Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(115 produits)
- CDK(547 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(227 produits)
- HSP(180 produits)
- Intégrine(269 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(273 produits)
- PKC(126 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3909 produits trouvés pour "Cycle cellulaire/point de contrôle"
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CDK4-IN-2
CAS :CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].Formule :C22H26F2N6O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.54CDK9-IN-9
CAS :CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).Formule :C22H23F2N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.51LDC3140
CAS :LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).Formule :C23H33N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :423.55MC-Val-Cit-PAB-Ispinesib
CAS :MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].Formule :C59H71ClN10O10Couleur et forme :SolidMasse moléculaire :1115.71Homouridine
CAS :Homouridine, an analogue of uridine, functions as an intermediate in the synthesis of MMP-2 inhibitor (compound I, IC50 = 150 μM).Formule :C10H14N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :258.23SB-267268
CAS :SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).Formule :C22H24F3N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :451.44KSP-IA
CAS :KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.Formule :C21H22F2N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.41Integrin Antagonists 27
CAS :Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.Formule :C24H20N4O5Couleur et forme :SolidMasse moléculaire :444.44G4/HDAC-IN-1
G4/HDAC-IN-1, a G4/HDAC dual inhibitor, IC50 1.1 µM, blocks TNBC growth, useful in cancer research.Formule :C36H49ClFN7O4Couleur et forme :SolidMasse moléculaire :698.27OXA-06 hydrochloride
CAS :OXA-06 hydrochloride, an ATP-competitive ROCK inhibitor, impedes anchorage-dependent growth and invasion in non-small cell lung cancer cell lines. It effectively inhibits cofilin phosphorylation without inducing apoptosis [1].Formule :C21H20Cl2FN3Couleur et forme :SolidMasse moléculaire :404.31NITD008
CAS :NITD008 (7-Deaza-2'-C-acetylene-adenosine) is an adenosine nucleoside inhibitor with antiviral activity that inhibits dengue and Zika viruses.Formule :C13H14N4O4Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :290.27Cdk4 Inhibitor
CAS :PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 < 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.Formule :C20H10BrN3O2Couleur et forme :SolidMasse moléculaire :404.2Luvixasertib hydrochloride
CAS :CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].Formule :C28H31ClN6O3Couleur et forme :SolidMasse moléculaire :535.04Pelitrexol
CAS :Pelitrexol (AG2037) is a GARFT inhibitor, which can inhibit the activity of mTORC1, block the cell cycle in the s-phase, with antiproliferative activity,NSCLC .Formule :C20H25N5O6SDegré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :463.51FAICAR
CAS :FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.Formule :C10H15N4O9PCouleur et forme :SolidMasse moléculaire :366.22Galidesivir hydrochloride
CAS :Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.Formule :C11H16ClN5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :301.735-Iodo-indirubin-3'-monoxime
CAS :5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFormule :C16H10IN3O2Couleur et forme :SolidMasse moléculaire :403.17SZ-015268
CAS :SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.Formule :C25H38N8O3Couleur et forme :SolidMasse moléculaire :498.62Anti-hepatic fibrosis agent 2
CAS :Compound 6k, also known as Anti-hepatic fibrosis agent 2, is an orally active inhibitor of the COL1A1 enzyme and exerts anti-fibrogenic effects by targeting theFormule :C26H41N3OCouleur et forme :SolidMasse moléculaire :411.62DUB-IN-7
CAS :DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Formule :C17H19N5OCouleur et forme :SolidMasse moléculaire :309.37CCT-251921
CAS :CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Formule :C21H23ClN6ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :410.9Ref: TM-T14901
1mg90,00€1mL*10mM (DMSO)192,00€5mg210,00€10mg308,00€25mg520,00€50mg745,00€100mg1.018,00€USP7-IN-13
CAS :USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].Formule :C24H28N4O3Couleur et forme :SolidMasse moléculaire :420.5GSK2646264
CAS :GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.Formule :C24H26N2O2Couleur et forme :SolidMasse moléculaire :374.48Carotegrast
CAS :Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.Formule :C27H24Cl2N4O5Couleur et forme :SolidMasse moléculaire :555.41CDK9-IN-8
