Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
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3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
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RNA polymerase II-IN-1
CAS :<p>RNA polymerase II-IN-1 (19iv), an amatoxin, inhibits Pol II at 36.66 nM IC50, is more toxic to cancer cells, less to normal cells than α-Amanitin.</p>Formule :C38H53N11O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :887.965'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
CAS :<p>5'-ODMT cEt N-Bzm5 C Phosphoramidite is a strong modified nucleic acid analog for antisense oligos.</p>Formule :C49H56N5O9PCouleur et forme :SolidMasse moléculaire :889.97AVG-233
CAS :<p>AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.</p>Formule :C26H22ClN5O3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :487.94Lamifiban
CAS :<p>Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.</p>Formule :C24H28N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.5Homouridine
CAS :<p>Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM).</p>Formule :C10H14N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.23Sovesudil
CAS :<p>Sovesudil (PHP-201) is a potent ROCK inhibitor with IC50 of 3.7 nM/2.3 nM for ROCK-I/II; lowers IOP without hyperemia.</p>Formule :C23H22FN3O3Couleur et forme :SolidMasse moléculaire :407.44DDD85646
CAS :<p>DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.</p>Formule :C21H24Cl2N6O2SDegré de pureté :97.8% - 99.76%Couleur et forme :SolidMasse moléculaire :495.4312R-LOX-IN-1
CAS :<p>12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX.</p>Formule :C15H11NO2Couleur et forme :SolidMasse moléculaire :237.25CDK7-IN-25
CAS :<p>CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].</p>Formule :C33H32N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :560.65DNA gyrase B-IN-3
CAS :<p>DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram</p>Formule :C14H9Cl2N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.21GSK2163632A
CAS :<p>GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.</p>Formule :C27H32N8O3SCouleur et forme :SolidMasse moléculaire :548.66FAICAR
CAS :<p>FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.</p>Formule :C10H15N4O9PCouleur et forme :SolidMasse moléculaire :366.22TC-A 2317 hydrochloride
CAS :<p>TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.</p>Formule :C19H29ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.93MC-Val-Cit-PAB-Ispinesib
CAS :<p>MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].</p>Formule :C59H71ClN10O10Couleur et forme :SolidMasse moléculaire :1115.71GSK2850163
CAS :<p>GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).</p>Formule :C24H29Cl2N3ODegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :446.41CCT241533 hydrochloride
CAS :<p>CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>Formule :C23H28ClFN4O4Degré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :478.953-Cyanovinylcarbazole phosphoramidite
CAS :<p>3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.</p>Formule :C50H53N4O6PCouleur et forme :SolidMasse moléculaire :836.95CDK8-IN-3
CAS :<p>CDK8-IN-3 is an inhibitor of CDK8.</p>Formule :C22H23N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.45USP1-IN-5
CAS :<p>USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less than</p>Formule :C27H23F3N8OCouleur et forme :SolidMasse moléculaire :532.52Phototrexate
CAS :<p>Phototrexate, a photochromic Methotrexate analog, is a UVA-activated, reversible DHFR inhibitor with antifolate properties (IC50: 6 nM cis vs. 34 μM trans).</p>Formule :C20H19N7O5Couleur et forme :SolidMasse moléculaire :437.41CI 972 anhydrous
CAS :<p>CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.</p>Formule :C11H12ClN5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :297.76COH1
CAS :<p>COH1 is a ribonucleotide reductase (RR) inhibitor utilized in research pertaining to cancer, mitochondrial diseases, and neurodegenerative disorders [1].</p>Formule :C11H10N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :250.27PD-1/PD-L1-IN-33
CAS :<p>PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM.</p>Formule :C26H27N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.53(S)-Cdc7-IN-18
CAS :<p>'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'</p>Formule :C19H21N5OSCouleur et forme :SolidMasse moléculaire :367.47LX7101 hydrochloride
CAS :<p>LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.</p>Formule :C23H29N7O3HClCouleur et forme :SolidMasse moléculaire :488ICAM-1-IN-1
CAS :<p>ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.</p>Formule :C15H11BrN2O2SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :363.23CDK7-IN-22
