Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(134 produits)
- PDK(9 produits)
- PERK(23 produits)
- Sérine/thréonine kinase(17 produits)
- Survivant(14 produits)
- TNF(93 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6222 produits trouvés pour "Apoptose"
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Fisetin quarterhydrate
Fisetin quarterhydrate, a natural flavonol present in numerous fruits and vegetables, exhibits benefits including antioxidant, anticancer, and neuroprotectiveFormule :C15H10O6H2OCouleur et forme :SolidMasse moléculaire :304.0583TNF-α-IN-6
CAS :TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).
Formule :C26H25N9O2Couleur et forme :SolidMasse moléculaire :495.547Calcimycin hemicalcium salt
CAS :Calcimycin (A-23187) is an antibiotic calcium ionophore that raises intracellular Ca2+ to induce cell death.Formule :C58H72CaN6O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1085.322(Rac)-AMXT-1501 4HCl
CAS :AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport.Formule :C32H72Cl4N6O2Degré de pureté :98.31%Couleur et forme :SolidMasse moléculaire :714.77YCH3124
YCH3124 (compound Z33) is an inhibitor of USP7, exhibiting anti-tumor activity with an IC50 value of 41.9 nM. This compound demonstrates substantial in vitro anti-proliferative effects on various tumor cells, including LNCaP (IC50= 3.6 nM) and CHP-212 (IC50=9.9 nM). Moreover, YCH3124 induces apoptosis in CHP-212 cells by disrupting the cell cycle process during the G1 phase.Formule :C30H34N4O5Couleur et forme :SolidMasse moléculaire :530.61HL435
HL435 is a heterobifunctional molecule that degrades BRD4 by linking with JQ1, with DC50 values of 11.9 nM and 21.9 nM in MDA-MB-231 and MCF-7 cells, respectively. It inhibits the proliferation of MDA-MB-231, MCF-7, 22Rv1, and A549 cells, arrests the cell cycle, and induces apoptosis. Additionally, HL435 exhibits antitumor activity in mouse models.Formule :C47H48BrClF3N7O7SMasse moléculaire :1025.21599RIP2 Kinase Inhibitor 4
CAS :RIP2 Kinase Inhibitor 4, a selective RIPK2 PROTAC, degrades RIPK2 (pIC50=8), inhibits TNF-α release.Formule :C50H66F2N14O7SCouleur et forme :SolidMasse moléculaire :1045.23Photosensitizer-5
Photosensitizer-5, a photodynamic agent, exhibits cytotoxicity towards HeLa and HepG2 cells, with IC50 values of 10.4 nM and 6.9 nM, respectively. It induces cell death through lipid peroxidation via an iron-independent ferroptosis pathway. Additionally, Photosensitizer-5 displays antitumor activity in HeLa-tumor-bearing mice.Formule :C35H26BF2IN4O2Couleur et forme :SolidMasse moléculaire :710.32Theophyllol
CAS :Theophyllol (theophylline sodium acetate) can alter calcium levels in subcellular fractions of rat brain cortex.Formule :C9H10N4Na2O4Couleur et forme :SolidMasse moléculaire :284.18Suc-Ala-Leu-Pro-Phe-pNA
CAS :Suc-Ala-Leu-Pro-Phe-pNA (Suc-ALPF-pNA), a substrate for FK-506 binding protein (FKBP) [1], showcases the intricate interactions necessary for specificFormule :C33H42N6O9Couleur et forme :SolidMasse moléculaire :666.72BWA-522
BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL)Formule :C43H51ClN4O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :771.34Estradiol (cypionate)
CAS :Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.Formule :C26H36O3Degré de pureté :99.53% - >99.99%Couleur et forme :White Or Off-White Crystalline PowderMasse moléculaire :396.56Anti-inflammatory agent 95
Anti-inflammatory agent 95 (Compound 2e) is a compound with potent anti-inflammatory properties, showing significant inhibition of NO production in LPS-induced RAW 264.7 mouse macrophages, with an IC50 of 8.8 μM. It also effectively suppresses the secretion of TNF-α and IL-1β, achieving inhibition rates of 60% and greater than 90% at 100 μM, respectively. Anti-inflammatory agent 95 holds promise for research into inflammatory diseases.Formule :C16H21NO4Couleur et forme :SolidMasse moléculaire :291.34dMCL1-2
CAS :dMCL1-2 is a PROTAC-based MCL1 degrader, binding at 30 nM, and induces apoptosis in leukemia.Formule :C61H66N10O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1163.3Fluorene
CAS :Compound PDK0379, with CAS No. 86-73-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0379 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C13H10Masse moléculaire :166.21ILS-920
CAS :ILS-920, a Rapamycin analog, has reduced immunosuppression, enhanced neuroprotection, and preferentially binds FKBP52 and L-type VGCC β1.Formule :C57H86N2O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1023.3Oxythiamine
CAS :Oxythiamine (Hydroxythiamin) is a TK inhibitor that inhibits cancer cell proliferation, induces cell cycle arrest, and induces apoptosis.
