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Cycle cellulaire/point de contrôle

Cycle cellulaire/point de contrôle

Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.

Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"

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3904 produits trouvés pour "Cycle cellulaire/point de contrôle"

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  • Anti-hepatic fibrosis agent 2

    CAS :
    Compound 6k, also known as Anti-hepatic fibrosis agent 2, is an orally active inhibitor of the COL1A1 enzyme and exerts anti-fibrogenic effects by targeting the
    Formule :C26H41N3O
    Couleur et forme :Solid
    Masse moléculaire :411.62

    Ref: TM-T83064

    5mg
    À demander
    50mg
    À demander
  • Mps1-IN-10

    CAS :
    Mps1-IN-6 (Compound 9) is a highly effective Mps1 inhibitor with an IC50 value of 6.4 nM and exhibits significant anti-proliferation and anti-tumor effects on
    Formule :C24H27N7O2
    Couleur et forme :Solid
    Masse moléculaire :445.52

    Ref: TM-T77779

    5mg
    À demander
    50mg
    À demander
  • HQ005

    CAS :
    HQ005, a potent CCNK degrader, exhibits an impressive DC50 value of 0.041 µM and functions as a molecular-glue degrader.
    Formule :C15H15N5O2S2
    Couleur et forme :Solid
    Masse moléculaire :361.44

    Ref: TM-T82177

    5mg
    À demander
    50mg
    À demander
  • TNH

    CAS :
    TNH, a dimeric compound, possesses the ability to penetrate living cells and facilitate the recruitment of proteins into cellular structures [1].
    Formule :C39H57ClN6O13
    Couleur et forme :Solid
    Masse moléculaire :853.36

    Ref: TM-T80972

    5mg
    À demander
    50mg
    À demander
  • PD-321852

    CAS :
    PD-321852, a Chk1 inhibitor, boosts gemcitabine's effect in pancreatic cancer cells, varying from minimal in Panc1 to >30-fold in MiaPaCa2.
    Formule :C24H19Cl2N3O3
    Couleur et forme :Solid
    Masse moléculaire :468.33

    Ref: TM-T68981

    25mg
    1.908,00€
    50mg
    2.502,00€
    100mg
    3.330,00€
  • DNA polymerase-IN-3

    CAS :
    DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications in
    Formule :C13H12O4
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :232.23

    Ref: TM-T79308

    5mg
    À demander
    50mg
    À demander
  • 3-Cyanovinylcarbazole phosphoramidite

    CAS :
    3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.
    Formule :C50H53N4O6P
    Couleur et forme :Solid
    Masse moléculaire :836.95

    Ref: TM-T74188

    5mg
    873,00€
    50mg
    1.665,00€
    100mg
    2.250,00€
  • CDK9-IN-2

    CAS :
    CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.
    Formule :C23H25ClFN5
    Degré de pureté :99%
    Couleur et forme :Solid
    Masse moléculaire :425.93

    Ref: TM-T14918

    1mg
    84,00€
    5mg
    177,00€
    10mg
    266,00€
    25mg
    460,00€
    50mg
    668,00€
    100mg
    945,00€
    1mL*10mM (DMSO)
    195,00€
  • BMT-090605

    CAS :
    BMT-090605: AAK1 inhibitor (IC50=0.6 nM), also affects BIKE (45 nM) and GAK (60 nM), has antinociceptive properties.
    Formule :C21H24N4O2
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :364.44

    Ref: TM-T14691

    25mg
    1.908,00€
    50mg
    2.502,00€
    100mg
    3.330,00€
  • 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)

    CAS :
    5'-ODMT cEt N-Bz A Phosphoramidite Amidite, a locked nucleic acid (LNA) analogue, exhibits hybridization and mismatch discrimination capabilities similar to LNA, and shows resistance to exonuclease digestion [1].
    Formule :C49H54N7O8P
    Couleur et forme :Solid
    Masse moléculaire :899.97

    Ref: TM-T74702

    1mg
    288,00€
    5mg
    702,00€
    10mg
    1.000,00€
    25mg
    1.478,00€
    50mg
    1.941,00€
    100mg
    2.617,00€
  • JNJ-26076713

