Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(127 produits)
- FOXO1(3 produits)
- IAP(65 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(126 produits)
- PDK(9 produits)
- PERK(24 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(91 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5622 produits trouvés pour "Apoptose"
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Antitumor agent-70
CAS :<p>Antitumor agent-70, a potent c-Kit kinase inhibitor, induces apoptosis with an IC50 of 0.12 μM, showing promise as a cancer therapy.</p>Formule :C21H18N4O2Couleur et forme :SolidMasse moléculaire :358.39HI5
CAS :<p>HI5: potent tubulin/IDO inhibitor, IC50 70 nM (HeLa), blocks kynurenine, G2/M arrest, spurs T cell activity, & triggers apoptosis.</p>Formule :C42H43N5O8Couleur et forme :SolidMasse moléculaire :745.82HS56
CAS :<p>HS56: ATP-competitive Pim/DAPK3 inhibitor, Ki: DAPK3 (0.26μM), Pim-3 (0.208μM), Pim-1 (2.94μM), Pim-2 (>100μM), reduces hypertension in mice.</p>Formule :C13H8ClN5OSCouleur et forme :SolidMasse moléculaire :317.75pan-HER-IN-2
CAS :<p>pan-HER-IN-2 (Compound C6) is an orally active, reversible, broad-spectrum HER inhibitor that acts on EGFR (IC50: 0.72 nM), HER4 (IC50: 2.0 nM), EGFRT790M (IC50</p>Formule :C19H15BrClN5OCouleur et forme :SolidMasse moléculaire :444.71Merck-22-6
CAS :<p>Merck-22-6 is an allosteric dual inhibitor of Akt1, Akt2.</p>Formule :C40H43N7O2Couleur et forme :SolidMasse moléculaire :653.82GL-V9
CAS :<p>GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.</p>Formule :C24H27NO5Couleur et forme :SolidMasse moléculaire :409.47Obatoclax
CAS :<p>Obatoclax (GX15-070), a pan-BCL-2 inhibitor (Ki 220 nM) induces autophagy, degrades cyclin D1, and has anti-cancer/antiparasitic properties.</p>Formule :C20H19N3ODegré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :317.38JS-K
CAS :<p>JS-K is a Nitric oxide donor. It has antiproliferative activity.</p>Formule :C13H16N6O8Couleur et forme :SolidMasse moléculaire :384.3LWG-301
<p>LWG-301, a GLS1 allosteric inhibitor, IC50 7 nM, impedes glutamine metabolism and prompts apoptosis; shows antitumor effects.</p>Formule :C28H38N8O3SCouleur et forme :SolidMasse moléculaire :566.72ARN5187 trihydrochloride
CAS :<p>ARN5187 trihydrochloride: a REV-ERBβ inhibitor that blocks transcription, autophagy, and induces apoptosis with lysosomal cytotoxicity.</p>Formule :C24H35Cl3FN3OCouleur et forme :SolidMasse moléculaire :506.912CT1-3
CAS :<p>CT1-3 is a potent anti-cancer compound targeting JNK/Bcl-2 pathways, blocking EMT in HCCs, and is non-toxic to liver/kidneys in mice.</p>Formule :C25H29NO3S2Couleur et forme :SolidMasse moléculaire :455.63αβ-Tubulin-IN-1
CAS :<p>αβ-Tubulin-IN-1 is a potent and orally active inhibitor of αβ-Tubulin.</p>Formule :C25H19N3O3Couleur et forme :SolidMasse moléculaire :409.44ZMF-10
CAS :<p>ZMF-10 inhibits PAK1 (IC50: 174 nM), PAK2, PAK3; affects apoptosis, ER stress, migration in cancer studies.</p>Formule :C19H17F6N7OCouleur et forme :SolidMasse moléculaire :473.38MMP-9-IN-3
CAS :<p>MMP-9-IN-3: MMP-9/AKT inhibitor (IC50: 5.56/2.11 nM), forms H-bonds, cytotoxic, induces apoptosis, used in cancer research.</p>Formule :C29H25N3O4Couleur et forme :SolidMasse moléculaire :479.53SMI-6860766
CAS :<p>SMI-6860766 is a CD40-Traf6 interactions blocker that acts by ameliorating the complications of diet-induced obesity in mice.</p>Formule :C15H11BrClNODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :336.61BPTQ
CAS :<p>BPTQ: DNA intercalator, halts cancer cell growth by blocking S/G2/M phases.</p>Formule :C17H16N4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.4PC-046
