Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
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3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
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Sovesudil hydrochloride
<p>Sovesudil (PHP-201) HCl: potent local ROCK inhibitor; targets ROCK I/II (IC50: 3.7/2.3 nM); lowers IOP, non-congesting.</p>Formule :C23H23ClFN3O3Couleur et forme :SolidMasse moléculaire :443.9CDK12/13 ligand 1
CAS :<p>ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.</p>Formule :C26H26BrN5OCouleur et forme :SolidMasse moléculaire :504.42Dyrk1A/B-IN-1
<p>Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.</p>Formule :C21H17N3O2S2Couleur et forme :SolidMasse moléculaire :407.51Polθ-IN-6
CAS :<p>Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.</p>Formule :C25H23N3O3SCouleur et forme :SolidMasse moléculaire :445.53BRD-7880
CAS :<p>BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.</p>Formule :C32H38N4O7Couleur et forme :SolidMasse moléculaire :590.67WRN inhibitor 12
CAS :<p>WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.</p>Formule :C33H33ClF3N9O5Couleur et forme :SolidMasse moléculaire :728.12Lobucavir
CAS :<p>Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).</p>Formule :C11H15N5O3Couleur et forme :SolidMasse moléculaire :265.27NRTT-IN-1
CAS :<p>NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.</p>Formule :C28H24FN5O5Couleur et forme :SolidMasse moléculaire :529.519DNA Gyrase-IN-13
CAS :<p>DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.</p>Formule :C15H21N3O3SCouleur et forme :SolidMasse moléculaire :323.41RMS-07
CAS :<p>RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.</p>Formule :C35H40N8O2Couleur et forme :SolidMasse moléculaire :604.74D-G23
CAS :<p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>Formule :C19H22N4O3Couleur et forme :SolidMasse moléculaire :354.403P162-0948
CAS :<p>P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. It reduces cell migration and the expression of EMT-related proteins in the A549 human alveolar epithelial cell line. Furthermore, P162-0948 decreases Smad phosphorylation, indicating disruption of the TGF-β/Smad signaling pathway, making it a promising compound for pulmonary fibrosis research.</p>Formule :C20H15FN4O2Couleur et forme :SolidMasse moléculaire :362.357GSK3335103
CAS :<p>GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.</p>Formule :C27H36FN3O4Couleur et forme :SolidMasse moléculaire :485.59Dyrk1A-IN-12
CAS :<p>Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).</p>Formule :C22H16FN3O2SCouleur et forme :SolidMasse moléculaire :405.4455-Iminodaunorubicin hydrochloride
CAS :<p>5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.</p>Formule :C27H31ClN2O9Couleur et forme :SolidMasse moléculaire :563.00CDK2 degrader 4
CAS :<p>CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.</p>Formule :C23H26ClN3O5Couleur et forme :SolidMasse moléculaire :459.923LZ9
CAS :<p>LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2, with potential applications in colorectal cancer (CRC) research.</p>Formule :C17H11F3N4O2Couleur et forme :SolidMasse moléculaire :360.29MtTMPK-IN-7
<p>MtTMPK-IN-7 inhibits MtbTMPK (IC50: 47 μM), active against M. brevis (MIC: 2.3-4.7 μM), useful for tuberculosis research.</p>Formule :C27H29ClN6O3Couleur et forme :SolidMasse moléculaire :521.01Rhodblock 1a
CAS :<p>Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.</p>Formule :C20H16N2O2Couleur et forme :SolidMasse moléculaire :316.353CDK2/4-IN-2
CAS :<p>CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.</p>Formule :C18H20F3N7O3S2Couleur et forme :SolidMasse moléculaire :503.52Kolavenic acid analog
CAS :<p>KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.</p>Formule :C25H38O4Couleur et forme :SolidMasse moléculaire :402.57Zalunfiban dihydrochloride
<p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>Formule :C16H20Cl2N8O2SCouleur et forme :SolidMasse moléculaire :459.35MtTMPK-IN-9
<p>MtTMPK-IN-9 moderately inhibits MtbTMPK (IC50: 48 μM), has submicromolar Mycobacterium activity, and is non-toxic, aiding tuberculosis research.</p>Formule :C25H26N6O7Couleur et forme :SolidMasse moléculaire :522.51(R)-CSN5i-3
CAS :<p>(R)-CSN5i-3 is CSN5i-3 of the R configuration.</p>Formule :C28H29F2N5O2Degré de pureté :99.76% - 99.97%Couleur et forme :SolidMasse moléculaire :505.56WRN inhibitor 11