    CAS :
    JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.
    Formule :C29H38N4O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :490.64

    Ref: TM-T27670

    25mg
    4.374,00€
  • Pencitabine

    CAS :
    Pen is an oral cancer drug that blocks DNA synthesis by inhibiting key enzymes and integrating into DNA.
    Formule :C15H20F3N3O6
    Couleur et forme :Solid
    Masse moléculaire :395.33

    Ref: TM-T61839

    25mg
    1.927,00€
    50mg
    2.507,00€
    100mg
    3.168,00€
  • PTC258

    CAS :
    PTC258 is a specific, orally active modulator of the splicing of the Elongator complex protein 1 gene (ELP1), enhancing its expression both in vitro and in vivo
    Formule :C16H18ClN3S2
    Couleur et forme :Solid
    Masse moléculaire :351.92

    Ref: TM-T81355

    5mg
    À demander
    50mg
    À demander
  • Lerociclib

    CAS :
    Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.
    Formule :C26H34N8O
    Degré de pureté :99%
    Couleur et forme :Solid
    Masse moléculaire :474.6

    Ref: TM-T11345

    1mg
    35,00€
    5mg
    75,00€
    10mg
    114,00€
    25mg
    208,00€
    50mg
    334,00€
    100mg
    494,00€
  • FT671

    CAS :
    FT671 is a non-covalent, selective USP7 inhibitor, disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, inhibits tumor growth.
    Formule :C24H23F4N7O3
    Degré de pureté :99.76%
    Couleur et forme :Solid
    Masse moléculaire :533.48

    Ref: TM-T12621L

    1mg
    À demander
    5mg
    131,00€
    10mg
    À demander
    25mg
    464,00€
    50mg
    803,00€
    100mg
    1.388,00€
  • SJ26

    CAS :
    SJ26 is a Wnt1 inhibitor known for its anticancer activity. It inhibits the expression of WNT1 and the downstream signaling pathways mediated by WNT1 in a G-quadruplex structure-dependent manner, thereby suppressing the migratory activity of cancer cells.
    Formule :C29H32ClN3O
    Couleur et forme :Solid
    Masse moléculaire :474.04

    Ref: TM-T200109

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • DYRKs-IN-2

    CAS :
    DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.
    Formule :C32H38ClN9O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :632.16

    Ref: TM-T11133

    25mg
    1.908,00€
    50mg
    2.502,00€
    100mg
    3.330,00€
  • MS-444

    CAS :
    MS-444 (BE-34776) is an MLCK and HuR inhibitor with antitumor activity that can be used to study triple-negative breast cancer and colorectal cancer.
    Formule :C13H10O4
    Degré de pureté :99.45% - 99.45%
    Couleur et forme :Solid
    Masse moléculaire :230.22

    Ref: TM-T16145

    2mg
    720,00€
  • ROCK2-IN-2

    CAS :
    ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
    Formule :C18H12N6OS
    Degré de pureté :99.65%
    Couleur et forme :Solid
    Masse moléculaire :360.39

    Ref: TM-T12747

    1mg
    50,00€
    5mg
    111,00€
    10mg
    177,00€
    25mg
    304,00€
    50mg
    447,00€
    100mg
    692,00€
    200mg
    888,00€
    1mL*10mM (DMSO)
    136,00€
  • PDD00031705

    CAS :
    PDD00031705 is a benzimidazolone core cell-inactive Poly (ADP-ribose) glycohydrolase (PARG) inhibitor.
    Formule :C20H22N6O3S3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :490.62

    Ref: TM-T12388

    25mg
    1.108,00€
    50mg
    1.449,00€
    100mg
    2.385,00€
  • 4′-DTMP

    CAS :
    4′-DTMP (4-Demethyltrimethoprim) is a DHFR inhibitor with antimicrobial activity against Escherichia coli.
    Formule :C13H16N4O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :276.29

    Ref: TM-T78238

    10mg
    34,00€
    25mg
    46,00€
    50mg
    70,00€
    100mg
    92,00€
  • AVG-233

    CAS :
    AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.
    Formule :C26H22ClN5O3
    Degré de pureté :99%
    Couleur et forme :Solid
    Masse moléculaire :487.94

