Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(6 produits)
- BCL(11 produits)
- Caspase(125 produits)
- FOXO1(3 produits)
- IAP(66 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(125 produits)
- PDK(9 produits)
- PERK(25 produits)
- Sérine/thréonine kinase(15 produits)
- Survivant(13 produits)
- TNF(92 produits)
- c-RET(51 produits)
- p53(62 produits)
Affichez 6 plus de sous-catégories
5599 produits trouvés pour "Apoptose"
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Anticancer agent 110
CAS :<p>Anticancer Agent 110 exhibits potent in vitro anti-leukemia activity, demonstrating high cytotoxicity against K-562 lineage chronic myelogenous leukemia cells</p>Formule :C18H13FN6OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.4UCB-5307
CAS :<p>UCB-5307 inhibits TNFR1, binds TNFα with 9 nM KD, shows slow kinetics (KD=6 nM), and penetrates hTNF/hTNFR1 complexes.</p>Formule :C22H21N3ODegré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :343.42CSN5i-3
CAS :<p>CSN5i-3 is a potent, selective, and orally available inhibitor of the proteolytic subunit of the CSN complex, CSN5, as an anticancer agent.Cost-effective and quality-assured.</p>Formule :C28H29F2N5O2Degré de pureté :99.56% - >99.99%Couleur et forme :SolidMasse moléculaire :505.56Triparanol
CAS :<p>Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1</p>Formule :C27H32ClNO2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :438UK-101
CAS :<p>UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c (LMP2), and β5 (LMP2), with IC50s of 104 nM, 15 μM, and 1 μM</p>Formule :C25H48N2O5SiDegré de pureté :99.08% - 99.25%Couleur et forme :SolidMasse moléculaire :484.74GSK2593074A
CAS :<p>GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.</p>Formule :C27H23N5OSDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :465.57Perphenazine dihydrochloride
CAS :<p>Perphenazine dihydrochloride: Oral dopamine, histamine-1 antagonist; targets D2, D3, 5-HT2A, Alpha-1A; may treat psychiatric disorders, cancer.</p>Formule :C21H28Cl3N3OSDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :476.89Epristeride
CAS :<p>Epristeride (ONO-9302) is a steroidal 5-alpha-reductase isoform 2 inhibitor that inhibits SR isoform 2. Epristeride reduces prostate size.</p>Formule :C25H37NO3Degré de pureté :98.12% - >99.99%Couleur et forme :SolidMasse moléculaire :399.57Tubulin inhibitor 11
CAS :<p>Potent, oral Tubulin inhibitor 11 hinders polymerization, targets Colchicine site, induces mitotic block, and apoptosis.</p>Formule :C22H23N3O3SDegré de pureté :98.32%Couleur et forme :SoildMasse moléculaire :409.5CCT020312
CAS :<p>CCT020312 (0-9 µM, 24 h) treatment of medium HT29 cells for 24 h resulted in a concentration-dependent loss of P-S608-pRB.Cost-effective and quality-assured.</p>Formule :C31H30Br2N4O2Degré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :650.4MMRi64
CAS :<p>MMRi64 inhibits Mdm2-MdmX, boosts p53, triggers apoptosis, and is used in cancer research.</p>Formule :C22H17Cl2N3ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :410.3CCT018159
CAS :<p>CCT018159: ATP-competitive HSP90 inhibitor, IC50 3.2 μM (human), 6.6 μM (yeast), blocks invasion, angiogenesis, induces G1 arrest and apoptosis.</p>Formule :C20H20N2O4Degré de pureté :98.78% - 99.79%Couleur et forme :SolidMasse moléculaire :352.38Ro24-7429
CAS :<p>Ro24-7429: oral HIV-1 Tat antagonist, RUNX1 inhibitor with anti-HIV, antifibrotic, and anti-inflammatory properties.</p>Formule :C14H13ClN4Degré de pureté :99.29% - 99.85%Couleur et forme :SolidMasse moléculaire :272.73MBM-55
CAS :<p>MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM.</p>Formule :C28H27FN6O2Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :498.55Ciglitazone
CAS :<p>Ciglitazone: potent PPARγ agonist, EC50 3 μM, oral hypoglycemic; reduces insulin, blood pressure, Th17 cells, VEGF; halts gastric cancer growth.</p>Formule :C18H23NO3SDegré de pureté :98.23% - 99.59%Couleur et forme :White Cyrstalline SolidMasse moléculaire :333.45TT01001
CAS :<p>TT01001, a mitoNEET agonist, may treat type II diabetes by reducing oxidative stress and preventing neuronal death.</p>Formule :C15H19Cl2N3O2SDegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :376.3Minodronic acid
