Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
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6223 produits trouvés pour "Apoptose"
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TopoII/tubulin-IN-1
TopoII/tubulin-IN-1 (Compound 1B8) is an inhibitor of TopoII/tubulin. It effectively suppresses the proliferation of tumor cells and reduces ROS levels, while inducing apoptosis and cell cycle arrest, without showing significant cytotoxicity to normal cells. TopoII/tubulin-IN-1 exhibits antitumor activity.Formule :C21H18ClN5O3Couleur et forme :SolidMasse moléculaire :423.85BRD9 ligand-5
CAS :BRD9 Ligand-5 (Compound 172-11) serves as a ligand for the target protein in PROTAC applications. It is utilized in the synthesis of CFT8634.Formule :C17H19NO4Couleur et forme :SolidMasse moléculaire :301.34TNF-α/IL-1β-IN-1
TNF-α/IL-1β-IN-1 (compound 11a) is an anti-inflammatory agent that effectively reduces the expression of TNF-α and IL-1β, inhibits oxidative stress and myocardial cell apoptosis, and demonstrates significant activity against septic myocardial injury. Additionally, it improves myocardial blood flow in vivo.Formule :C41H58N2O7Couleur et forme :SolidMasse moléculaire :690.91Thalidomide-O-amido-PEG3-C2-NH2
CAS :Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linker for PROTACs with a 3-unit PEG.Formule :C23H30N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.51EGFR-IN-169
EGFR-IN-169 is an epidermal growth factor receptor (EGFR) inhibitor derived from ginsenoside, with an IC50 of 5.19 μM. It disrupts colorectal cancer cell migration and growth by inhibiting the EGFR-mediated RalA/EMT pathway. With an IC50 of 4.46 μM against HCT-116 cells and a selectivity index (SI) of 16.92, EGFR-IN-169 also inhibits CDKs, induces G0/G1 cell cycle arrest, and suppresses cell migration and invasion. Additionally, EGFR-IN-169 reduces mitochondrial membrane potential, induces apoptosis and reactive oxygen species (ROS) production. It is applicable in cancer research, particularly for colorectal cancer.Couleur et forme :Odour SolidAnticancer agent 267
Anticanceragent 267 (Compound 5q) serves as an activator of RIPK3 and MLKL. It effectively inhibits the proliferation of several cancer cell lines, with IC50 values of 9.79, 10.77, and 5.94 μM for MDA-MB-231, MDA-MB-486, and MCF-7, respectively. The compound induces cell cycle arrest at the subG1 phase and triggers necroptosis in MDA-MB-231 cells. Additionally, Anticanceragent 267 demonstrates antitumor activity in mouse xenograft models.Formule :C13H11N5O4SCouleur et forme :SolidMasse moléculaire :333.329(E),11(E),13(E)-Octadecatrienoic Acid
CAS :β-ESA, a polyunsaturated fatty acid in seed oils, inhibits Caco-2 cell growth dose- and time-dependently.Formule :C18H30O2Couleur et forme :SolidMasse moléculaire :278.436ERK1/2 inhibitor 13
ERK1/2 inhibitor 13 (Compound 21y) is an orally bioavailable ERK inhibitor that targets ERK1 and ERK2, with IC50 values of 91.71 nM and 97.87 nM, respectively. It effectively suppresses the proliferation of cancer cell lines MCF-7, 4T1, MDA-MB-468, and HCC1970 with IC50 values of 0.67 μM, 2.76 μM, 2.15 μM, and 1.68 μM, respectively. Additionally, it inhibits cancer cell migration, induces apoptosis and autophagy in MCF-7 cells, and demonstrates anti-tumor and anti-metastatic effects in a 4T1 xenograft mouse model.Formule :C36H29BrF6N4OCouleur et forme :SolidMasse moléculaire :727.54β-Amyloid (1-40) (rat)
CAS :Rat form of the beta-Amyloid (1-40) peptideFormule :C190H291N51O57SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :4233.76YTHDF2-IN-1
YTHDF2-IN-1 (Compound CK-75) is an inhibitor of YT521-B homology domain family 2 (YTHDF2) with a dissociation constant (Kd) of 26.2 μM, and it effectively blocks the interaction between YTHDF2 and m6A RNA. It suppresses colony formation in JAR cells and exhibits antiproliferative activity in various cancer cell lines, with an IC50 in the micromolar range. Additionally, YTHDF2-IN-1 induces apoptosis in K562 cells and causes cell cycle arrest at the G0/G1 phase.Formule :C21H14N2O4Couleur et forme :SolidMasse moléculaire :358.35ZZM-1220
ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP.Formule :C25H29N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :447.53Fuscin
CAS :Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).Formule :C15H16O5Couleur et forme :SolidMasse moléculaire :276.288Cardanol (C15:1)