CAS :<p>PC-046, a tubulin binder, targets DPC4/SMAD4-deficient tumors, inhibits growth in vitro, and is effective in SCID mice with high oral bioavailability (71%).</p>Formule :C22H18N2O3Couleur et forme :SolidMasse moléculaire :358.39Tubulin inhibitor 23
CAS :<p>Potent Tubulin inhibitor 23 (IC50: 4.8 μM) induces apoptosis and has dose-dependent antiangiogenic properties, promising for leukemia research.</p>Formule :C26H23NO6SCouleur et forme :SolidMasse moléculaire :477.53CAY10682
CAS :<p>(±)-Nutlin-3 & CAY10682 inhibit p53-Mdm2; CAY also blocks NF-κB, IKKs phosphorylation, and cancer cell growth (IC50s = 2-6 μM).</p>Formule :C30H25BrFN5OCouleur et forme :SolidMasse moléculaire :570.45n-Octyl caffeate
CAS :<p>n-Octyl caffeate demonstrates anti-cancer and apoptosis-inducing properties in highly liver-metastatic murine colon 26-L5 carcinoma cell lines.</p>Formule :C17H24O4Couleur et forme :SolidMasse moléculaire :292.37Anticancer agent 57
CAS :<p>Anticancer agent 57 blocks TNBC cell growth with IC50: 6.43-8 μM, induces apoptosis, and shrinks tumors in mice.</p>Formule :C20H21Cl2NO2Couleur et forme :SolidMasse moléculaire :378.29JMX0293
<p>JMX0293, a salicylamide derivative, inhibits STAT3, inducing MDA-MB-231 cell apoptosis with IC50=3.38μM, while sparing MCF-10A (IC50>60μM).</p>Formule :C25H30Cl2N4O7Couleur et forme :SolidMasse moléculaire :569.43Rohinitib
CAS :<p>Rohinitib, an eIF4A inhibitor, triggers apoptosis in AML cells and lessens tumor load in models.</p>Formule :C29H31NO8Couleur et forme :SolidMasse moléculaire :521.56SCAL-255
CAS :<p>SCAL-255 is a mitochondrial complex I (CI) inhibitor, exhibiting potent inhibition with an IC50 of 1.14 μM.</p>Formule :C27H28F3N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :527.54Filanesib
CAS :<p>Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.</p>Formule :C20H22F2N4O2SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :420.48ANO1-IN-3
CAS :<p>ANO1-IN-3 (Compound 3n) can induces apoptosis that is a potent and selective inhibitor of ANO1 with an IC 50 of 1.23 μM [1].</p>Formule :C20H17NO3Couleur et forme :SolidMasse moléculaire :319.35CAY10503
CAS :<p>CAY10503: proapoptotic, anti-growth agent; arrests cell cycle at G0-G1; IC50 = 7-23 μM; induces HL60 differentiation in 72 hours.</p>Formule :C18H14O3Couleur et forme :SolidMasse moléculaire :278.3ADU-S100
CAS :<p>ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.</p>Formule :C20H24N10O10P2S2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :690.54MPT0B214
CAS :<p>MPT0B214, a potent microtubule inhibitor, disrupts tubulin polymerization and kills various cancer cells, including drug-resistant types.</p>Formule :C20H20N2O5Couleur et forme :SolidMasse moléculaire :368.38PD-1/PD-L1-IN-29
CAS :<p>PD-1/PD-L1-IN-29 (S4-1) is a potent inhibitor of the PD-1/PD-L1 interaction, with an IC50 value of 6.1 nM.</p>Formule :C26H24N2O6Couleur et forme :SolidMasse moléculaire :460.48TNF-α-IN-18
CAS :<p>TNF-α-IN-18 is a small molecule TNF-α inhibitor that blocks NF-κB translocation, alleviates sepsis in models, and protects against rheumatoid arthritis in mice.</p>Formule :C16H7ClF2O4Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :336.67Dinoprost
CAS :<p>Dinoprost (Prostaglandin F2a) is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient.</p>Formule :C20H34O5Degré de pureté :97.94% - 98.04%Couleur et forme :White To Off-White Crystalline SolidMasse moléculaire :354.48Casein Kinase inhibitor A51
CAS :Casein Kinase inhibitor A51 is a CK1α inhibitor with anticancer activity used in the study of breast and prostate cancer.Formule :C18H25ClN6Degré de pureté :98.42% - 99.88%Couleur et forme :SolidMasse moléculaire :360.88RIPK1-IN-13
