Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(546 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(227 produits)
- HSP(179 produits)
- Intégrine(262 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(126 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3888 produits trouvés pour "Cycle cellulaire/point de contrôle"
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CCT129202
CAS :CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.Formule :C23H25ClN8OSDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :497.02SMN-C3
CAS :SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).Formule :C24H28N6ODegré de pureté :99.01% - 99.05%Couleur et forme :SolidMasse moléculaire :416.52Debio-0123
CAS :Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.Formule :C26H28Cl2N6ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :511.45GNE-375
CAS :GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.Formule :C25H29N3O5Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :451.51Ref: TM-T27423
1mg111,00€5mg264,00€10mg409,00€25mg670,00€50mg964,00€100mg1.414,00€1mL*10mM (DMSO)299,00€Roxifiban acetate
CAS :Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used inFormule :C23H33N5O8Degré de pureté :97.91% - 98.36%Couleur et forme :SolidMasse moléculaire :507.54CF53
CAS :CF53: potent, selective oral BET inhibitor; Ki <1 nM, Kd 2.2 nM, IC50 2 nM for BRD4 BD1; high affinity for BRD2/3/4/BRDT; effective anti-tumor agent.Formule :C24H25N7O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :443.5Ref: TM-T10773
1mg92,00€5mg200,00€10mg299,00€25mg484,00€50mg658,00€100mg892,00€1mL*10mM (DMSO)215,00€LY3295668
CAS :LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Formule :C24H26ClF2N5O2Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :489.95αvβ1 integrin-IN-1
CAS :αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.Formule :C26H34N6O6SDegré de pureté :99.39% - 99.69%Couleur et forme :SolidMasse moléculaire :558.65Ref: TM-T13473
1mg109,00€5mg260,00€10mg409,00€25mg660,00€50mg888,00€100mg1.224,00€200mg1.648,00€1mL*10mM (DMSO)319,00€Filibuvir
CAS :Filibuvir (PF-00868554) inhibits HCV polymerase genotypes 1a/1b, EC50s 59 nM.Formule :C29H37N5O3Degré de pureté :99.28% - >99.99%Couleur et forme :SolidMasse moléculaire :503.64LNA-Adenosine
CAS :LNA-Adenosine (LNA-A) is a nucleoside analogue that acts as a ligand for adenosine A3 receptors.Formule :C11H13N5O4Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :279.25IMP-1710
CAS :IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Formule :C23H19N5ODegré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :381.43Plogosertib
CAS :Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.Formule :C34H48N8O3Degré de pureté :99.22% - 99.85%Couleur et forme :SolidMasse moléculaire :616.797Ref: TM-T71399
1mg205,00€5mg537,00€10mg802,00€25mg1.395,00€50mg1.935,00€100mg2.502,00€1mL*10mM (DMSO)712,00€Gossypolone
CAS :Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.Formule :C30H26O10Degré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :546.52Ref: TM-T31987
1mg175,00€5mg404,00€10mg593,00€25mg888,00€50mg1.251,00€100mg1.693,00€500mg3.402,00€1mL*10mM (DMSO)507,00€B I09
CAS :B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells.Formule :C16H17NO5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :303.31Antiviral agent 34
CAS :Antiviral Agent 34 is an antiviral compound that inhibits influenza virus and inhibits the proliferation of influenza virus by modulating RNA polymerase.Formule :C29H33N3O2SDegré de pureté :99.51%Couleur et forme :SoildMasse moléculaire :487.66BDP9066
CAS :BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.Formule :C20H24N6Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :348.44Ref: TM-T14521
1mg54,00€5mg114,00€10mg178,00€25mg409,00€50mg708,00€100mg1.224,00€500mg2.448,00€1mL*10mM (DMSO)126,00€Cdk1/2 Inhibitor III