CAS :<p>WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.</p>Formule :C34H35ClF3N9O5Couleur et forme :SolidMasse moléculaire :742.15LY 254155
CAS :<p>LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.</p>Formule :C19H23N5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.48LNA-GTP
CAS :<p>LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.</p>Formule :C11H16N5O14P3Couleur et forme :SolidMasse moléculaire :535.194,5'-Dimethylangelicin-NHS
<p>NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.</p>Formule :C21H19NO7SCouleur et forme :SolidMasse moléculaire :429.44DYRKs-IN-1 hydrochloride
CAS :<p>DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) & DYRK1B (8 nM IC50) with antitumor properties.</p>Formule :C30H31Cl2N7O4Couleur et forme :SolidMasse moléculaire :624.52DNA gyrase B-IN-1
<p>DNA gyrase B-IN-1, a potent inhibitor of P. aeruginosa DNA gyrase B, has IC50 of 2.2 μM with high affinity and stability.</p>Formule :C23H18ClF3N6O4SCouleur et forme :SolidMasse moléculaire :566.94α5β1 integrin agonist-1
CAS :<p>α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.</p>Formule :C24H26FN5O9Couleur et forme :SolidMasse moléculaire :547.49(R)-Atuveciclib
CAS :<p>Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].</p>Formule :C18H18FN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.43RAD51-IN-7
CAS :<p>RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)</p>Formule :C25H31N5O4S2Couleur et forme :SolidMasse moléculaire :529.67DNA ligase-IN-2
CAS :<p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is >64 μg/mL.</p>Formule :C13H8FN3O3Couleur et forme :SolidMasse moléculaire :273.219AR-13324 M1 metabolite
CAS :<p>AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.</p>Formule :C19H19N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.37Methyl 3-oxodecanoate
CAS :<p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>Formule :C11H20O3Couleur et forme :SolidMasse moléculaire :200.275DS96432529
<p>DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.</p>Formule :C18H26N4O3SCouleur et forme :SoildMasse moléculaire :378.49CDK9-IN-13
<p>CDK9-IN-13 is a potent and selective CDK inhibitor (IC50<3 nM). CDK9-IN-13 has a very short half-life in rodents.</p>Formule :C27H35N5O2Couleur et forme :SolidMasse moléculaire :461.62'-O-MOE-GMP
CAS :<p>2'-O-MOE-GMP is a nucleotide analogue that can be utilized in the synthesis of oligonucleotides.</p>Formule :C13H20N5O9PCouleur et forme :SolidMasse moléculaire :421.30Chk1-IN-5
CAS :<p>Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.</p>Formule :C18H18FN7O2Couleur et forme :SolidMasse moléculaire :383.38CDK9-IN-38
CAS :<p>CDK9-IN-38 (compound 14) is a CDK9 inhibitor with IC50 values of 1.2 nM for wild-type CDK9 and 3.3 nM for the L156F mutant. It effectively inhibits tumor growth both in vitro and in vivo.</p>Formule :C22H23N5O3SCouleur et forme :SolidMasse moléculaire :437.515CDK6-IN-1
CAS :<p>CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.</p>Formule :C30H23N5Couleur et forme :SolidMasse moléculaire :453.54N-Isobutyryl-2', 3'-acetyl-guanosine
CAS :<p>N-Isobutyryl-2', 3'-acetyl-guanosine is a derivative of guanosine.</p>Formule :C18H23N5O8Couleur et forme :SolidMasse moléculaire :437.404CYP2C19-IN-1
<p>CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.</p>Formule :C26H26N2O6SCouleur et forme :SolidMasse moléculaire :494.56CDK7-IN-31
CAS :<p>CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.</p>Formule :C27H32F5N6O2PCouleur et forme :SolidMasse moléculaire :598.55T-2513 hydrochloride
CAS :<p>T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.</p>Formule :C25H28ClN3O5Couleur et forme :SolidMasse moléculaire :485.96CHK-IN-1
CAS :<p>CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.</p>Formule :C18H19ClFN5OSDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :407.89Hesperadin hydrochloride
<p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.12LNA-AMP
CAS :<p>LNA-AMP is a nucleotide analog used in the synthesis of oligonucleotides.</p>Formule :C11H14N5O7PCouleur et forme :SolidMasse moléculaire :359.23CDK1-IN-7
CAS :<p>CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.</p>Formule :C23H19ClN4O3Couleur et forme :SolidMasse moléculaire :434.88CDK8-IN-9
<p>CDK8-IN-9, potent CDK8 inhibitor (IC50: 48.6 nM), curbs tumor growth, useful for colorectal cancer research.</p>Couleur et forme :SolidDyrk1A-IN-2
