Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(135 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6225 produits trouvés pour "Apoptose"
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CYP51/PD-L1-IN-3
CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μMFormule :C27H28N6O2Couleur et forme :SolidMasse moléculaire :468.55YT117R
YT117R is a PROTAC that targets degradation of FKBP12 and BRD4.Formule :C50H52ClN9O7SCouleur et forme :SolidMasse moléculaire :958.52Ac-DNLD-CHO
CAS :Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is an inhibitor of Caspase-3/7, exhibiting IC50 values of 9.89 nM and 245 nM, and approximate Ki values of 0.68 nM and 55.7Formule :C20H31N5O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.49MKC-1
CAS :MKC-1 (Ro-31-7453) is an oral bisindolylmaleimide inhibitor that disrupts tubulin polymerization, potentially halting cancer cell division.Formule :C22H16N4O4Degré de pureté :99.63% - 99.85%Couleur et forme :SolidMasse moléculaire :400.39Ref: TM-T9831
500mgÀ demander1mg54,00€5mg118,00€1mL*10mM (DMSO)127,00€10mg168,00€25mg293,00€50mg423,00€100mg588,00€YL5084
CAS :YL5084 is a selective JNK2/3 inhibitor with IC50s: JNK2 (70 nM), JNK3 (84 nM), and antiproliferative, apoptosis-inducing effects.Formule :C35H36N8O2Couleur et forme :SolidMasse moléculaire :600.71PROTAC EGFR degrader 5
CAS :PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.Formule :C57H72FN13O5SCouleur et forme :SolidMasse moléculaire :1070.33LSD1-IN-24
CAS :LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing responseFormule :C18H20N2OSDegré de pureté :99.61%Couleur et forme :SoildMasse moléculaire :312.43Ref: TM-T67871
1mg34,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg110,00€25mg212,00€50mg349,00€100mg532,00€200mg705,00€PD0166285 dihydrochloride
CAS :PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.Formule :C26H29Cl4N5O2Couleur et forme :SolidMasse moléculaire :585.35Ac-FEID-CMK TFA
Ac-FEID-CMK TFA is a zebrafish GSDMEb-derived peptide inhibitor that acts by inhibiting the caspy2-mediated atypical inflammatory vesicle pathway.Formule :C29H38ClF3N4O11Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :711.08Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Couleur et forme :Odour SolidEldecalcitol
CAS :Eldecalcitol, orally active vitamin D analog, boosts bone density and treats osteoporosis.Formule :C30H50O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.72COG-1410 acetate
COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.Formule :C66H125N21O16Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :1468.837-Methoxy-1-tetralone
CAS :7-Methoxy-1-tetralone may have insecticidal activity.Formule :C11H12O2Degré de pureté :99.85% - 99.89%Couleur et forme :White CrystalMasse moléculaire :176.21PD-1/PD-L1 inhibitory peptide C8
PD-1/PD-L1 inhibitory peptide C8 disrupts the PD-1/PD-L1 interaction, leading to the activation of CD8+ and CD4+ T cells and an increase in IFN-γ secretion. In mouse models, PD-1/PD-L1 inhibitory peptide C8 has demonstrated antitumor activity.Formule :C51H72N14O14S2Couleur et forme :SolidMasse moléculaire :1169.33Ac-VDQQD-pNA
CAS :Ac-VDQQD-pNA serves as a substrate for Caspase 2, which cleaves it to yield the yellow compound pNA (p-nitroaniline).Formule :C31H43N9O14Couleur et forme :SolidMasse moléculaire :765.73Human PD-L1 inhibitor V
CAS :Human PD-L1 Inhibitor V is a peptide that binds to the human PD-1 protein with an affinity characterized by a dissociation constant (Kd) of 3.32 μM, effectivelyFormule :C65H104N20O18SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1485.713-Methoxy-9H-Carbazole
CAS :3-methoxy-9H-carbazole: photosensitizer, anti-breast cancer, from Klauseneria spp., induces apoptosis.Formule :C13H11NODegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :197.23Antiproliferative agent-42