CAS :Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.Formule :C15H13F2N7O2S2Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :425.44Thymectacin
CAS :Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.Formule :C21H25BrN3O9PDegré de pureté :97.05% - 99.49%Couleur et forme :SolidMasse moléculaire :574.32(R)-Simurosertib
CAS :(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.Formule :C17H19N5OSDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :341.43H-1152 dihydrochloride
CAS :H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.Formule :C16H23Cl2N3O2SDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :392.34Ref: TM-T35328
1mg60,00€5mg135,00€10mg215,00€25mg415,00€50mg655,00€100mg888,00€1mL*10mM (DMSO)147,00€AZD4573
CAS :AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.Formule :C22H28ClN5O2Degré de pureté :99% - 99.51%Couleur et forme :SolidMasse moléculaire :429.94Lomibuvir
CAS :Lomibuvir (VCH-222, VX-222) is an allosteric inhibitor of HCV NS5B with Kd 17 nM, blocks RNA elongation, EC50 5.2 nM for 1b/Con1.Formule :C25H35NO4SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :445.61CeMMEC1
CAS :CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).Formule :C19H16N2O4Degré de pureté :98.9% - 99.92%Couleur et forme :SolidMasse moléculaire :336.34Sorivudine
CAS :Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.Formule :C11H13BrN2O6Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :349.13PNR-3-80
CAS :PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 μM, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.Formule :C24H14ClN3O3SCouleur et forme :SolidMasse moléculaire :459.90DIDS
CAS :DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.Formule :C16H10N2O6S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.52(Rac)-Plevitrexed
CAS :(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.53(R)-CSN5i-3
CAS :(R)-CSN5i-3 is CSN5i-3 of the R configuration.Formule :C28H29F2N5O2Degré de pureté :99.76% - 99.97%Couleur et forme :SolidMasse moléculaire :505.56SCH-1473759
CAS :SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Formule :C20H26N8OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.54CLK1/2-IN-1
CAS :CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.Formule :C21H20F3N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.42CDK9-IN-38
CAS :CDK9-IN-38 (compound 14) is a CDK9 inhibitor with IC50 values of 1.2 nM for wild-type CDK9 and 3.3 nM for the L156F mutant. It effectively inhibits tumor growth both in vitro and in vivo.Formule :C22H23N5O3SCouleur et forme :SolidMasse moléculaire :437.515Chk1-IN-5
CAS :Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.Formule :C18H18FN7O2Couleur et forme :SolidMasse moléculaire :383.38Bersiporocin
CAS :Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.
Formule :C15H19Cl2N3ODegré de pureté :98.88% - 99.79%Couleur et forme :SolidMasse moléculaire :328.242'-O-MOE-GMP
CAS :2'-O-MOE-GMP is a nucleotide analogue that can be utilized in the synthesis of oligonucleotides.
Formule :C13H20N5O9PCouleur et forme :SolidMasse moléculaire :421.30N-Isobutyryl-2', 3'-acetyl-guanosine
CAS :N-Isobutyryl-2', 3'-acetyl-guanosine is a derivative of guanosine.Formule :C18H23N5O8Couleur et forme :SolidMasse moléculaire :437.404Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.12FT709
CAS :FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.Formule :C23H22N4O7SCouleur et forme :SolidMasse moléculaire :498.51RNAP-σ interaction inhibitor-2
CAS :RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor targeting the interaction between RNA polymerase and the sigma factor. It demonstrates inhibitory activity against S. aureus with a minimum inhibitory concentration (MIC) of 2 µg/mL.Formule :C27H19Cl3N2O6S2Couleur et forme :SolidMasse moléculaire :637.939DNA polymerase-IN-6
