Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(546 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(226 produits)
- HSP(179 produits)
- Intégrine(253 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(124 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3872 produits trouvés pour "Cycle cellulaire/point de contrôle"
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Y-99
CAS :Y-99 is a PORCN inhibitor with an IC50 value of 155.4 nM for suppressing the Wnt/β-catenin signaling pathway. Additionally, Y-99 inhibits the expression of p-LRP6, β-catenin, and c-Myc.Formule :C18H17F2N5O3Couleur et forme :SolidMasse moléculaire :389.36Cdc7-IN-10
CAS :Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.Formule :C20H22F2N4O2SCouleur et forme :SolidMasse moléculaire :420.48MY05
CAS :MY05 selectively targets c-MYC within cells and disrupts the interaction between MYC and MAX. It binds to intracellular c-MYC, modulating its thermal stability, reducing the transcriptional targets of c-MYC, and exhibiting anticancer activity (TNBC, triple-negative breast cancer).Formule :C19H11ClN4OCouleur et forme :SolidMasse moléculaire :346.77PARG-IN-7
CAS :PARG-IN-7 (Example 38) is a Poly ADP-ribose glycohydrolase (PARG) inhibitor with an IC50 of less than 0.1 μM. It reduces the viability of HCC1806-XRCC1 knockdown (KD) cells, exhibiting an IC50 of less than 1 μM. PARG-IN-7 is applicable in cancer research.Formule :C22H24F2N8O3S2Couleur et forme :SolidMasse moléculaire :550.61α5β1 integrin agonist-1
CAS :α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.Formule :C24H26FN5O9Couleur et forme :SolidMasse moléculaire :547.493'-NH2-CTP
CAS :3'-NH2-CTP is a nucleotide analog modified with an amino group at the 3' position of CTP.Formule :C9H17N4O13P3Couleur et forme :SolidMasse moléculaire :482.17Glycyl H-1152 hydrochloride
CAS :Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.Formule :C18H26Cl2N4O3SCouleur et forme :SolidMasse moléculaire :449.39Haspin-IN-2
CAS :Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).Formule :C12H8N4O3Couleur et forme :SolidMasse moléculaire :256.22Eprociclovir Na
CAS :Eprociclovir Na (A-5021) is 15x stronger than acyclovir at inhibiting herpesviruses, showing promise for EHV1 and herpetic keratitis treatment.Formule :C11H14N5NaO3Couleur et forme :SolidMasse moléculaire :287.25isoGTP lithium
CAS :isoGTP (Isoguanosine-5'-triphosphate) lithium is a GTP analog.Formule :C10H12Li4N5O14P3Couleur et forme :SolidMasse moléculaire :546.91Zalunfiban dihydrochloride
Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.Formule :C16H20Cl2N8O2SCouleur et forme :SolidMasse moléculaire :459.35MtTMPK-IN-7
MtTMPK-IN-7 inhibits MtbTMPK (IC50: 47 μM), active against M. brevis (MIC: 2.3-4.7 μM), useful for tuberculosis research.Formule :C27H29ClN6O3Couleur et forme :SolidMasse moléculaire :521.01Aurora/LIM kinase-IN-1
Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.Formule :C16H20N6OCouleur et forme :SolidMasse moléculaire :312.378-Azakinetin riboside
CAS :8-Azakinetin riboside, a structural analog of kinetin riboside, exhibits cytotoxic activity [1].Formule :C14H16N6O5Couleur et forme :SolidMasse moléculaire :348.31Cdc7-IN-8
CAS :Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)Formule :C19H21N5O2Couleur et forme :SolidMasse moléculaire :351.40PKMYT1-IN-2
CAS :PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].Formule :C22H19N5O2Couleur et forme :SolidMasse moléculaire :385.422'-F-AMP
CAS :2'-F-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.Formule :C10H13FN5O6PCouleur et forme :SolidMasse moléculaire :349.21BRD-7880
CAS :BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.Formule :C32H38N4O7Couleur et forme :SolidMasse moléculaire :590.67Dyrk1A/B-IN-1
Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.Formule :C21H17N3O2S2Couleur et forme :SolidMasse moléculaire :407.51Sovesudil hydrochloride
Sovesudil (PHP-201) HCl: potent local ROCK inhibitor; targets ROCK I/II (IC50: 3.7/2.3 nM); lowers IOP, non-congesting.Formule :C23H23ClFN3O3Couleur et forme :SolidMasse moléculaire :443.9TA-316
CAS :Agent induces megakaryocytes/platelets from stem cells to treat thrombopenia.Formule :C28H25BrN4O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :641.566-N-Hydroxylaminopurine
