Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
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3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
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5-Iodo-indirubin-3'-monoxime
CAS :<p>5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s</p>Formule :C16H10IN3O2Couleur et forme :SolidMasse moléculaire :403.17Galidesivir hydrochloride
CAS :<p>Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.</p>Formule :C11H16ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :301.73Zaurategrast
CAS :<p>Zaurategrast is an effective and oral-effective inhibitor of the α4-integrin.</p>Formule :C26H25BrN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.41Riviciclib
CAS :<p>Riviciclib, a CDK inhibitor (CDK9/T1, CDK4/D1, CDK1/B), has IC50s: 20, 63, 79 nM respectively, and fights cisplatin-resistant tumors.</p>Formule :C21H20ClNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :401.84Kif15-IN-2
CAS :<p>Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.</p>Formule :C20H20N6O4SDegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :440.48KY386
CAS :<p>KY386 is a potent and selective DHX33 helicase inhibitor with an IC50 value of 19 nM.</p>Formule :C21H19N5O2SCouleur et forme :SolidMasse moléculaire :405.47Xylocydine
CAS :<p>Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.</p>Formule :C12H14BrN5O5Couleur et forme :SolidMasse moléculaire :388.175,6,7,8-Tetrahydro-8-deazahomofolic acid
CAS :<p>5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor and other folate related enzymes inhibitor.</p>Formule :C21H26N6O6Couleur et forme :SolidMasse moléculaire :458.47UNC-2170
CAS :<p>UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.</p>Formule :C14H21BrN2ODegré de pureté :97.44%Couleur et forme :SolidMasse moléculaire :313.23USP7-IN-13
CAS :<p>USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].</p>Formule :C24H28N4O3Couleur et forme :SolidMasse moléculaire :420.5AAPK-25
CAS :<p>AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.</p>Formule :C21H13Cl2N3O2SDegré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :442.32Cdc7-IN-12
CAS :<p>Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).</p>Formule :C16H14N2O2SCouleur et forme :SolidMasse moléculaire :298.36BMT-090605
CAS :<p>BMT-090605: AAK1 inhibitor (IC50=0.6 nM), also affects BIKE (45 nM) and GAK (60 nM), has antinociceptive properties.</p>Formule :C21H24N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.44hDHODH-IN-1
CAS :<p>hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.</p>Formule :C17H14N2O2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :278.31EHT 5372
CAS :<p>EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.</p>Formule :C17H11Cl2N5OSCouleur et forme :SolidMasse moléculaire :404.27Butylparaben sodium
CAS :<p>Butylparaben sodium significantly impacts the later phases of spermatogenesis in the testes by impairing hormonal regulation and/or RNA and protein synthesis [1</p>Formule :C11H13NaO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :216.21PDD00031705
CAS :<p>PDD00031705 is a benzimidazolone core cell-inactive Poly (ADP-ribose) glycohydrolase (PARG) inhibitor.</p>Formule :C20H22N6O3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.62T521
CAS :<p>T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.</p>Formule :C17H14FNO5S2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :395.43WRN inhibitor 1
CAS :<p>WRN Inhibitor 1 (example 7) is an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN), selectively targeting its helicase domain.</p>Formule :C16H13FN2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.35ROCK-IN-10
CAS :<p>ROCK-IN-10 (compound 50) serves as a powerful inhibitor of ROCK, exhibiting IC50 values of 6 nM for ROCK1 and 4 nM for ROCK2, respectively. It demonstrates over 100-fold selectivity towards ROCK1 and ROCK2 when compared to other kinases [1].</p>Formule :C25H25N5O3Couleur et forme :SolidMasse moléculaire :443.507PD-L1-IN-2
CAS :<p>PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity.</p>Formule :C33H38N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :586.68JNJ-26076713
CAS :<p>JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.</p>Formule :C29H38N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.64Myt1-IN-2
