Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(137 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(18 produits)
- Survivant(14 produits)
- TNF(94 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6231 produits trouvés pour "Apoptose"
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KWCN-41
CAS :KWCN-41, Selective RIPK1 inhibitor (IC50=88 nM), inhibits necrosis specifically, anti-inflammatory effects.Formule :C18H17N3O2Couleur et forme :SolidMasse moléculaire :307.35PROTAC Bcl-xL degrader-1
PROTAC Bcl-xL degrader-1 targets Bcl-xL & IAP E3 ligases, degrades Bcl-xL, toxic to human platelets & MyLa 1929 (IC50: 62 nM, 8.5 μM).Formule :C76H96ClF3N10O11S3Couleur et forme :SolidMasse moléculaire :1514.28Thalidomide-O-PEG4-NHS ester
CAS :Thalidomide-O-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker, commonly employed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].Formule :C28H33N3O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :619.57Didocosahexaenoin
CAS :Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.Formule :C25H40O5Couleur et forme :SolidMasse moléculaire :420.58STM3006
CAS :STM3006 is an orally active, selective and and potent METTL3 inhibitor with antitumor activity for the study of acute myeloid leukemia (AML).Formule :C25H27BrN8Degré de pureté :97.16%Couleur et forme :SoildMasse moléculaire :519.44hMAO-B-IN-11
hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinson's and Alzheimer's.Couleur et forme :Odour SolidBcl-2-IN-2
CAS :Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL.Formule :C48H57N7O7SCouleur et forme :SolidMasse moléculaire :876.09Thalidomide-Piperazine-PEG2-NH2
CAS :Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker for PROTAC, combining cereblon ligand with a PEG2 linker.Formule :C23H31N5O6Couleur et forme :SolidMasse moléculaire :473.53BK50164
CAS :BK50164: CD73 inhibitor, IC50=13.089µM; binds CD99, KD=1.5µM; anticancer, induces apoptosis, arrests sub-G1.Formule :C13H13ClFN5O7Couleur et forme :SolidMasse moléculaire :405.72Fludarabine triphosphate trisodium
Fludarabine triphosphate (F-ara-ATP) trisodium inhibits DNA synthesis; IC50 2.3 μM, Ki 6.1 μM, blocks DNA primase, prompts apoptosis.Formule :C10H12FN5Na3O13P3Couleur et forme :SolidMasse moléculaire :591.12AM-8553
CAS :AM-8553 is potent and selective piperidine the MDM2-p53 interaction inhibitor.Formule :C25H29Cl2NO4Couleur et forme :SolidMasse moléculaire :478.41Thalidomide-NH-PEG4-COOH
CAS :Thalidomide-NH-PEG4-COOH is a E3 ligase ligand-linker for synthesizing the selective degrader dCBP-1 targeting p300/CBP.Formule :C24H31N3O10Couleur et forme :SolidMasse moléculaire :521.523Jacaric Acid
CAS :Conjugated 18-C ω-6 fatty acid from Jacaranda seeds, induces cancer cell apoptosis via oxidative stress; metabolizes to cytotoxic CLA.Formule :C18H30O2Couleur et forme :SolidMasse moléculaire :278.436Calcimycin hemimagnesium
CAS :Calcimycin hemimagnesium is an antibiotic, ionophore, and ATPase inhibitor that boosts intracellular Ca2+, causing cell death and apoptosis.Formule :C58H72MgN6O12Couleur et forme :SolidMasse moléculaire :1069.53EAD1
CAS :EAD1 is a useful organic compound for research related to life sciences. The catalog number is T35329 and the CAS number is 1644388-26-0.