CAS :6-N-Hydroxylaminopurine is a base analog with mutagenic activity.Formule :C5H5N5OMasse moléculaire :151.13LNA-GDP
CAS :LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.Formule :C11H15N5O11P2Couleur et forme :SolidMasse moléculaire :455.21L-I-OddU
CAS :L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).Formule :C8H9IN2O5Couleur et forme :SolidMasse moléculaire :340.07CB 30900
CAS :CB30900 is a novel and effective thymidylate synthase inhibitor.Formule :C31H32FN5O9Couleur et forme :SolidMasse moléculaire :637.61RNase L ligand 3
CAS :RNase L ligand 3 is an RNase L ligand employed in the synthesis of F3-PEG8-RiboTAC.Formule :C27H27N3OSCouleur et forme :SolidMasse moléculaire :441.59AGH-107
CAS :AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.Formule :C13H12IN3Couleur et forme :SolidMasse moléculaire :337.16CDK9 autophagic degrader 1
CAS :CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.Formule :C34H39N7O4S2Couleur et forme :SolidMasse moléculaire :673.8485'-DMT-5-F-2'-dU Phosphoramidite
CAS :5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.Formule :C39H46FN4O8PCouleur et forme :SolidMasse moléculaire :748.777SF0166
CAS :SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Formule :C23H27F2N5O4Couleur et forme :SolidMasse moléculaire :475.493′-Amino-2′,3′-dideoxy-CTP
CAS :3′-Amino-2′,3′-dideoxy-CTP is an analog of nucleoside triphosphates. It selectively inhibits DNA polymerase β.Formule :C9H17N4O12P3Couleur et forme :SolidMasse moléculaire :466.17CDK7-IN-17
CAS :CDK7-IN-17 (compound 11) is a pyrimidine-derived CDK7 inhibitor for studying transcription-disrupted cancers.Formule :C24H26F3N6OPDegré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :502.47USP7-IN-10
CAS :USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.Formule :C26H29ClN4O3SCouleur et forme :SolidMasse moléculaire :513.05CDK7/12-IN-1
CAS :CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.Formule :C25H34N8OCouleur et forme :SolidMasse moléculaire :462.59Kolavenic acid analog
CAS :KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.Formule :C25H38O4Couleur et forme :SolidMasse moléculaire :402.572'-(2-Nitrobenzyl)-ATP
CAS :2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.Formule :C17H21N6O15P3Couleur et forme :SolidMasse moléculaire :642.30DS96432529
DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.Formule :C18H26N4O3SCouleur et forme :SoildMasse moléculaire :378.49LNA-UTP
CAS :LNA-UTP is a nucleotide analogue used in the synthesis of oligonucleotides.Formule :C10H15N2O15P3Couleur et forme :SolidMasse moléculaire :496.15Ladirubicin
CAS :Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.Formule :C29H31NO11SCouleur et forme :SolidMasse moléculaire :601.62CBP/p300-IN-2
CAS :CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc).Formule :C27H29F2N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.56CDK9-IN-11
CAS :CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].Formule :C20H25N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.43MRL-436
CAS :MRL-436 is an RNA polymerase inhibitor with antibacterial activity. Its effectiveness depends on the β' subunit and the 622nd residue of the RNAP ω subunit. MRL-436 can inhibit Rifampicin-resistant RNA polymerase derivatives and shows antibacterial activity against Rifampicin-resistant strains.Formule :C24H22N4OCouleur et forme :SolidMasse moléculaire :382.463'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite
CAS :3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite serves as a precursor of adenosine nucleotide monomers used in the solid-phase synthesis of oligonucleotides, particularly for modifying oligonucleotides such as terminally modified DNA strands. It features Trityl (Tr), Cyanoethyl (CE), and Dimethylformamidine (DMF) protective groups, classifying it as a ddNTP adenosine nucleoside suitable for applications like oligonucleotide solid-phase synthesis, probe design, and chain termination sequencing.Formule :C41H50N9O3PCouleur et forme :SolidMasse moléculaire :747.87USP7-797
CAS :USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Formule :C27H28ClN3O3SDegré de pureté :95.90% - 95.90%Couleur et forme :SolidMasse moléculaire :510.052′-OMe-UDP