    Ref: TM-T63253

    1mg
    190,00€
  • CCT241533 hydrochloride

    CAS :
    CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
    Formule :C23H28ClFN4O4
    Degré de pureté :97.13%
    Couleur et forme :Solid
    Masse moléculaire :478.95

    Ref: TM-T10718L

    1mg
    70,00€
    2mg
    90,00€
    5mg
    150,00€
    10mg
    227,00€
    25mg
    487,00€
    50mg
    807,00€
    100mg
    1.198,00€
    500mg
    2.412,00€
    1mL*10mM (DMSO)
    167,00€
  • LX7101 hydrochloride

    CAS :
    LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.
    Formule :C23H29N7O3HCl
    Couleur et forme :Solid
    Masse moléculaire :488

    Ref: TM-T85304

    10mg
    À demander
    50mg
    À demander
  • ROCK2-IN-7

    CAS :
    ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.
    Formule :C26H28FN5O
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :445.53

    Ref: TM-T81261

    5mg
    À demander
    50mg
    À demander
  • DHODH-IN-14

    CAS :
    DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.
    Formule :C15H7F4N3O3
    Degré de pureté :99.81%
    Couleur et forme :Solid
    Masse moléculaire :353.23

    Ref: TM-T11023

    1mg
    109,00€
    2mg
    163,00€
    5mg
    243,00€
    10mg
    355,00€
    25mg
    532,00€
    50mg
    750,00€
    100mg
    1.009,00€
    500mg
    À demander
    1mL*10mM (DMSO)
    250,00€
  • TAK 029

    CAS :
    TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.
    Formule :C19H23N5O7
    Couleur et forme :Solid
    Masse moléculaire :433.42

    Ref: TM-T28913

    25mg
    1.773,00€
    50mg
    2.322,00€
    100mg
    3.060,00€
  • Voruciclib hydrochloride

    CAS :
    Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
    Formule :C22H20Cl2F3NO5
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :506.3

    Ref: TM-T13309

    5mg
    1.133,00€
    25mg
    À demander
    50mg
    À demander
    100mg
    À demander
  • AR-13503

    CAS :
    AR-13503, a Netarsudil metabolite, is a ROCK inhibitor, potentially treating glaucoma and lowering eye pressure.
    Formule :C19H19N3O2
    Couleur et forme :Solid
    Masse moléculaire :321.37

    Ref: TM-T71120

    25mg
    1.773,00€
    50mg
    2.322,00€
    100mg
    3.060,00€
  • LX7101

    CAS :
    LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
    Formule :C23H29N7O3
    Degré de pureté :99.08%
    Couleur et forme :Solid
    Masse moléculaire :451.52

    Ref: TM-T15798

    1mg
    58,00€
  • USP7-IN-1

    CAS :
    USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).
    Formule :C23H24ClN3O3
    Degré de pureté :99.82%
    Couleur et forme :Solid
    Masse moléculaire :425.91

    Ref: TM-T13268

    1mg
    92,00€
    5mg
    178,00€
    10mg
    269,00€
    25mg
    429,00€
    50mg
    610,00€
    100mg
    820,00€
    200mg
    1.071,00€
    1mL*10mM (DMSO)
    207,00€
  • EHT 5372

    CAS :
    EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.
    Formule :C17H11Cl2N5OS
    Couleur et forme :Solid
    Masse moléculaire :404.27

    Ref: TM-T61985

    25mg
    1.459,00€
    50mg
    1.900,00€
  • GSK2850163

    CAS :
    GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).
    Formule :C24H29Cl2N3O
    Degré de pureté :99.04%
    Couleur et forme :Solid
    Masse moléculaire :446.41

    Ref: TM-T11488

    5mg
    66,00€
    10mg
    105,00€
    25mg
    215,00€
    50mg
    340,00€
    100mg
    512,00€
    1mL*10mM (DMSO)
    73,00€
  • ROCK-IN-8

    CAS :
    ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,
    Formule :C30H25FN4O4S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :556.61

