Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
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6222 produits trouvés pour "Apoptose"
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SB 699551
CAS :SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.Formule :C34H45N3ODegré de pureté :99.83%Couleur et forme :SoildMasse moléculaire :511.74Ref: TM-T23325L
1mg190,00€5mg471,00€10mg662,00€25mg1.036,00€50mg1.429,00€100mg1.821,00€200mg2.489,00€Lw13
Lw13 is a PROTAC targeting Hsp90, exhibiting maximal degradation efficacy at a concentration of 0.05 μM in Siha cells. Lw13 induces apoptosis and demonstrates potent antitumor activity both in vitro and in vivo.Formule :C46H55F3N8O8Masse moléculaire :904.4095Thalidomide-NH-amido-C6-NH2 hydrochloride
Thalidomide-NH-amido-C6-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that includes a thalidomide-based cereblon ligand and a linker, designed for the synthesis of PROTAC.Formule :C21H28ClN5O5Masse moléculaire :465.1779EGFR-IN-107
EGFR-IN-107 (compound 3r) is an orally active EGFR inhibitor with IC50 values of 0.4333 μM for EGFRWT and 0.0438 μM for EGFRL858R/T790M. It exhibits antiproliferative activity, effectively inhibiting the proliferation of H1975 cells and inducing apoptosis (apoptosis). EGFR-IN-107 is applicable in cancer research.Formule :C34H36FN7O2Masse moléculaire :593.29145RIPK2-IN-4
RIPK2-IN-4 is a potent and specific inhibitor of RIPK2 with an IC50 value of 5 nM.Formule :C16H10N6S2Masse moléculaire :350.04084PRDX1-IN-2
PRDX1-IN-2 (compound 15) is a selective inhibitor of the antioxidant enzyme Peroxiredoxin 1 (PRDX1) with an IC50 of 0.35 μM. It reduces mitochondrial membrane potential in SW620 cells, potentially due to increased ROS resulting from PRDX1 inhibition, leading to apoptosis. PRDX1-IN-2 is applicable in colorectal cancer research.Necrosis inhibitor 2 (hydrocholide)
Necrosis inhibitor 2 hydrochloride (Compound B19) is an agent that inhibits cellular necrosis. It is useful for researching diseases associated with necrotic pathways, including inflammation, cancer, metabolic disorders, and neurodegenerative diseases.Formule :C24H26ClN5O5Masse moléculaire :499.16225Thalidomide-NH-C4-NH2 TFA
CAS :Compound 29c, a Thalidomide-linker conjugate for potent PROTAC BRD2/BRD4 degrader-1, targets BET proteins.Formule :C19H21F3N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.39AZD5582 TFA
AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFAFormule :C60H79F3N8O10Degré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :1129.31Ref: TM-T36201L
1mg55,00€5mg96,00€1mL*10mM (DMSO)144,00€10mg149,00€25mg259,00€50mg442,00€100mg647,00€Anticancer agent 204
Anticanceragent 204 (Compound 6) is a fluorinated derivative of cinnamamides with anticancer activity. It can arrest the cell cycle of HepG2 cells in the G1 phase and induces apoptosis by reducing mitochondrial membrane polarization (MMP) levels.Formule :C26H18FN5O3SMasse moléculaire :499.11144Furazolidone
CAS :Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Formule :C8H7N3O5Degré de pureté :99.96%Couleur et forme :Yellow Crystals From Dmf (N N-Dimethylformamide) SolidMasse moléculaire :225.16LZFPN-90
LZFPN-90 (LZ90) is a dual-target compound aimed at NAMPT and PD-L1. It inhibits the interaction between PD-1/PD-L1 and NAMPT activity. LZFPN-90 suppresses cell growth in a NAMPT-dependent manner, blocking the cell cycle and subsequently inducing apoptosis. Additionally, LZFPN-90 exhibits target-dependent antitumor activity, impacting metabolic processes and the immune system.Formule :C33H36N8O2SMasse moléculaire :608.26819Oligomycin B
CAS :Oligomycin B is an antibiotic isolated from marine Streptomyces, is an eukaryotic ATP synthase inhibitor, induces apoptosis.Formule :C45H72O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :805.05Thymidine 3',5'-disphosphate
CAS :pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.Formule :C10H16N2O11P2Couleur et forme :SolidMasse moléculaire :402.19PROTAC GPX4 degrader-2
PROTACGPX4 degrader-2 (compound 18a) is a proteolysis-targeting chimera (PROTAC) that targets the degradation of glutathione peroxidase 4 (GPX4), with a DC50, 48h value of 1.68 μM. It induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. Additionally, PROTACGPX4 degrader-2 exhibits antiproliferative activity.Formule :C50H61ClN8O9Masse moléculaire :952.425WEE1-IN-7
WEE1-IN-7 (compound 12h) is a potent, orally active WEE1 inhibitor with an IC50 value of 2.1 nM. This compound induces apoptosis and causes cell cycle arrest in the S phase, demonstrating antitumor activity.TS-24
CAS :TS-24 is a cysteine protease histone S (CTSS) inhibitor that promotes BRCA1-mediated apoptosis.
