Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(135 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6225 produits trouvés pour "Apoptose"
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Spexin TFA
Spexin TFA: GAL2/GAL3 agonist (EC50: 45.7/112.2 nM), no activity at GAL1, reduces appetite, fatty acid uptake, and LH secretion; anxiolytic.Formule :C76H115F3N20O21SCouleur et forme :SolidMasse moléculaire :1733.9Thalidomide-NH-C6-NH2
CAS :Thalidomide-NH-C6-NH2 is a synthetic conjugate compound designed as an E3 ligase ligand-linker.Formule :C19H24N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.42KC01
CAS :KC01 selectively inhibits ABHD16A (IC50: 0.2-0.5 μM), much more potent than KC02 (>10 μM); human ABHD16A IC50: 90±20 nM.Formule :C22H39NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.558NC-R17
NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-Formule :C53H67N7O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :914.14Antitumor agent-36
Antitumor agent-36: potent anti-cancer; causes DNA damage, triggers apoptosis, enhances immune response by upregulating T cells.Formule :C32H30Cl2N2O6PtCouleur et forme :SolidMasse moléculaire :804.58MET/PDGFRA-IN-2
MET/PDGFRA-IN-2 (compound 8h) serves as an inhibitor of MET and PDGFRA proteins, promoting apoptosis in cells and impeding the proliferation of MET-positiveFormule :C29H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :491.59Z-Ala-Ala-Asp-CMK
CAS :Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor that blocks granzyme B protease activity, for inflammatory diseases and tumours.Formule :C19H24ClN3O7Degré de pureté :99.967%Couleur et forme :SolidMasse moléculaire :441.86XZ739
CAS :XZ739: Cereblon-based PROTAC, degrades BCL-XL (DC50 2.5 nM in MOLT-4, 16hr), induces caspase apoptosis.Formule :C65H76ClF3N8O12S3Couleur et forme :SolidMasse moléculaire :1349.99Curcumin 5-8
CAS :CUR5-8: potent, oral CUR analog, reduces lipid droplets, boosts autophagy, hinders apoptosis, enhances insulin sensitivity.Formule :C20H21NO4Couleur et forme :SolidMasse moléculaire :339.39Antitumor photosensitizer-3
Antitumor Photosensitizer-3 (Compound I), a chlorin derivative, effectively induces apoptosis and necrosis in tumor cells upon exposure to 650 nm laserFormule :C48H34N4O4Couleur et forme :SolidMasse moléculaire :730.81RMC-9805
CAS :RMC-9805(Zoldonrasib) is a KRAS G12D inhibitor with anti-tumor and anti-proliferative activity for the study of pancreatic cancer.Formule :C63H88F3N11O7Degré de pureté :98.10% - 99.99%Couleur et forme :SolidMasse moléculaire :1168.44Ref: TM-T78212
1mg120,00€5mg295,00€10mg460,00€1mL*10mM (DMSO)650,00€25mg753,00€50mg1.099,00€100mg1.620,00€BM-1074
CAS :BM-1074 is a potent and highly efficacious inhibitor of Bcl-2/Bcl-xL with Ki value of < 1nM [1].Formule :C50H57ClN8O7S3Couleur et forme :SolidMasse moléculaire :1013.69DA5-HTL
DA5-HTL is a compound that combines dasatinib with the HaloTag system, effectively inhibiting the growth of tumor cells, with a GI50 of 1.923 nM.Formule :C39H58Cl2N8O8SMasse moléculaire :868.34754PDE4-IN-28
PDE4-IN-28 (Compound G1) is an inhibitor of PDE4D, with an IC50 of 29 nM. It suppresses the production of TNF-α and NO, with IC50 values of 13.32 μM and 2.32 μM, respectively. In a rat pressure ulcer (PU) model, PDE4-IN-28 exhibits anti-inflammatory, antibacterial, and analgesic properties, while promoting HUVEC cell migration to enhance wound healing.Couleur et forme :Odour SolidMD-222
CAS :MD-222: a first-in-class, highly potent PROTAC that degrades MDM2, activates p53, and exhibits anticancer properties.Formule :C48H47Cl2FN6O6Couleur et forme :SolidMasse moléculaire :893.84DPP-4-IN-8
DPP-4-IN-8 (compound 27) is a potent and selective inhibitor of dipeptidyl peptidase 4 (DPP4), with an inhibition constant (Ki) of 0.96 μM.Formule :C16H12ClNO6Couleur et forme :SolidMasse moléculaire :349.72IC 86621
CAS :IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Formule :C12H15NO3Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :221.25CDK4/6/HDAC-IN-1
CDK4/6/HDAC-IN-1 (Compound N14) is a dual-target inhibitor of CDK4/6 and HDAC, with IC50 values of 7.23 nM for CDK4, 13.20 nM for CDK6, 55.66 nM for HDAC1, and 48.38 nM for HDAC6. It induces apoptosis and G0/G1 phase arrest through the HDAC-p21-CDK signaling pathway and can inhibit hepatocellular carcinoma.Formule :C35H39N9O5Couleur et forme :SolidMasse moléculaire :665.742PROTAC Bcl-xL degrader-3