CAS :<p>Myt1-IN-2, a highly potent Myt1 inhibitor, exhibits remarkable anticancer properties with an IC50 value below 10 nM (WO2021195782A1; compound 28) [1].</p>Formule :C18H16N6O2SCouleur et forme :SolidMasse moléculaire :380.42Synstatin (92-119)
CAS :<p>Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and</p>Formule :C133H207N35O46Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3032.27Cdk4 Inhibitor
CAS :<p>PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 < 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.</p>Formule :C20H10BrN3O2Couleur et forme :SolidMasse moléculaire :404.2CCT241533
CAS :<p>CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).</p>Formule :C23H27FN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.48PVZB1194
CAS :<p>PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through</p>Formule :C13H9F4NO2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.28PF-6808472
CAS :<p>PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.</p>Formule :C25H27FN8O3SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :538.6USP1-IN-6
CAS :<p>USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.</p>Formule :C29H27F3N8OCouleur et forme :SolidMasse moléculaire :560.57PLK4-IN-4
CAS :<p>PLK4-IN-4 (compound 22), a potent inhibitor of PLK4, exhibits an IC50 value of 7.9 nM, suggesting its potential use in cancer research [1].</p>Formule :C21H23F2N9Couleur et forme :SolidMasse moléculaire :439.46SB-267268
CAS :<p>SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).</p>Formule :C22H24F3N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :451.44CCT-251921
CAS :<p>CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).</p>Formule :C21H23ClN6ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :410.9Inixaciclib
CAS :<p>Inixaciclib is a potent CDK inhibitor, can be used to research anticancer.</p>Formule :C26H30F2N6OCouleur et forme :SolidMasse moléculaire :480.55DNA Gyrase-IN-8
CAS :<p>DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].</p>Formule :C19H14BrN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :408.25Integrin Antagonists 27
CAS :<p>Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.</p>Formule :C24H20N4O5Couleur et forme :SolidMasse moléculaire :444.44Litronesib
CAS :<p>Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.</p>Formule :C23H37N5O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :511.7Tirofiban HCl
CAS :<p>Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.</p>Formule :C22H37ClN2O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :477.06ML 315 hydrochloride
CAS :<p>ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].</p>Formule :C18H14Cl3N3O2Couleur et forme :SolidMasse moléculaire :410.682CDK4-IN-2
CAS :<p>CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].</p>Formule :C22H26F2N6O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.54Bisindolylmaleimide X hydrochloride
CAS :<p>Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).</p>Formule :C26H25ClN4O2Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :460.96BMT-090605 hydrochloride
CAS :<p>BMT-090605 HCl: AAK1 inhibitor (IC50=0.6 nM), also targets BIKE (IC50=45 nM) & GAK (IC50=60 nM), with potential in neuropathic pain research.</p>Formule :C21H25ClN4O2Couleur et forme :SolidMasse moléculaire :400.91αvβ6 integrin inhibitor 2
CAS :<p>αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.</p>Formule :C21H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.49USP7-IN-12
CAS :<p>USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].</p>Formule :C29H28ClFN4O2SCouleur et forme :SolidMasse moléculaire :551.07NTRC 0066-0
CAS :<p>NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.</p>Formule :C33H39N7O2Degré de pureté :98.30%Couleur et forme :SolidMasse moléculaire :565.71Trovafloxacin mesylate
CAS :<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Formule :C21H19F3N4O6SDegré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :512.46Thymectacin
CAS :<p>Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.</p>Formule :C21H25BrN3O9PDegré de pureté :97.05% - 99.49%Couleur et forme :SolidMasse moléculaire :574.32CF53
CAS :<p>CF53: potent, selective oral BET inhibitor; Ki <1 nM, Kd 2.2 nM, IC50 2 nM for BRD4 BD1; high affinity for BRD2/3/4/BRDT; effective anti-tumor agent.</p>Formule :C24H25N7O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :443.5LNA-Adenosine