CAS :CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).Formule :C31H32FN7O3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :569.63αvβ1 integrin-IN-2
CAS :αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.Formule :C29H38N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.64USP1-IN-6
CAS :USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.Formule :C29H27F3N8OCouleur et forme :SolidMasse moléculaire :560.57CDK4/6-IN-17
CAS :CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.Formule :C27H28F4N8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.56CDK8-IN-3
CAS :CDK8-IN-3 is an inhibitor of CDK8.Formule :C22H23N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :389.453-Hydroxyxanthone
CAS :3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFormule :C13H8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :212.2H3B-968
CAS :H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonucleaseFormule :C22H18F6N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :548.46SC-52012
CAS :SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.Formule :C25H30N4O6Degré de pureté :97.20%Couleur et forme :SolidMasse moléculaire :482.53hDHODH-IN-1
CAS :hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.Formule :C17H14N2O2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :278.31Ref: TM-T11546
1mg34,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg103,00€25mg200,00€50mg290,00€100mg404,00€200mg545,00€12R-LOX-IN-1
CAS :12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX.Formule :C15H11NO2Couleur et forme :SolidMasse moléculaire :237.25Alatrofloxacin
CAS :Alatrofloxacin is a prodrug of trovafloxacin.Formule :C26H25F3N6O5Couleur et forme :SolidMasse moléculaire :558.51MOMA-341
CAS :MOMA-341, ATP-competitive WRN allosteric inhibitor (Cys727 site), induces DNA damage and tumor regression in dMMR/MSI-H models, for solid tumors.Formule :C28H26F4N6O3Couleur et forme :SolidMasse moléculaire :570.54PLK1/p38γ-IN-1
CAS :PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellularFormule :C21H26ClN3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.9MS-444
CAS :MS-444 (BE-34776) is an MLCK and HuR inhibitor with antitumor activity that can be used to study triple-negative breast cancer and colorectal cancer.Formule :C13H10O4Degré de pureté :99.45% - 99.45%Couleur et forme :SolidMasse moléculaire :230.22ROCK-IN-7
CAS :ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Formule :C17H17N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :327.4Gly-Arg-Gly-Asp-Ser TFA
CAS :Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.Formule :C19H31F3N8O11Couleur et forme :SolidMasse moléculaire :604.49DNA polymerase-IN-1
CAS :DNA polymerase-IN-1 exhibits antiproliferative activity against tumor cells and inhibits Taq DNA polymerase as a DNA polymerase inhibitor.Formule :C10H7ClO4Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :226.61BI-1950
CAS :BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Formule :C32H26Cl2FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.5Myt1-IN-2
CAS :Myt1-IN-2, a highly potent Myt1 inhibitor, exhibits remarkable anticancer properties with an IC50 value below 10 nM (WO2021195782A1; compound 28) [1].Formule :C18H16N6O2SCouleur et forme :SolidMasse moléculaire :380.42ROCK2-IN-2
CAS :ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Formule :C18H12N6OSDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :360.39Ref: TM-T12747
1mg50,00€5mg111,00€1mL*10mM (DMSO)136,00€10mg177,00€25mg304,00€50mg447,00€100mg692,00€200mg888,00€Chroman 1
CAS :Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Formule :C24H28N4O4Degré de pureté :99.67% - 99.84%Couleur et forme :SolidMasse moléculaire :436.5Ref: TM-T14960
1mg73,00€5mg160,00€1mL*10mM (DMSO)173,00€10mg250,00€25mg430,00€50mg645,00€100mg888,00€FT671
CAS :FT671 is a non-covalent, selective USP7 inhibitor, disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, inhibits tumor growth.Formule :C24H23F4N7O3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :533.48Xylocydine
CAS :Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.Formule :C12H14BrN5O5Couleur et forme :SolidMasse moléculaire :388.17RAD51-IN-4
CAS :RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.Formule :C31H34FN5O5S2Couleur et forme :SolidMasse moléculaire :639.76Mevociclib
CAS :Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Formule :C31H35ClN8O2Degré de pureté :98.02% - 98.02%Couleur et forme :SolidMasse moléculaire :587.11DHX9-IN-6
CAS :DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.Formule :C23H18ClFN4O4S2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :533ML 315 hydrochloride
CAS :ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].
