Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(135 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6225 produits trouvés pour "Apoptose"
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CTP-347
CAS :CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.Formule :C19H20FNO3Couleur et forme :SolidMasse moléculaire :331.38Citreoviridin
CAS :Citreoviridin from Penicillium citreoviride blocks brain Na+/K+-ATPase; boosts Na+/K+- and Mg2+-ATPase in microsomes dose-dependently.Formule :C23H30O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.48ATWLPPRAANLLMAAS
CAS :ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent antitumor capabilities. It effectively inhibits the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induces apoptosis (apoptosis).Formule :C76H123N21O20SMasse moléculaire :1682.98Taxamairin B
CAS :Taxamairin B is a potent anti-inflammatory compound that inhibits the expression of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) and reduces theFormule :C22H24O4Couleur et forme :SolidMasse moléculaire :352.42SH-5
CAS :SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene productsFormule :C29H59O10PCouleur et forme :SolidMasse moléculaire :598.75Bfl-1-IN-6
Bfl-1-IN-6 (Compound 20) is an orally active inhibitor of Bcl-2-related protein A1 (BFL1) with an IC50 of 19 nM. This compound can stabilize BFL1 protein, activate cleaved caspase 3, and demonstrates antitumor activity in mouse models.Formule :C22H24ClFN2O2Couleur et forme :SolidMasse moléculaire :402.89BGC4
BGC4 is a gold(III) complex based on biphenyl. It inhibits human recombinant thioredoxin reductase (TrxR) with an IC50 of 10.7 μM, exhibits cytotoxicity with an IC50 of 5.4 μM in MDA-MB-231 cells, and induces apoptosis. Additionally, BGC4 demonstrates antitumor activity in mouse models.Formule :C30H32AuClF3N3Couleur et forme :SolidMasse moléculaire :724.01Z-DQMD-FMK
CAS :Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
Formule :C29H40FN5O11SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :685.72Chloranil
CAS :Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.Formule :C6Cl4O2Degré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :245.88FKBP12 ligand-1
CAS :FKBP12 ligand-1 is the target protein ligand for MC-25B, which is a PROTAC targeting FKBP12.Formule :C32H41NO9Couleur et forme :SolidMasse moléculaire :583.669Hellebrin
CAS :Cytotoxic and antiproliferative effects of Hellebrin on breast and lung cancer cells.Formule :C36H52O15Couleur et forme :SolidMasse moléculaire :724.79DD0-2363
DD0-2363 (Compound 32d) is a dual-target inhibitor of WDR5-MLL1/HDAC. It can suppress the proliferation of acute myeloid leukemia cells and induce apoptosis. With its antitumor properties, DD0-2363 is applicable for research on acute myeloid leukemia.Formule :C36H36ClFN6O4Couleur et forme :SolidMasse moléculaire :671.16FAK-IN-24
CAS :FAK-IN-24 (Compound 9f) is a potent FAK inhibitor with an IC50 of 0.815 nM. It induces DNA damage and apoptosis, and exhibits activity against glioblastoma. FAK-IN-24 effectively inhibits proliferation of glioblastoma cell lines U87-MG (IC50= 15 nM) and U251 (IC50= 20 nM), and suppresses tumor growth in U87-MG xenograft models.Formule :C39H45Cl2F3N8O3Couleur et forme :SolidMasse moléculaire :801.728TCF4/β-catenin-IN-1
TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin that induces apoptosis. This compound enhances the expression of p53, caspase-3, caspase-8, caspase-9, and Bax proteins, while reducing Bcl-2 protein levels. TCF4/β-catenin-IN-1 also inhibits CYP3A4, CYP1A2, and CYP2C19, demonstrating significant cytotoxic activity in cancer cells.Formule :C23H15N7O3Couleur et forme :SolidMasse moléculaire :437.41GD3 Ganglioside sodium
GD3 Ganglioside sodium is a crucial ganglioside in human melanoma and functions as an inducer of mitochondrial permeability. It targets mitochondria directly in a manner controlled by bcl-2. Following the aggregation of death-inducing receptors, ceramide accumulates rapidly, synthesizes GD3 ganglioside, and triggers apoptosis.Couleur et forme :SolidHYS-072
HYS-072 is an orally active derivative of chrysin with antitumor properties. It induces apoptosis (Apoptosis) and autophagy (Autophagy) by inhibiting the PI3K/AKT/mTOR signaling pathway, and suppresses tumor growth in xenograft models in vivo by modulating autophagy-related pathways. HYS-072 is applicable for research in treating triple-negative breast cancer.Formule :C27H26N2O5Couleur et forme :SolidMasse moléculaire :458.51DC-Y13-27
Dc-y13-27, a derivative of DC-Y13, is a potent YTHDF2 inhibitor (KD: 37.9 μM).Formule :C14H10N2O2SDegré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :270.31AVJ16
CAS :AVJ16 as a member of the insulin growth factor 2 mRNA-binding protein family, binds to the mRNA of certain genes to regulate protein translation.Formule :C28H27N3O4Degré de pureté :98.87% - 99.72%Couleur et forme :SolidMasse moléculaire :469.53Ref: TM-T9980