CAS :DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.Formule :C26H28ClFN8O4Couleur et forme :SolidMasse moléculaire :571.003PKMYT1-IN-7
CAS :PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM for PKMYT1 and 0.06 μM for pCDK1. It inhibits the phosphorylation of CDK1 at T14 and Y15 sites and exhibits anticancer activity both in vitro and in vivo.Formule :C17H18FN5O3Couleur et forme :SolidMasse moléculaire :359.355Plevitrexed
CAS :Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor & reduced folate carrier, treats gastric cancer.Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.53RAD51-IN-8
RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.Formule :C16H14Cl2FN3O2Couleur et forme :SolidMasse moléculaire :370.21LNA-GMP
CAS :LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.Formule :C11H14N5O8PCouleur et forme :SolidMasse moléculaire :375.236-B345TTQ
CAS :6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.Formule :C22H20BrNO4Couleur et forme :SolidMasse moléculaire :442.303Galidesivir
CAS :Galidesivir (BCX4430) is an antiviral compound that inhibits viral RNA-dependent RNA polymerase (RdRp) activity and reduces lung infections in infected animals.Formule :C11H15N5O3Degré de pureté :96.73% - 99.13%Couleur et forme :SolidMasse moléculaire :265.27WRN inhibitor 13
CAS :WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.Formule :C16H20N2O5SCouleur et forme :SolidMasse moléculaire :352.405AR-13324 M1 metabolite
CAS :AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.Formule :C19H19N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.37Aurora A inhibitor 4
CAS :Aurora A inhibitor4 (compound C9) is a potent inhibitor of Aurora A, with GI50 values of 4.26 μM in DU 145 cells and 7.08 μM in HT-29 cells.Formule :C22H23N5O3Couleur et forme :SolidMasse moléculaire :405.45DYRK1-IN-1
CAS :DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.Formule :C12H12N6Couleur et forme :SolidMasse moléculaire :240.26LNA-GDP
CAS :LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.Formule :C11H15N5O11P2Couleur et forme :SolidMasse moléculaire :455.21Tubulin inhibitor 49
CAS :Tubulin inhibitor 49 is a tubulin polymerization inhibitor that disrupts the cellular microtubule network, arrests the cell cycle. toxic toward HeLa cells.Formule :C18H14F3N3OSDegré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :377.38Pseudouridine 5'-OTBDPS
CAS :Pseudouridine5'-OTBDPS [5-(5-O-TBDPS-β-D-ribofuranosyl)uracil] is an intermediate of Pseudouridine.Formule :C25H30N2O6SiCouleur et forme :SolidMasse moléculaire :482.60Mitotic kinesin-IN-1 hydrochloride
CAS :Mitotic kinesin-IN-1 hydrochloride (Example 80) is an inhibitor of mitotic kinesin, which suppresses cell proliferation by hindering mitosis. This compound is applicable in research related to cancer, cardiac hypertrophy, immune and inflammatory diseases, and fungal infections.Formule :C22H26ClF2N3OSCouleur et forme :SolidMasse moléculaire :453.98Metesind Glucuronate
CAS :Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.Formule :C29H34N4O10SCouleur et forme :SolidMasse moléculaire :630.67PARG-IN-6
CAS :PARG-IN-6 (Compound 2) is an orally bioavailable PARG inhibitor with an IC50 of 0.3 nM. It exhibits significant anticancer activity against cancer cells, with an IC50 of 0.0368 μM for HCC1395 cells. PARG-IN-6 shows potential for research in colon cancer, appendiceal cancer, and pancreatic cancer.Formule :C24H25F4N7O4S3Couleur et forme :SolidMasse moléculaire :647.698-Oxo-dATP
CAS :8-Oxo-dATP can be hydrolyzed to its monophosphate form by the oxidation of purine nucleoside triphosphate MTH1, preventing erroneous incorporation during DNA replication or transcription.Formule :C10H12Li4N5O13P3Couleur et forme :SolidMasse moléculaire :530.913UMPK ligand 1
CAS :UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).
