Apoptose

Dasatinib monohydrate, an oral SRC-kinase inhibitor, counters imatinib-resistant chronic myeloid leukemia.

<p>Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis.</p>

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat LOX1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat LOX1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat LOX1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat LOX1 in the samples is then determined by comparing the OD of the samples to the standard curve.

<p>(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.</p>

Flurbiprofen is an anti-inflammatory, analgesic, antipyretic that reduces bone resorption by inhibiting carbonic anhydrase.

(E)-Methyl 4-coumarate (OMpCA) is a predicted metabolite generated by BioTransformer1 that is produced by the metabolism of methyl 3-phenylprop-2-enoate.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Pig GDNF. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Pig GDNF. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Pig GDNF, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Pig GDNF in the samples is then determined by comparing the OD of the samples to the standard curve.

<p>Trimebutine maleate (Polibutin) is a weak mu-opioid agonist and has antimuscarinic effects.</p>

<p>Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.</p>

Tetrahydropalmatine (DL-Tetrahydropalmatine) is an active component isolated from corydalis, suppressing amygdaloid release of dopamine to inhibit an epileptic

Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor.

Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and

Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine.

Isatuximab targets CD38 in blood cancers, with high expression in multiple myeloma, inducing apoptosis and impairing cellular functions.

Maritoclax (Marinopyrrole A) (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value

PZL-A, PZL-A, an activator of mtDNA synthesis, restored the activity of POLγ mutant variant.

<p>Onvatilimab (JNJ-61610588) is a human IgG1 κ monoclonal antibody with antitumor effects for advanced head and neck cancers.</p>

Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.

<p>Cetrimonium bromide (Lauroseptol) is is a mixture of different quaternary ammonium salts, which is a known component of the broad-spectrum antiseptic cetrimide.</p>

Eugenol (Allylguaiacol) is a Standardized Chemical Allergen.