CAS :Cardanol (C15:1), found in cashew nut shell liquid, induces mitochondria-associated apoptosis in human melanoma cells.Formule :C21H34ODegré de pureté :98.48% - 99.77%Couleur et forme :SolidMasse moléculaire :302.49Ref: TM-TN3594
100mgÀ demander1mg92,00€2mg135,00€5mg259,00€1mL*10mM (DMSO)268,00€10mg371,00€25mg583,00€50mg800,00€KWCN-41
CAS :KWCN-41, Selective RIPK1 inhibitor (IC50=88 nM), inhibits necrosis specifically, anti-inflammatory effects.Formule :C18H17N3O2Couleur et forme :SolidMasse moléculaire :307.35VEGFR-2-IN-68
VEGFR-2-IN-68 (13b) is an inhibitor of VEGFR-2 with an IC50 value of 41.51 nM. It can induce apoptosis and cause G2/M cell cycle arrest, as well as exhibit anti-cancer metastasis properties.Formule :C27H25N5O2SCouleur et forme :SolidMasse moléculaire :483.1729AZD5153
CAS :AZD5153 is an orally active and selective BET/BRD4 bromodomain inhibitor with an IC50 value of 1.7nM for BRD4.Formule :C25H33N7O3Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :479.57HMGB1-IN-1
HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/Formule :C57H75N3O15Couleur et forme :SolidMasse moléculaire :1042.22Thalidomide-O-PEG4-NHS ester
CAS :Thalidomide-O-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker, commonly employed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].Formule :C28H33N3O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :619.57Antiangiogenic agent 6
Antiangiogenic agent 6 (Pt-1) effectively inhibits angiogenesis and induces necroptosis in tumor cells.Formule :C37H24F6N3PPtCouleur et forme :SolidMasse moléculaire :850.66GPI-1485
CAS :GPI-1485 (GM1485) (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.Formule :C12H19NO4Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :241.28Ref: TM-T9820
1mg58,00€5mg126,00€1mL*10mM (DMSO)141,00€10mg178,00€25mg340,00€50mg505,00€100mg715,00€200mg1.054,00€TNF-α (46-65), human
CAS :Human TNF alpha (46-65) peptide.Formule :C110H172N24O30Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2310.69PROTAC-O4I2
CAS :PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM.Formule :C29H29ClN6O5SDegré de pureté :97.45%Couleur et forme :SolidMasse moléculaire :609.1Ref: TM-T74186
1mg56,00€5mg119,00€1mL*10mM (DMSO)133,00€10mg178,00€25mg409,00€50mg710,00€100mg1.153,00€500mg2.322,00€A-1155905
CAS :A-1155905 is an MCL-1 inhibitor with anticancer activity, demonstrating a half maximal inhibitory concentration (IC50) of 33.5 Nm and a dissociation constant (Ki) of 0.58 nM. This compound selectively binds to MCL-1 and possesses sufficient affinity to disrupt the MCL-1-Bim complex in live cells. The induction of death in MCL-1-dependent cell lines by A-1155905 is reliant on caspase proteins and occurs through apoptosis.Formule :C46H51FN6O6Couleur et forme :SolidMasse moléculaire :802.93BIO8898
BIO8898: potent CD40-CD154 inhibitor, IC50 of 25 µM, prevents CD40L-induced apoptosis.Formule :C53H64N8O6Couleur et forme :SolidMasse moléculaire :909.13Asudemotide
CAS :Asudemotide is a bioactive chemical.Formule :C58H80N10O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1189.31JAK05
JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.Formule :C27H27ClN4O9SCouleur et forme :SolidMasse moléculaire :619.043Thevetiaflavone
CAS :Thevetiaflavone, a natural flavonoid from W. indica, blocks LDH leakage, boosting cell survival.Formule :C16H12O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :284.26NL13
NL13, a Polo-like kinase 4 (PLK4) inhibitor, exhibits an IC 50 value of 2.32 μM. It demonstrates the ability to suppress the viability of PC3 and DU145 prostate cancer cells with respective IC 50 values of 3.51 μM and 2.53 μM. NL13 also inhibits tumor growth in prostate cancer mice. Additionally, it deactivates the AKT signaling pathway by reducing CCNB1/CDK1 levels, leading to G2/M cell cycle arrest and initiating apoptosis through caspase-9/caspase-3 cleavage.Formule :C22H19Cl2NO2Couleur et forme :SolidMasse moléculaire :400.3Jacaric Acid
CAS :Conjugated 18-C ω-6 fatty acid from Jacaranda seeds, induces cancer cell apoptosis via oxidative stress; metabolizes to cytotoxic CLA.Formule :C18H30O2Couleur et forme :SolidMasse moléculaire :278.4366-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