    Ref: TM-T79809

    5mg
    À demander
    50mg
    À demander
  • CCT-251921

    CAS :
    CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).
    Formule :C21H23ClN6O
    Degré de pureté :99.07%
    Couleur et forme :Solid
    Masse moléculaire :410.9

    Ref: TM-T14901

    1mg
    90,00€
    5mg
    210,00€
    10mg
    308,00€
    25mg
    520,00€
    50mg
    745,00€
    100mg
    1.018,00€
    1mL*10mM (DMSO)
    192,00€
  • DHX9-IN-6

    CAS :
    DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.
    Formule :C23H18ClFN4O4S2
    Degré de pureté :99.71%
    Couleur et forme :Solid
    Masse moléculaire :533

    Ref: TM-T86202

    1mg
    187,00€
    5mg
    465,00€
    10mg
    692,00€
    25mg
    1.074,00€
    50mg
    1.454,00€
  • ROCK-IN-7

    CAS :
    ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].
    Formule :C17H17N3O2S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :327.4

    Ref: TM-T79080

    5mg
    À demander
    50mg
    À demander
  • DNA polymerase-IN-1

    CAS :
    DNA polymerase-IN-1 exhibits antiproliferative activity against tumor cells and inhibits Taq DNA polymerase as a DNA polymerase inhibitor.
    Formule :C10H7ClO4
    Degré de pureté :99.16%
    Couleur et forme :Solid
    Masse moléculaire :226.61

    Ref: TM-T80644

    1mg
    175,00€
    5mg
    434,00€
    10mg
    622,00€
    25mg
    973,00€
    50mg
    1.341,00€
    100mg
    1.773,00€
  • Chroman 1

    CAS :
    Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).
    Formule :C24H28N4O4
    Degré de pureté :99.67% - 99.84%
    Couleur et forme :Solid
    Masse moléculaire :436.5

    Ref: TM-T14960

    1mg
    73,00€
    5mg
    160,00€
    10mg
    250,00€
    25mg
    430,00€
    50mg
    645,00€
    100mg
    888,00€
    1mL*10mM (DMSO)
    173,00€
  • ATN-161

    CAS :
    ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.
    Formule :C23H35N9O8S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :597.64

    Ref: TM-T10398

    1mg
    48,00€
    5mg
    90,00€
  • Senexin C

    CAS :
    Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.
    Formule :C28H27N5O
    Degré de pureté :98.06%
    Couleur et forme :Solid
    Masse moléculaire :449.55

    Ref: TM-T62702

    1mg
    170,00€
    5mg
    430,00€
    10mg
    628,00€
    1mL*10mM (DMSO)
    475,00€
  • DHX9-IN-4

    CAS :
    DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.
    Formule :C21H22ClN5O4S2
    Degré de pureté :98.12%
    Couleur et forme :Solid
    Masse moléculaire :508.01

    Ref: TM-T86200

    1mg
    236,00€
    5mg
    587,00€
    10mg
    837,00€
    25mg
    1.251,00€
    50mg
    1.693,00€
  • Brodimoprim

    CAS :
    Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR).
    Formule :C13H15BrN4O2
    Degré de pureté :98% - 99.71%
    Couleur et forme :Solid
    Masse moléculaire :339.19

    Ref: TM-T19858

    1mg
    39,00€
    5mg
    84,00€
    10mg
    120,00€
    25mg
    200,00€
    50mg
    299,00€
    100mg
    432,00€
  • Netropsin dihydrochloride

    CAS :
    Netropsin dihydrochloride, a small MGB, blocks topoisomerase I/II, hindering cleavable complex stabilization.
    Formule :C18H28Cl2N10O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :503.39

    Ref: TM-T12209

    25mg
    622,00€
    50mg
    827,00€
    100mg
    1.243,00€
  • Senexin A hydrochloride

    CAS :
    Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].
    Formule :C17H15ClN4
    Couleur et forme :Solid
    Masse moléculaire :310.78

    Ref: TM-T84893

    10mg
    À demander
    50mg
    À demander
  • Teclistamab

    CAS :
    Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.
    Degré de pureté :95%
    Couleur et forme :Liquid
    Masse moléculaire :143.64 kDa

