Apoptose
Les inhibiteurs de l'apoptose sont des composés qui empêchent ou retardent le processus de mort cellulaire programmée, connu sous le nom d'apoptose. Ces inhibiteurs sont essentiels pour étudier les mécanismes de survie cellulaire et sont utilisés pour enquêter sur les maladies où l'apoptose est dysrégulée, telles que le cancer, les troubles neurodégénératifs et les maladies auto-immunes. En modulant l'apoptose, ces inhibiteurs peuvent aider au développement de thérapies visant à contrôler la mort cellulaire. Chez CymitQuimica, nous offrons une sélection complète d'inhibiteurs de l'apoptose de haute qualité pour soutenir vos recherches en biologie cellulaire, oncologie et domaines connexes.
Sous-catégories appartenant à la catégorie "Apoptose"
- ASK(9 produits)
- BCL(1 produits)
- Caspase(154 produits)
- FOXO1(2 produits)
- IAP(67 produits)
- Mdm2(12 produits)
- PD-1/PD-L1(140 produits)
- PDK(9 produits)
- PERK(24 produits)
- Sérine/thréonine kinase(19 produits)
- Survivant(14 produits)
- TNF(94 produits)
- c-RET(61 produits)
- p53(63 produits)
Affichez 6 plus de sous-catégories
6497 produits trouvés pour "Apoptose"
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Anticancer agent 53
CAS :Anticancer agent 53 exhibits potent in vitro cytotoxicity, triggers apoptosis, halts S/G2/M cycle, and has antitumor effects without toxicity.Formule :C31H25FN4O6SCouleur et forme :SolidMasse moléculaire :600.62Tubulin inhibitor 13
CAS :Tubulin inhibitor 13 (E27), IC50 16.1 μM, blocks tubulin polymerization, cancer cell migration, and invasion, induces apoptosis.Formule :C25H21N3O4Couleur et forme :SolidMasse moléculaire :427.45T-1-PMPA
CAS :T-1-PMPA, a potent EGFR inhibitor, demonstrates apoptotic properties and effectively inhibits EGFR WT and EGFR 790m, with IC50 values of 86 nM and 561.73 nM, respectively [1].Formule :C16H17N5O3Couleur et forme :SolidMasse moléculaire :327.34FKBP12 PROTAC dTAG-13
CAS :FKBP12 PROTAC dTAG-13 is a PROTAC and selective degrader for target validation by splicing FKBP12 F36V with CRBN and thereby degrading FKBP12 F36V.Formule :C57H68N4O15Degré de pureté :97.31%Couleur et forme :SolidMasse moléculaire :1049.17UR-AK49
CAS :UR-AK49 (compound 11) is an agonist for the human histamine H1 and H2 receptors. It exhibits an EC50 of 23 nM in the GTPase assay involving hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 is applicable in neurologically related research.Formule :C16H27N5OCouleur et forme :SolidMasse moléculaire :305.42SBI-0640726
CAS :SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.Formule :C23H15ClN2O2Couleur et forme :SolidMasse moléculaire :386.83BMS-751324
CAS :BMS-751324: p38α MAPK inhibitor with carbamyl-methyl, esters, phosphate from HPA. Reduces rat arthritis swelling and TNFα.Formule :C32H35N6O10PCouleur et forme :SolidMasse moléculaire :694.63DOR agonist 2
CAS :Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.Formule :C29H26N2O3Couleur et forme :SolidMasse moléculaire :450.53Erythromycin B
CAS :Erythromycin B exhibits antimalarial activity by effectively inhibiting the asexual growth of Plasmodium falciparum.Formule :C37H67NO12Couleur et forme :SolidMasse moléculaire :717.93Apoptosis inducer 42
CAS :Apoptosis inducer42 is an apoptosis inducer that triggers late-stage apoptosis and inhibits the secretion of IL-6. It exhibits high cytotoxicity toward cancer cells and is applicable in cancer research, including studies on colon cancer.Formule :C11H13OPSCouleur et forme :SolidMasse moléculaire :224.26VDX-111
CAS :VDX-111, an analog of vitamin D, exhibits cytotoxicity in ovarian cancer cells by upregulating the RIPK1/RIPK3 pathway and inducing necroptosis. It also promotes the expression of cytokines and demonstrates antitumor activity in a mouse model [1].Formule :C29H45BrO4Couleur et forme :SolidMasse moléculaire :537.57HBV/HDV-IN-2
CAS :HBV/HDV-IN-2 (Compd 143) functions as an inhibitor for HBV, HDV, and PD-1/PD-L1, demonstrating an EC 50 of 35 nM in T cell activation.Formule :C38H44ClN7O5Couleur et forme :SolidMasse moléculaire :714.25TNF-α-IN-14
CAS :TNF-α-IN-14, a potent TNFα inhibitor, exhibits a selective inhibition profile with an IC50 of 1.1 µM and demonstrates antiinflammatory properties (WO2001072735A2; compound 12) [1].Formule :C22H26O6Couleur et forme :SolidMasse moléculaire :386.44ASP9831
CAS :ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.Formule :C20H23N3O3Couleur et forme :SolidMasse moléculaire :353.42Tubulin polymerization-IN-61
CAS :Tubulin polymerization-IN-61 (Compound 9a), a tubulin polymerization inhibitor, disrupts the microtubule skeleton, arrests the cell cycle at the G2/M phase, induces Apoptosis, and impedes cancer cell migration and colony formation. This compound demonstrates antitumor efficacy in vivo within the 4T1 xenograft model [1].Formule :C22H21N3O5Couleur et forme :SolidMasse moléculaire :407.42GPD-1116
CAS :GPD-1116 is an orally active inhibitor of phosphodiesterase (PDE)4 and PDE1. The compound effectively reduces smoke-induced apoptosis in lung cells. Additionally, GPD-1116 has shown efficacy in various animal disease models, including emphysema, acute lung injury, chronic obstructive pulmonary disease (COPD), asthma, and pulmonary arterial hypertension.Formule :C22H16N4OCouleur et forme :SolidMasse moléculaire :352.39Thalidomide-NH-amido-PEG2-C2-NH2
CAS :Thalidomide-NH-amido-PEG2-C2-NH2 is a synthetic E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker. It is utilized in the synthesis of PROTACs.Formule :C21H27N5O7Masse moléculaire :461.47CP-31398
CAS :CP-31398 stabilizes the active conformation of p53 in cancer cells with either mutated or wild-type p53, enhancing its activity. Additionally, CP-31398 upregulates target genes of p53 such as p21WAF1/Cip1 and KILLER/DR5. This compound possesses tumor-suppressive properties.Formule :C22H26N4OCouleur et forme :SolidMasse moléculaire :362.47ASK1-IN-7
CAS :ASK1-IN-7 (Compound 4c) is an ASK1 inhibitor and a derivative of the ASK1 inhibitor scaffold 5-(5-Phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin-4-one. This compound is potentially applicable in research involving ASK1 signaling pathways, including studies on cellular stress response, inflammatory response, neurodegenerative diseases, and cardiovascular diseases.Formule :C13H8N2O2S2Couleur et forme :SolidMasse moléculaire :288.345MD102
CAS :MD102, with an IC50 value of 0.35 μM, is a potent TG2 inhibitor that stabilizes p53 by inhibiting TG2. This results in a decrease in p-AKT and p-mTOR downstream signaling, ultimately inducing tumor cell apoptosis [1].Formule :C13H4BrCl2FN2O2Couleur et forme :SolidMasse moléculaire :389.99
