Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(546 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(227 produits)
- HSP(180 produits)
- Intégrine(269 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(126 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3904 produits trouvés pour "Cycle cellulaire/point de contrôle"
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MtTMPK-IN-1
MtTMPK-IN-1 inhibits MtTMPK with 2.5 μM IC50, shows moderate anti-tuberculosis activity, and is low in cytotoxicity.Formule :C22H24N4O3Couleur et forme :SolidMasse moléculaire :392.45CDK4-IN-1
CAS :CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50Formule :C22H29ClN8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.97GTSE1-IN-1
CAS :GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.Formule :C21H24FN7Couleur et forme :SolidMasse moléculaire :393.46TY-011
CAS :TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Formule :C18H16ClN5Couleur et forme :SolidMasse moléculaire :337.81Werner syndrome RecQ helicase-IN-2
CAS :Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Formule :C32H34F3N9O5Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :681.67FR-β ligand 1
CAS :FR-β ligand 1 (III) is a ligand that specifically targets folate receptors, exhibiting antitumor activity, high selectivity, and strong affinity.Formule :C22H25N5O6Couleur et forme :SolidMasse moléculaire :455.465-Methylcytosine hydrochloride
CAS :5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.Formule :C5H8ClN3OCouleur et forme :SolidMasse moléculaire :161.593'-Deoxy-GTP
CAS :3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.Formule :C10H16N5O13P3Couleur et forme :SolidMasse moléculaire :507.181Mazethramycin
CAS :Mazethramycin is an antitumor antibiotic that exerts its effects by disrupting DNA replication and RNA synthesis within cells. It is utilized in cancer research.Formule :C17H19N3O4Masse moléculaire :329.35SCH-1473759
CAS :SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Formule :C20H26N8OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.54MY05
CAS :MY05 selectively targets c-MYC within cells and disrupts the interaction between MYC and MAX. It binds to intracellular c-MYC, modulating its thermal stability, reducing the transcriptional targets of c-MYC, and exhibiting anticancer activity (TNBC, triple-negative breast cancer).Formule :C19H11ClN4OCouleur et forme :SolidMasse moléculaire :346.77TA-316
CAS :Agent induces megakaryocytes/platelets from stem cells to treat thrombopenia.Formule :C28H25BrN4O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :641.56CLK1/4-IN-1
CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.Formule :C18H14ClNO4SCouleur et forme :SolidMasse moléculaire :375.83CDK2 degrader 6
CAS :CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.Formule :C23H22F5N5O3Couleur et forme :SolidMasse moléculaire :511.44Antitumor agent-74
Antitumor agent-74, a quinazoline derivative, inhibits DNA, arrests cell cycle, and induces apoptosis with agent-75.Formule :C26H23FN6Couleur et forme :SolidMasse moléculaire :438.5ROCK-IN-11
CAS :ROCK-IN-11 (example 94) is an effective inhibitor of ROCK1 and ROCK2, with an IC50 of ≤ 5 μM, and plays a significant role in cancer research.Formule :C22H20N4O4SCouleur et forme :SolidMasse moléculaire :436.484CHK1 inhibitor
CAS :CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Formule :C17H21BrN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.282'-O-MOE-GTP
CAS :2'-O-MOE-GTP is a nucleotide analog utilized in the synthesis of oligonucleotides.Formule :C13H22N5O15P3Couleur et forme :SolidMasse moléculaire :581.26(R)-CSN5i-3
CAS :(R)-CSN5i-3 is CSN5i-3 of the R configuration.Formule :C28H29F2N5O2Degré de pureté :99.76% - 99.97%Couleur et forme :SolidMasse moléculaire :505.56RAD51-IN-6
CAS :RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)Formule :C27H40N3O5PSCouleur et forme :SolidMasse moléculaire :549.66APE1-IN-3
CAS :APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.Formule :C17H16O4Couleur et forme :SolidMasse moléculaire :284.31CHK1-IN-2
CAS :CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).Formule :C20H22N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.48N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine
CAS :N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is a nucleoside analog that resembles the natural nucleotide adenosine in structure. It acts as an activator of ribonucleotide reductase, facilitating the conversion of ribonucleotides into deoxyribonucleotides.Formule :C38H35N5O6Couleur et forme :SolidMasse moléculaire :657.714RNAP-σ interaction inhibitor-1
CAS :RNAP-σ interaction inhibitor-1 (compound 5d) acts as an inhibitor of the interaction between RNA polymerase and the sigma factor. It exhibits activity against Streptococci with a minimum inhibitory concentration (MIC) ranging from 1-2 µg/mL.Formule :C19H11Cl3N2O6S2Couleur et forme :SolidMasse moléculaire :533.79AR-13324 M1 metabolite
CAS :AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.Formule :C19H19N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :321.37WEE1 degrader 1
WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.Formule :C30H31N5O3Couleur et forme :SolidMasse moléculaire :509.6TMX-3013
CAS :TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.Formule :C17H14BrFN6O3SCouleur et forme :SolidMasse moléculaire :481.3UMPK ligand 1
CAS :UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).