Formule :C12H16N3O2SDegré de pureté :96.14% - 99.51%Couleur et forme :SolidMasse moléculaire :266.3422-SLF
22-SLF is a PROTAC degrader that operates by FBXO22-dependent degradation of FK506 Binding Protein 12 (FKBP12) with a DC50 of 0.5 µM. Additionally, 22-SLF can degrade other endogenous proteins, such as BRD4 and the EML4-ALK fusion protein (EML4-ALK fusion protein).Apoptosis inducer 27
Apoptosisinducer 27 (compound 1c) is a potent inhibitor of MDA-MB-231 breast cancer cells, demonstrating an IC50 of 12.8 μM and inducing early apoptosis in these cells. Additionally, it can bind to DNA molecules as well as Bax and Bcl-2 proteins, thereby inducing DNA damage.Formule :C29H37BrN2Couleur et forme :SolidMasse moléculaire :493.52Thyrotropin
CAS :Thyrotropin (TSH), a thyroid-stimulating hormone, is synthesized by thyrotrope cells in the anterior pituitary gland and modulates the endocrine activity of theCouleur et forme :SolidTrehalose-6,6'-dibehenate
CAS :Trehalose-6,6'-dibehenate, a bioactive glycolipid, is applicable for the preparation of vaccine adjuvant [1].Formule :C56H106O13Couleur et forme :SolidMasse moléculaire :987.43Bleomycin A5
CAS :Bleomycin A5, or Pingyangmycin, is an oral glycopeptide antibiotic and acts as an antineoplastic and apoptosis inducer.Formule :C57H89N19O21S2Couleur et forme :SolidMasse moléculaire :1440.56Tubulin polymerization-IN-45
Tubulin polymerization-IN-45, a tubulin-targeting agent, acts as a tubulin polymerization inhibitor by binding to the tubulin's colchicine site.Formule :C20H18N4O3Couleur et forme :SolidMasse moléculaire :362.38Emavusertib Phosphate
CAS :Emavusertib Phosphate (also known as CA-4948) is a potent inhibitor of IRAK4 and FLT3, exhibiting antitumor activity. In ABC DLBCL and AML cell lines, it demonstrates significant cellular efficacy. Furthermore, CA-4948 shows moderate to high selectivity across a panel of 329 kinases and possesses favorable ADME and PK profiles, including good oral bioavailability in mice, rats, and dogs. It achieves over 90% tumor growth inhibition in relevant tumor models and correlates excellently with in vivo PD modulation.Formule :C24H28N7O9PMasse moléculaire :589.49LWY713
LWY713 is a PROTAC-based FLT3 degrader (DC50=0.64 nM) that selectively induces FLT3 degradation through a cereblon and proteasome-dependent mechanism. It inhibits cell proliferation and causes G0/G1 phase arrest and apoptosis (apoptosis) in MV4-11 cells. In MV4-11 xenograft models, LWY713 demonstrates significant in vivo antitumor activity. The E3 ligase ligand and linker consist of Lenalidomide-Glycolic acid, while the target protein ligand's active control is NaproxenGilteritinib.Formule :C43H54N10O8Masse moléculaire :838.41261Boanmycin
CAS :Boanmycin, an antibiotic exhibiting antitumor activity, induces cellular senescence and apoptosis [1] [2] [3].Formule :C60H96N20O21S2Couleur et forme :SolidMasse moléculaire :1497.66Disitertide diammonium
Disitertide (P144) is a TGF-β1 receptor blocker, PI3K inhibitor, and apoptosis inducer.Formule :C68H115N19O22S2Couleur et forme :SolidMasse moléculaire :1614.88PDL1 degrader-2