    Ref: TM-T76881

    1mg
    661,00€
    5mg
    1.525,00€
    10mg
    2.025,00€
    25mg
    3.000,00€
    50mg
    4.058,00€
    100mg
    5.470,00€
  • AAPK-25

    CAS :
    AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.
    Formule :C21H13Cl2N3O2S
    Degré de pureté :97.05%
    Couleur et forme :Solid
    Masse moléculaire :442.32

    Ref: TM-T10215

    1mg
    54,00€
    5mg
    118,00€
    10mg
    172,00€
    25mg
    313,00€
    50mg
    469,00€
    100mg
    680,00€
    1mL*10mM (DMSO)
    131,00€
  • CCG-232964

    CAS :
    CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].
    Formule :C15H15ClN2O3S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :338.81

    Ref: TM-T82766

    5mg
    À demander
    50mg
    À demander
  • Bisindolylmaleimide X hydrochloride

    CAS :
    Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).
    Formule :C26H25ClN4O2
    Degré de pureté :99.23%
    Couleur et forme :Solid
    Masse moléculaire :460.96

    Ref: TM-T10550

    1mg
    56,00€
    5mg
    127,00€
    10mg
    215,00€
    25mg
    411,00€
    50mg
    648,00€
    1mL*10mM (DMSO)
    140,00€
  • Mefenidil

    CAS :
    Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.
    Formule :C12H11N3
    Degré de pureté :98.27%
    Couleur et forme :Solid
    Masse moléculaire :197.24

    Ref: TM-T33272

    1mg
    137,00€
    5mg
    314,00€
    10mg
    427,00€
    25mg
    600,00€
    50mg
    798,00€
    100mg
    1.099,00€
    200mg
    1.468,00€
  • XL413 hydrochloride

    CAS :
    XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7. XL413 hydrochloride also inhibits CK2 and PIM1.
    Formule :C14H13Cl2N3O2
    Degré de pureté :98.81% - 99.8%
    Couleur et forme :Solid
    Masse moléculaire :326.18

    Ref: TM-T6735

    1mg
    50,00€
    5mg
    109,00€
    10mg
    152,00€
    25mg
    268,00€
    50mg
    447,00€
    100mg
    672,00€
    200mg
    888,00€
    500mg
    1.369,00€
  • NU6300

    CAS :
    NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties and also functions as a GSDMD (Gasdermin D) inhibitor.
    Formule :C20H23N5O3S
    Degré de pureté :96.08%
    Couleur et forme :Solid
    Masse moléculaire :413.49

    Ref: TM-T16360

    5mg
    899,00€
  • WRN inhibitor 2

    CAS :
    WRN Inhibitor 2 (example 118), a potent inhibitor of the WRN (Werner Syndrome ATP-dependent helicase enzyme), exhibits a pIC50 value of 7.0 or greater [1].
    Formule :C15H11F3N2O5S2
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :420.38

    Ref: TM-T79178

    5mg
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    50mg
    À demander
  • CDK9-IN-23

    CAS :
    CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].
    Formule :C22H25ClN4O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :428.91

    Ref: TM-T79037

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    50mg
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  • QR-6401

    CAS :
    QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/
    Formule :C19H23N5O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :369.42

    Ref: TM-T79014

    5mg
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    50mg
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  • Tacaciclib

    CAS :
    Tacaciclib is a cyclin-dependent kinase (CDK) inhibitor with observed antineoplastic activity [1].
    Formule :C30H36N6O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :528.65

    Ref: TM-T79862

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    50mg
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  • PF-6808472

    CAS :
    PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.
    Formule :C25H27FN8O3S
    Degré de pureté :99.02%
    Couleur et forme :Solid
    Masse moléculaire :538.6

    Ref: TM-T33955

    1mg
    50,00€
    5mg
    105,00€
    10mg
    177,00€
    25mg
    409,00€
    50mg
    708,00€
    1mL*10mM (DMSO)
    127,00€
  • N-desmethyl Netupitant

    CAS :
    N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.
    Formule :C29H30F6N4O
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :564.57

    Ref: TM-T12212

    25mg
    1.504,00€
    50mg
    1.963,00€
    100mg
    2.520,00€
  • Palbociclib orotate