Formule :C15H22N4O5SCouleur et forme :SolidMasse moléculaire :370.424TASIN-30
CAS :TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.Formule :C18H30N2O3SCouleur et forme :SolidMasse moléculaire :354.51GSK_WRN4
CAS :GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer researchFormule :C16H20N2O4SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :336.41CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.43CLK1/2-IN-1
CAS :CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.Formule :C21H20F3N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :443.42FT709
CAS :FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.Formule :C23H22N4O7SCouleur et forme :SolidMasse moléculaire :498.51PT109
CAS :PT109 is a multikinase inhibitor that targets JNK and other kinases, playing a crucial role in anti-inflammatory, antioxidative, neurogenic, and synaptogenic processes. Specifically, PT109 inhibits JNK isoforms with the following IC50 values: JNK1 at 0.143 μM, JNK2 at 0.831 μM, and JNK3 at 0.285 μM. It also inhibits SGK isoforms (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM) and ROCK2 (IC50=34 μM). Additionally, PT109 reprograms polymorphic glioblastoma multiforme (GBM) into oligodendroglia via the PTBP1/PKM1/2 pathway and alters the metabolic pattern of GBM to exhibit antiglioma activity.Formule :C23H31N3OS2Couleur et forme :SolidMasse moléculaire :429.64(Rac)-Plevitrexed
CAS :(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.53β-catenin-IN-8
CAS :β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.Formule :C15H12ClN3O2SCouleur et forme :SolidMasse moléculaire :333.79HBV-IN-48
CAS :HBV-IN-48, an HBV inhibitor, exhibits potent antiviral activity against HBV in HepDE19 cells, demonstrated by its EC 50 value of 0.005 μM. Additionally, it effectively reduces serum HBV DNA levels in mouse models of HBV infection.Formule :C22H15F4N3O3Couleur et forme :SolidMasse moléculaire :445.37DNA polymerase-IN-6
CAS :DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.Formule :C26H28ClFN8O4Couleur et forme :SolidMasse moléculaire :571.003CDK7-IN-31
CAS :CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.Formule :C27H32F5N6O2PCouleur et forme :SolidMasse moléculaire :598.55CIB-L43
CAS :CIB-L43 is a oral TRBP inhibitor, inhibit miR-21, increase PTEN and Smad7, and block the AKT and TGF-β，inhibit proliferation and migration.Formule :C15H16N2O3SDegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :304.36CDK6-IN-1
CAS :CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.Formule :C30H23N5Couleur et forme :SolidMasse moléculaire :453.54CDK9-IN-38
CAS :CDK9-IN-38 (compound 14) is a CDK9 inhibitor with IC50 values of 1.2 nM for wild-type CDK9 and 3.3 nM for the L156F mutant. It effectively inhibits tumor growth both in vitro and in vivo.Formule :C22H23N5O3SCouleur et forme :SolidMasse moléculaire :437.515CHK1-IN-4
CAS :CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.Formule :C18H18BrN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.29Chk1-IN-5
CAS :Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.Formule :C18H18FN7O2Couleur et forme :SolidMasse moléculaire :383.38CTX-712
CAS :CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.Formule :C19H17FN8O2Couleur et forme :SolidMasse moléculaire :408.39Dencatistat
CAS :Dencatistat is a highly selective and oral cytidine triphosphate synthase 1 CTPS1 inhibitor specific.CTPS1-IN-2 for B-cell, T-cell lymphomas and solid tumors.Formule :C24H27N7O5SDegré de pureté :98.85%Couleur et forme :SolidMasse moléculaire :525.58WRN inhibitor 7
CAS :WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].Formule :C27H23N3O6Couleur et forme :SolidMasse moléculaire :485.492'-O-MOE-GMP
CAS :2'-O-MOE-GMP is a nucleotide analogue that can be utilized in the synthesis of oligonucleotides.