Antiproliferative Agent-42 (Compound 7m), a dihydrodipyrrolo compound, exhibits antiproliferative activity against the Panc-1 cell line, with an IC 50 of 12.54Couleur et forme :Odour SolidCIB-1476
CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.Formule :C28H28N2O6SCouleur et forme :SolidMasse moléculaire :520.6PROTAC FLT-3 degrader 1
CAS :PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.Formule :C52H61N9O9S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1020.23FPR1 antagonist 1
Compound 24a, an FPR1 antagonist, demonstrates potent inhibition of the formyl peptide receptor 1 (FPR1) with an IC50 value of 25 nM.Formule :C25H28O5Couleur et forme :SolidMasse moléculaire :408.49SLF-amido-C2-COOH
CAS :SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.Formule :C34H44N2O9Degré de pureté :95.8%Couleur et forme :SolidMasse moléculaire :624.72VPC-70063
CAS :VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.Formule :C16H12F6N2SDegré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :378.34Ref: TM-T60019
1mg49,00€5mg101,00€1mL*10mM (DMSO)130,00€10mg152,00€25mg268,00€50mg385,00€100mg560,00€200mg790,00€Satratoxin H
CAS :Satratoxin H is an air- and food-borne mycotoxin, which has been implicated in human health damage.Formule :C29H36O9Couleur et forme :SolidMasse moléculaire :528.598GPLGIAGQ acetate
GPLGIAGQ acetate: MMP2-cleavable peptide; stimulus-sensitive linker for MMP2-targeted liposomal/micellar carriers in photodynamic therapy.Formule :C33H57N9O12Degré de pureté :97.85%Couleur et forme :SolidMasse moléculaire :771.86HDAC6-IN-16
HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colonyFormule :C23H19N3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :417.48eIF4E-IN-5
eIF4E-IN-5 (Compound 6n) is a cell-permeable eIF4E inhibitor that binds to capped mRNA, thereby inhibiting cap-dependent translation [1].Formule :C30H39Cl2N6O8PCouleur et forme :SolidMasse moléculaire :713.55PD-1/PD-L1-IN-52
PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.Couleur et forme :Odour SolidDH-18
DH-18 is an inhibitor of matrix metalloproteinase-2 (MMP-2), exhibiting IC50 values of 139.45 nM for MMP-2, 518.11 nM for MMP-9, and 833.34 nM for MMP-8. The compound promotes cell apoptosis and causes cell cycle arrest in the G0/G1 phase. DH-18 also inhibits cell growth, making it potential for research in chronic myeloid leukemia.Formule :C26H23F6N3O5SCouleur et forme :SolidMasse moléculaire :603.53Bfl-1-IN-5
Bfl-1-IN-5 (Compound (R,R,S)-26) is a selective inhibitor of Bfl-1, demonstrating an IC50 of 0.022 μM. This compound enhances the activity of caspase-3/7, with an EC50 of 0.37 μM, and also inhibits the viability of SU-DHL-1 cells, showing an EC50 of 1.3 μM.Formule :C24H24F3N3O2Couleur et forme :SolidMasse moléculaire :443.46CDK-TCIP1
CAS :CDK-TCIP1 is a bivalent molecule that links the CDK9 inhibitor SNS-032 with the BCL6 ligand BI3812. It effectively and specifically kills cells overexpressing BCL6, with an EC50 of 7.7 nM for SUDHL5 cells.Formule :C48H62ClN11O8S2Couleur et forme :SolidMasse moléculaire :1020.66RMC-9805
CAS :RMC-9805(Zoldonrasib) is a KRAS G12D inhibitor with anti-tumor and anti-proliferative activity for the study of pancreatic cancer.Formule :C63H88F3N11O7Degré de pureté :98.10% - 99.99%Couleur et forme :SolidMasse moléculaire :1168.44Ref: TM-T78212
1mg120,00€5mg295,00€10mg460,00€1mL*10mM (DMSO)650,00€25mg753,00€50mg1.099,00€100mg1.620,00€dFKBP-1
CAS :dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].Formule :C53H64N6O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1009.11HEMTAC CDK4/6 degrader 1
CAS :HEMTAC CDK4/6 degrader 1, a PROTAC targeting HSP90/CDK4/6, Kd of 35.7 μM, disrupts B16F10 melanoma cell cycle, and induces apoptosis.Formule :C48H53ClN16O4Couleur et forme :SolidMasse moléculaire :953.49BY13