PD-L1degrader-2 (Compound B3) is an orally effective AUTAC degrader that degrades PD-L1 via the autophagy-lysosome pathway with a DC50 of 0.5 μM. It inhibits the interaction between PD-1 and PD-L1, with an IC50 of 22.8 nM. PD-L1degrader-2 upregulates the expression of Atg9b, Lamp1, and Mitf, activating the autophagy-lysosome system. It exhibits antitumor activity in the CT26 mouse model.Formule :C45H48N8O5Couleur et forme :SolidMasse moléculaire :780.91EP5-1
EP5-1 is an antimicrobial peptide with antibacterial, antifungal, antitumor, and antiviral properties, notably inducing apoptosis in cancer cells andFormule :C16H27N5O8SCouleur et forme :SolidMasse moléculaire :449.48Destruxin B
CAS :Destruxin B: cyclic peptide from Metarhizium fungus, induces apoptosis in lung cancer via mitochondrial pathway.Formule :C30H51N5O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.766UZH1a
CAS :UZH1a: METTL3 inhibitor, IC50 280 nM, used for epitranscriptomic modulation and has antitumor properties.Formule :C32H42N6O3Couleur et forme :SoildMasse moléculaire :558.71Apoptosis inducer 3
CAS :Apoptosis Inducer 3 (Compound 3), a selective apoptosis triggering agent, induces both apoptosis and late-apoptosis phases, demonstrating cytotoxic effectsFormule :C49H55ClN2O7Couleur et forme :SolidMasse moléculaire :819.42FHD-286
CAS :FHD-286 is an inhibitor of BRM/BRG1 ATPase and can be used for studies on the treatment of BAF-related disorders such as acute myeloid leukemia.Formule :C24H30N6O6S2Degré de pureté :99.73%Couleur et forme :SolidMasse moléculaire :562.66Ref: TM-T9749
1mg144,00€5mg283,00€1mL*10mM (DMSO)359,00€10mg454,00€25mg615,00€50mg777,00€100mg1.064,00€PARP1-IN-27
PARP1-IN-27 (Compound 9B) serves as an inhibitor of both PARP1 and PARP2, exhibiting IC 50 values of 2.53 nM and 6.45 nM, respectively, in SUM149PT cells. This compound effectively suppresses the proliferation of BRCA-mutated cancer cell lines such as SUM149PT, HCC1937, and Capan-1, with respective IC 50 values of 0.62, 1.91, and 4.26 μM. Additionally, PARP1-IN-27 exacerbates DNA double-strand breaks, enhances ROS production, causes G2/M phase cell cycle arrest, and triggers apoptosis in SUM149PT cells.Formule :C17H12FNO4Couleur et forme :SolidMasse moléculaire :313.28Emavusertib Tosylate
CAS :Emavusertib Tosylate (also known as CA-4948) is a potent inhibitor of IRAK4/FLT3 with demonstrated antitumor activity. In cell lines such as ABC DLBCL and AML, CA-4948 exhibits strong cellular efficacy. Among 329 evaluated kinases, it shows medium to high selectivity. The compound has excellent oral bioavailability and favorable pharmacokinetic properties in ADME and PK profiles. In preclinical models involving mice, rats, and dogs, CA-4948 demonstrated good oral bioavailability and displayed over 90% tumor growth inhibition in relevant tumor models, correlating well with in vivo pharmacodynamic regulation.Formule :C31H33N7O8SMasse moléculaire :663.712-Deoxyphorbol 13-palmitate
CAS :12-Deoxyphorbol 13-palmitate, a monomer derived from the roots of Euphorbia fischeriana, exhibits notable antitumor activity. This compound induces cell cycle arrest and apoptosis in gastric cancer cells by modulating key cell cycle regulators, such as cyclin B, cyclin A, and CDC2. Additionally, 12-Deoxyphorbol 13-palmitate significantly diminishes liver fibrosis by targeting APOL2 and impairing the APOL2–SERCA2–PERK–HES1 signaling pathway.Formule :C36H58O6Couleur et forme :SolidMasse moléculaire :586.84Minocycline