Formule :C13H20N5O9PCouleur et forme :SolidMasse moléculaire :421.30CDK1-IN-4
CDK1-IN-4 inhibits CDK1 (IC50: 44.52 nM), CDK2/CDK5 less potently, impacts cell cycle, used in cancer studies.Formule :C26H24ClN5SCouleur et forme :SolidMasse moléculaire :474.02N-Isobutyryl-2', 3'-acetyl-guanosine
CAS :N-Isobutyryl-2', 3'-acetyl-guanosine is a derivative of guanosine.Formule :C18H23N5O8Couleur et forme :SolidMasse moléculaire :437.404Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.126K465
CAS :6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.Formule :C26H33ClFN9ODegré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :542.05TH9619
CAS :TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). Anticancer.Formule :C17H18FN7O7Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :451.37Ref: TM-T87512
1mg130,00€5mg314,00€10mg505,00€25mg1.009,00€50mg1.603,00€100mg2.142,00€1mL*10mM (DMSO)348,00€MTH1 activator-1
CAS :MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.Formule :C29H23F3N4O2Couleur et forme :SolidMasse moléculaire :516.514RNAP-σ interaction inhibitor-2
CAS :RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor targeting the interaction between RNA polymerase and the sigma factor. It demonstrates inhibitory activity against S. aureus with a minimum inhibitory concentration (MIC) of 2 µg/mL.Formule :C27H19Cl3N2O6S2Couleur et forme :SolidMasse moléculaire :637.939PKMYT1-IN-9
CAS :PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.Formule :C17H14FN5OCouleur et forme :SolidMasse moléculaire :323.324OPN expression inhibitor 1
CAS :OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.Formule :C25H33N3O5Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :455.55Ref: TM-T62820
1mg126,00€5mg258,00€10mg385,00€25mg695,00€50mg1.009,00€100mg1.314,00€1mL*10mM (DMSO)259,00€PNR-3-80
CAS :PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 μM, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.Formule :C24H14ClN3O3SCouleur et forme :SolidMasse moléculaire :459.90FR-145715
CAS :FR-145715 is a histamine H2 receptor antagonist characterized by its specific anti-Helicobacter pylori activity. This compound is utilized in the study of gastric lesions.Formule :C16H21N5O2SCouleur et forme :SolidMasse moléculaire :347.44PKMYT1-IN-7
CAS :PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM for PKMYT1 and 0.06 μM for pCDK1. It inhibits the phosphorylation of CDK1 at T14 and Y15 sites and exhibits anticancer activity both in vitro and in vivo.Formule :C17H18FN5O3Couleur et forme :SolidMasse moléculaire :359.355DB18
CAS :DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].Formule :C24H18ClN7O3Couleur et forme :SolidMasse moléculaire :487.9Antimalarial agent 44
Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.Formule :C37H37N5O7Couleur et forme :SolidMasse moléculaire :663.72CDK9/PARP-IN-1
CAS :CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.Formule :C38H34F2N8O3Couleur et forme :SolidMasse moléculaire :688.725CDK7-IN-26
CAS :CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.Formule :C22H22FN6OPSMasse moléculaire :468.49PolQi1
CAS :PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.Formule :C18H14ClF5N4O2Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :448.77Plevitrexed
CAS :Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor & reduced folate carrier, treats gastric cancer.Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.53RAD51-IN-8
RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.Formule :C16H14Cl2FN3O2Couleur et forme :SolidMasse moléculaire :370.21LNA-GMP
CAS :LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.Formule :C11H14N5O8PCouleur et forme :SolidMasse moléculaire :375.23NVP-BQS481
CAS :NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs).Formule :C27H33F3N4O2Couleur et forme :SolidMasse moléculaire :502.576-B345TTQ
CAS :6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.Formule :C22H20BrNO4Couleur et forme :SolidMasse moléculaire :442.303Morpholino U subunit
CAS :Morpholino U subunit is one of the fundamental components of morpholino oligonucleotides, capable of pairing with adenine in target RNA.Formule :C30H32ClN4O5PCouleur et forme :SolidMasse moléculaire :595.03Galidesivir
CAS :Galidesivir (BCX4430) is an antiviral compound that inhibits viral RNA-dependent RNA polymerase (RdRp) activity and reduces lung infections in infected animals.Formule :C11H15N5O3Degré de pureté :96.73% - 99.13%Couleur et forme :SolidMasse moléculaire :265.27Deoxythymidine-5'-triphosphate-d15
CAS :Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is a deuterium-labeled form of deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is a triphosphate nucleotide utilized in DNA synthesis.Formule :C10H15Li2N2O14P3Couleur et forme :SolidMasse moléculaire :509.133'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite
CAS :3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite is a nucleoside phosphoramidite monomer featuring protective group modifications, suitable for RNA oligonucleotide synthesis.Formule :C42H51N8O5PCouleur et forme :SolidMasse moléculaire :778.88Antifolate agent 1