CAS :<p>LNA-Adenosine (LNA-A) is a nucleoside analogue that acts as a ligand for adenosine A3 receptors.</p>Formule :C11H13N5O4Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :279.25SMN-C3
CAS :<p>SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).</p>Formule :C24H28N6ODegré de pureté :99.01% - 99.05%Couleur et forme :SolidMasse moléculaire :416.52AZD4573
CAS :<p>AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.</p>Formule :C22H28ClN5O2Degré de pureté :99% - 99.51%Couleur et forme :SolidMasse moléculaire :429.94LY3295668
CAS :<p>LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.</p>Formule :C24H26ClF2N5O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :489.95DHX9-IN-2
CAS :<p>DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.</p>Formule :C18H16ClN3O3S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :421.92BDP9066
CAS :<p>BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.</p>Formule :C20H24N6Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :348.44Cdk1/2 Inhibitor III
CAS :<p>Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.</p>Formule :C15H13F2N7O2S2Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :425.44αvβ1 integrin-IN-1
CAS :<p>αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.</p>Formule :C26H34N6O6SDegré de pureté :99.74% - >99.99%Couleur et forme :SolidMasse moléculaire :558.65Roxifiban acetate
CAS :<p>Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used in</p>Formule :C23H33N5O8Degré de pureté :97.91% - 98.36%Couleur et forme :SolidMasse moléculaire :507.54CFI-402257
CAS :<p>CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.</p>Formule :C28H30N6O3Degré de pureté :96.66% - 99.51%Couleur et forme :SolidMasse moléculaire :498.58Debio-0123
CAS :<p>Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.</p>Formule :C26H28Cl2N6ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :511.45Plogosertib
CAS :<p>Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.</p>Formule :C34H48N8O3Degré de pureté :99.22% - 99.85%Couleur et forme :SolidMasse moléculaire :616.797PD-L1-IN-3
CAS :<p>PD-L1-IN-3 is a PD-1/PD-L1 inhibitor for the study of tumors and immune diseases.</p>Formule :C19H15ClFN2OSDegré de pureté :99.47%Couleur et forme :SoildMasse moléculaire :373.85CCT129202
CAS :<p>CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.</p>Formule :C23H25ClN8OSDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :497.02B I09
CAS :<p>B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells.</p>Formule :C16H17NO5Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :303.31(R)-Simurosertib
CAS :<p>(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.</p>Formule :C17H19N5OSDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :341.43Sorivudine
CAS :<p>Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.</p>Formule :C11H13BrN2O6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :349.13Lomibuvir
CAS :<p>Lomibuvir (VCH-222, VX-222) is an allosteric inhibitor of HCV NS5B with Kd 17 nM, blocks RNA elongation, EC50 5.2 nM for 1b/Con1.</p>Formule :C25H35NO4SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :445.61CLK1/4-IN-1
<p>CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.</p>Formule :C18H14ClNO4SCouleur et forme :SolidMasse moléculaire :375.83PAIR2
CAS :<p>PAIR2 is a selective IRE1α RNase partial antagonist, blocking its ATP site and preventing KIRA from hindering XBP1 splicing.</p>Formule :C27H26F4N6O3SCouleur et forme :SolidMasse moléculaire :590.592-Amino-2'-fluoro-2'-deoxyadenosine
CAS :<p>2-Amino-2'-fluoro-2'-deoxyadenosine is a component of nucleic acids.</p>Formule :C10H13FN6O3Couleur et forme :SolidMasse moléculaire :284.25CTX-712
CAS :<p>CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.</p>Formule :C19H17FN8O2Couleur et forme :SolidMasse moléculaire :408.392'-Deoxycytidine hydrate
CAS :<p>2'-Deoxycytidine (Deoxycytidine) hydrate is a component of nucleic acids.</p>Formule :C9H15N3O5Couleur et forme :SolidMasse moléculaire :245.23KWR095
CAS :<p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>Formule :C33H31ClF3N9O4Couleur et forme :SolidMasse moléculaire :710.105Terpendole E
CAS :<p>Terpendole E is an atypical L5 site inhibitor.</p>Formule :C28H39NO3Couleur et forme :SolidMasse moléculaire :437.61ATIC-IN-2
CAS :<p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>Formule :C4H4N4O3SCouleur et forme :SolidMasse moléculaire :188.165DENV-IN-6
