
Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(115 produits)
- CDK(546 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(227 produits)
- HSP(180 produits)
- Intégrine(268 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(126 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
Affichez 10 plus de sous-catégories
3904 produits trouvés pour "Cycle cellulaire/point de contrôle"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Anti-hepatic fibrosis agent 2
CAS :Compound 6k, also known as Anti-hepatic fibrosis agent 2, is an orally active inhibitor of the COL1A1 enzyme and exerts anti-fibrogenic effects by targeting theFormule :C26H41N3OCouleur et forme :SolidMasse moléculaire :411.62Mps1-IN-10
CAS :Mps1-IN-6 (Compound 9) is a highly effective Mps1 inhibitor with an IC50 value of 6.4 nM and exhibits significant anti-proliferation and anti-tumor effects onFormule :C24H27N7O2Couleur et forme :SolidMasse moléculaire :445.52HQ005
CAS :HQ005, a potent CCNK degrader, exhibits an impressive DC50 value of 0.041 µM and functions as a molecular-glue degrader.Formule :C15H15N5O2S2Couleur et forme :SolidMasse moléculaire :361.44TNH
CAS :TNH, a dimeric compound, possesses the ability to penetrate living cells and facilitate the recruitment of proteins into cellular structures [1].Formule :C39H57ClN6O13Couleur et forme :SolidMasse moléculaire :853.36PD-321852
CAS :PD-321852, a Chk1 inhibitor, boosts gemcitabine's effect in pancreatic cancer cells, varying from minimal in Panc1 to >30-fold in MiaPaCa2.Formule :C24H19Cl2N3O3Couleur et forme :SolidMasse moléculaire :468.33DNA polymerase-IN-3
CAS :DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications inFormule :C13H12O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :232.233-Cyanovinylcarbazole phosphoramidite
CAS :3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.Formule :C50H53N4O6PCouleur et forme :SolidMasse moléculaire :836.95CDK9-IN-2
CAS :CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formule :C23H25ClFN5Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :425.93Ref: TM-T14918
1mg84,00€5mg177,00€10mg266,00€25mg460,00€50mg668,00€100mg945,00€1mL*10mM (DMSO)195,00€BMT-090605
CAS :BMT-090605: AAK1 inhibitor (IC50=0.6 nM), also affects BIKE (45 nM) and GAK (60 nM), has antinociceptive properties.Formule :C21H24N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :364.445'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
CAS :5'-ODMT cEt N-Bz A Phosphoramidite Amidite, a locked nucleic acid (LNA) analogue, exhibits hybridization and mismatch discrimination capabilities similar to LNA, and shows resistance to exonuclease digestion [1].Formule :C49H54N7O8PCouleur et forme :SolidMasse moléculaire :899.97JNJ-26076713
CAS :JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.Formule :C29H38N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.64Pencitabine
CAS :Pen is an oral cancer drug that blocks DNA synthesis by inhibiting key enzymes and integrating into DNA.Formule :C15H20F3N3O6Couleur et forme :SolidMasse moléculaire :395.33PTC258
CAS :PTC258 is a specific, orally active modulator of the splicing of the Elongator complex protein 1 gene (ELP1), enhancing its expression both in vitro and in vivoFormule :C16H18ClN3S2Couleur et forme :SolidMasse moléculaire :351.92Lerociclib
CAS :Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.Formule :C26H34N8ODegré de pureté :99%Couleur et forme :SolidMasse moléculaire :474.6FT671
CAS :FT671 is a non-covalent, selective USP7 inhibitor, disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, inhibits tumor growth.Formule :C24H23F4N7O3Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :533.48SJ26
CAS :SJ26 is a Wnt1 inhibitor known for its anticancer activity. It inhibits the expression of WNT1 and the downstream signaling pathways mediated by WNT1 in a G-quadruplex structure-dependent manner, thereby suppressing the migratory activity of cancer cells.Formule :C29H32ClN3OCouleur et forme :SolidMasse moléculaire :474.04DYRKs-IN-2
CAS :DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.Formule :C32H38ClN9O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :632.16MS-444
CAS :MS-444 (BE-34776) is an MLCK and HuR inhibitor with antitumor activity that can be used to study triple-negative breast cancer and colorectal cancer.Formule :C13H10O4Degré de pureté :99.45% - 99.45%Couleur et forme :SolidMasse moléculaire :230.22ROCK2-IN-2
CAS :ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Formule :C18H12N6OSDegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :360.39Ref: TM-T12747
1mg50,00€5mg111,00€10mg177,00€25mg304,00€50mg447,00€100mg692,00€200mg888,00€1mL*10mM (DMSO)136,00€PDD00031705
CAS :PDD00031705 is a benzimidazolone core cell-inactive Poly (ADP-ribose) glycohydrolase (PARG) inhibitor.Formule :C20H22N6O3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.624′-DTMP