CAS :2′-OMe-UDP is a nucleotide analog utilized in the synthesis of oligonucleotides.Formule :C10H16N2O12P2Couleur et forme :SolidMasse moléculaire :418.19Aurora A inhibitor 1
CAS :Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)Formule :C25H28ClF2N5O2Couleur et forme :SolidMasse moléculaire :503.97CDK2-IN-18
CAS :CDK2-IN-18 (compound 8q) serves as a powerful inhibitor of CDK 2/E and CDK 4/D1, showing IC50 values of 8 nM and 46 nM, respectively. It effectively inhibits tumor cell proliferation [1].Formule :C21H23N7O2SCouleur et forme :SolidMasse moléculaire :437.52Xanthosine-5'-Triphosphate trisodium
CAS :Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).Formule :C10H12N4Na3O15P3Couleur et forme :SolidMasse moléculaire :590.111Cimpuciclib tosylate
CAS :Cimpuciclib tosylate, a selective CDK4 inhibitor (IC50: 0.49 nM), exhibits anti-tumor activity.Formule :C37H43FN8O4SCouleur et forme :SolidMasse moléculaire :714.85WRN inhibitor 13
CAS :WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.Formule :C16H20N2O5SCouleur et forme :SolidMasse moléculaire :352.40514α-Demethylase/DNA Gyrase-IN-1
14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.Formule :C26H22N4O4Couleur et forme :SolidMasse moléculaire :454.48Mitotic kinesin-IN-1 hydrochloride
CAS :Mitotic kinesin-IN-1 hydrochloride (Example 80) is an inhibitor of mitotic kinesin, which suppresses cell proliferation by hindering mitosis. This compound is applicable in research related to cancer, cardiac hypertrophy, immune and inflammatory diseases, and fungal infections.Formule :C22H26ClF2N3OSCouleur et forme :SolidMasse moléculaire :453.98Valopicitabine
CAS :Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronicFormule :C15H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.37Uridine 3',5'-diphosphate
CAS :Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].Formule :C9H14N2O12P2Couleur et forme :SolidMasse moléculaire :404.16DHX9-IN-9
CAS :DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].Formule :C21H21ClFN5O3S2Couleur et forme :SolidMasse moléculaire :510GHP-88309
CAS :GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.Formule :C16H11FN2OCouleur et forme :SolidMasse moléculaire :266.27PARG-IN-6
CAS :PARG-IN-6 (Compound 2) is an orally bioavailable PARG inhibitor with an IC50 of 0.3 nM. It exhibits significant anticancer activity against cancer cells, with an IC50 of 0.0368 μM for HCC1395 cells. PARG-IN-6 shows potential for research in colon cancer, appendiceal cancer, and pancreatic cancer.Formule :C24H25F4N7O4S3Couleur et forme :SolidMasse moléculaire :647.69L-2'-Fd4C
CAS :L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].Formule :C9H10FN3O3Couleur et forme :SolidMasse moléculaire :227.19Pol I-IN-1
Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibitionFormule :C23H22N4O2Couleur et forme :SolidMasse moléculaire :386.45DHICA
CAS :DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of eumelanin, as well as acting as a moderate potency agonist of GPR35. In the U2OS cell line, DHICA demonstrates the ability to induce β-arrestin translocation signaling with an EC50 value of 23.2 μM. Additionally, it plays a significant role in promoting and protecting against DNA damage.Formule :C9H7NO4Couleur et forme :SolidMasse moléculaire :193.16D-G23
CAS :D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.Formule :C19H22N4O3Couleur et forme :SolidMasse moléculaire :354.403Antifolate agent 1
CAS :Antifolateagent 1 (Compound 1) is an antifolate agent featuring a single-carbon bridge. It lacks RFC transport, shows no affinity for FRα and FRβ, and exhibits no GARFTase inhibition activity. Antifolateagent 1 serves as a negative control in the development of folate receptor-targeted antifolate agents.Formule :C19H19N5O6Couleur et forme :SolidMasse moléculaire :413.38DIDS
CAS :DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.Formule :C16H10N2O6S4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.52Tubulin inhibitor 49
CAS :Tubulin inhibitor 49 is a tubulin polymerization inhibitor that disrupts the cellular microtubule network, arrests the cell cycle. toxic toward HeLa cells.Formule :C18H14F3N3OSDegré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :377.38Rhodblock 1a
CAS :Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.
