovary (CHO) cells [1].</p>Degré de pureté :98%Couleur et forme :Liquid(R)-JAK2/STAT3-IN-10a
CAS :<p>(R)-JAK2/STAT3-IN-10a is the R-isomer of JAK2/STAT3-IN-1.JAK2/STAT3-IN-1 is a structural domain inhibitor of GP130 D1 with antitumor activity.</p>Formule :C34H35BrF3N5O2Degré de pureté :97.99%Couleur et forme :SoildMasse moléculaire :682.571-Methyl-1H-pyrrolo[2,3-b]pyridine
CAS :<p>1-Methyl-1H-pyrrolo[2,3-b]pyridine exhibits cytotoxicity against MCF-7 cells and can be used in related research in the field of life sciences.</p>Formule :C8H8N2Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :132.16Thalidomide-NH-C10-COOH
<p>Compound 6b is a synthetic Thalidomide-VHL E3 ligase-linker for PROTACs.</p>Formule :C24H31N3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.52Bax inhibitor peptide, negative control
CAS :<p>The compound is a negative control peptide for the Bax inhibitor peptides V5 and P5.</p>Formule :C28H52N6O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :600.81YF135
CAS :<p>YF135 is a reversible-covalent KRAS G12C PROTAC that degrades its target via the VHL-proteasome pathway.</p>Formule :C63H75ClN12O7SCouleur et forme :SolidMasse moléculaire :1179.86Psalmotoxin 1
CAS :<p>Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.</p>Formule :C200H312N62O57S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :4689.41Pro-GA
CAS :<p>Pro-GA is a cell-permeable γ-glutamylcyclotransferase (γ-GGCT) inhibitor that inhibit proliferation in multiple bladder cancer cell lines. antitumour.</p>Formule :C12H19NO7Couleur et forme :SolidMasse moléculaire :289.28Antitumor photosensitizer-7
<p>Antitumor photosensitizer-7 (compound 15), a photosensitizer possessing anti-cancer properties, demonstrates substantial cytotoxic effects on the G361 melanoma cell line when exposed to 414 nm blue light irradiation.</p>Formule :C23H20N2O3Couleur et forme :SolidMasse moléculaire :372.42EGFR-IN-78
<p>EGFR-IN-78 (compound A5), a 2-aminopyrimidine derivative, serves as a reversible EGFR C797S-TK inhibitor and an apoptosis inducer.</p>Formule :C23H32BrN7O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :550.51Fluoxetine-Conjugated Platinum(IV) prodrug-1
<p>Fluoxetine-Conjugated Platinum(IV) prodrug-1 is an eEF2K inhibitor that can hinder the proliferation of cancer cells, induce DNA damage, and cause cell cycle arrest at the S phase, leading to apoptosis (Apoptosis). It also promotes the accumulation of reactive oxygen species (ROS) and disrupts mitochondrial function. This prodrug inhibits the migration and invasion of TNBC cells by suppressing MMP-2 activity and induces autophagy in TNBC cells through AMPK activation. In the 4T1-Luc mouse model, it exhibits antitumor activity and triggers immune suppression. Fluoxetine-Conjugated Platinum(IV) prodrug-1 is relevant for research in triple-negative breast cancer (TNBC).</p>Formule :C21H28Cl2F3N3O5PtCouleur et forme :SolidMasse moléculaire :724.1006CWI1-2
CAS :<p>CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2.</p>Formule :C22H17Cl3N6O3Degré de pureté :98.27%Couleur et forme :SoildMasse moléculaire :519.77Acrixolimab
CAS :<p>Acrixolimab is a humanized IgG4-κ monoclonal antibody that selectively targets PD-1 [1] [2].</p>Degré de pureté :98%Couleur et forme :LiquidPacmilimab
CAS :<p>Pacmilimab (CX-072) is a Probody immune checkpoint inhibitor targeting programmed death ligand 1 (PD-L1) with anti-tumor activity for the study of solid tumors.</p>Degré de pureté :98.8% (SDS-PAGE); 96.3% (SEC-HPLC) - 98.8% (SDS-PAGE); 96.3% (SEC-HPLC)Couleur et forme :LiquidProlgolimab
CAS :<p>Prolgolimab (BCD-100) is an anti-PD-1 antibody used in melanoma research.</p>Degré de pureté :>95%Couleur et forme :LiquidCNDAC hydrochloride
CAS :<p>CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.</p>Formule :C10H13ClN4O4Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :288.69BU 224 hydrochloride