Formule :C20H15NO2Degré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :301.34Topoisomerase II inhibitor 17
TopoisomeraseII inhibitor 17 (compound 4c) is a thiazolopyrimidine-based inhibitor of Topoisomerase II with an IC50 of 0.23 μM. This compound significantly disrupts the cell cycle and induces apoptosis.Formule :C25H22Cl3N3O5SMasse moléculaire :581.03458Ru-Poma
Ru-Poma is an Ru(II)-based photosensitizer designed to enhance the efficacy of photodynamic therapy (PDT) against tumors resistant to Cisplatin. It targets Pomalidomide to partially degrade CRBN, inducing ferroptosis by increasing lipid peroxides and downregulating GPX4 and GAPDH expression. In A549 cells, Ru-Poma exhibits cytotoxicity with IC50 values of 18.46 μM in the dark and 0.37 μM under illumination.Formule :C89H75Cl2N11O11Ru·7H2OTubulin polymerization-IN-43
CAS :Tubulin polymerization-IN-43 disrupts microtubules, arrests cell cycle, and induces apoptosis in leukemia by targeting colchicine sites.Formule :C17H13F4N3ODegré de pureté :99.98%Couleur et forme :SoildMasse moléculaire :351.33-Methoxy-9H-Carbazole
CAS :3-methoxy-9H-carbazole: photosensitizer, anti-breast cancer, from Klauseneria spp., induces apoptosis.Formule :C13H11NODegré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :197.23Antimycobacterial agent-5
Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide compound that targets the Mycobacterium electron transport chain (ETC) respiratory CIII2CIV2 supercomplex. It acts on Mycobacterium smegmatis CIII2CIV2 with an IC50 of 441 nM.Formule :C25H34ClN3OMasse moléculaire :427.23904CBI1
CBI1 is a covalent BAX inhibitor. It selectively derivatizes BAX at C126 and inhibits BAX activation by triggering a ligand or through point mutations. CBI1 prevents the lipidation and oligomerization of BAX by t-2-hex. It also inhibits BAX activation induced by BH3 ligands, F116A mutation, or t-2-hex.Formule :C15H19BrN4OS2Masse moléculaire :415.37PD-1/PD-L1-IN-39
PD-1/PD-L1-IN-39 (X 14) is an orally active PD-1/PD-L1 inhibitor with an IC50 value of 15.73 nM. It exhibits strong binding affinity to human and mouse PD-L1, with KD values of 14.62 and 392 nM, respectively. PD-1/PD-L1-IN-39 also demonstrates antitumor activity.Formule :C23H20ClFN2O3Masse moléculaire :426.11465PD-L1-IN-5
PD-L1-IN-5 (X22) is an orally active PD-L1 inhibitor with an IC50 of 785.6 nM, demonstrating antitumor activity in vivo.Endoplasmic Reticulum Stress Compound Library
A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);Couleur et forme :Odour SolidRef: TM-L9700
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderVarlilumab
CAS :Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.Degré de pureté :SDS-PAGE:95% SEC-HPLC:98.65%Couleur et forme :LiquidMasse moléculaire :146 kDaPROTAC GPX4 degrader-4
CAS :PROTACGPX4 degrader-4 is a GPX4 PROTAC degrader with a DC50 of 5.32 nM. It inhibits the activity of cancer cell lines RT4, T24, and J82 with IC50 values of 0.09, 2.97, and 7.58 μM, respectively. This compound elevates lipid ROS levels and induces ferroptosis in T24 and RT4 cells. In T24 tumor-bearing BALB/c nude mouse models, PROTACGPX4 degrader-4 demonstrates antitumor activity. It is applicable to bladder cancer research.Formule :C43H58N2O13Couleur et forme :SolidMasse moléculaire :810.93MS105
CAS :MS105 is an orally active, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. It recruits the VHL E3 ligase through a VHL ligand fragment, facilitating ubiquitination and proteasomal degradation of PTK6, thereby inhibiting the proliferation and migration of breast cancer cells and inducing apoptosis (apoptosis). MS105 is a promising compound for breast cancer research.Formule :C56H70FN13O6SCouleur et forme :SolidMasse moléculaire :1072.30CWI1-2
CAS :CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2.Formule :C22H17Cl3N6O3Degré de pureté :98.27%Couleur et forme :SoildMasse moléculaire :519.77Anti-inflammatory agent 35
CAS :Anti-inflammatory agent 35 is a potent anti-inflammatory agent.Formule :C27H29NO8Degré de pureté :99.98%Couleur et forme :SoildMasse moléculaire :495.52Pantoprazole Sodium Hydrate
CAS :Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagusFormule :C16H14F2N3NaO4SH2ODegré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :432.37Human PD-L1 inhibitor IV
CAS :PD-L1 inhibitor IV, a polypeptide, competitively blocks hPD-1 with a Kd of 1.38 μM, preventing hPD-1/hPD-L1 interaction.Formule :C80H113N25O27Couleur et forme :SolidMasse moléculaire :1856.932d-(KLAKLAK)2, Proapoptotic Peptide