CAS :<p>CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].</p>Formule :C22H25F3N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.47TNP-351
CAS :<p>Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer.</p>Formule :C21H24N6O5Couleur et forme :SolidMasse moléculaire :440.45Halofuginone hydrochloride
CAS :<p>Halofuginone hydrochloride (RU-19110), a derivative of Febrifugine, functions as a competitive inhibitor of prolyl-tRNA synthetase, displaying a Ki value of 18.3 nM. This compound effectively inhibits type-I collagen synthesis, providing therapeutic benefits in osteoarthritis (OA) by impeding TGF-β signaling. Additionally, it serves as a potent pulmonary vasodilator, mainly through the activation of Kv channels and the inhibition of various calcium channels including voltage-gated, receptor-operated, and store-operated ones. Beyond its vascular effects, Halofuginone hydrochloride exhibits a broad spectrum of biological activities, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrotic properties, supported by multiple studies.</p>Formule :C16H18BrCl2N3O3Couleur et forme :SolidMasse moléculaire :451.14SHP2/CDK4-IN-1
CAS :<p>SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.</p>Formule :C33H35ClF2N10OSCouleur et forme :SolidMasse moléculaire :693.21KM05382
CAS :<p>KM05382 inhibits CDK9 and the transcription of GAPDH.</p>Formule :C20H19ClN2O3S2Couleur et forme :SolidMasse moléculaire :434.96Fosfluridine tidoxil
CAS :<p>Fosfluridine tidoxil, a thymidylate synthase inhibitor, is used potentially for the treatment of colorectal cancer, and breast cancer.</p>Formule :C34H62FN2O10PSCouleur et forme :SolidMasse moléculaire :740.9CDK9-IN-9
CAS :<p>CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).</p>Formule :C22H23F2N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.51XL413 hydrochloride
CAS :<p>XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7. XL413 hydrochloride also inhibits CK2 and PIM1.</p>Formule :C14H13Cl2N3O2Degré de pureté :98.81% - 99.8%Couleur et forme :SolidMasse moléculaire :326.18Mefenidil
CAS :<p>Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.</p>Formule :C12H11N3Degré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :197.24Luvixasertib hydrochloride
CAS :<p>CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].</p>Formule :C28H31ClN6O3Couleur et forme :SolidMasse moléculaire :535.04Cdc7-IN-7
CAS :<p>Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.</p>Formule :C21H22N4O5Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :410.42Leucettinib-92
CAS :<p>Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM</p>Formule :C21H22N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.49Palmitoyl 3-carbacyclic phosphatidic acid
CAS :<p>Palmitoyl 3-carbacyclic phosphatidic acid, a palmitoylated Carba-like cyclophosphatidic acid and LPA (lysophosphatidic acid) analog, possesses distinct biological activities compared to LPA, including the inhibition of RhoA activation and melanoma cell migration. This compound has demonstrated efficacy in inhibiting experimental lung metastasis and reducing tumor nodule counts in a B16-F0 xenograft mouse model [1].</p>Formule :C20H39O5PCouleur et forme :SolidMasse moléculaire :390.49Mevociclib
CAS :<p>Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.</p>Formule :C31H35ClN8O2Degré de pureté :98.02% - 98.02%Couleur et forme :SolidMasse moléculaire :587.11Methotrexate-γ-aspartate
CAS :<p>Methotrexate-gamma-aspartate has growth inhibitory effects. It is used in antibody-targeted liposomes.</p>Formule :C24H27N9O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :569.53L-Methioninamide hydrochloride
CAS :<p>L-Methioninamide hydrochloride is a potent inhibitor of methionyl-tRNA synthetase that reduces the toxicity of CDDP.</p>Formule :C5H13ClN2OSDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :184.69H3B-968
CAS :<p>H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonuclease</p>Formule :C22H18F6N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :548.46AR-13503
CAS :<p>AR-13503, a Netarsudil metabolite, is a ROCK inhibitor, potentially treating glaucoma and lowering eye pressure.</p>Formule :C19H19N3O2Couleur et forme :SolidMasse moléculaire :321.37KSP-IA
CAS :<p>KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.</p>Formule :C21H22F2N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.41Lotrafiban
CAS :<p>Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.</p>Formule :C23H32N4O4Couleur et forme :SolidMasse moléculaire :428.52DCB-3503
CAS :<p>DCB-3503, a tylophorine analog, may fight cancer and aid immunosuppression by hindering protein synthesis and modulating HSC70 ATPase function.</p>Formule :C24H27NO5Couleur et forme :SolidMasse moléculaire :409.47Pencitabine
