Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6223 produits trouvés pour "Apoptose"
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β-Glucuronide-dPBD-PEG5-NH2 TFA
CAS :β-Glucuronide-dPBD-PEG5-NH2 TFA is a β-glucuronide-linked pyrrolobenzodiazepine dimer employed in the synthesis of the antibody-drug conjugate (ADC) cIRCR201-Formule :C80H102F3N7O37Couleur et forme :SolidMasse moléculaire :1810.69Z-Asp-CH2-DCB
CAS :Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.Formule :C20H17Cl2NO7Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :454.26FA4-Cu
FA4-Cu is a compound formed from the effective pancreatic cancer inhibitor FA4 and Cu(II), which can induce apoptosis by triggering ER and mitochondrial stress.Formule :C27H33Cl2CuN5O2SCouleur et forme :SolidMasse moléculaire :626.12,2'-Dihydroxy chalcone
CAS :2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.Formule :C15H12O3Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :240.25PROTAC GPX4 degrader-1
CAS :PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080Formule :C50H57ClN10O10Couleur et forme :SolidMasse moléculaire :993.5Thalidomide-O-C6-NH2
CAS :Thalidomide-O-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1].Formule :C19H23N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :373.4HDAC6-IN-22
HDAC6-IN-22 (compound 30), an HDAC6 inhibitor, exhibits an IC50 of 4.63 nM and demonstrates antiproliferative effects against multiple myeloma both in vitro andFormule :C24H24N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.47PROTAC Bcl-xL degrader-2
PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.Formule :C68H80N8O14S3Couleur et forme :SolidMasse moléculaire :1329.6RMC-6291
CAS :RMC-6291: Oral, covalent KRAS G12C inhibitor, blocks signaling, forms tri-complex with CypA, suppresses RAS activity in tumors.Formule :C55H78FN9O8Degré de pureté :98.73% - 99.92%Couleur et forme :SolidMasse moléculaire :1012.26Disitertide
CAS :Disitertide (P144) is an inhibitor of TGF-β1.Formule :C68H109N17O22S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1580.84Pimagedine
CAS :Pimagedine is a prototype therapeutic agent for the prevention of formation of advanced glycation endproducts.Formule :CH6N4Couleur et forme :SolidMasse moléculaire :74.09PRMT5-IN-31
PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 andFormule :C21H24N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.43S65487 hydrochloride
CAS :S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y.Formule :C41H42Cl2N6O4Couleur et forme :SolidMasse moléculaire :753.73Enterodiol
Enterodiol is a natural product that can be used as a reference standard.Formule :C18H22O4Couleur et forme :SolidMasse moléculaire :302.37Thalidomide-NH-C6-NH2 TFA
CAS :Thalidomide-based cereblon ligand linked to PROTAC technology as E3 ligase ligand-linker.Formule :C21H25F3N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.44PROTAC KDM4 degrader-1
PROTACKDM4 degrader-1 (Compound 11) is a proteolysis-targeting chimera (PROTAC) degrader specifically designed for KDM4. It effectively degrades KDM4A-C while sparing KDM4D. In esophageal cancer cells, PROTACKDM4 degrader-1 demonstrates strong antiproliferative activity, inducing apoptosis and cell cycle arrest, and inhibits lysine demethylation of histone H3.Couleur et forme :Odour SolidRIPK2/3-IN-1
RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3.Formule :C24H16N4O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :456.54CS4
CS4 is a selective HDAC inhibitor, with IC50 values for HDAC1, HDAC6, HDAC8, HDAC4, and HDAC11 reported as 38 nM, 12 nM, 5.8 μM, 19 μM, and 61 μM, respectively. It enhances the acetylation of α-tubulin and histone 3 (histone 3). Additionally, CS4 activates PPARγ and blocks glycolysis (glycolysis). It induces cell cycle arrest at the G2 phase and triggers apoptosis (apoptosis), exhibiting anticancer effects both in vitro and in vivo.Couleur et forme :Odour SolidAc-DNLD-CHO