Formule :C18H14Cl3N3O2Couleur et forme :SolidMasse moléculaire :410.682Cytarabine 5′-monophosphate
CAS :Cytarabine 5′-monophosphate (ara-CMP), an active metabolite of the nucleoside analog cytarabine formed by deoxycytidine kinase, is incorporated into DNA by DNA polymerase α, significantly slowing DNA synthesis. It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM and improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg.Formule :C9H14N3O8PCouleur et forme :SolidMasse moléculaire :323.198DNA Gyrase-IN-8
CAS :DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].Formule :C19H14BrN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :408.25NTRC 0066-0
CAS :NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.Formule :C33H39N7O2Degré de pureté :98.30%Couleur et forme :SolidMasse moléculaire :565.71ATN-161
CAS :ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.Formule :C23H35N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :597.645′-Guanylyl methylenediphosphonate sodium
CAS :5′-Guanylyl methylenediphosphonate (sodium) serves as a GTP analogue and acts as a specific, competitive inhibitor of the GTP reaction in protein synthesis [1].Formule :C11H15N5Na3O13P3Couleur et forme :SolidMasse moléculaire :587.15DAM-IN-1
CAS :DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.Formule :C16H17NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :287.31Cdc7-IN-12
CAS :Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).Formule :C16H14N2O2SCouleur et forme :SolidMasse moléculaire :298.36WRN inhibitor 5
CAS :WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).Formule :C23H20N2O6SCouleur et forme :SolidMasse moléculaire :452.48CDK7-IN-14
CAS :CDK7-IN-14 (compound 3) is a pyrimidine-derived CDK7 inhibitor applicable for studying cancers associated with transcriptional dysregulation.Formule :C22H24F3N6OPDegré de pureté :99.24% - 99.48%Couleur et forme :SolidMasse moléculaire :476.43CCT241533
CAS :CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formule :C23H27FN4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.48Senexin C
CAS :Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Formule :C28H27N5ODegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :449.55MU-380
CAS :MU-380 is an effective and selective inhibitor of CHK1.Formule :C15H15BrF3N7Couleur et forme :SolidMasse moléculaire :430.23DNA gyrase B-IN-3
CAS :DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against GramFormule :C14H9Cl2N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.21Votoplam
CAS :Votoplam functions as a gene splicing modulator, employed in the inhibition of Huntington's disease [1].Formule :C21H25N9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.48SB-743921 free base
CAS :SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).Formule :C31H33ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.06Brodimoprim
CAS :Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR).Formule :C13H15BrN4O2Degré de pureté :98% - 99.71%Couleur et forme :SolidMasse moléculaire :339.19DHX9-IN-4
CAS :DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.Formule :C21H22ClN5O4S2Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :508.01Myt1-IN-3
CAS :Myt1-IN-3 is a potent inhibitor of Myt1 (IC50 <10 nM) [1].Formule :C18H19N5O2Couleur et forme :SolidMasse moléculaire :337.38Spirofylline
CAS :Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.Formule :C24H28N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :480.52Nε-(1-Carboxyethyl)-L-lysine
CAS :Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.Formule :C9H18N2O4Couleur et forme :SolidMasse moléculaire :218.25CDK9-IN-29
CAS :CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.Formule :C29H33F2N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.6USP1-IN-5
CAS :USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less thanFormule :C27H23F3N8OCouleur et forme :SolidMasse moléculaire :532.52G-5758
CAS :G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.Formule :C27H24F4N6O3SCouleur et forme :SolidMasse moléculaire :588.58GW814408X
CAS :GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Formule :C19H16N6OMasse moléculaire :344.375'-ODMT cEt m5U Phosphoramidite (Amidite)
CAS :5'-ODMT cEt m5U Phosphoramidite Amidite, a locked nucleic acid (LNA) analog, demonstrates exceptional safety and antisense activity [1] [2].Formule :C42H51N4O9PCouleur et forme :SolidMasse moléculaire :786.85RNA polymerase II-IN-1