CAS :<p>Pen is an oral cancer drug that blocks DNA synthesis by inhibiting key enzymes and integrating into DNA.</p>Formule :C15H20F3N3O6Couleur et forme :SolidMasse moléculaire :395.33RAD51-IN-4
CAS :<p>RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.</p>Formule :C31H34FN5O5S2Couleur et forme :SolidMasse moléculaire :639.76Myt1-IN-3
CAS :<p>Myt1-IN-3 is a potent inhibitor of Myt1 (IC50 <10 nM) [1].</p>Formule :C18H19N5O2Couleur et forme :SolidMasse moléculaire :337.38VER-00158411
CAS :<p>VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).</p>Formule :C31H34N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :538.64Lotrafiban hydrochloride
CAS :<p>Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.</p>Formule :C23H33ClN4O4Couleur et forme :SolidMasse moléculaire :464.99L 738167
CAS :<p>L 738167 is a potent antagonist of the long-acting fibrinogen receptor.</p>Formule :C25H34N6O6SCouleur et forme :SolidMasse moléculaire :546.64SB-743921 free base
CAS :<p>SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).</p>Formule :C31H33ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.06WEE1-IN-4
CAS :<p>Wee1 Inhibitor I is an ATP-binding site-targeting Wee1 inhibitor.</p>Formule :C20H11ClN2O3Couleur et forme :SolidMasse moléculaire :362.77Antifolate C1
CAS :<p>Antifolate C1 blocks purine creation, favors uptake via folate receptors/PCFT over RFC.</p>Formule :C19H21N5O6SCouleur et forme :SolidMasse moléculaire :447.46Balapiravir hydrochloride
CAS :<p>Balapiravir HCl, an NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Formule :C21H31ClN6O8Couleur et forme :SolidMasse moléculaire :530.96BIO-7662
CAS :<p>BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.</p>Formule :C38H48N6O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :748.895-DACTHF
CAS :<p>5,11-methenyltetrahydrohomofolate blocks GAR & AIR transformylase; used as an anti-purine drug.</p>Formule :C19H24N6O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.435'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
CAS :<p>5'-ODMT cEt N-Bz A Phosphoramidite Amidite, a locked nucleic acid (LNA) analogue, exhibits hybridization and mismatch discrimination capabilities similar to LNA, and shows resistance to exonuclease digestion [1].</p>Formule :C49H54N7O8PCouleur et forme :SolidMasse moléculaire :899.97Tacaciclib
CAS :<p>Tacaciclib is a cyclin-dependent kinase (CDK) inhibitor with observed antineoplastic activity [1].</p>Formule :C30H36N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.65Diazoketone methotrexate
CAS :<p>Diazoketone methotrexate is an analog of methotrexate with potential antitumor activity.</p>Formule :C21H22N10O4Couleur et forme :SolidMasse moléculaire :478.46PLK1-IN-4
CAS :<p>PLK1-IN-4: strong PLK1 blocker (<0.508 nM IC50), inhibits cancer cell growth, triggers G2/M arrest and apoptosis.</p>Formule :C24H25F3N6O4SCouleur et forme :SolidMasse moléculaire :550.55TAK 029
CAS :<p>TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.</p>Formule :C19H23N5O7Couleur et forme :SolidMasse moléculaire :433.42MU-380
CAS :<p>MU-380 is an effective and selective inhibitor of CHK1.</p>Formule :C15H15BrF3N7Couleur et forme :SolidMasse moléculaire :430.23CDK7-IN-14
CAS :<p>CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).</p>Formule :C22H24F3N6OPCouleur et forme :SolidMasse moléculaire :476.43FT206
CAS :<p>FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].</p>Formule :C25H29N5OSCouleur et forme :SolidMasse moléculaire :447.6N-desmethyl Netupitant
CAS :<p>N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.</p>Formule :C29H30F6N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.57PLK1-IN-7
CAS :<p>PLK1-IN-7 (compound 30e) is a potent inhibitor exhibiting an IC50 value of 0.66 nM and demonstrates significant antiproliferative and antitumor activities [1].</p>Formule :C24H24F4N8O2Couleur et forme :SolidMasse moléculaire :532.49Pelitrexol
CAS :<p>Pelitrexol (AG2037) is a GARFT inhibitor, which can inhibit the activity of mTORC1, block the cell cycle in the s-phase, with antiproliferative activity,NSCLC .</p>Formule :C20H25N5O6SDegré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :463.51IIIM-290
CAS :<p>IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).</p>Formule :C23H21Cl2NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :462.32CDK9-IN-19
CAS :<p>CDK9-IN-19: Potent CDK9 inhibitor, anti-cancer, moderate pharmacokinetics, low hERG impact, effective in AML research.</p>Formule :C26H22F2N4O5Couleur et forme :SolidMasse moléculaire :508.47DHX9-IN-4
CAS :<p>DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.</p>Formule :C21H22ClN5O4S2Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :508.01Senexin C
CAS :<p>Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.</p>Formule :C28H27N5ODegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :449.55BI-1950