CAS :6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to studyFormule :C9H6BrN3ODegré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :252.07PERK-IN-4
CAS :PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Formule :C24H19F4N5ODegré de pureté :99.44% - 99.49%Couleur et forme :SolidMasse moléculaire :469.43GSK-3β inhibitor 15
GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-Formule :C17H16N6OSCouleur et forme :SolidMasse moléculaire :352.41Pim-1 kinase inhibitor 4
Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity andFormule :C19H12ClN3ODegré de pureté :97.37%Couleur et forme :SolidMasse moléculaire :333.77Ref: TM-T77526
1mg109,00€2mg160,00€5mg261,00€10mg374,00€25mg583,00€50mg803,00€100mg1.063,00€200mg1.431,00€(D)-PPA 1 TFA
(D)-PPA 1 TFA is a hydrolysis-resistant D-peptide antagonist and a potent PD-1/PD-L1 inhibitor, exhibiting an affinity for PD-1 of 0.51 μM and demonstratingFormule :C72H99F3N20O23Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1669.67HPOB
CAS :HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.Formule :C17H18N2O4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :314.34SF1126
CAS :SF1126 is a first-in-class PI3K/BRD4 inhibitor and RGDS-conjugated LY294002 prodrug, enhancing solubility and targeting tumor integrins.Formule :C39H48N8O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :852.84PK095
CAS :PK095 is a proprietary compound in the guanidine - based F1F0-ATPase inhibitor family.
Formule :C20H18N4O2SDegré de pureté :96.84%Couleur et forme :SoildMasse moléculaire :378.45Nrf2 activator-11
Nrf2 activator-11 (compound M11) is a Nrf2 activator that possesses blood-brain barrier permeability and offers anti-oxidation, anti-inflammation, anti-ferroptosis, and anti-apoptosis properties. It is applicable for use in studying cerebral ischemia-reperfusion (CI/R) injury models.Formule :C20H23N3O2Couleur et forme :SolidMasse moléculaire :337.42CTP-347
CAS :CTP-347, a deuterated version of paroxetine, is potentially the best non-hormonal drug in its class for the treatment of hot flashes.Formule :C19H20FNO3Couleur et forme :SolidMasse moléculaire :331.38DRI-C21041 (DIEA)
DRI-C21041 DIEA serves as an inhibitor of CD40/CD40L interaction, exhibiting an inhibitory concentration (IC50) of 0.31 μM.Formule :C38H40N4O7SCouleur et forme :SolidMasse moléculaire :696.81DHFR-IN-23
DHFR-IN-23 (compound 5) is a dual inhibitor of DNA binders/DHFR, exhibiting an IC50 value of 0.08 μM against hDHFR. It serves as an apoptosis inducer and is applicable in research on ER+ breast cancer.Couleur et forme :Odour Solidc-Met-IN-24
c-Met-IN-24 (compound 3g) serves as a dual-target inhibitor for STAT-3 (=4.7 μM) and c-MET (=12.67 μM), exhibiting anticancer properties. It arrests the G2/M cell cycle and induces apoptosis in SNB-75 cells, making it applicable in the research of central nervous system cancers.Formule :C20H15ClN4O4SCouleur et forme :SolidMasse moléculaire :442.88Ecdysone
CAS :Ecdysone is a major steroid hormone in insects and herbs.Formule :C27H44O6Degré de pureté :99.22%Couleur et forme :PowderMasse moléculaire :464.63Voreloxin
CAS :Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.Formule :C18H19N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.44Glutathione arsenoxide hydrochloride
Glutathione arsenoxide hydrochloride: anti-cancer, inhibits tumour metabolism, targets ANT, promotes apoptosis, marks cell proteins.Formule :C18H26AsClN4O9SDegré de pureté :99.74%Couleur et forme :SoildMasse moléculaire :584.86HDAC-IN-57
CAS :HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4Formule :C21H19N3O4Degré de pureté :98.62%Couleur et forme :SoildMasse moléculaire :377.39Mcl-1 inhibitor 14
Compound (Ra)-10, also known as Mcl-1 inhibitor 14, is a potent inhibitor of myeloid cell leukemia-1 (MCL-1), exhibiting a K_i of 0.018 nM, and holds potentialFormule :C39H41ClFN5O5SCouleur et forme :SolidMasse moléculaire :746.29Placulumab
CAS :Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.Couleur et forme :LiquidHematein
CAS :Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).Formule :C16H12O6Degré de pureté :98%Couleur et forme :Dark Brown Crystalline PowderMasse moléculaire :300.26PROTAC Bcl-xL degrader-3
CAS :PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader.Formule :C82H105ClF3N11O11S4Couleur et forme :SolidMasse moléculaire :1641.49
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