CAS :RNA polymerase II-IN-1 (19iv), an amatoxin, inhibits Pol II at 36.66 nM IC50, is more toxic to cancer cells, less to normal cells than α-Amanitin.Formule :C38H53N11O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :887.965'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
CAS :5'-ODMT cEt N-Bzm5 C Phosphoramidite is a strong modified nucleic acid analog for antisense oligos.Formule :C49H56N5O9PCouleur et forme :SolidMasse moléculaire :889.97αvβ6 integrin inhibitor 2
CAS :αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.Formule :C21H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.49PVZB1194
CAS :PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis throughFormule :C13H9F4NO2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.28DCB-3503
CAS :DCB-3503, a tylophorine analog, may fight cancer and aid immunosuppression by hindering protein synthesis and modulating HSC70 ATPase function.Formule :C24H27NO5Couleur et forme :SolidMasse moléculaire :409.47Zaurategrast
CAS :Zaurategrast (CDP323) is an oral α4-integrin antagonist that blocks VCAM-1 interactions and is used to study immune cell trafficking.Formule :C26H25BrN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.41LX7101 hydrochloride
CAS :LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.Formule :C23H29N7O3HClCouleur et forme :SolidMasse moléculaire :488Synstatin (92-119)
CAS :Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 andFormule :C133H207N35O46Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3032.27ROCK-IN-9
CAS :ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.Formule :C20H20FN5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :381.4L 738167
CAS :L 738167 is a potent antagonist of the long-acting fibrinogen receptor.Formule :C25H34N6O6SCouleur et forme :SolidMasse moléculaire :546.64PTC258
CAS :PTC258 is a specific, orally active modulator of the splicing of the Elongator complex protein 1 gene (ELP1), enhancing its expression both in vitro and in vivoFormule :C16H18ClN3S2Couleur et forme :SolidMasse moléculaire :351.92Mps1-IN-10
CAS :Mps1-IN-6 (Compound 9) is a highly effective Mps1 inhibitor with an IC50 value of 6.4 nM and exhibits significant anti-proliferation and anti-tumor effects onFormule :C24H27N7O2Couleur et forme :SolidMasse moléculaire :445.522'-Deoxypseudoisocytidine
CAS :2'-Deoxypseudoisocytidine is a nucleoside analogue.Formule :C9H13N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :227.22WRN inhibitor 1
CAS :WRN Inhibitor 1 (example 7) is an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN), selectively targeting its helicase domain.Formule :C16H13FN2O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.35TC-A 2317 hydrochloride
CAS :TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Formule :C19H29ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.93ROCK2-IN-7
CAS :ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.Formule :C26H28FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.53BMT-090605 hydrochloride
CAS :BMT-090605 HCl: AAK1 inhibitor (IC50=0.6 nM), also targets BIKE (IC50=45 nM) & GAK (IC50=60 nM), with potential in neuropathic pain research.Formule :C21H25ClN4O2Couleur et forme :SolidMasse moléculaire :400.91BMT-090605
CAS :BMT-090605: AAK1 inhibitor (IC50=0.6 nM), also affects BIKE (45 nM) and GAK (60 nM), has antinociceptive properties.Formule :C21H24N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.44Lerociclib
CAS :Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.Formule :C26H34N8ODegré de pureté :99%Couleur et forme :SolidMasse moléculaire :474.6COH1
CAS :COH1 is a ribonucleotide reductase (RR) inhibitor utilized in research pertaining to cancer, mitochondrial diseases, and neurodegenerative disorders [1].Formule :C11H10N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :250.27Leucettinib-92
CAS :Leucettinib-92 is a multi-kinase inhibitor of DYRK and CLK families with differential nanomolar activity, supporting studies of kinase signaling regulation.Formule :C21H22N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.49L-739758
CAS :L-739758 is a glycoprotein IIb/IIIa inhibitor.Formule :C22H26N4O5S3Couleur et forme :SolidMasse moléculaire :522.66CI 972 anhydrous
CAS :CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.Formule :C11H12ClN5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :297.76CDK7-IN-22
CAS :CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].Formule :C22H25F3N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.47