Formule :C24H27Cl2N7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :484.42eIF4A3-IN-5
CAS :eIF4A3-IN-5 potently inhibits eIF4AI/II, promising for cancer research.Formule :C26H22N2O7Couleur et forme :SolidMasse moléculaire :474.469SF1126
CAS :SF1126 is a first-in-class PI3K/BRD4 inhibitor and RGDS-conjugated LY294002 prodrug, enhancing solubility and targeting tumor integrins.Formule :C39H48N8O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :852.84MDM2/4-p53-IN-2
MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.Formule :C25H17Cl3FN3O3Couleur et forme :SolidMasse moléculaire :532.789,11-Dehydroergosterol peroxide
CAS :9,11-Dehydroergosterol peroxide is a useful organic compound for research related to life sciences.Formule :C28H42O3Couleur et forme :SolidMasse moléculaire :426.641DRI-C21041 (DIEA)
DRI-C21041 DIEA serves as an inhibitor of CD40/CD40L interaction, exhibiting an inhibitory concentration (IC50) of 0.31 μM.Formule :C38H40N4O7SCouleur et forme :SolidMasse moléculaire :696.81DHFR-IN-23
DHFR-IN-23 (compound 5) is a dual inhibitor of DNA binders/DHFR, exhibiting an IC50 value of 0.08 μM against hDHFR. It serves as an apoptosis inducer and is applicable in research on ER+ breast cancer.Couleur et forme :Odour SolidMalformin A
CAS :Malformin A, from A. niger, is a plant growth regulator and has anti-TMV and cancer cell cytotoxic properties. Intraperitoneal LD50 in mice is 3.1 mg/kg.Formule :C23H39N5O5S2Couleur et forme :SolidMasse moléculaire :529.72Ganoderic acid Mf
CAS :Ganoderic acid Mf: antitumor triterpenoid, arrests G1 cell cycle, selective for cancer cells, triggers apoptosis via mitochondria.Formule :C32H48O5Couleur et forme :SolidMasse moléculaire :512.72Thalidomide-NH-PEG8-Ts
CAS :Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.Formule :C36H49N3O14SCouleur et forme :SolidMasse moléculaire :779.86HDAC-IN-57
CAS :HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4Formule :C21H19N3O4Degré de pureté :98.62%Couleur et forme :SoildMasse moléculaire :377.39Mcl-1 inhibitor 14
Compound (Ra)-10, also known as Mcl-1 inhibitor 14, is a potent inhibitor of myeloid cell leukemia-1 (MCL-1), exhibiting a K_i of 0.018 nM, and holds potentialFormule :C39H41ClFN5O5SCouleur et forme :SolidMasse moléculaire :746.29Anticancer agent 153
Anticancer Agent 153 (Compound 3) promotes apoptosis through the generation of Reactive Oxygen Species (ROS) and elevates the loss of Mitochondrial MembraneFormule :C16H11Cl2N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.18Apoptosis inducer 12
CAS :Apoptosis Inducer 12 (Compound 3z) is a compound that promotes cell death via the mitochondrial pathway and is utilized in cancer research [1].Formule :C26H27N3O5Couleur et forme :SolidMasse moléculaire :461.51Fluorescein-diisobutyrate-6-amide
CAS :Fluorescein-diisobutyrate-6-amide, a powerful inducer of ferroptosis, shows promise for cancer research applications [1].Formule :C62H61ClN6O16Couleur et forme :SolidMasse moléculaire :1181.63Ac-YVAD-CHO acetate
Ac-YVAD-CHO acetate, potent reversible ICE and caspase-1 inhibitor; K_i: 3.0 nM (mouse), 0.76 nM (human); blocks IL-lβ production.Formule :C25H36N4O10Couleur et forme :SolidMasse moléculaire :552.57TD52 dihydrochloride
TD52 dihydrochloride, an Erlotinib derivative, inhibits protein phosphatase 2A and induces apoptosis in TNBC by disrupting CIP2A/PP2A/p-Akt signaling.Formule :C24H18Cl2N4Degré de pureté :97.23%Couleur et forme :SoildMasse moléculaire :433.33Delmitide
CAS :Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis.Formule :C59H105N17O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1228.57HEMTAC CDK4/6 degrader 1