<p>Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.</p>Formule :C27H32N6O4Couleur et forme :SolidMasse moléculaire :504.58Dmf-dg
CAS :<p>Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a nucleoside of deoxyguanosine (dG) with a dimethylaminomethylene (DMF) base protection, employed in the synthesis of oligonucleotides.</p>Formule :C13H18N6O4Couleur et forme :SolidMasse moléculaire :322.32UMPK ligand 1
CAS :<p>UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).</p>Formule :C15H22N4O5SCouleur et forme :SolidMasse moléculaire :370.4242'-F-CDP
CAS :<p>2'-F-CDP is a nucleotide analog that can be utilized in the synthesis of oligonucleotides.</p>Formule :C9H14FN3O10P2Couleur et forme :SolidMasse moléculaire :405.17β-catenin-IN-8
CAS :<p>β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.</p>Formule :C15H12ClN3O2SCouleur et forme :SolidMasse moléculaire :333.79PLK1-IN-5
CAS :<p>PLK1-IN-5, a potent PLK1 inhibitor, has an IC50 of less than 500 nM and demonstrates anticancer effects (WO2008113711A1; compound I-4) [1].</p>Formule :C28H39N7O3Couleur et forme :SolidMasse moléculaire :521.65(Rac)-Plevitrexed
CAS :<p>(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).</p>Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.53INX-315
CAS :<p>INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.</p>Formule :C19H21N7O3SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :427.48Dyrk1A-IN-8
CAS :<p>Dyrk1A-IN-8 is an active molecule that can be used in life science related research. The CAS number of Dyrk1A-IN-8 is 101578-13-6.</p>Formule :C17H21N3OCouleur et forme :SolidMasse moléculaire :283.37CHK1-IN-11
CAS :<p>CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.</p>Formule :C20H22N8O2Couleur et forme :SolidMasse moléculaire :406.44CDK2 degrader 6
CAS :<p>CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.</p>Formule :C23H22F5N5O3Couleur et forme :SolidMasse moléculaire :511.44LNA-CTP
CAS :<p>LNA-CTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>Formule :C10H16N3O14P3Couleur et forme :SolidMasse moléculaire :495.17RNAP-σ interaction inhibitor-2
CAS :<p>RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor targeting the interaction between RNA polymerase and the sigma factor. It demonstrates inhibitory activity against S. aureus with a minimum inhibitory concentration (MIC) of 2 µg/mL.</p>Formule :C27H19Cl3N2O6S2Couleur et forme :SolidMasse moléculaire :637.939Antiviral agent 67
CAS :<p>Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.</p>Formule :C19H19N3OCouleur et forme :SolidMasse moléculaire :305.374CD 10899
CAS :<p>CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].</p>Formule :C34H50N8O4Couleur et forme :SolidMasse moléculaire :634.81iPAF1C
CAS :<p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>Formule :C27H26BrFN4OCouleur et forme :SolidMasse moléculaire :521.42CDK1-IN-6
<p>CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.</p>Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.432,5-Di-tert-butyl-1,4-benzoquinone
CAS :<p>2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.</p>Formule :C14H20O2Couleur et forme :SolidMasse moléculaire :220.31Mps1-IN-8
CAS :<p>Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].</p>Formule :C35H47N8O6PCouleur et forme :SolidMasse moléculaire :706.77WRN inhibitor 7
CAS :<p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>Formule :C27H23N3O6Couleur et forme :SolidMasse moléculaire :485.49N-Nitrosonornicotine
CAS :<p>N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.</p>Formule :C9H11N3OCouleur et forme :SolidMasse moléculaire :177.2DB18
CAS :<p>DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].</p>Formule :C24H18ClN7O3Couleur et forme :SolidMasse moléculaire :487.9VPC-80051
CAS :<p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>Formule :C16H13F2N3OCouleur et forme :SolidMasse moléculaire :301.291LIMK-IN-2
CAS :<p>LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].</p>Formule :C28H27N5O2Couleur et forme :SolidMasse moléculaire :465.555'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine
CAS :<p>5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine is a nucleoside synthesized through oxime ring-opening at the 5' position and methylation at the 2' position. In chemotaxis assays, 5'-O-Dmt-n2-isobutyryl-2'-o-methyl-d-guanosine demonstrates tissue affinity.</p>Formule :C36H39N5O8Couleur et forme :SolidMasse moléculaire :669.724TMX-3013