Formule :C15H22N4O5SCouleur et forme :SolidMasse moléculaire :370.424GHP-88309
CAS :GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.Formule :C16H11FN2OCouleur et forme :SolidMasse moléculaire :266.27Valopicitabine
CAS :Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronicFormule :C15H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.37NSC 641396
CAS :NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.Formule :C18H13NO3Couleur et forme :SolidMasse moléculaire :291.301PolQi1
CAS :PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.Formule :C18H14ClF5N4O2Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :448.7714α-Demethylase/DNA Gyrase-IN-1
14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.Formule :C26H22N4O4Couleur et forme :SolidMasse moléculaire :454.48DHICA
CAS :DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of eumelanin, as well as acting as a moderate potency agonist of GPR35. In the U2OS cell line, DHICA demonstrates the ability to induce β-arrestin translocation signaling with an EC50 value of 23.2 μM. Additionally, it plays a significant role in promoting and protecting against DNA damage.Formule :C9H7NO4Couleur et forme :SolidMasse moléculaire :193.16Cimpuciclib tosylate
CAS :Cimpuciclib tosylate, a selective CDK4 inhibitor (IC50: 0.49 nM), exhibits anti-tumor activity.Formule :C37H43FN8O4SCouleur et forme :SolidMasse moléculaire :714.85Xanthosine-5'-Triphosphate trisodium
CAS :Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).Formule :C10H12N4Na3O15P3Couleur et forme :SolidMasse moléculaire :590.111CDK9-IN-11
CAS :CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].Formule :C20H25N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.43ART615
ART615 is a related isomer of ART558. ART615 inhibits Polθ by <10% at 12 μM and is able to act as a control for ART558 (IC50:7.9 nM).Formule :C21H21F3N4O2Couleur et forme :SolidMasse moléculaire :418.41Ladirubicin
CAS :Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.Formule :C29H31NO11SCouleur et forme :SolidMasse moléculaire :601.622'-(2-Nitrobenzyl)-ATP
CAS :2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.Formule :C17H21N6O15P3Couleur et forme :SolidMasse moléculaire :642.30USP7-IN-10
CAS :USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.Formule :C26H29ClN4O3SCouleur et forme :SolidMasse moléculaire :513.05SF0166
CAS :SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Formule :C23H27F2N5O4Couleur et forme :SolidMasse moléculaire :475.49GSK3335103
CAS :GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Formule :C27H36FN3O4Couleur et forme :SolidMasse moléculaire :485.595'-DMT-5-F-2'-dU Phosphoramidite
CAS :5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.Formule :C39H46FN4O8PCouleur et forme :SolidMasse moléculaire :748.777PT109
CAS :PT109 is a multikinase inhibitor that targets JNK and other kinases, playing a crucial role in anti-inflammatory, antioxidative, neurogenic, and synaptogenic processes. Specifically, PT109 inhibits JNK isoforms with the following IC50 values: JNK1 at 0.143 μM, JNK2 at 0.831 μM, and JNK3 at 0.285 μM. It also inhibits SGK isoforms (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM) and ROCK2 (IC50=34 μM). Additionally, PT109 reprograms polymorphic glioblastoma multiforme (GBM) into oligodendroglia via the PTBP1/PKM1/2 pathway and alters the metabolic pattern of GBM to exhibit antiglioma activity.Formule :C23H31N3OS2Couleur et forme :SolidMasse moléculaire :429.64Rhodblock 1a
CAS :Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.