CAS :Minocycline is a useful organic compound for research related to life sciences. The catalog number is T131626 and the CAS number is 10118-90-8.Formule :C23H27N3O7Couleur et forme :SolidMasse moléculaire :457.48Capsazepine
CAS :Formule :C19H21ClN2O2SDegré de pureté :>98.0%(HPLC)(qNMR)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :376.90PI-103 Hydrochloride
CAS :PI-103 Hydrochloride is a dual PI3K/Akt and mTOR inhibitor exhibiting nM-level inhibition of p110α, p110β, p110δ, p110γ, DNA-PK, mTORC1, and mTORC2.Formule :C19H17ClN4O3Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :384.82(-)-Gallocatechin Gallate
CAS :Formule :C22H18O11Degré de pureté :>95.0%(HPLC)Couleur et forme :White to Light yellow powder to crystalMasse moléculaire :458.38Pancratistatin
CAS :Pancratistatin, an isoquinoline from Hymenocallis littoralis, triggers apoptosis in melanoma and is studied for neuroblastoma, leukemia, and breast cancer.Formule :C14H15NO8Couleur et forme :SolidMasse moléculaire :325.27Edaravone-d5
CAS :Edaravone, a potent free radical scavenger, prevents MMP-9-induced brain bleeds in rats and has a deuterium variant, Edaravone D5.Formule :C10H10N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :179.23Primidone (Standard)
CAS :Primidone (Standard) is the standard substance of Primidone, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Primidone (NCI-C56360) is a potent anticonvulsant agent. It is a neuronal voltage-gated sodium channel blocker and has value in the study of epilepsy, essential tremor, and psychiatric disorders.Formule :C12H14N2O2Couleur et forme :Crystals (Ntp 1992)Masse moléculaire :218.25Methylstat
CAS :Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability.Formule :C28H31N3O6Degré de pureté :98.34% - 98.34%Couleur et forme :SolidMasse moléculaire :505.56LG100268
CAS :LG100268 is a selective, and oral RXR agonist，inducing transcriptional activation in adipocytes; inhibits keratin 17 increases PD-L1 expression.Formule :C24H29NO2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :363.49PI3Kα-IN-9
CAS :PI3Kα-IN-9 is an inhibitor of PI3Kα and PI3Kα with antiproliferative activity, inhibits PI3Kα, PI3Kγ, PI3Kδ, and PI3Kβ, induces apoptosis.Formule :C18H21N7O3Degré de pureté :98.29%Couleur et forme :SolidMasse moléculaire :383.4Barbadin
CAS :Barbadin is an inhibitor of β-arrestin/β2-adaptin interaction.Barbadin enhances the effects of lorcaserin on weight loss and can be used to study obesity.Formule :C19H15N3OSDegré de pureté :98.93% - 99.10%Couleur et forme :SolidMasse moléculaire :333.41Propylparaben sodium
CAS :Propylparaben sodium, a plant-based preservative used in cosmetics, pharma, and food, hinders follicle growth and sperm health.Formule :C10H12NaO3Couleur et forme :SolidMasse moléculaire :203.193Z-Ile-Leu-aldehyde
CAS :Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch.Formule :C20H30N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.46EPZ020411
CAS :EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).Formule :C25H38N4O3Couleur et forme :SolidMasse moléculaire :442.6