CAS :<p>DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.</p>Formule :C23H26ClFN4OSCouleur et forme :SolidMasse moléculaire :461MtTMPK-IN-3
CAS :<p>MtTMPK-IN-3 inhibits Mycobacterium tuberculosis kinase with IC50 0.12μM, MIC 12.5μM on Mtb, cytotoxic EC50 12.5μM on MRC-5 cells.</p>Formule :C23H23Cl2N3O3Couleur et forme :SolidMasse moléculaire :460.35MtTMPK-IN-1
<p>MtTMPK-IN-1 inhibits MtTMPK with 2.5 μM IC50, shows moderate anti-tuberculosis activity, and is low in cytotoxicity.</p>Formule :C22H24N4O3Couleur et forme :SolidMasse moléculaire :392.45CDK7-IN-18
CAS :<p>CDK7-IN-18: potent, pyrimidine-based CDK7 inhibitor with cancer research potential.</p>Formule :C22H24F3N7OSCouleur et forme :SolidMasse moléculaire :491.53LY309887
CAS :<p>LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.</p>Formule :C19H23N5O6SCouleur et forme :SolidMasse moléculaire :449.48IRE1α kinase-IN-4
CAS :<p>IRE1α kinase-IN-4 (compound 6) is a potent inhibitor of IRE1α, exhibiting a Ki value of 140 nM. It acts as an ATP-competitive ligand for IRE1α [1].</p>Formule :C29H31N7O2Couleur et forme :SolidMasse moléculaire :509.6Polθ-IN-5
CAS :<p>Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.</p>Formule :C23H18ClF2N7O3SCouleur et forme :SolidMasse moléculaire :545.95GSK_WRN4
CAS :<p>GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research</p>Formule :C16H20N2O4SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :336.41GHP-88309
CAS :<p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>Formule :C16H11FN2OCouleur et forme :SolidMasse moléculaire :266.27CDK4/6-IN-24
CAS :<p>CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.</p>Formule :C32H41N7O3Couleur et forme :SolidMasse moléculaire :571.713Valopicitabine
CAS :<p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>Formule :C15H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.37Pol I-IN-1
<p>Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition</p>Formule :C23H22N4O2Couleur et forme :SolidMasse moléculaire :386.45L-2'-Fd4C
CAS :<p>L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].</p>Formule :C9H10FN3O3Couleur et forme :SolidMasse moléculaire :227.196K465
CAS :<p>6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.</p>Formule :C26H33ClFN9ODegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :542.05EFdA-TP tetrasodium
CAS :<p>EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.</p>Formule :C12H11FN5Na4O12P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :621.1214α-Demethylase/DNA Gyrase-IN-1
<p>14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.</p>Formule :C26H22N4O4Couleur et forme :SolidMasse moléculaire :454.48PKMYT1-IN-9
CAS :<p>PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.</p>Formule :C17H14FN5OCouleur et forme :SolidMasse moléculaire :323.324MtTMPK-IN-5
<p>MtTMPK-IN-5 inhibits Mtb TMPK with IC50 of 34 μM and fights tuberculosis with MIC of 12.5 μM, aiding TB research.</p>Formule :C21H23N5O2Couleur et forme :SolidMasse moléculaire :377.44CHK1-IN-2
CAS :<p>CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).</p>Formule :C20H22N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.48CDK9/PARP-IN-1
CAS :<p>CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.</p>Formule :C38H34F2N8O3Couleur et forme :SolidMasse moléculaire :688.725Aurora A inhibitor 1
CAS :<p>Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)</p>Formule :C25H28ClF2N5O2Couleur et forme :SolidMasse moléculaire :503.97Werner syndrome RecQ helicase-IN-2
CAS :<p>Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.</p>Formule :C32H34F3N9O5Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :681.67RAD51-IN-5
CAS :<p>RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)</p>Formule :C26H38N4O5S2Couleur et forme :SolidMasse moléculaire :550.73Mazethramycin
CAS :<p>Mazethramycin is an antitumor antibiotic that exerts its effects by disrupting DNA replication and RNA synthesis within cells. It is utilized in cancer research.</p>Formule :C17H19N3O4Masse moléculaire :329.35Zorubicin
CAS :<p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>Formule :C34H35N3O10Couleur et forme :SolidMasse moléculaire :645.66TASIN-30
CAS :<p>TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.</p>Formule :C18H30N2O3SCouleur et forme :SolidMasse moléculaire :354.512′-OMe-ADP
CAS :<p>2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.</p>Formule :C11H17N5O10P2Couleur et forme :SolidMasse moléculaire :441.23