CAS :Minodronic acid (YM-529) is a P2X2/3 antagonist with anticancer properties, inhibiting cell growth and metastasis, and used in osteoporosis research.Formule :C9H12N2O7P2Degré de pureté :98.02%Couleur et forme :SolidMasse moléculaire :322.15GCN2-IN-1
CAS :<p>GCN2-IN-1 (A-92) is an effective GCN2 inhibitor and can be used in research on the treatment of cancer as a chemotherapeutic agent.</p>Formule :C19H18N10ODegré de pureté :99.49% - 99.64%Couleur et forme :SolidMasse moléculaire :402.41EB1
CAS :<p>EB1 is an MNK kinase inhibitor that inhibits cancer cell growth, promotes apoptosis, and inhibits eIF4E phosphorylation.</p>Formule :C18H14N4Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :286.33p53-MDM2-IN-1
CAS :<p>p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 µM.</p>Formule :C23H20ClN3O3Degré de pureté :99.98%Couleur et forme :SoildMasse moléculaire :421.88GSK-3β inhibitor 3
CAS :<p>GSK-3β inhibitor 3 is a covalent inhibitor (IC50: 6.6 μM) of glycogen synthase kinase 3β (GSK-3β) that is potent, selective, and irreversible.GSK-3β inhibitor 3</p>Formule :C18H14FNO2SDegré de pureté :97.53%Couleur et forme :SolidMasse moléculaire :327.37CMLD-2
CAS :<p>CMLD-2 is a HuR-ARE inhibitor (Ki: 350 nM) that promotes apoptosis, has antitumor properties, and reduces thyroid cancer cell viability.</p>Formule :C31H31NO6Degré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :513.58ZDLD20
CAS :<p>ZDLD20 is a CDK4 inhibitor with anti-HCT116 and anticancer activity that inhibits colony formation and blocks the G1 phase of the cell cycle.</p>Formule :C22H22N6ODegré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :386.45A09-003
CAS :<p>A09-003 Inhibits the proliferation of leukemia cell lines and inhibits the increase of leukemia sequence-1 protein in HI bone marrow cells.</p>Formule :C23H26N4ODegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :374.48HBDDE
CAS :<p>HBDDE inhibits PKCα/γ (IC50: 43/50 μM), favors them over PKCδ/βI/βII, and induces neuronal apoptosis. Derived from ellagic acid.</p>Formule :C16H18O8Degré de pureté :97.94%Couleur et forme :SolidMasse moléculaire :338.31RET-IN-23
CAS :<p>RET-IN-23 is an orally available and highly potent RET inhibitor with significant antitumor activity for the study of non-small cell lung cancer.</p>Formule :C28H28FN11Degré de pureté :97.46%Couleur et forme :SolidMasse moléculaire :537.59PARP/PI3K-IN-1
CAS :PARP/PI3K-IN-1 is a PARP and PI3K dual inhibitor with anticancer and antiproliferative activities for the study of breast, pancreatic and lung cancers.Formule :C33H28F4N8O3Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :660.62Etomoxir
CAS :<p>Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a) (IC50=5-20 nM), inhibits fatty acid oxidation. High-Quality, Low-Cost!</p>Formule :C17H23ClO4Degré de pureté :98% - 99.39%Couleur et forme :SolidMasse moléculaire :326.82CTA 056
CAS :<p>CTA 056 is an ITK inhibitor that inhibits the growth of MOLT-4 xenograft tumors in mice and can be used to study autoimmune disorders.</p>Formule :C35H34N6ODegré de pureté :97.22% - 97.76%Couleur et forme :SolidMasse moléculaire :554.68JY-2
CAS :<p>JY-2 is a forkhead transcription factor O1 (FoxO1) inhibitor with antidiabetic activity that inhibits FoxO1 transcription and can be used to study psoriasis.</p>Formule :C13H7Cl2N3ODegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :292.12NM-3
CAS :<p>NM-3, an oral anti-angiogenic and anti-tumor agent, modulates radiation and blocks VEGF to curb endothelial growth and induce apoptosis.</p>Formule :C13H12O6Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :264.23Tiomolibdate diammonium
CAS :<p>Tiomolibdate diammonium (NSC-286644) blocks SOD1 and COX, acting as an antiangiogenic and antitumor agent.</p>Formule :H8MoN2S4Degré de pureté :98%Couleur et forme :Brown To Black Iridescent Crystalline PowderMasse moléculaire :260.28MTI-31
CAS :<p>MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.</p>Formule :C26H30N6O3Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :474.55INI-43