Formule :C20H16N2O2Couleur et forme :SolidMasse moléculaire :316.353Antifolate agent 1
CAS :Antifolateagent 1 (Compound 1) is an antifolate agent featuring a single-carbon bridge. It lacks RFC transport, shows no affinity for FRα and FRβ, and exhibits no GARFTase inhibition activity. Antifolateagent 1 serves as a negative control in the development of folate receptor-targeted antifolate agents.Formule :C19H19N5O6Couleur et forme :SolidMasse moléculaire :413.38CDK9 autophagic degrader 1
CAS :CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.Formule :C34H39N7O4S2Couleur et forme :SolidMasse moléculaire :673.848CDK2/4-IN-2
CAS :CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.Formule :C18H20F3N7O3S2Couleur et forme :SolidMasse moléculaire :503.523'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite
CAS :3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite is a nucleoside phosphoramidite monomer featuring protective group modifications, suitable for RNA oligonucleotide synthesis.Formule :C42H51N8O5PCouleur et forme :SolidMasse moléculaire :778.88Deoxythymidine-5'-triphosphate-d15
CAS :Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is a deuterium-labeled form of deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is a triphosphate nucleotide utilized in DNA synthesis.Formule :C10H15Li2N2O14P3Couleur et forme :SolidMasse moléculaire :509.13Sovesudil hydrochloride
Sovesudil (PHP-201) HCl: potent local ROCK inhibitor; targets ROCK I/II (IC50: 3.7/2.3 nM); lowers IOP, non-congesting.Formule :C23H23ClFN3O3Couleur et forme :SolidMasse moléculaire :443.9Morpholino U subunit
CAS :Morpholino U subunit is one of the fundamental components of morpholino oligonucleotides, capable of pairing with adenine in target RNA.Formule :C30H32ClN4O5PCouleur et forme :SolidMasse moléculaire :595.03CHK1-IN-4
CAS :CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.Formule :C18H18BrN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.29Dyrk1A/B-IN-1
Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.Formule :C21H17N3O2S2Couleur et forme :SolidMasse moléculaire :407.51BRD-7880
CAS :BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.Formule :C32H38N4O7Couleur et forme :SolidMasse moléculaire :590.67MtTMPK-IN-7
MtTMPK-IN-7 inhibits MtbTMPK (IC50: 47 μM), active against M. brevis (MIC: 2.3-4.7 μM), useful for tuberculosis research.Formule :C27H29ClN6O3Couleur et forme :SolidMasse moléculaire :521.01CHK1-IN-2
CAS :CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).Formule :C20H22N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.48Zalunfiban dihydrochloride
Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.Formule :C16H20Cl2N8O2SCouleur et forme :SolidMasse moléculaire :459.35Mazethramycin
CAS :Mazethramycin is an antitumor antibiotic that exerts its effects by disrupting DNA replication and RNA synthesis within cells. It is utilized in cancer research.Formule :C17H19N3O4Masse moléculaire :329.35WEE1/PKMYT1-IN-1
CAS :WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.
Formule :C16H16N4O3Couleur et forme :SolidMasse moléculaire :312.323α5β1 integrin agonist-1
CAS :α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.Formule :C24H26FN5O9Couleur et forme :SolidMasse moléculaire :547.49TH9619
CAS :TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). Anticancer.Formule :C17H18FN7O7Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :451.37Ref: TM-T87512
1mg130,00€5mg314,00€10mg505,00€25mg1.009,00€50mg1.603,00€100mg2.142,00€1mL*10mM (DMSO)348,00€JY-3-094
CAS :JY-3-094 is a selective Myc inhibitor that targets the hydrophobic domain of Myc and inhibits the formation of the Myc-Max heterodimer, with an IC50 of 33 μM, and can be used for cancer research.Formule :C13H8N4O5Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :300.23Werner syndrome RecQ helicase-IN-2
CAS :Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Formule :C32H34F3N9O5Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :681.67PCNA-IN-1
CAS :PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.Formule :C19H18I3NO3Couleur et forme :SolidMasse moléculaire :689.065CDK4-IN-1
CAS :CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50Formule :C22H29ClN8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.97LNA-GTP
CAS :LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.Formule :C11H16N5O14P3Couleur et forme :SolidMasse moléculaire :535.19CDK1-IN-7
CAS :CDK1-IN-7 (compound M7) is a potent CDK1 inhibitor. It effectively suppresses the proliferation and migration of HCT116 and Lovo cells, making it a valuable tool for colorectal cancer research.Formule :C23H19ClN4O3Couleur et forme :SolidMasse moléculaire :434.88DNA gyrase B-IN-1
DNA gyrase B-IN-1, a potent inhibitor of P. aeruginosa DNA gyrase B, has IC50 of 2.2 μM with high affinity and stability.Formule :C23H18ClF3N6O4SCouleur et forme :SolidMasse moléculaire :566.94Tripolin B
CAS :Tripolin B is an ATP-competitive inhibitor of Aurora kinases, with IC50 values of 2.5 µM and 6 µM for Aurora A and Aurora B kinases, respectively. However, it exhibits no inhibitory effect within cells.Formule :C12H9N3OMasse moléculaire :211.22