CAS :<p>BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.</p>Formule :C32H26Cl2FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.5Teclistamab
CAS :<p>Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.</p>Degré de pureté :95%Couleur et forme :LiquidWRN inhibitor 5
CAS :<p>WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Formule :C23H20N2O6SCouleur et forme :SolidMasse moléculaire :452.48DHX9-IN-6
CAS :<p>DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.</p>Formule :C23H18ClFN4O4S2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :533PLK1/p38γ-IN-1
CAS :<p>PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellular</p>Formule :C21H26ClN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.9Carotegrast
CAS :<p>Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.</p>Formule :C27H24Cl2N4O5Couleur et forme :SolidMasse moléculaire :555.41LDC3140
CAS :<p>LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).</p>Formule :C23H33N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.55GSK2646264
CAS :<p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>Formule :C24H26N2O2Couleur et forme :SolidMasse moléculaire :374.48PD-1/PD-L1-IN-27
CAS :<p>PD-1/PD-L1-IN-27: potent anti-cancer, IC50 134nM, minimal T cell harm, boosts CD8+ T cells, reduces fatigue.</p>Formule :C44H35NO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.75USP1-IN-3
CAS :<p>USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.</p>Formule :C27H24F3N7OCouleur et forme :SolidMasse moléculaire :519.52NVS-SM2
CAS :<p>NVS-SM2 boosts SMN2 splicing, enhances exon 7 inclusion, and raises SMN protein levels orally.</p>Formule :C23H30N6OCouleur et forme :SolidMasse moléculaire :406.52DHODH-IN-14
CAS :<p>DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.</p>Formule :C15H7F4N3O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :353.23CDK9-IN-2
CAS :<p>CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.</p>Formule :C23H25ClFN5Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :425.93Netropsin dihydrochloride
CAS :<p>Netropsin dihydrochloride, a small MGB, blocks topoisomerase I/II, hindering cleavable complex stabilization.</p>Formule :C18H28Cl2N10O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :503.39CCT251455
CAS :<p>CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.</p>Formule :C26H26ClN7O2Degré de pureté :99.1% - 99.1%Couleur et forme :SolidMasse moléculaire :503.98TAS-114
CAS :<p>TAS-114 is a dUTPase and DPD inhibitor that modulates catabolic pathways to improve systemic availability of 5-FU.</p>Formule :C21H29N3O6SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :451.54Emzadirib
CAS :<p>Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.</p>Formule :C27H40N4O6S2Degré de pureté :99.79% - 99.9%Couleur et forme :SolidMasse moléculaire :580.76Solitomab
CAS :<p>Solitomab (AMG 110) is a bispecific antibody targeting CD3 and EpCAM, used in uterine/ovarian carcinosarcoma research.</p>Couleur et forme :LiquidPD-1/PD-L1-IN-26
CAS :<p>PD-1/PD-L1-IN-26 is a strong inhibitor with IC50 of 0.0380 μM that may boost immune response in cancer by aiding CD4+ T cell entry to tumors.</p>Formule :C43H52N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :752.89Senexin A hydrochloride
CAS :<p>Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].</p>Formule :C17H15ClN4Couleur et forme :SolidMasse moléculaire :310.78DNA polymerase-IN-3
CAS :<p>DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications in</p>Formule :C13H12O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :232.23Spirofylline
CAS :<p>Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.</p>Formule :C24H28N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.52CDK4/6-IN-15
CAS :<p>CDK4/6-IN-15: Oral, selective CDK4/6 inhibitor, halts cancer cell growth, G1 arrest, suppresses Rb phosphorylation.</p>Formule :C21H27FN8SCouleur et forme :SolidMasse moléculaire :442.568-NH2-ATP tetrasodium
CAS :<p>8-NH2-ATP tetrasodium, an inactive ATP variant, originates from 8-NH2-Ado tetrasodium, which triggers the apoptosis-associated cleavage of poly (ADP-ribose) polymerase [1] [2].</p>Formule :C10H13N6Na4O13P3Couleur et forme :SolidMasse moléculaire :610.12OXA-06 hydrochloride
CAS :<p>OXA-06 hydrochloride, an ATP-competitive ROCK inhibitor, impedes anchorage-dependent growth and invasion in non-small cell lung cancer cell lines. It effectively inhibits cofilin phosphorylation without inducing apoptosis [1].</p>Formule :C21H20Cl2FN3Couleur et forme :SolidMasse moléculaire :404.31SC-52012
CAS :<p>SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.</p>Formule :C25H30N4O6Degré de pureté :97.20%Couleur et forme :SolidMasse moléculaire :482.53