CAS :PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader.Formule :C82H105ClF3N11O11S4Couleur et forme :SolidMasse moléculaire :1641.49Narasin
CAS :Narasin inhibits dengue virus, treats coccidiosis without harm to cells, and induces cancer cell apoptosis.Formule :C43H72O11Couleur et forme :SolidMasse moléculaire :765.03Ilicicolin A
CAS :Ilicicolin A is a useful organic compound for research related to life sciences. The catalog number is T125289 and the CAS number is 22581-06-2.Formule :C23H31ClO3Couleur et forme :SolidMasse moléculaire :390.95Antibiotic DC 81
CAS :DC 81: Streptomyces-derived antitumor antibiotic, potent nucleic acid synthesis inhibitor, binds DNA sequences, forms covalent adducts.Formule :C13H14N2O3Couleur et forme :SolidMasse moléculaire :246.26S2/IAPinh
S2/IAPinh is a conjugate composed of an inhibitor of apoptosis proteins inhibitor (IAPinh) and a ligand of sigma 2 SW43. It demonstrates anti-proliferative and apoptosis-inducing activity by degrading inhibitor of apoptosis proteins (clAP-1).Formule :C52H75Cl2FN6O6SMasse moléculaire :1000.48299Ganoderic acid T1
Ganoderic acid T1, a derivative of Ganoderic acid T, triggers cancer cell apoptosis by boosting ROS and activating caspases.Formule :C34H50O7Couleur et forme :SolidMasse moléculaire :570.76c-JUN peptide
CAS :Peptide from c-Jun (33-57) blocks JNK binding, inhibits phosphorylation, upregulates p21, and induces HeLa cell apoptosis.
Formule :C121H210N36O34SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2743.55cis,trans-Germacrone
CAS :cis,trans-Germacrone is an antitumor, antioxidant isomer that inhibits lung cancer and affects Akt/MDM2/p53.Formule :C15H22OCouleur et forme :SolidMasse moléculaire :218.33BRD9 ligand-5
CAS :BRD9 Ligand-5 (Compound 172-11) serves as a ligand for the target protein in PROTAC applications. It is utilized in the synthesis of CFT8634.Formule :C17H19NO4Couleur et forme :SolidMasse moléculaire :301.34Hematein
CAS :Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).Formule :C16H12O6Degré de pureté :98%Couleur et forme :Dark Brown Crystalline PowderMasse moléculaire :300.26MPP hydrochloride
MPP hydrochloride is a selective estrogen receptor (ERR) modulator.Formule :C29H32ClN3O3Degré de pureté :99.75% - 99.90%Couleur et forme :SolidMasse moléculaire :506.04Ref: TM-T21897L
1mg50,00€5mg99,00€1mL*10mM (DMSO)110,00€10mg160,00€25mg313,00€50mg528,00€100mg707,00€200mg973,00€Garlic oil
CAS :Garlic oil can inhibit lung tumors caused by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by inducing second-phase drug metabolizing enzymes.Formule :C18H32OS7Couleur et forme :SolidMasse moléculaire :488.87(-)-Rasfonin
CAS :Rasfonin, a fungal metabolite from T. terrophilus, halts mouse splenocyte growth; IC50: 0.7 μg/ml (ConA), 0.5 μg/ml (LPS).Formule :C25H38O6Couleur et forme :SolidMasse moléculaire :434.57ASR-488
CAS :ASR-488, an activator of the mRNA-binding protein CPEB1, promotes apoptosis and suppresses the growth of bladder cancer [1].Formule :C33H40O7SCouleur et forme :SolidMasse moléculaire :580.73GSNOR-IN-1
GSNOR-IN-1 is a prodrug of GSNOR-IN-2 and functions as an S-nitrosoglutathione reductase (GSNOR) inhibitor capable of crossing the blood-brain barrier. GSNOR-IN-1 offers significant protective effects against damage induced by oxygen-glucose deprivation/reoxygenation (OGD/R). It regulates calcium signaling and synaptic function through Clstn1 S-nitrosylation and inhibits neuronal apoptosis. Additionally, GSNOR-IN-1 markedly reduces infarct volume in rat models of ischemic stroke while enhancing neurological function. With its neuroprotective properties, GSNOR-IN-1 holds potential for ischemic stroke research.Couleur et forme :Odour Solid2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol
CAS :2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol inhibits the proliferation of the THP-1 cell line and anti-infective Leishmania and Toxoplasma gondii RH.Formule :C10H12O2Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :164.20ADPM06
CAS :ADPM06: nonporphyrin PDT agent; leads in apoptosis, strong IC50 in µM against human tumors.Formule :C34H24BBr2F2N3O2Couleur et forme :SolidMasse moléculaire :715.19JNK-1-IN-3