Formule :C20H16N2O2Couleur et forme :SolidMasse moléculaire :316.3532′-O-MOE-CMP
CAS :2′-O-MOE-CMP is a nucleotide analogue utilized in the synthesis of oligonucleotides.Formule :C12H20N3O9PCouleur et forme :SolidMasse moléculaire :381.28Tripolin B
CAS :Tripolin B is an ATP-competitive inhibitor of Aurora kinases, with IC50 values of 2.5 µM and 6 µM for Aurora A and Aurora B kinases, respectively. However, it exhibits no inhibitory effect within cells.Formule :C12H9N3OMasse moléculaire :211.22KI-CDK9d-32
CAS :KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.Formule :C39H45N9O4Couleur et forme :SolidMasse moléculaire :703.83IRE1α kinase-IN-5
IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α.Formule :C28H30N6O3SCouleur et forme :SolidMasse moléculaire :530.64Dyrk1A-IN-4
CAS :Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.Formule :C14H13F3N6Couleur et forme :SolidMasse moléculaire :322.29HNC-1664
CAS :HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.Formule :C12H13FIN3O3Couleur et forme :SolidMasse moléculaire :393.153GSK3335103
CAS :GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Formule :C27H36FN3O4Couleur et forme :SolidMasse moléculaire :485.59BET/Aurora kinase-IN-1
CAS :BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.Formule :C25H30FN7OCouleur et forme :SolidMasse moléculaire :463.55Polθ-IN-7
CAS :Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.Formule :C28H35F3N6O2Couleur et forme :SolidMasse moléculaire :544.612BRD4 Inhibitor-40
CAS :BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.Formule :C27H32N8OCouleur et forme :SolidMasse moléculaire :484.596Des-ethyl-carafiban
CAS :Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.Formule :C22H23N5O5Couleur et forme :SolidMasse moléculaire :437.448DNA Gyrase-IN-16
CAS :DNA Gyrase-IN-16 (Compound 9) is an inhibitor of DNA gyrase, with an IC50 of 1.609 μM. It exhibits antibacterial properties, effectively inhibiting S. aureus and MRSA, with a MIC of 3.125 μM for both.
Formule :C17H15N3O3Couleur et forme :SolidMasse moléculaire :309.319KWR095
CAS :KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.Formule :C33H31ClF3N9O4Couleur et forme :SolidMasse moléculaire :710.105Tizolemide
CAS :Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.Formule :C11H14ClN3O3S2Couleur et forme :SolidMasse moléculaire :335.83ROCK/HDAC-IN-1
ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.Formule :C19H22N4O3SCouleur et forme :SolidMasse moléculaire :386.47LY309887
CAS :LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.Formule :C19H23N5O6SCouleur et forme :SolidMasse moléculaire :449.483'-Deoxy-GTP
CAS :3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.Formule :C10H16N5O13P3Couleur et forme :SolidMasse moléculaire :507.181L-Tyrosyl-L-glutamic acid
CAS :L-Tyrosyl-L-glutamic acid acts as an inhibitor of the amino acid permease GAP1.Formule :C14H18N2O6Couleur et forme :SolidMasse moléculaire :310.3CDK4/6-IN-24
CAS :CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.Formule :C32H41N7O3Couleur et forme :SolidMasse moléculaire :571.713MU1409
CAS :MU1409 is an MRE11 nuclease inhibitor with an IC50 of 12.1 μM. It also inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. MU1409 impacts cellular DNA repair and prevents the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for studying BRCA2 mutation-induced cancers.Formule :C20H14BrN3O3SCouleur et forme :SolidMasse moléculaire :456.312TREX1-IN-4
CAS :TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.Formule :C24H19ClN6O4Couleur et forme :SolidMasse moléculaire :490.898DL-Alanosine
CAS :DL-Alanosine is an amino acid analog with antitumor activity.Formule :C3H7N3O4Couleur et forme :SolidMasse moléculaire :149.105Zeltociclib
CAS :Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.Formule :C18H20F3N4O2PCouleur et forme :SolidMasse moléculaire :412.346HPH-15
CAS :HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.Formule :C19H31N3S4Couleur et forme :SolidMasse moléculaire :429.73LNA-AMP
CAS :LNA-AMP is a nucleotide analog used in the synthesis of oligonucleotides.Formule :C11H14N5O7PCouleur et forme :SolidMasse moléculaire :359.23Dyrk1A-IN-12
CAS :Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).Formule :C22H16FN3O2SCouleur et forme :SolidMasse moléculaire :405.445CDK/HDAC-IN-1
CDK/HDAC-IN-1 inhibits CDK2/4/6 & HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.Formule :C20H18N4O4Couleur et forme :SolidMasse moléculaire :378.38Polθ-IN-5
CAS :Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.Formule :C23H18ClF2N7O3SCouleur et forme :SolidMasse moléculaire :545.95IXA62
CAS :IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.Formule :C24H23N3O3Couleur et forme :SolidMasse moléculaire :401.458CHK-IN-1
CAS :CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.Formule :C18H19ClFN5OSDegré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :407.89CDK2 degrader 4
CAS :CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.Formule :C23H26ClN3O5Couleur et forme :SolidMasse moléculaire :459.923SGC-CLK-1
CAS :SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.Formule :C19H15F3N6O2Couleur et forme :SolidMasse moléculaire :416.36c-Myc inhibitor 4
Potent oral c-Myc inhibitor 4 reduces the proto-oncogene linked to tumor development.Formule :C26H33FN6O3Couleur et forme :SolidMasse moléculaire :496.58BWC0977
CAS :BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.Formule :C22H21FN6O5Couleur et forme :SolidMasse moléculaire :468.44ATIC-IN-2
CAS :ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.Formule :C4H4N4O3SCouleur et forme :SolidMasse moléculaire :188.165