CAS :<p>RIPK1-IN-13 inhibits RIPK1 (IC50=1139 nM), potentially blocking necrosis and treating inflammation.</p>Formule :C21H20ClN3O3Couleur et forme :SolidMasse moléculaire :397.85(S)-PERK-IN-5
CAS :<p>(S)-PERK-IN-5 is the S-enantiomer of PERK-IN-5. (S)-PERK-IN-5 is a PERK inhibitor (IC50: 0.101-0.250 μM).</p>Formule :C25H26F2N4O3Couleur et forme :SolidMasse moléculaire :468.5Se-Methylselenocysteine hydrochloride
CAS :<p>Se-Methylselenocysteine hydrochloride, a precursor to Methylselenol, exhibits significant cancer chemopreventive and antioxidant activities.</p>Formule :C4H10ClNO2SeDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :218.54CDK6/PIM1-IN-1
CAS :<p>CDK6/PIM1-IN-1: A dual inhibitor for CDK6 (39 nM IC50) & PIM1 (88 nM), also targets CDK4 (3.6 nM IC50), halts AML cell growth, and induces apoptosis.</p>Formule :C25H28FN9Couleur et forme :SolidMasse moléculaire :473.55BRD0476
CAS :<p>BRD0476 prevents pancreatic β-cell death by blocking IFN-γ-induced JAK2 & STAT1 without inhibiting JAK kinase activity.</p>Formule :C35H38N4O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :674.76PBENZ-DBRMD
CAS :<p>PBENZ-DBRMD inhibits DIO3, has anti-growth effects, and aids apoptosis, showing promise for cancer research.</p>Formule :C11H5Br2NO4Couleur et forme :SolidMasse moléculaire :374.97Erbstatin
CAS :<p>Erbstatin is a tyrosine-protein kinase inhibitor. When combined with foroxymithine, it has antineoplastic activity against L-1210 leukemia.</p>Formule :C9H9NO3Couleur et forme :SolidMasse moléculaire :179.17BI-0282
CAS :<p>BI-0282 (Compound 1) is a potent inhibitor of the MDM2-p53 interaction.</p>Formule :C30H23Cl2FN4O4Couleur et forme :SolidMasse moléculaire :593.43TJ08
CAS :<p>TJ08 has anticancer properties and can effectively induce G1/S phase blockade while promoting apoptosis in a variety of cancer cells.</p>Formule :C22H16FN3O4Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :405.38Anticancer agent 164
CAS :<p>CML-IN-1, also known as compound 7 and compound 4, is a potent anticancer agent that demonstrates a strong induced-apoptosis effect in the human chronic myeloid</p>Formule :C21H23F3N8O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.58Anticancer agent 147
CAS :<p>Compound 6j (Anticancer agent 147), a sophoridine derivative and ferroptosis inducer, promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS</p>Formule :C32H40BrN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :578.58Telomerase-IN-5
CAS :<p>Telomerase-IN-5 is a potent inhibitor of telomerase with antiproliferative properties, and it induces apoptosis [1].</p>Formule :C22H20N4OS2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.55PI3K/Akt/mTOR-IN-3
CAS :<p>PI3K/Akt/mTOR-IN-3 is a powerful inhibitor, halting MCF-7, HeLa, and HepG2 cell migration and triggering S phase arrest and apoptosis.</p>Formule :C34H51NO2Couleur et forme :SolidMasse moléculaire :505.77RO2468
CAS :<p>RO2468 is a potent and orally active inhibitor of the p53-MDM2.</p>Formule :C30H30Cl2FN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :614.49TH-Z835
CAS :<p>TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM.</p>Formule :C30H38N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.66ZC0101
CAS :<p>ZC0101: potent oral IDO1/TrxR inhibitor. IC50: 0.084/7.98 μM. Induces apoptosis, ROS in cancer cells.</p>Formule :C17H15N3O2Couleur et forme :SolidMasse moléculaire :293.32Cl-amidine
CAS :<p>Cl-amidine, an oral PAD inhibitor (IC50: 0.8-6.2 μM for PAD1/3/4), induces apoptosis in cancer cells.</p>Formule :C14H19ClN4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :310.78