    CAS :
    Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.
    Formule :C29H33N9O6
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :603.63

    Ref: TM-T72507

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    50mg
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  • Butylparaben sodium

    CAS :
    Butylparaben sodium significantly impacts the later phases of spermatogenesis in the testes by impairing hormonal regulation and/or RNA and protein synthesis [1
    Formule :C11H13NaO3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :216.21

    Ref: TM-T82803

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  • CDK4-IN-2

    CAS :
    CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].
    Formule :C22H26F2N6O4S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :508.54

    Ref: TM-T79046

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    50mg
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  • CDK9-IN-9

    CAS :
    CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).
    Formule :C22H23F2N5O2S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :459.51

    Ref: TM-T10747

    25mg
    1.780,00€
  • 5-Iodo-indirubin-3'-monoxime

    CAS :
    5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s
    Formule :C16H10IN3O2
    Couleur et forme :Solid
    Masse moléculaire :403.17

    Ref: TM-T10172

    5mg
    268,00€
    25mg
    888,00€
    50mg
    1.224,00€
    100mg
    1.674,00€
  • G4/HDAC-IN-1


    G4/HDAC-IN-1, a G4/HDAC dual inhibitor, IC50 1.1 µM, blocks TNBC growth, useful in cancer research.
    Formule :C36H49ClFN7O4
    Couleur et forme :Solid
    Masse moléculaire :698.27

    Ref: TM-T72946

    25mg
    1.639,00€
    50mg
    2.142,00€
    100mg
    2.790,00€
  • NITD008

    CAS :
    NITD008 (7-Deaza-2'-C-acetylene-adenosine) is an adenosine nucleoside inhibitor with antiviral activity that inhibits dengue and Zika viruses.
    Formule :C13H14N4O4
    Degré de pureté :98.04%
    Couleur et forme :Solid
    Masse moléculaire :290.27

    Ref: TM-T16325

    1mg
    139,00€
  • CDK7-IN-22

    CAS :
    CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].
    Formule :C22H25F3N6
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :430.47

    Ref: TM-T79169

    25mg
    1.639,00€
    50mg
    2.142,00€
    100mg
    2.790,00€
  • Alatrofloxacin

    CAS :
    Alatrofloxacin is a prodrug of trovafloxacin.
    Formule :C26H25F3N6O5
    Couleur et forme :Solid
    Masse moléculaire :558.51

    Ref: TM-T23703

    25mg
    1.639,00€
    50mg
    2.142,00€
    100mg
    2.790,00€
  • Myt1-IN-2

    CAS :
    Myt1-IN-2, a highly potent Myt1 inhibitor, exhibits remarkable anticancer properties with an IC50 value below 10 nM (WO2021195782A1; compound 28) [1].
    Formule :C18H16N6O2S
    Couleur et forme :Solid
    Masse moléculaire :380.42

    Ref: TM-T61615

    25mg
    1.927,00€
    50mg
    2.507,00€
    100mg
    3.168,00€
  • Xylocydine

    CAS :
    Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.
    Formule :C12H14BrN5O5
    Couleur et forme :Solid
    Masse moléculaire :388.17

    Ref: TM-T68875

    25mg
    1.639,00€
    50mg
    2.142,00€
    100mg
    2.790,00€
  • Cdc7-IN-12

    CAS :
    Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).
    Formule :C16H14N2O2S
    Couleur et forme :Solid
    Masse moléculaire :298.36

    Ref: TM-T60659

    25mg
    1.927,00€
    50mg
    2.507,00€
    100mg
    3.168,00€
  • MU-380

    CAS :
    MU-380 is an effective and selective inhibitor of CHK1.
    Formule :C15H15BrF3N7
    Couleur et forme :Solid
    Masse moléculaire :430.23

    Ref: TM-T24506

    25mg
    1.773,00€
    50mg
    2.322,00€
    100mg
    3.060,00€
  • SB-743921 free base

    CAS :
    SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).
    Formule :C31H33ClN2O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :517.06