CAS :4′-DTMP (4-Demethyltrimethoprim) is a DHFR inhibitor with antimicrobial activity against Escherichia coli.Formule :C13H16N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :276.29AVG-233
CAS :AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.Formule :C26H22ClN5O3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :487.94CCT241533 hydrochloride
CAS :CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formule :C23H28ClFN4O4Degré de pureté :97.13%Couleur et forme :SolidMasse moléculaire :478.95Ref: TM-T10718L
1mg70,00€2mg90,00€5mg150,00€10mg227,00€25mg487,00€50mg807,00€100mg1.198,00€500mg2.412,00€1mL*10mM (DMSO)167,00€LX7101 hydrochloride
CAS :LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.Formule :C23H29N7O3HClCouleur et forme :SolidMasse moléculaire :488ROCK2-IN-7
CAS :ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.Formule :C26H28FN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :445.53DHODH-IN-14
CAS :DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.Formule :C15H7F4N3O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :353.23Ref: TM-T11023
1mg109,00€2mg163,00€5mg243,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€500mgÀ demander1mL*10mM (DMSO)250,00€TAK 029
CAS :TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.Formule :C19H23N5O7Couleur et forme :SolidMasse moléculaire :433.42Voruciclib hydrochloride
CAS :Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).Formule :C22H20Cl2F3NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.3AR-13503
CAS :AR-13503, a Netarsudil metabolite, is a ROCK inhibitor, potentially treating glaucoma and lowering eye pressure.Formule :C19H19N3O2Couleur et forme :SolidMasse moléculaire :321.37LX7101
CAS :LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Formule :C23H29N7O3Degré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :451.52USP7-IN-1
CAS :USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Formule :C23H24ClN3O3Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :425.91Ref: TM-T13268
1mg92,00€5mg178,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)207,00€EHT 5372
CAS :EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.Formule :C17H11Cl2N5OSCouleur et forme :SolidMasse moléculaire :404.27GSK2850163
CAS :GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).Formule :C24H29Cl2N3ODegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :446.41ROCK-IN-8
CAS :ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,Formule :C30H25FN4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.61CCT-251921
CAS :CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Formule :C21H23ClN6ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :410.9Ref: TM-T14901
1mg90,00€5mg210,00€10mg308,00€25mg520,00€50mg745,00€100mg1.018,00€1mL*10mM (DMSO)192,00€DHX9-IN-6
CAS :DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.Formule :C23H18ClFN4O4S2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :533ROCK-IN-7
CAS :ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Formule :C17H17N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :327.4DNA polymerase-IN-1
CAS :DNA polymerase-IN-1 exhibits antiproliferative activity against tumor cells and inhibits Taq DNA polymerase as a DNA polymerase inhibitor.Formule :C10H7ClO4Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :226.61Chroman 1
CAS :Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Formule :C24H28N4O4Degré de pureté :99.67% - 99.84%Couleur et forme :SolidMasse moléculaire :436.5Ref: TM-T14960
1mg73,00€5mg160,00€10mg250,00€25mg430,00€50mg645,00€100mg888,00€1mL*10mM (DMSO)173,00€ATN-161
CAS :ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.Formule :C23H35N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :597.64Senexin C
CAS :Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Formule :C28H27N5ODegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :449.55DHX9-IN-4
CAS :DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.Formule :C21H22ClN5O4S2Degré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :508.01Brodimoprim
CAS :Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR).Formule :C13H15BrN4O2Degré de pureté :98% - 99.71%Couleur et forme :SolidMasse moléculaire :339.19Netropsin dihydrochloride
CAS :Netropsin dihydrochloride, a small MGB, blocks topoisomerase I/II, hindering cleavable complex stabilization.Formule :C18H28Cl2N10O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :503.39Senexin A hydrochloride
CAS :Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].Formule :C17H15ClN4Couleur et forme :SolidMasse moléculaire :310.78Teclistamab
CAS :Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Degré de pureté :95%Couleur et forme :LiquidMasse moléculaire :143.64 kDaAAPK-25
CAS :AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formule :C21H13Cl2N3O2SDegré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :442.32Ref: TM-T10215