1mg130,00€5mg313,00€1mL*10mM (DMSO)323,00€10mg500,00€25mg807,00€50mg1.108,00€100mg1.485,00€200mg1.998,00€FKBP12 Ligand-Linker Conjugate 1
CAS :FKBP12 Ligand-Linker Conjugate 1 is a complex comprising a target protein ligand for FKBP12 and a linker, which is utilized in the synthesis of the PROTAC degrader MC-25B.Formule :C42H63N3O11Couleur et forme :SolidMasse moléculaire :785.963AXL/Angiokinase-IN-1
AXL/Angiokinase-IN-1 (compound 11b) is an inhibitor of AXL/triple angiokinase, with an IC50 of 3.75 nM for AXL expression. This compound suppresses epithelial-mesenchymal transition (EMT) in Bxpc-3 cells and prevents metastasis in lung cancer cells. Additionally, AXL/Angiokinase-IN-1 impairs the functions of vascular and fibroblast cells and induces apoptosis in both cancer and fibroblast cells. It is characterized by low toxicity and favorable metabolic stability.Formule :C31H34ClN5O2Couleur et forme :SolidMasse moléculaire :544.09RBN013209
CAS :RBN013209 is a potent CD38 inhibitor. RBN013209 is useful in the treatment of cancer.Formule :C19H24N6O3Degré de pureté :99.84%Couleur et forme :SoildMasse moléculaire :384.43Ref: TM-T60099
1mg58,00€5mg126,00€1mL*10mM (DMSO)138,00€10mg178,00€25mg356,00€50mg512,00€100mg713,00€IPH10
IPH10 is an anticancer agent with strong antitumor effects in vivo and exhibits no liver or kidney toxicity. It significantly increases the reactive oxygen species (ROS) levels in tumor cells, decreases mitochondrial membrane potential, and induces apoptosis (apoptosis) in these cells.Formule :C32H33NO4Couleur et forme :SolidMasse moléculaire :495.61Betamethasone
CAS :Betamethasone (NSC-39470), a glucocorticoid steroid, has immunosuppressive and anti-inflammatory properties.Formule :C22H29FO5Degré de pureté :98% - 99.71%Couleur et forme :White Or Almost White Powder Solid CrystallineMasse moléculaire :392.46Urelumab
CAS :"Urelumab (BMS-66513), a humanized IgG4 mAb CD137 agonist, boosts T-cell/NK cell-mediated cytotoxicity and anti-tumor activity."Degré de pureté :97.70%Couleur et forme :LiquidMasse moléculaire :145.90 kDaHKB99
CAS :HKB99 suppresses NSCLC growth, metastasis, and overcomes erlotinib resistance.Formule :C23H18N2O6SDegré de pureté :97.35% - 97.35%Couleur et forme :SolidMasse moléculaire :450.46KRASG12C IN-16
KRASG12C IN-16 (Compound SK-17) is a selective, covalent, and orally active KRASG12C inhibitor. It can induce apoptosis and effectively prevent the activation of the MAPK and PI3K/mTOR signaling pathways. Additionally, KRASG12C IN-16 exhibits antitumor activity against pancreatic cancer.Formule :C28H35ClN8O2Couleur et forme :SolidMasse moléculaire :551.08AChE-IN-81
AChE-IN-81 (compound 22) is a reversible, selective inhibitor of AChE with an 80.0% inhibition rate and an IC50 of 3.7 μM. It binds to AChE with an affinity (Kd) of 5.37 μM. AChE-IN-81 effectively reduces apoptosis in zebrafish brain cells and shows potential neuroprotective activity in an H2O2-induced SH-SY5Y cell damage model.Formule :C37H54ClNO5Couleur et forme :SolidMasse moléculaire :628.28Topo I/II-IN-2
Topo I/II-IN-2 (Compound 3g) is an inhibitor of both Topo I and Topo II. It exhibits inhibitory activity against NCI-H446 and NCI-H1048 cells with IC50 values of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial apoptosis, disrupts mitochondrial function, and stimulates activity generation. Additionally, it inhibits the PI3K/Akt/mTOR pathway, effectively preventing the proliferation, invasion, and migration of small cell lung cancer (SCLC) cells in vitro.Formule :C25H26N2O4Couleur et forme :SolidMasse moléculaire :418.48PKM2 modulator 1
PKM2 modulator 1 (compound C998) is an effective PKM2 inhibitor with antiproliferative activity. It induces apoptosis and holds potential for research in glioblastoma studies.Formule :C26H25N3O3Couleur et forme :SolidMasse moléculaire :427.5BAG3/HSP70-IN-1
USP1-IN-11 (compound 38-P2) is a selective, reversible, and non-competitive inhibitor of USP1 (Ubiquitin-specific protease 1). It activates the DDR (DNA damage repair) pathway, leading to cell cycle arrest and apoptosis, thereby inhibiting cell survival. USP1-IN-11 increases sensitivity to Olaparib in drug-resistant cells and works synergistically with Andrographolide in cancer cells with functional BRCA. In the MDA-MB-436 xenograft model, USP1-IN-11 demonstrates significant dose-dependent antitumor activity.Formule :C28H39N7O4Couleur et forme :SolidMasse moléculaire :537.65Thalidomide-PEG3-NH2
CAS :Thalidomide-PEG3-NH2: a cereblon-based E3 ligase ligand-linker for PROTAC tech.Formule :C19H23N3O7Couleur et forme :SolidMasse moléculaire :405.407Syringolin A
CAS :Syringolin A is a useful organic compound for research related to life sciences. The catalog number is T125354 and the CAS number is 212115-96-3.