CAS :JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.Formule :C19H17FN4O3Degré de pureté :97.551%Couleur et forme :SolidMasse moléculaire :368.36Z-VEID-FMK
CAS :Z-VEID-FMK is a selective caspase-6 peptide inhibitor that irreversibly covalently binds to the enzyme, thereby inhibiting apoptosis and DNA breakage.Formule :C31H45FN4O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :652.71PROTAC FLT3/CDK9 degrader-1
Potent PROTAC degrader for FLT3/CDK9, induces apoptosis, and shows promise for FLT3-ITD mutated AML research.Formule :C48H62N12O7Couleur et forme :SolidMasse moléculaire :919.08Antitumor agent-201
Antitumor agent-201 (Compound 10) is a Golgi apparatus-targeting chloride ion transport activator with an EC50 for promoting transmembrane chloride ion transport of 1.53 mol% and an IC50 against HepG2 cells of 7.13 μM. By selectively acting on the Golgi apparatus, Antitumor agent-201 disrupts chloride ion homeostasis, decreases the expression of key proteins such as GM130 and GRASP55, and alters Golgi structure and function. This process induces Golgi apparatus autophagy, triggers apoptosis in cancer cells, and causes cell cycle arrest at the G2/M phase, thereby exhibiting anticancer activity. Antitumor agent-201 is applicable for research in the field of cancer-related diseases.Couleur et forme :Odour SolidCXCR4-IN-2
CXCR4-IN-2 (compound A1), a potent bifunctional fluorinated small molecule, inhibits CXCR4 and exhibits anticancer properties by exerting cytotoxicity (IC 50:Formule :C21H20F6N4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.47PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withCouleur et forme :Odour SolidRef: TM-L1300
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderCalcimycin hemimagnesium
CAS :Calcimycin hemimagnesium is an antibiotic, ionophore, and ATPase inhibitor that boosts intracellular Ca2+, causing cell death and apoptosis.Formule :C58H72MgN6O12Couleur et forme :SolidMasse moléculaire :1069.53Vorsetuzumab
CAS :Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a monoclonal antibody targeting the CD70 antibody.Degré de pureté :SDS-PAGE:95% SEC-HPLC:99.29%Couleur et forme :LiquidMasse moléculaire :146.1 kDaEmavusertib hydrochloride
CAS :Emavusertib (CA-4948) hydrochloride, a selective and potent IRAK4/FLT3 inhibitor, is designed for oral administration. It achieves an IC 50 of 57 nM against IRAK4 in a FRET kinase assay and demonstrates anti-tumor activity [1] [2] [3].Formule :C24H26ClN7O5Couleur et forme :SolidMasse moléculaire :527.96anti-TNBC agent-8
Anti-TNBC agent-8 (Compound TP2) is a photodynamic therapeutic compound that targets mitochondrial DNA G-quadruplexes (mtG4). Under white light exposure, it exhibits an IC50 of 0.42 μM against 4T1 cells. Anti-TNBC agent-8 tightly binds to mtG4, leading to the production of substantial reactive oxygen species (ROS) under illumination. This results in the loss of mitochondrial membrane potential (MMP), reduced ATP production, elevated ROS levels, and significant apoptosis in triple-negative breast cancer (TNBC) cells, thus demonstrating its tumor growth inhibitory activity. Anti-TNBC agent-8 is applicable for research in TNBC.Couleur et forme :Odour SolidEM 163
CAS :EM 163是一种 TIR-TIR 相互作用抑制剂，它是MyD88蛋白的TIR（Toll/白细胞介素-1受体）结构域拟态。EM 163针对IL-1受体中的TIR 结构域，阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B（SEB）引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中，EM 163阻断p38的激活和IL-1β对化学诱导的长期电位（LTP）引发的蛋白质合成的抑制作用。Formule :C44H60IN5O4Degré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :849.88Ref: TM-T41142
1mg114,00€5mg264,00€10mg354,00€1mL*10mM (DMSO)414,00€25mg592,00€50mg843,00€100mg1.144,00€500mg2.295,00€Annonacin
CAS :Annonacin is a cytotoxic acetogenin in Graviola leaf extract; it blocks mitochondrial complex and inhibits NKA/SERCA ATPase pumps.Formule :C35H64O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :596.88APG-1387
CAS :APG-1387 inhibits IAPs, degrades cIAP1/2, XIAP, boosts chemosensitivity, and induces apoptosis in NPC.Formule :C60H72N10O10S2Couleur et forme :SolidMasse moléculaire :1157.41Citreoviridin
CAS :Citreoviridin from Penicillium citreoviride blocks brain Na+/K+-ATPase; boosts Na+/K+- and Mg2+-ATPase in microsomes dose-dependently.Formule :C23H30O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.48NSC90616
NSC90616 is a mutant p53 rescue compound [1] .Formule :C23H30FNa2O9PCouleur et forme :SolidMasse moléculaire :546.43
