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Apoptose

Apoptose

Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.

Sous-catégories appartenant à la catégorie "Apoptose"

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6039 produits trouvés pour "Apoptose"

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  • Le logo de CymitQuimica
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    GL0388

    GL0388, a Bax activator, induces apoptosis, hinders breast cancer growth, and has IC50 of 0.299-1.57 μM.
    Formule :C21H17FN2O
    Couleur et forme :Solid
    Masse moléculaire :332.37

    Ref: TM-T60997

  • Tuspetinib dihydrochloride
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    Tuspetinib dihydrochloride

    CAS :
    Tuspetinib (HM43239) dihydrochloride is a selective FLT3 inhibitor with oral bioactivity, exhibiting IC50 values of 1.1 nM for FLT3 wild type, 1.8 nM for FLT3ITD mutant type, and 1.0 nM for FLT3D835Y mutant type. As a reversible type I inhibitor, it directly suppresses FLT3 kinase activity and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib dihydrochloride inhibits the proliferation of leukemia cells and induces apoptosis (apoptosis).
    Formule :C29H35Cl3N6
    Couleur et forme :Solid
    Masse moléculaire :573.99

    Ref: TM-T212318

  • SSB-2548
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    SSB-2548

    CAS :
    SSB-2548 is a CXCR-4 inhibitor that suppresses the proliferation and migration of acute myeloid leukemia cells and induces apoptosis (apoptosis). It is well absorbed in the gastrointestinal tract and can be used for leukemia research.
    Formule :C18H17N5O2
    Couleur et forme :Solid
    Masse moléculaire :335.36

    Ref: TM-T205550

  • HC-5404-Fu
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    HC-5404-Fu

    CAS :
    HC-5404-Fu is an inhibitor of PERK with anti-tumor activity. This compound inhibits the signaling pathway of the endoplasmic reticulum stress response. Additionally, HC-5404-Fu increases the sensitivity of renal cell carcinoma cells to vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors (TKIs). It holds potential for research into renal cell carcinoma, stomach cancer, metastatic breast cancer, small cell lung cancer, and other solid tumors.
    Formule :C28H28F2N4O7
    Couleur et forme :Solid
    Masse moléculaire :570.54

    Ref: TM-T200111

  • 6:2 Cl-PFAES
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    6:2 Cl-PFAES

    CAS :
    6:2 Cl-PFAES exhibits reproductive toxicity by elevating the levels of serum estradiol and vitellogenin in adult males, which can harm the embryonic development of offspring.
    Formule :C8ClF16KO4S
    Couleur et forme :Solid
    Masse moléculaire :570.67

    Ref: TM-T201602

  • PD-L1/Nampt-IN-1
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    PD-L1/Nampt-IN-1

    CAS :
    PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.
    Formule :C28H28N4O2
    Couleur et forme :Solid
    Masse moléculaire :452.55

    Ref: TM-T212272

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    mTOR/HDAC6-IN-1

    mTOR/HDAC6-IN-1 inhibits HDAC6 (IC50: 56 nM) & mTOR (IC50: 133.7 nM), may treat TNBC by inducing autophagy and apoptosis.
    Formule :C20H20ClN5O2
    Couleur et forme :Solid
    Masse moléculaire :397.86

    Ref: TM-T61888

  • Ganoderic acid R
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    Ganoderic acid R

    CAS :
    Ganoderic acid R: potent anticancer, induces apoptosis, cytotoxic to MDR and sensitive tumor cells.
    Formule :C34H50O6
    Couleur et forme :Solid
    Masse moléculaire :554.76

    Ref: TM-T72737

  • DDO-8958
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    DDO-8958

    CAS :
    DDO-8958 is an orally active and selective BET BD1 inhibitor, exhibiting a KD of 5.6 nM for BRD4 BD1. It shows low nanomolar inhibitory activity across all BET BD1 bromodomains except for BRDT BD1. DDO-8958 inhibits tumor cell proliferation and migration, induces apoptosis and cell cycle arrest, and demonstrates antitumor activity.
    Formule :C22H22FN5O2
    Couleur et forme :Solid
    Masse moléculaire :407.441

    Ref: TM-T205605

  • PKM2 modulator 2
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    PKM2 modulator 2

    CAS :
    <p>PKM2 modulator 2 (compound C599) is a potent inhibitor of PKM2, displaying antiproliferative activity and inducing apoptosis. This compound holds potential for research in glioblastoma.</p>
    Formule :C21H13FN4O3
    Couleur et forme :Solid
    Masse moléculaire :388.351