Formule :C24H39N5O6Couleur et forme :SolidMasse moléculaire :493.605S-Adenosyl-L-methionine iodide
CAS :S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].Formule :C15H23IN6O5SCouleur et forme :SolidMasse moléculaire :526.355α-dihydro Levonorgestrel
CAS :5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel .Formule :C21H30O2Couleur et forme :SolidMasse moléculaire :314.469Tralokinumab
CAS :Tralokinumab: human IgG4 monoclonal antibody, blocks IL-13, may treat atopic dermatitis.Degré de pureté :SDS-PAGE:95% SEC-HPLC:99.99%Couleur et forme :LiquidMasse moléculaire :144.14 kDaAvotaciclib hydrochloride
Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, includingFormule :C13H12ClN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :317.73Annonacin
CAS :Annonacin is a cytotoxic acetogenin in Graviola leaf extract; it blocks mitochondrial complex and inhibits NKA/SERCA ATPase pumps.Formule :C35H64O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :596.88Anticancer agent 268
Anticanceragent 268 (Compound 4k) is a potential antitumor agent. It exhibits antiproliferative effects on HepG2 cells, with an IC50 value of 6.08 μM. Additionally, Anticanceragent 268 induces apoptosis and inhibits colony formation and migration of HepG2 cells.Couleur et forme :Odour SolidHydrocinchonine
CAS :Hydrocinchonine is an Alkaloid from Olea europaea and is found in fruits.Formule :C19H24N2OCouleur et forme :SolidMasse moléculaire :296.41dTAGV-1-NEG
CAS :Negative control for dTAGV-1.Formule :C68H90N6O14SCouleur et forme :SolidMasse moléculaire :1247.56Emavusertib hydrochloride
CAS :Emavusertib (CA-4948) hydrochloride, a selective and potent IRAK4/FLT3 inhibitor, is designed for oral administration. It achieves an IC 50 of 57 nM against IRAK4 in a FRET kinase assay and demonstrates anti-tumor activity [1] [2] [3].Formule :C24H26ClN7O5Couleur et forme :SolidMasse moléculaire :527.96Leucettamol A
CAS :Leucettamol A, from Leucetta microraphis, blocks LTB4 receptor and prevents Ubc13-Uev1A complex formation.Formule :C30H52N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :472.758Thalidomide-O-amide-C5-NH2
CAS :Thalidomide-O-amide-C5-NH2 is a synthetic E3 ligase linker combining cereblon ligand and PROTAC linker.Formule :C20H24N4O6Couleur et forme :SolidMasse moléculaire :416.432-Acetamidophenol
CAS :2-Acetamidophenol (Orthocetamol) has analgesic and antipyretic effects. 2-Acetamidophenol is an isomer of Paracetamol (4-acetamidophenol).
Formule :C8H9NO2Degré de pureté :>99.99%Couleur et forme :Light Brown PowderMasse moléculaire :151.16KRN 5500
CAS :KRN 5500, a derivative of the nucleoside antibiotic spicamycin, has a wide range of antitumor activity against human cancer cell lines.Formule :C28H43N7O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :589.68WKYMVM
CAS :WKYMVM is a N-formyl peptide receptor (FPR1) agonist.Formule :C41H61N9O7S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :856.11Cholesteryl Hemisuccinate Tris Salt
CAS :Cholesteryl Hemisuccinate Tris Salt is a cholesteryl ester with anticancer activity.Cholesteryl hemisuccinate has antitumor activity and inhibits tumor growth.Formule :C35H61NO7Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :607.86RET-IN-28
CAS :RET-IN-28 (Compound 16) is an inhibitor of RET (a transmembrane receptor tyrosine kinase). It specifically inhibits the activity of a mutant RET enzyme (RET-V804M) and is utilized in cancer research.Formule :C26H29N9Couleur et forme :SolidMasse moléculaire :467.57Kinamycin C
CAS :Kinamycin C is a bacterial metabolite used as an anticancer agent.Formule :C24H20N2O10Couleur et forme :SolidMasse moléculaire :496.428NQO2-IN-1
CAS :NQO2-IN-1, a resveratrol analog, is a potent NQO2 inhibito,antitumor,generation of ROS and up-regulation of DR5 (death receptor 5) to promote apoptosis.Formule :C18H18N2O3Degré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :310.35