CAS :Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is an inhibitor of Caspase-3/7, exhibiting IC50 values of 9.89 nM and 245 nM, and approximate Ki values of 0.68 nM and 55.7Formule :C20H31N5O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :501.49YN14-H
YN14-H is a PROTAC degrader that targets KRASG12C. It effectively inhibits the growth of NCI-H358 and MIA PaCa-2 cells, with IC50 values of 0.042 μM and 0.021 μM, respectively, and DC50 values of 28.9 nM and 18.1 nM. YN14-H significantly induces apoptosis and suppresses cell migration. It demonstrates favorable pharmacokinetics and excellent in vivo antitumor activity.Couleur et forme :Odour SolidAlbanol B
CAS :Albanol B, from mulberries, combats Alzheimer's, bacteria, and oxidation, hinders cancer growth, and triggers cell arrest and apoptosis.Formule :C34H22O8Couleur et forme :SolidMasse moléculaire :558.53dTAG-47
CAS :dTAG-47 targets FKBP12 F36V for protein degradation, useful in basal-like breast cancer research.Formule :C59H73N5O14Couleur et forme :SolidMasse moléculaire :1076.24BMf-BH3
BMf-BH3 is a Bcl-2 family peptide, key in HDAC inhibition affecting acetylation balance.Formule :C131H214N45O35SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :3012.5ZS3-046
ZS3-046 is a TAF1 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of TAF1. It can activate p53 and induce apoptosis in acute myeloid leukemia (AML) cells. Additionally, ZS3-046 demonstrates anti-tumor efficacy in AML xenograft mouse models.Formule :C49H57N9O7Couleur et forme :SolidMasse moléculaire :883.4381Thalidomide-NH-C5-NH2 hydrochloride
CAS :Functionalized cereblon ligand with E3 ligase and alkylC5 linker for PROTAC R&D; ready for protein conjugation. Formerly Pomalidomide-linker 4.Formule :C18H23ClN4O4Couleur et forme :SolidMasse moléculaire :394.85YT117R
YT117R is a PROTAC that targets degradation of FKBP12 and BRD4.Formule :C50H52ClN9O7SCouleur et forme :SolidMasse moléculaire :958.52FB49
FB49 is a selective Bcl-2-associated athanogene 3 (BAG3) inhibitor with a Ki of 45 μM.Formule :C17H18N2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.4YL-5092
CAS :YL-5092, YTHDC1 inhibitor (IC50=7.4 nM), induces G0/G1 arrest and apoptosis, used for acute myeloid leukemia (AML).Formule :C22H14F3N3O2SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :441.43Ref: TM-T200229
1mgÀ demander5mgÀ demander25mgÀ demander100mgÀ demander1mL*10mM (DMSO)À demander10mg289,00€50mg888,00€Anticancer agent 154
Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causing mitochondrial damage, and promotes cell apoptosis and DNA damage.Formule :C22H23N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45PD-1/PD-L1-IN-51
PD-1/PD-L1-IN-51 (Compound III-4) is an inhibitor of PD-1/PD-L1 (IC50: hPD-L1 at 2.9 nM). It binds directly to PD-L1, blocking the interaction between PD-1 and PD-L1, and enhancing the release of IFN-γ. Additionally, PD-1/PD-L1-IN-51 exhibits antitumor activity.Couleur et forme :Odour SolidZYH-23
ZYH-23 is a potent inhibitor of necroptosis. It targets HSP90 to inhibit the phosphorylation of RIPK1, RIPK3, and MLKL, effectively blocking programmed cell necrosis.Formule :C41H50N4O3Couleur et forme :SolidMasse moléculaire :646.38829PD-1/PD-L1-IN-52
PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.Couleur et forme :Odour SolidCOG-1410 acetate
COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases.Formule :C66H125N21O16Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :1468.83Mas7
CAS :Amphiphilic peptide Mas7, a structural analogue of mastoparan is a known activator of heterotrimeric Gi-proteins and its downstream effectors.Formule :C67H124N18O15Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1421.81PROTAC SMARCA2/4 degrader-38