CAS :d-(KLAKLAK)2 is an antimicrobial and antitumor peptide, notable within the group of antimicrobial peptides, and exhibits strong anticancer properties. It kills bacteria by disrupting their cell membranes, causing leakage of cell contents. Additionally, d-(KLAKLAK)2 inhibits tumor cell proliferation by inducing apoptosis through mitochondrial swelling and membrane damage.Formule :C72H139N21O14Couleur et forme :SolidMasse moléculaire :1523.01IDH1/2-IN-1
IDH1/2-IN-1 (Compound 6b) is a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. This compound effectively inhibits tumor growth by suppressing tumor cell proliferation and activating antioxidative enzymes to enhance host defense. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating significant anti-tumor activity. It is also utilized in leukemia research.Couleur et forme :Odour SolidUNC10245380
UNC10245380 is a CIB1 inhibitor with an IC50 of 8 μM. It also inhibits the phosphorylation of AKT and ERK while upregulating the expression of TRAIL-R1/D5. UNC10245380 specifically kills cancer cells that are dependent on CIB1, demonstrating its potential value in the development of CIB1 probes and cancer research.Couleur et forme :Odour SolidAc-FEID-CMK
Ac-FEID-CMK: Potent inhibitor for zebrafish GSDMEb, reduces pyroptosis, and lessens septic AKI.Formule :C27H37ClN4O9Couleur et forme :SolidMasse moléculaire :597.06Necroptosis-IN-3
CAS :Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.Formule :C12H17NOSDegré de pureté :99.85%Couleur et forme :SoildMasse moléculaire :223.33Ac-LEVD-CHO
CAS :Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].Formule :C22H36N4O9Couleur et forme :SolidMasse moléculaire :500.54Human PD-L1 inhibitor III
CAS :Human PD-L1 inhibitor III is a human PD-L1 inhibitor.Formule :C97H155N29O29SCouleur et forme :SolidMasse moléculaire :2223.54Pulchinenoside B
CAS :Compound T2S0062 is a natural product for research related to life sciences. The catalog number is T2S0062 and the CAS number is 135247-95-9.Formule :C59H96O26Couleur et forme :SolidMasse moléculaire :1221.39ISB2001
ISB2001 is a human trispecific antibody targeting CD38, CD3, and BCMA. It is applicable for research on relapsed/refractory multiple myeloma (RRMM). The recommended isotype control is IgG1-kappa-IgG1-Fab.Couleur et forme :Odour LiquidCLEFMA
CAS :CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.Formule :C23H17Cl2NO4Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :442.29Ref: TM-T9582
1mg64,00€5mg131,00€1mL*10mM (DMSO)149,00€10mg188,00€25mg299,00€50mg427,00€100mg575,00€200mg750,00€FAK-IN-25
FAK-IN-25 (4c) is an inhibitor of FAK with an IC50 value of 50.98 nM. It induces apoptosis and causes cell cycle arrest in the G1 phase, making it relevant for cancer research.Formule :C22H13ClN4OS2Couleur et forme :SolidMasse moléculaire :448.95CDK2-IN-45
CDK2-IN-45 is a CDK2 inhibitor with an IC50 value of 0.64 μM. It effectively inhibits the proliferation of DU-145 and PC-3 cell lines, with IC50 values of 2.20 μM and 4.17 μM, respectively. Additionally, CDK2-IN-45 induces G0/G1 phase cell cycle arrest and apoptosis. It is utilized in prostate cancer research.Formule :C25H16ClN5SCouleur et forme :SolidMasse moléculaire :453.95Bcl-B inhibitor 1
CAS :Bcl-B inhibitor 1 is a Bcl-B inhibitor with antitumor activity that binds to and inactivates pro-apoptotic proteins in the BH3 structural domain.Formule :C17H15N3OSDegré de pureté :99.55%Couleur et forme :SoildMasse moléculaire :309.39EGFR/VEGFR2-IN-1
EGFR/VEGFR2-IN-1 (Compound 10e) serves as an inhibitor for VEGFR-2 and EGFR, with respective IC50 values of 0.26 and 0.14 μM. It inhibits microtubule protein polymerization with an IC50 of 40.9 μM and induces cell apoptosis (Apoptosis). EGFR/VEGFR2-IN-1 is applicable in research related to anti-leukemia and anti-lymphoma treatments.Couleur et forme :Odour SolidIRF1-IN-2
CAS :IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.Formule :C18H20N2O4SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :360.43PQ401
CAS :PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Formule :C18H16ClN3O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :341.79VEGFR-2-IN-53
VEGFR-2-IN-53 (Compound 15w) is an inhibitor of VEGFR-2 with an IC50 value of 4.34 μM. It induces cell apoptosis (Apoptosis) and inhibits angiogenesis by blocking VEGFR-2 activity and preventing cell migration. Additionally, it shows an IC50 of 3.87 μM in inhibiting the growth of MCF-7 cells, making it pertinent for research in cancer therapeutics.Couleur et forme :Odour Solid