CAS :<p>TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.</p>Formule :C17H14BrFN6O3SCouleur et forme :SolidMasse moléculaire :481.3PKMYT1-IN-2
CAS :<p>PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].</p>Formule :C22H19N5O2Couleur et forme :SolidMasse moléculaire :385.42PLK1-IN-11
CAS :<p>PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.</p>Formule :C12H11N5OCouleur et forme :SolidMasse moléculaire :241.2492'-O-MOE-GTP
CAS :<p>2'-O-MOE-GTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>Formule :C13H22N5O15P3Couleur et forme :SolidMasse moléculaire :581.26PKMYT1-IN-7
CAS :<p>PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM for PKMYT1 and 0.06 μM for pCDK1. It inhibits the phosphorylation of CDK1 at T14 and Y15 sites and exhibits anticancer activity both in vitro and in vivo.</p>Formule :C17H18FN5O3Couleur et forme :SolidMasse moléculaire :359.355PolQi1
CAS :<p>PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.</p>Formule :C18H14ClF5N4O2Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :448.77NusB-IN-1
<p>NusB-IN-1 (22r) is an oral bacterial rRNA inhibitor, effective against MRSA and VRSA.</p>Formule :C21H16N2O3Couleur et forme :SolidMasse moléculaire :344.36ROCK-IN-11
CAS :<p>ROCK-IN-11 (example 94) is an effective inhibitor of ROCK1 and ROCK2, with an IC50 of ≤ 5 μM, and plays a significant role in cancer research.</p>Formule :C22H20N4O4SCouleur et forme :SolidMasse moléculaire :436.484WEE1-IN-11
CAS :<p>WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.</p>Formule :C26H29FN8OS2Couleur et forme :SolidMasse moléculaire :552.69PPA-037
CAS :<p>PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.</p>Formule :C25H27N7Couleur et forme :SolidMasse moléculaire :425.53WEE1 degrader 1
<p>WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.</p>Formule :C30H31N5O3Couleur et forme :SolidMasse moléculaire :509.6CDK2-IN-18
CAS :<p>CDK2-IN-18 (compound 8q) serves as a powerful inhibitor of CDK 2/E and CDK 4/D1, showing IC50 values of 8 nM and 46 nM, respectively. It effectively inhibits tumor cell proliferation [1].</p>Formule :C21H23N7O2SCouleur et forme :SolidMasse moléculaire :437.52Haspin-IN-1
<p>Haspin-IN-1 blocks haspin (IC50: 119 nM) and inhibits CLK1, DYRK1A, CDK9 with potential as an anticancer drug.</p>Formule :C12H8N4O2SCouleur et forme :SolidMasse moléculaire :272.28Uridine 3',5'-diphosphate
CAS :<p>Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].</p>Formule :C9H14N2O12P2Couleur et forme :SolidMasse moléculaire :404.16Dyrk1A-IN-4
CAS :<p>Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.</p>Formule :C14H13F3N6Couleur et forme :SolidMasse moléculaire :322.29DHX9-IN-9
CAS :<p>DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].</p>Formule :C21H21ClFN5O3S2Couleur et forme :SolidMasse moléculaire :510Plevitrexed
CAS :<p>Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor & reduced folate carrier, treats gastric cancer.</p>Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.532′-O-MOE-CMP
CAS :<p>2′-O-MOE-CMP is a nucleotide analogue utilized in the synthesis of oligonucleotides.</p>Formule :C12H20N3O9PCouleur et forme :SolidMasse moléculaire :381.28RAD51-IN-8
<p>RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.</p>Formule :C16H14Cl2FN3O2Couleur et forme :SolidMasse moléculaire :370.21CIB-L43
CAS :<p>CIB-L43 is a oral TRBP inhibitor, inhibit miR-21, increase PTEN and Smad7, and block the AKT and TGF-β，inhibit proliferation and migration.</p>Formule :C15H16N2O3SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :304.36Cdc7-IN-18
CAS :<p>Cdc7-IN-18 (1-2) inhibits CDC7 enzyme (IC50: 1.29 nM) and COLO205 cell proliferation (IC50: 53.62 nM).</p>Formule :C19H21N5OSCouleur et forme :SolidMasse moléculaire :367.47Polθ-IN-8
CAS :<p>Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.</p>Formule :C22H22ClN7O3SCouleur et forme :SolidMasse moléculaire :499.97Cdc7-IN-19
CAS :<p>Cdc7-IN-19 (compound 1-1) is a potent CDC7 inhibitor with an IC 50 of 1.49 nM [1].</p>Formule :C19H21N5O2Couleur et forme :SolidMasse moléculaire :351.40CDK8-IN-14
CAS :<p>CDK8-IN-14 (compound 12) effectively inhibits CDK8, demonstrating an IC50 of 39.2 nM, and exhibits potent anti-AML cell proliferation effects, with a GC50 value of 0.02±0.01μM in MOLM-13 cells and 0.03±0.01μM in MV4-11 cells [1].</p>Formule :C18H13N3O2Couleur et forme :SolidMasse moléculaire :303.31