    Ref: TM-T28694

    25mg
    1.773,00€
    50mg
    2.322,00€
    100mg
    3.060,00€
  • Myt1-IN-3

    CAS :
    Myt1-IN-3 is a potent inhibitor of Myt1 (IC50 <10 nM) [1].
    Formule :C18H19N5O2
    Couleur et forme :Solid
    Masse moléculaire :337.38

    Ref: TM-T61056

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • CDK4/6-IN-15

    CAS :
    CDK4/6-IN-15: Oral, selective CDK4/6 inhibitor, halts cancer cell growth, G1 arrest, suppresses Rb phosphorylation.
    Formule :C21H27FN8S
    Couleur et forme :Solid
    Masse moléculaire :442.56

    Ref: TM-T72928

    25mg
    3.889,00€
    50mg
    5.445,00€
    100mg
    7.624,00€
  • SZ-015268

    CAS :
    SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.
    Formule :C25H38N8O3
    Couleur et forme :Solid
    Masse moléculaire :498.62

    Ref: TM-T63383

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • CI 972 anhydrous

    CAS :
    CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.
    Formule :C11H12ClN5OS
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :297.76

    Ref: TM-T14964

    25mg
    1.639,00€
    50mg
    2.142,00€
    100mg
    2.790,00€
  • CDK/HDAC-IN-3

    CAS :
    CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3,
    Formule :C24H18Cl2N6O3
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :509.34

    Ref: TM-T78906

    25mg
    1.773,00€
    50mg
    2.322,00€
    100mg
    3.060,00€
  • Inixaciclib

    CAS :
    Inixaciclib is a potent CDK inhibitor, can be used to research anticancer.
    Formule :C26H30F2N6O
    Couleur et forme :Solid
    Masse moléculaire :480.55

    Ref: TM-T69662

    25mg
    1.773,00€
    50mg
    2.322,00€
    100mg
    3.060,00€
  • 2'-Deoxypseudoisocytidine

    CAS :
    2'-Deoxypseudoisocytidine is a nucleoside analogue.
    Formule :C9H13N3O4
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :227.22

    Ref: TM-T10099

    25mg
    1.504,00€
    50mg
    1.963,00€
    100mg
    2.520,00€
  • Luvixasertib hydrochloride

    CAS :
    CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].
    Formule :C28H31ClN6O3
    Couleur et forme :Solid
    Masse moléculaire :535.04

    Ref: TM-T84711

    10mg
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    50mg
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  • USP7-IN-13

    CAS :
    USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].
    Formule :C24H28N4O3
    Couleur et forme :Solid
    Masse moléculaire :420.5

    Ref: TM-T84710

    10mg
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    50mg
    À demander
  • SHP2/CDK4-IN-1

    CAS :
    SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.
    Formule :C33H35ClF2N10OS
    Couleur et forme :Solid
    Masse moléculaire :693.21

    Ref: TM-T72836

    25mg
    1.369,00€
    50mg
    1.783,00€
    100mg
    2.250,00€
  • DNA gyrase B-IN-3

    CAS :
    DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram
    Formule :C14H9Cl2N3O4S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :386.21

    Ref: TM-T78776

    25mg
    1.504,00€
    50mg
    1.963,00€
    100mg
    2.520,00€
  • Raluridine

    CAS :
    Raluridine is an HIV treatment inhibiting RNA-directed DNA polymerase with IC50 of 1.8 microM, compared to FLT, AZT, ddI, and ddC.
    Formule :C9H10ClFN2O4
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :264.64

    Ref: TM-T19689

    25mg
    1.773,00€
    50mg
    2.322,00€
    100mg
    3.060,00€
  • USP7-IN-12

    CAS :
    USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].
    Formule :C29H28ClFN4O2S
    Couleur et forme :Solid
    Masse moléculaire :551.07

    Ref: TM-T79164

    5mg
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    50mg
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  • ROCK-IN-10

    CAS :
    ROCK-IN-10 (compound 50) serves as a powerful inhibitor of ROCK, exhibiting IC50 values of 6 nM for ROCK1 and 4 nM for ROCK2, respectively. It demonstrates over 100-fold selectivity towards ROCK1 and ROCK2 when compared to other kinases [1].
    Formule :C25H25N5O3
    Couleur et forme :Solid
    Masse moléculaire :443.507