CAS :<p>INI-43 targets Kpnβ1, disrupting nuclear transport in cervical/esophageal cancers, affecting NFAT, NFκB, AP-1, NF localization.</p>Formule :C22H23N7Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :385.46HDAC-IN-60
CAS :<p>HDAC-IN-60 (compound 21a), a potent histone deacetylase (HDAC) inhibitor, promotes intracellular reactive oxygen species (ROS) production, induces DNA damage,</p>Formule :C20H26N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.43CPT-Se3
CAS :<p>CPT-Se3, a camptothecin derivative, boosts anticancer activity, triggers apoptosis in Hep G2, and is cytotoxic to various cells with IC50 of 2.19-4.7 μM.</p>Formule :C24H20N2O6Se2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :590.35Atiprimod dimaleate
CAS :<p>Atiprimod Dimaleate is a JAK2 inhibitor.</p>Formule :C30H52N2O8Couleur et forme :SolidMasse moléculaire :568.74K145 hydrochloride
CAS :<p>K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM.</p>Formule :C18H25ClN2O3SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :384.92CDKI-83
CAS :<p>CDKI-83, a potent CDK9 inhibitor, inhibits tumor growth with GI50 <1μM and triggers apoptosis in A2780 cells, showing promise as an anti-cancer agent.</p>Formule :C21H23N7O3S2Couleur et forme :SolidMasse moléculaire :485.58A-1293102
CAS :<p>A-1293102 is a potent, selective inhibitor of BCL-XL, effective in inducing apoptosis in tumor cells reliant on BCL-XL [1].</p>Formule :C42H40F3N7O7S5Couleur et forme :SolidMasse moléculaire :972.13DLC-50
CAS :<p>DLC-50 is a dual inhibitor of PARP-1 and HDAC-1, exhibiting IC50 values of 1.2 nM and 31 nM respectively. It hinders the proliferation of cancer cells such as MDA-MB-436, MDA-MB-231, and MCF-7 with IC50 values of 0.3 μM, 2.7 μM, and 2.41 μM respectively. Additionally, DLC-50 induces apoptosis in MDA-MB-231 cells and causes cell cycle arrest at the G2 phase.</p>Formule :C28H32FN5O4S2Couleur et forme :SolidMasse moléculaire :585.71Anticancer agent 128
CAS :<p>Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, exhibiting IC50 values of 24.9 nM, 19</p>Formule :C26H38N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.6SM-1295
CAS :<p>SM-1295: IAP antagonist, Kd 3077 nM XIAP-BIR3, 3.2 nM c-IAP1-BIR3, 9.5 nM c-IAP2-BIR3.</p>Formule :C29H36BrN5O4Couleur et forme :SolidMasse moléculaire :598.53DX3-235
CAS :<p>DX3-235 is an oxidative phosphorylation (OXPHOS) inhibitor on mitochondrial complex I function in galactose-containing media, resulting in reduced ATP.</p>Formule :C26H39N5O6S2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :581.75GDC-2394
CAS :<p>GDC-2394: Oral, selective NLRP3 inhibitor; blocks IL-1β (human 0.4μM, mouse 0.1μM), spares NLRC4.</p>Formule :C20H25N5O4SCouleur et forme :SolidMasse moléculaire :431.5115-Deoxy-Δ12,14-prostaglandin A1
CAS :<p>15-Deoxy-Δ12,14-Prostaglandin A1, a deoxyanalog of prostaglandins, inhibits NF-κB signaling and induces apoptosis. It also prevents TNF-α-induced upregulation of inflammatory endothelial cell adhesion molecules (CAM) and reduces monocyte arrest [1].</p>Formule :C20H30O3Couleur et forme :SolidMasse moléculaire :318.457BTM-3528
CAS :<p>BTM-3528 is a mitochondrial protease OMA1 activator that induces an overactivation of the mitochondrial integrated stress response (ISR).</p>Formule :C24H19F4N3O2S2Degré de pureté :99.37% - 99.37%Couleur et forme :SolidMasse moléculaire :521.55TM5441 sodium
CAS :<p>TM5441, an orally bioavailable plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 values ranging from 13.9 to 51.1 μM, effectively induces intrinsic apoptosis across multiple human cancer cell lines. Additionally, it mitigates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence [1] [2].</p>Formule :C21H16ClN2NaO6Couleur et forme :SolidMasse moléculaire :450.8Anticancer agent 81
CAS :<p>Compound 37b3, an anticancer, halts tumor growth, triggers cell death, and pairs with Trastuzumab to form T-PBA, an ADC with targeted delivery.</p>Formule :C46H46N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :762.89Anticancer agent 118
CAS :<p>Anticancer Agent 118, an N‑acylated ciprofloxacin derivative, exhibits antibacterial efficacy against Gram-positive strains and antiproliferative effects on</p>Formule :C19H19ClFN3O4Couleur et forme :SolidMasse moléculaire :407.82