BY13 is an SRC-3 PROTAC degrader with a DC50 of 0.031 μM. It selectively obstructs the ER signaling pathway by downregulating ERα levels, showing greater selectivity over the androgen receptor (AR). BY13 effectively addresses endocrine resistance in breast cancer by inducing cell cycle arrest at the G1 phase and triggering apoptosis. Additionally, it surpasses Fulvestrant in efficacy and significantly inhibits the growth of resistant breast tumors in LCC2 xenograft mouse models, exhibiting no noticeable toxicity.Couleur et forme :Odour SolidCompound TPX-0046
CAS :Compound TPX-0046 is an inhibitor of RET. Compound TPX-0046 can inhibit the RET autophosphorylation. Compound TPX-0046 can be used for the research of cancer.Formule :C21H21FN6O3Degré de pureté :99.94%Couleur et forme :SoildMasse moléculaire :424.43ARD-61
CAS :ARD-61: potent PROTAC, degrades AR/PR in AR+ cancers, triggers apoptosis, inhibits tumor growth in mice.Formule :C61H71ClN8O7SCouleur et forme :SolidMasse moléculaire :1095.8LSD1-IN-36
LSD1-IN-36, an effective LSD1 inhibitor with an IC50 value of 0.8 nM, induces cell apoptosis and arrests the cell cycle. This compound also exhibits antitumor activity.Formule :C22H25N3O6SCouleur et forme :SolidMasse moléculaire :459.52MS1943
CAS :MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).Formule :C42H54N8O3Degré de pureté :95.41% - 95.82%Couleur et forme :SolidMasse moléculaire :718.93Ref: TM-T13780
1mg39,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)120,00€10mg130,00€25mg250,00€50mg439,00€100mg802,00€200mg1.324,00€L-threo-PPMP
CAS :L-threo-PPMP blocks GlcT, curbs glycosphingolipid creation, and triggers cell death, showing anti-cancer effects.Formule :C29H50N2O3Couleur et forme :SolidMasse moléculaire :474.73PAR4 antagonist 8
PAR4 antagonist8 (Compound 20f) is an effective oral and selective PAR4 antagonist with an IC50 of 15.32 nM, boasting favorable pharmacokinetic properties. It effectively inhibits human platelet aggregation induced by PAR4 agonists (IC50=6.39 nM) and also suppresses platelet aggregation in mice. PAR4 antagonist8 is utilized in anti-thrombotic research.Formule :C28H19F2N5O4SMasse moléculaire :559.54TS-24
CAS :TS-24 is a cysteine protease histone S (CTSS) inhibitor that promotes BRCA1-mediated apoptosis.
Formule :C20H15NO2Degré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :301.34BCL-XL-IN-1
BCL-XL-IN-1 (Compound 11) is a selective inhibitor of BCL-XL, exhibiting a Ki of less than 0.01 nM against BCL-XLTR-FERT. It is primarily used in cancer research.Formule :C46H55N7O6SCouleur et forme :SolidMasse moléculaire :834.04KTX-582
CAS :KTX-582: potent IRAK4/Ikaros degrader (DC50=4/5nM), induces MYD88 MT DLBCL apoptosis & tumor regression in lymphoma.Formule :C45H51F3N8O7Couleur et forme :SolidMasse moléculaire :872.93KGYY15
CAS :KGYY15 (Mouse KGYY15), a peptide that targets CD40, exhibits weak inhibition of the CD40-CD40L interaction, with an IC50 exceeding 1 mM. At a concentration of 100 μM, KGYY15 activates the NF-κB pathway by 33%.Formule :C84H129N21O22SCouleur et forme :SolidMasse moléculaire :1817.12TNF/IFNγ-IN-1
CAS :TNF/IFNγ-IN-1 (TGA) is a TNF and IFN-γ inhibitor with antioxidant and anti-inflammatory activities for neurodegenerative diseases such as Alzheimer.Formule :C20H23N3O6Degré de pureté :99.39%Couleur et forme :SoildMasse moléculaire :401.41Sarglaroids F
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+Formule :C38H44O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :692.75Mcl-1 inhibitor 15
Mcl-1 Inhibitor 15 (Compound (Ra)-15), with a K i of 0.02 nM, is utilized in cancer research [1].Formule :C40H42ClFN6O4SCouleur et forme :SolidMasse moléculaire :757.32Enniatin A1
CAS :Enniatin A1, a cyclic hexadepsipeptide from Fusarium, induces apoptosis and disrupts ERK, inhibiting ACAT (IC50: 49 μM).Formule :C35H61N3O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :667.885TNF-α-IN-11
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.Formule :C24H26N2O5Couleur et forme :SolidMasse moléculaire :422.47