1mg54,00€5mg118,00€10mg172,00€25mg313,00€50mg469,00€100mg680,00€1mL*10mM (DMSO)131,00€CCG-232964
CAS :CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].Formule :C15H15ClN2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :338.81Bisindolylmaleimide X hydrochloride
CAS :Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).Formule :C26H25ClN4O2Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :460.96Mefenidil
CAS :Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.Formule :C12H11N3Degré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :197.24XL413 hydrochloride
CAS :XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7. XL413 hydrochloride also inhibits CK2 and PIM1.Formule :C14H13Cl2N3O2Degré de pureté :98.81% - 99.8%Couleur et forme :SolidMasse moléculaire :326.18Ref: TM-T6735
1mg50,00€5mg109,00€10mg152,00€25mg268,00€50mg447,00€100mg672,00€200mg888,00€500mg1.369,00€NU6300
CAS :NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties and also functions as a GSDMD (Gasdermin D) inhibitor.Formule :C20H23N5O3SDegré de pureté :96.08%Couleur et forme :SolidMasse moléculaire :413.49WRN inhibitor 2
CAS :WRN Inhibitor 2 (example 118), a potent inhibitor of the WRN (Werner Syndrome ATP-dependent helicase enzyme), exhibits a pIC50 value of 7.0 or greater [1].Formule :C15H11F3N2O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.38CDK9-IN-23
CAS :CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].Formule :C22H25ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.91QR-6401
CAS :QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/Formule :C19H23N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.42Tacaciclib
CAS :Tacaciclib is a cyclin-dependent kinase (CDK) inhibitor with observed antineoplastic activity [1].Formule :C30H36N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.65PF-6808472
CAS :PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.Formule :C25H27FN8O3SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :538.6N-desmethyl Netupitant
CAS :N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.Formule :C29H30F6N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.57Palbociclib orotate
CAS :Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.Formule :C29H33N9O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :603.63Butylparaben sodium
CAS :Butylparaben sodium significantly impacts the later phases of spermatogenesis in the testes by impairing hormonal regulation and/or RNA and protein synthesis [1Formule :C11H13NaO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :216.21CDK4-IN-2
CAS :CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].Formule :C22H26F2N6O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.54CDK9-IN-9
CAS :CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).Formule :C22H23F2N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.515-Iodo-indirubin-3'-monoxime
CAS :5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFormule :C16H10IN3O2Couleur et forme :SolidMasse moléculaire :403.17G4/HDAC-IN-1
G4/HDAC-IN-1, a G4/HDAC dual inhibitor, IC50 1.1 µM, blocks TNBC growth, useful in cancer research.Formule :C36H49ClFN7O4Couleur et forme :SolidMasse moléculaire :698.27NITD008
CAS :NITD008 (7-Deaza-2'-C-acetylene-adenosine) is an adenosine nucleoside inhibitor with antiviral activity that inhibits dengue and Zika viruses.Formule :C13H14N4O4Degré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :290.27CDK7-IN-22
CAS :CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].Formule :C22H25F3N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.47Alatrofloxacin
CAS :Alatrofloxacin is a prodrug of trovafloxacin.Formule :C26H25F3N6O5Couleur et forme :SolidMasse moléculaire :558.51Myt1-IN-2
CAS :Myt1-IN-2, a highly potent Myt1 inhibitor, exhibits remarkable anticancer properties with an IC50 value below 10 nM (WO2021195782A1; compound 28) [1].Formule :C18H16N6O2SCouleur et forme :SolidMasse moléculaire :380.42Xylocydine
CAS :Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.Formule :C12H14BrN5O5Couleur et forme :SolidMasse moléculaire :388.17Cdc7-IN-12
CAS :Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).Formule :C16H14N2O2SCouleur et forme :SolidMasse moléculaire :298.36MU-380
CAS :MU-380 is an effective and selective inhibitor of CHK1.Formule :C15H15BrF3N7Couleur et forme :SolidMasse moléculaire :430.23SB-743921 free base
CAS :SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).Formule :C31H33ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.06Myt1-IN-3
CAS :Myt1-IN-3 is a potent inhibitor of Myt1 (IC50 <10 nM) [1].Formule :C18H19N5O2Couleur et forme :SolidMasse moléculaire :337.38CDK4/6-IN-15
CAS :CDK4/6-IN-15: Oral, selective CDK4/6 inhibitor, halts cancer cell growth, G1 arrest, suppresses Rb phosphorylation.Formule :C21H27FN8SCouleur et forme :SolidMasse moléculaire :442.56SZ-015268