    Ref: TM-T205205

  • SIRT-IN-7
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    SIRT-IN-7

    CAS :
    SIRT-IN-7 (Compound 7ba) is a SIRT inhibitor. It effectively suppresses the expression of SIRT1, SIRT2, and SIRT3, leading to increased acetylation and activation of p53. Additionally, SIRT-IN-7 inhibits the proliferation of breast cancer cells and induces apoptosis and autophagy, demonstrating antitumor activity.
    Formule :C24H16BrClN2OS
    Couleur et forme :Solid
    Masse moléculaire :495.819

    Ref: TM-T205485

  • RWJ-56110
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    RWJ-56110

    CAS :
    protease-activated receptor-1 (PAR1) antagonist
    Formule :C41H43Cl2F2N7O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :790.73

    Ref: TM-T23282

  • SIJ1777
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    SIJ1777

    CAS :
    SIJ1777, a derivative of GNF-7, exhibits potent anticancer effects against melanoma cells harboring BRAFI/II/III mutations. The compound significantly inhibits the activation of MEK, ERK, and AKT. Furthermore, SIJ1777 notably induces apoptosis (cell death) and effectively prevents migration, invasion, and anchorage-independent growth of melanoma cells with BRAFI/II/III mutations.
    Formule :C26H23F3N8O2
    Couleur et forme :Solid
    Masse moléculaire :536.51

    Ref: TM-T200137

  • SC428
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    SC428

    CAS :
    SC428 acts as an inhibitor of the androgen receptor (AR), specifically targeting the N-terminal domain of AR. This compound effectively diminishes the transactivation of various AR forms, including AR-V7, ARv567es, full-length AR (AR-FL), and its LBD mutants. Additionally, SC428 significantly inhibits AR-FL nuclear translocation, chromatin binding, and AR-regulated gene transcription under androgen stimulation. In vitro, SC428 suppresses the proliferation of tumor cells. In vivo, it inhibits tumor growth in mice transplanted with 22Rv1 cells by inducing apoptosis.
    Formule :C15H10F3N3OS
    Couleur et forme :Solid
    Masse moléculaire :337.32

    Ref: TM-T200348

  • INNO-220
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    INNO-220

    CAS :
    INNO-220 is an orally active, CRBN-dependent molecular glue degrader that targets CK1α. By degrading CK1α, INNO-220 induces cell cycle arrest at the G0/G1 phase and triggers apoptosis (Apoptosis). It disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, inhibiting the NF-κB signaling pathway in T cells and lymphoma cells with activating mutations in CARD11. INNO-220 offers a novel direction for lymphoma research.
    Formule :C23H20N4O3
    Couleur et forme :Solid
    Masse moléculaire :400.43

    Ref: TM-T211026

  • Le logo de CymitQuimica
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    p53 Activator 11

    CAS :
    P53 Activator 11 (compound A-1) is a highly effective p53 activator, demonstrating an EC50 value of 0.478 µM for p53 (Y220C). It holds potential for cancer research [1].
    Formule :C26H29N7O2S
    Masse moléculaire :503.62

    Ref: TM-T87091

  • PD-L1/VISTA-IN-1
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    PD-L1/VISTA-IN-1

    CAS :
    <p>PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual inhibitor targeting PD-L1 and VISTA. It effectively hinders the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), leading to the reactivation of T cells. Additionally, PD-L1/VISTA-IN-1 exhibits antitumor activity.</p>
    Formule :C22H24N4O4
    Couleur et forme :Solid
    Masse moléculaire :408.45

    Ref: TM-T205067

  • NLRP3-IN-81
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    NLRP3-IN-81

    CAS :
    NLRP3-IN-81 (N102) is an inhibitor capable of crossing the blood-brain barrier, effectively countering NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 μM for Nigericin-induced pyroptosis. It significantly suppresses caspase-1 activation and IL-1β release that depend on NLRP3. Additionally, NLRP3-IN-81 disrupts the interaction between NLRP3 and the adaptor protein ASC, while inhibiting ASC oligomerization. This compound is applicable in research on pyroptosis-related diseases, such as inflammatory bowel disease and type 2 diabetes.
    Formule :C16H15F3N2O3S
    Couleur et forme :Solid
    Masse moléculaire :372.36

    Ref: TM-T210731

  • Flizasertib
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    Flizasertib

    CAS :
    Flizasertib is a serine/threonine kinase inhibitor that acts by inhibiting RIPK1, which has anti-inflammatory and therapeutic effects on immune disorders.
    Formule :C15H14FN3O
    Degré de pureté :99.39% - 99.57%
    Couleur et forme :Solid
    Masse moléculaire :271.29

    Ref: TM-T69711

  • Le logo de CymitQuimica
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    NF-κB-IN-4

    NF-κB-IN-4 (compound 17) is a potent inhibitor of NF-κB pathway which can cross blood brain barrier (BBB).
    Formule :C18H15FN4O
    Couleur et forme :Solid
    Masse moléculaire :322.34

    Ref: TM-T60868