CAS :<p>BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.</p>Formule :C12H12ClN3Degré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :233.7K-252c
CAS :<p>K-252c is a staurosporine analog isolated from Nocardiopsis sp.</p>Formule :C20H13N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.34Poly (I:C):Kanamycin (1:1)
<p>Poly (I:C):Kanamycin (1:1) is an equimolar mixture of Poly(I:C) and kanamycin. TLR3 agonist commonly used as a vaccine adjuvant; enhanced Poly(I:C) stability.</p>Couleur et forme :SolidThalidomide-Piperazine 5-fluoride hydrochloride
CAS :<p>Thalidomide-Piperazine 5-fluoride hydrochloride, a derivative of the cereblon (CRBN) inhibitor Thalidomide, serves as a ligand for E3 ubiquitin ligase (Ligands for E3 Ligase), facilitating the synthesis of PROTACs [1].</p>Formule :C17H18ClFN4O4Couleur et forme :SolidMasse moléculaire :396.8AUNP-12
CAS :<p>AUNP-12, a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.</p>Formule :C142H226N40O48Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3261.55PPIA-IN-1
<p>PPIA-IN-1 (Compound 20b) is an inhibitor of peptidyl-prolyl isomerase A (PPIA) with a KD of 0.52 μM. It demonstrates antiproliferative activity across various cancer cell lines, including an IC50 of 0.69 μM in HCT116 cells, induces cell cycle arrest at the G0/G1 phase, and exhibits antimetastatic effects in HCT116 cells. PPIA-IN-1 elevates ROS levels, causing DNA damage, ER stress, and mitochondrial dysfunction, and induces apoptosis in HCT116 cells via the MAPK pathway. Additionally, PPIA-IN-1 shows antitumor activity in a CT26 xenograft mouse model.</p>Formule :C23H21Cl2FN4O7Couleur et forme :SolidMasse moléculaire :555.34AKT-IN-18
<p>AKT-IN-18, an Akt inhibitor, demonstrates an IC50 value of 69.45 μM in A549 cells, effectively impeding Akt activity.</p>Formule :C19H14ClN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :411.86Mangafodipir trisodium
CAS :<p>Mangafodipir trisodium can enhance contrast in magnetic resonance imaging (MRI) of the liver, is a contrast agent delivered intravenously.</p>Formule :C22H27MnN4Na3O14P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :757.32Tauro-β-muricholic acid
CAS :<p>Tauro-β-muricholic acid (TβMCA), a trihydroxylated bile acid, acts as a competitive and reversible FXR antagonist (IC 50 = 40 μM) and exhibits antiapoptotic</p>Formule :C26H45NO7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :515.78-Bromo-cAMP
CAS :<p>8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.</p>Formule :C10H11BrN5O6PDegré de pureté :97.30%Couleur et forme :SolidMasse moléculaire :408.1Thalidomide-O-amido-PEG4-azide
CAS :<p>Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative serving as a linker for Proteolysis Targeting Chimeras (PROTACs) synthesis [1].</p>Formule :C25H32N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :576.56Feladilimab
CAS :<p>Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.</p>Degré de pureté :SDS-PAGE:95% SEC-HPLC:98%Couleur et forme :LiquidMasse moléculaire :145.24 kDa2,4,6-trichloroanisole
CAS :<p>2,4,6-trichloroanisole inhibits the cell viability of CHO and C32 cell lines and apoptosis, antibacterial activity against Plasmodium falciparum.</p>Formule :C7H5Cl3ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :211.47Latikafusp
CAS :<p>Latikafusp (AMG 256) is a fusion protein that is a PD-1 blocker and IL-21R agonist with antitumor activity.</p>Degré de pureté :97.1% (SDS-PAGE); 97.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 97.4% (SEC-HPLC)Couleur et forme :LiquidBIO8898
<p>BIO8898: potent CD40-CD154 inhibitor, IC50 of 25 µM, prevents CD40L-induced apoptosis.</p>Formule :C53H64N8O6Couleur et forme :SolidMasse moléculaire :909.13BAY1082439
CAS :<p>BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2].</p>Formule :C25H30N6O5Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :494.54
![1-Methyl-1H-pyrrolo[2,3-b]pyridine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTN9609.webp&w=3840&q=75)