    Ref: TM-T84502

    10mg
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  • Cdk4 Inhibitor

    CAS :
    PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 < 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.
    Formule :C20H10BrN3O2
    Couleur et forme :Solid
    Masse moléculaire :404.2

    Ref: TM-T84413

    10mg
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  • DUB-IN-7

    CAS :
    DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].
    Formule :C17H19N5O
    Couleur et forme :Solid
    Masse moléculaire :309.37

    Ref: TM-T79672

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  • Gly-Arg-Gly-Asp-Ser TFA

    CAS :
    Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.
    Formule :C19H31F3N8O11
    Couleur et forme :Solid
    Masse moléculaire :604.49

    Ref: TM-T75761

    5mg
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    50mg
    À demander
  • Aurora kinase inhibitor-8

    CAS :
    Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.
    Formule :C30H29N7O3
    Couleur et forme :Solid
    Masse moléculaire :535.6

    Ref: TM-T63773

    25mg
    1.485,00€
    50mg
    1.935,00€
  • BMT-090605 hydrochloride

    CAS :
    BMT-090605 HCl: AAK1 inhibitor (IC50=0.6 nM), also targets BIKE (IC50=45 nM) & GAK (IC50=60 nM), with potential in neuropathic pain research.
    Formule :C21H25ClN4O2
    Couleur et forme :Solid
    Masse moléculaire :400.91

    Ref: TM-T61941

    25mg
    1.629,00€
    50mg
    2.125,00€
    100mg
    3.250,00€
  • (S)-Cdc7-IN-18

    CAS :
    '(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'
    Formule :C19H21N5OS
    Couleur et forme :Solid
    Masse moléculaire :367.47

    Ref: TM-T61435

    25mg
    1.927,00€
    50mg
    2.507,00€
    100mg
    3.168,00€
  • CCT-271850

    CAS :
    CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.
    Formule :C24H29N7O
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :431.53

    Ref: TM-T23865

    25mg
    1.639,00€
    50mg
    2.142,00€
    100mg
    2.790,00€
  • MC-Val-Cit-PAB-Ispinesib

    CAS :
    MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].
    Formule :C59H71ClN10O10
    Couleur et forme :Solid
    Masse moléculaire :1115.71

    Ref: TM-T84703

    10mg
    À demander
    50mg
    À demander
  • FAICAR

    CAS :
    FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.
    Formule :C10H15N4O9P
    Couleur et forme :Solid
    Masse moléculaire :366.22

    Ref: TM-T84746

    10mg
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    50mg
    À demander
  • 12R-LOX-IN-1

    CAS :
    12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX.
    Formule :C15H11NO2
    Couleur et forme :Solid
    Masse moléculaire :237.25

    Ref: TM-T83457

    5mg
    À demander
    50mg
    À demander
  • RAD51-IN-4

    CAS :
    RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.
    Formule :C31H34FN5O5S2
    Couleur et forme :Solid
    Masse moléculaire :639.76

    Ref: TM-T73107

    25mg
    1.773,00€
    50mg
    2.322,00€
    100mg
    3.060,00€
  • RNA polymerase II-IN-1

    CAS :
    RNA polymerase II-IN-1 (19iv), an amatoxin, inhibits Pol II at 36.66 nM IC50, is more toxic to cancer cells, less to normal cells than α-Amanitin.
    Formule :C38H53N11O12S
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :887.96

    Ref: TM-T74630

    5mg
    À demander
    50mg
    À demander
  • Aurora Kinases-IN-4

    CAS :
    Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.
    Formule :C26H28N8O
    Degré de pureté :98%
    Couleur et forme :Solid
    Masse moléculaire :468.55

    Ref: TM-T78753

    25mg
    1.504,00€
    50mg
    1.963,00€
    100mg
    2.520,00€
  • G-5758

    CAS :
    G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.
    Formule :C27H24F4N6O3S
    Couleur et forme :Solid
    Masse moléculaire :588.58

    Ref: TM-T87983

    25mg
    1.584,00€
    50mg
    2.115,00€
    100mg
    2.673,00€