CAS :SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.Formule :C25H38N8O3Couleur et forme :SolidMasse moléculaire :498.62CI 972 anhydrous
CAS :CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.Formule :C11H12ClN5OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :297.76CDK/HDAC-IN-3
CAS :CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3,Formule :C24H18Cl2N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :509.34Inixaciclib
CAS :Inixaciclib is a potent CDK inhibitor, can be used to research anticancer.Formule :C26H30F2N6OCouleur et forme :SolidMasse moléculaire :480.552'-Deoxypseudoisocytidine
CAS :2'-Deoxypseudoisocytidine is a nucleoside analogue.Formule :C9H13N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :227.22Luvixasertib hydrochloride
CAS :CFI-402257 hydrochloride, a highly selective and orally bioavailable inhibitor targeting TTK/Mps1, demonstrates an in vitro IC50 value of 1.7 nM against TTK. This compound exhibits anti-cancer activity [1].Formule :C28H31ClN6O3Couleur et forme :SolidMasse moléculaire :535.04USP7-IN-13
CAS :USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].Formule :C24H28N4O3Couleur et forme :SolidMasse moléculaire :420.5SHP2/CDK4-IN-1
CAS :SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.Formule :C33H35ClF2N10OSCouleur et forme :SolidMasse moléculaire :693.21DNA gyrase B-IN-3
CAS :DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against GramFormule :C14H9Cl2N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.21Raluridine
CAS :Raluridine is an HIV treatment inhibiting RNA-directed DNA polymerase with IC50 of 1.8 microM, compared to FLT, AZT, ddI, and ddC.Formule :C9H10ClFN2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :264.64USP7-IN-12
CAS :USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].Formule :C29H28ClFN4O2SCouleur et forme :SolidMasse moléculaire :551.07ROCK-IN-10
CAS :ROCK-IN-10 (compound 50) serves as a powerful inhibitor of ROCK, exhibiting IC50 values of 6 nM for ROCK1 and 4 nM for ROCK2, respectively. It demonstrates over 100-fold selectivity towards ROCK1 and ROCK2 when compared to other kinases [1].Formule :C25H25N5O3Couleur et forme :SolidMasse moléculaire :443.507Cdk4 Inhibitor
CAS :PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness requires higher concentrations (IC 50 = 520 nM and 2.1 µM, respectively) and demonstrates minimal activity against CaMKII, PKA, or GSK-3β (IC 50 ≥ 12.4 µM). PD 0332991 efficiently inhibits tumor cell growth in HCT-116 and NCI-H460 cell lines with an IC 50 < 3.0 µM, primarily through blocking Rb phosphorylation and inducing G1 cell cycle arrest.Formule :C20H10BrN3O2Couleur et forme :SolidMasse moléculaire :404.2DUB-IN-7
CAS :DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Formule :C17H19N5OCouleur et forme :SolidMasse moléculaire :309.37Gly-Arg-Gly-Asp-Ser TFA
CAS :Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.Formule :C19H31F3N8O11Couleur et forme :SolidMasse moléculaire :604.49Aurora kinase inhibitor-8
CAS :Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.Formule :C30H29N7O3Couleur et forme :SolidMasse moléculaire :535.6BMT-090605 hydrochloride
CAS :BMT-090605 HCl: AAK1 inhibitor (IC50=0.6 nM), also targets BIKE (IC50=45 nM) & GAK (IC50=60 nM), with potential in neuropathic pain research.Formule :C21H25ClN4O2Couleur et forme :SolidMasse moléculaire :400.91(S)-Cdc7-IN-18
CAS :'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'Formule :C19H21N5OSCouleur et forme :SolidMasse moléculaire :367.47CCT-271850
CAS :CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.Formule :C24H29N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.53MC-Val-Cit-PAB-Ispinesib
CAS :MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].Formule :C59H71ClN10O10Couleur et forme :SolidMasse moléculaire :1115.71FAICAR
CAS :FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.Formule :C10H15N4O9PCouleur et forme :SolidMasse moléculaire :366.2212R-LOX-IN-1
CAS :12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX.Formule :C15H11NO2Couleur et forme :SolidMasse moléculaire :237.25RAD51-IN-4
CAS :RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.Formule :C31H34FN5O5S2Couleur et forme :SolidMasse moléculaire :639.76RNA polymerase II-IN-1
CAS :RNA polymerase II-IN-1 (19iv), an amatoxin, inhibits Pol II at 36.66 nM IC50, is more toxic to cancer cells, less to normal cells than α-Amanitin.Formule :C38H53N11O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :887.96Aurora Kinases-IN-4
CAS :Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.Formule :C26H28N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.55G-5758
CAS :G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.Formule :C27H24F4N6O3SCouleur et forme :SolidMasse moléculaire :588.58