PROTACSMARCA2/4 degrader-38 is a SMARCA2/4 PROTAC degrader with DC50 values of 3.0 nM and 4.0 nM, respectively. It facilitates the ubiquitination and degradation of SMARCA2/4 and can block the G0/G1 phase of the cell cycle, leading to the induction of apoptosis. PROTACSMARCA2/4 degrader-38 is applicable in acute myeloid leukemia (AML) research.Couleur et forme :Odour SolidAc-AAVALLPAVLLALLAP-LEHD-CHO
CAS :Ac-AAVALLPAVLLALLAP-LEHD-CHO is a caspase inhibitor targeting caspases 4, 5, and 9, demonstrating protective effects in MCF-7 cells treated withFormule :C97H162N22O25Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2036.46EPZ020411 hydrochloride
CAS :EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.Formule :C25H39ClN4O3Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :479.05Ref: TM-T22325
1mg57,00€5mg124,00€1mL*10mM (DMSO)138,00€10mg203,00€25mg350,00€50mg533,00€100mg763,00€Lisaftoclax
CAS :Lisaftoclax, an oral Bcl-2/Bcl-xl inhibitor (IC50: 2 nM & 5.9 nM), treats CLL by promoting leukemia cell death.Formule :C45H48ClN7O8SDegré de pureté :97.14% - 99.66%Couleur et forme :SolidMasse moléculaire :882.42Ref: TM-T10483
1mg177,00€5mg394,00€1mL*10mM (DMSO)558,00€10mg565,00€25mg837,00€50mg1.121,00€100mg1.520,00€PROTAC HDAC6 degrader 1
CAS :Compound A6, a potent PROTAC HDAC6 degrader, has a DC50 of 3.5 nM and induces apoptosis in myeloid leukemia cells.Formule :C37H46N6O10Couleur et forme :SolidMasse moléculaire :734.8Thalidomide-NH-C6-NH2
CAS :Thalidomide-NH-C6-NH2 is a synthetic conjugate compound designed as an E3 ligase ligand-linker.Formule :C19H24N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.42(±)-Indoxacarb
CAS :(±)-Indoxacarb is a pyrazoline insecticide with insecticidal activity and cytotoxicity, blocks sodium channels in insect neurons, and can induce apoptosis.
Formule :C22H17ClF3N3O7Couleur et forme :SolidMasse moléculaire :527.83NC-R17
NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-Formule :C53H67N7O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :914.14PMT-O9-1A
PMT-O9-1A is an effective PD-L1 degrader that reduces PD-L1 protein expression and exhibits cytotoxic properties. Additionally, PMT-O9-1A possesses anticancer activity.Formule :C22H25ClN2O4Couleur et forme :SolidMasse moléculaire :416.90MET/PDGFRA-IN-2
MET/PDGFRA-IN-2 (compound 8h) serves as an inhibitor of MET and PDGFRA proteins, promoting apoptosis in cells and impeding the proliferation of MET-positiveFormule :C29H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :491.59RIPK1-IN-27
RIPK1-IN-27 (compound 19) is an inhibitor of RIPK1.Formule :C27H28N4O3Couleur et forme :SolidMasse moléculaire :456.54Fluoxetine-Conjugated Platinum(IV) prodrug-1
Fluoxetine-Conjugated Platinum(IV) prodrug-1 is an eEF2K inhibitor that can hinder the proliferation of cancer cells, induce DNA damage, and cause cell cycle arrest at the S phase, leading to apoptosis (Apoptosis). It also promotes the accumulation of reactive oxygen species (ROS) and disrupts mitochondrial function. This prodrug inhibits the migration and invasion of TNBC cells by suppressing MMP-2 activity and induces autophagy in TNBC cells through AMPK activation. In the 4T1-Luc mouse model, it exhibits antitumor activity and triggers immune suppression. Fluoxetine-Conjugated Platinum(IV) prodrug-1 is relevant for research in triple-negative breast cancer (TNBC).Formule :C21H28Cl2F3N3O5PtCouleur et forme :SolidMasse moléculaire :724.1006CIB-1476
CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.Formule :C28H28N2O6SCouleur et forme :SolidMasse moléculaire :520.6PD-1/PD-L1-IN-50
Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.Couleur et forme :Odour SolidLTB
LTB is a prodrug formed through the conjugation of the glycolysis inhibitor (Lonidamine) and the PD1/PDL1 blocker (BMS-1) via a thioketal bond. LTB can encapsulate the photosensitizer Chlorin e6 (Ce6), constructing a co-delivery photodynamic nanoplatfform through self-assembly (LTB-6 NPs).Formule :C53H59Cl2N3O7S2Couleur et forme :SolidMasse moléculaire :985.09