CAS :HEMTAC CDK4/6 degrader 1, a PROTAC targeting HSP90/CDK4/6, Kd of 35.7 μM, disrupts B16F10 melanoma cell cycle, and induces apoptosis.Formule :C48H53ClN16O4Couleur et forme :SolidMasse moléculaire :953.49Metronidazole hydrochloride
CAS :Oral nitroimidazole antibiotic; treats anaerobic infections; may cause inflammation and muscle contractions with long-term use.Formule :C6H10ClN3O3Couleur et forme :SolidMasse moléculaire :207.62Nrf2 activator-9
Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-densityFormule :C26H27N5O4Couleur et forme :SolidMasse moléculaire :473.52SB-1295
SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 μM, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells.Formule :C23H22ClNO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.88HC Toxin
CAS :HC Toxin: cyclic tetrapeptide, reversible HDAC inhibitor (IC50=30 nM), upregulates 15-lipoxygenase-1, induces fetal hemoglobin, from C. carbonum.Formule :C21H32N4O6Couleur et forme :SolidMasse moléculaire :436.509Chol-CTPP
Chol-CTPP targets the BBB and glioma cells; when combined with Chol-TPP, forms Lip-CTPP, enhancing anti-glioma drug efficacy.Formule :C144H263N3O53Couleur et forme :SolidMasse moléculaire :2884.62HDAC3-IN-2
HDAC3-IN-2 (compound 4i), a pyrazinyl hydrazide-based HDAC3 inhibitor with an IC50 of 14 nM, effectively targets triple-negative breast cancer cells.Formule :C16H21N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :315.37EGFR T790M/L858R-IN-2
EGFRT790M/L858R-IN-2: selective inhibitor, IC50: 3.5 nM (mutant), 1290 nM (WT); reduces p-EGFR/AKT/ERK1/2, triggers apoptosis, G1 arrest, anti-cancer.Formule :C28H28FN7OCouleur et forme :SolidMasse moléculaire :497.57Inuviscolide
CAS :Inuviscolide induces apoptosis, G2/M arrest in melanoma, and has anti-cancer, anti-inflammatory effects.Formule :C15H20O3Couleur et forme :SolidMasse moléculaire :248.327,3′,5′-Trihydroxyflavanone
CAS :7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression.Formule :C15H12O5Couleur et forme :SolidMasse moléculaire :272.25Antitumor agent-103
Antitumor Agent-103 (compound 24l) induces apoptosis and possesses antiproliferative and anti-colony formation properties.Formule :C36H36N8O9S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :788.85AS-99 free base
CAS :AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity.Formule :C27H30F3N5O3S2Couleur et forme :SolidMasse moléculaire :593.68Thalidomide-5-NH-PEG2-NH2 hydrochloride
CAS :Thalidomide-5-NH-PEG2-NH2 hydrochloride is a cereblon ligand based on Thalidomide, designed to recruit CRBN proteins. It has the capability to be linked with target protein ligands via a linker, facilitating the formation of PROTAC molecules, such as THAL-SNS-032.Formule :C19H25ClN4O6Couleur et forme :SolidMasse moléculaire :440.88UZH1
CAS :UZH1, a mix of active METTL3 inhibitor UZH1a (IC50 280 nM) and inactive UZH1b (IC50 28 μM), modifies epitranscriptomics and has antitumor properties.Formule :C32H42N6O3Couleur et forme :SoildMasse moléculaire :558.71Mechercharmycin A
CAS :Mechercharmycin A, a cytotoxic compound, was isolated from Thermoactinomyces sp. YM3-251, a marine source. It demonstrates potent antitumor activity.Formule :C35H32N8O7SCouleur et forme :SolidMasse moléculaire :708.75ChoKα inhibitor-5
ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.Formule :C54H68Br2N4S4Couleur et forme :SolidMasse moléculaire :1061.21NecroIr2
NecroIr2, an iridium(III) compound, induces necroptosis in Cisplatin-resistant A549R lung cancer cells and disrupts mitochondria.Formule :C46H30ClIrN6O2Couleur et forme :SolidMasse moléculaire :926.44APG-1387
CAS :APG-1387 inhibits IAPs, degrades cIAP1/2, XIAP, boosts chemosensitivity, and induces apoptosis in NPC.Formule :C60H72N10O10S2Couleur et forme :SolidMasse moléculaire :1157.41