CAS :Antifolateagent 1 (Compound 1) is an antifolate agent featuring a single-carbon bridge. It lacks RFC transport, shows no affinity for FRα and FRβ, and exhibits no GARFTase inhibition activity. Antifolateagent 1 serves as a negative control in the development of folate receptor-targeted antifolate agents.Formule :C19H19N5O6Couleur et forme :SolidMasse moléculaire :413.38DYRK1-IN-1
CAS :DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.Formule :C12H12N6Couleur et forme :SolidMasse moléculaire :240.26CDK9-IN-13
CDK9-IN-13 is a potent and selective CDK inhibitor (IC50<3 nM). CDK9-IN-13 has a very short half-life in rodents.Formule :C27H35N5O2Couleur et forme :SolidMasse moléculaire :461.62′-OMe-ADP
CAS :2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.Formule :C11H17N5O10P2Couleur et forme :SolidMasse moléculaire :441.23DHICA
CAS :DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of eumelanin, as well as acting as a moderate potency agonist of GPR35. In the U2OS cell line, DHICA demonstrates the ability to induce β-arrestin translocation signaling with an EC50 value of 23.2 μM. Additionally, it plays a significant role in promoting and protecting against DNA damage.Formule :C9H7NO4Couleur et forme :SolidMasse moléculaire :193.16EFdA-TP tetrasodium
CAS :EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.Formule :C12H11FN5Na4O12P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :621.12Pseudouridine 5'-OTBDPS
CAS :Pseudouridine5'-OTBDPS [5-(5-O-TBDPS-β-D-ribofuranosyl)uracil] is an intermediate of Pseudouridine.Formule :C25H30N2O6SiCouleur et forme :SolidMasse moléculaire :482.60AB25583
CAS :AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.Formule :C22H17ClN4O3SCouleur et forme :SolidMasse moléculaire :452.91PARG-IN-6
CAS :PARG-IN-6 (Compound 2) is an orally bioavailable PARG inhibitor with an IC50 of 0.3 nM. It exhibits significant anticancer activity against cancer cells, with an IC50 of 0.0368 μM for HCC1395 cells. PARG-IN-6 shows potential for research in colon cancer, appendiceal cancer, and pancreatic cancer.Formule :C24H25F4N7O4S3Couleur et forme :SolidMasse moléculaire :647.69DYRKs-IN-1 hydrochloride
CAS :DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) & DYRK1B (8 nM IC50) with antitumor properties.Formule :C30H31Cl2N7O4Couleur et forme :SolidMasse moléculaire :624.52CDK8-IN-11 hydrochloride
CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.Formule :C19H16ClF3N4O2Couleur et forme :SolidMasse moléculaire :424.8Mitotic kinesin-IN-1 hydrochloride
CAS :Mitotic kinesin-IN-1 hydrochloride (Example 80) is an inhibitor of mitotic kinesin, which suppresses cell proliferation by hindering mitosis. This compound is applicable in research related to cancer, cardiac hypertrophy, immune and inflammatory diseases, and fungal infections.Formule :C22H26ClF2N3OSCouleur et forme :SolidMasse moléculaire :453.98Cdc7-IN-18
CAS :Cdc7-IN-18 (1-2) inhibits CDC7 enzyme (IC50: 1.29 nM) and COLO205 cell proliferation (IC50: 53.62 nM).Formule :C19H21N5OSCouleur et forme :SolidMasse moléculaire :367.47(R)-Atuveciclib
CAS :Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].Formule :C18H18FN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.434,5'-Dimethylangelicin-NHS
NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.Formule :C21H19NO7SCouleur et forme :SolidMasse moléculaire :429.44PKMYT1-IN-2
CAS :PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].Formule :C22H19N5O2Couleur et forme :SolidMasse moléculaire :385.422′-OMe-UDP
CAS :2′-OMe-UDP is a nucleotide analog utilized in the synthesis of oligonucleotides.Formule :C10H16N2O12P2Couleur et forme :SolidMasse moléculaire :418.19USP7-797
CAS :USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Formule :C27H28ClN3O3SDegré de pureté :95.90% - 95.90%Couleur et forme :SolidMasse moléculaire :510.05GHP-88309
CAS :GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.Formule :C16H11FN2OCouleur et forme :SolidMasse moléculaire :266.273'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite
CAS :3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite serves as a precursor of adenosine nucleotide monomers used in the solid-phase synthesis of oligonucleotides, particularly for modifying oligonucleotides such as terminally modified DNA strands. It features Trityl (Tr), Cyanoethyl (CE), and Dimethylformamidine (DMF) protective groups, classifying it as a ddNTP adenosine nucleoside suitable for applications like oligonucleotide solid-phase synthesis, probe design, and chain termination sequencing.Formule :C41H50N9O3PCouleur et forme :SolidMasse moléculaire :747.87Valopicitabine
CAS :Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronicFormule :C15H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.3714α-Demethylase/DNA Gyrase-IN-1
14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.Formule :C26H22N4O4Couleur et forme :SolidMasse moléculaire :454.48MRL-436
CAS :MRL-436 is an RNA polymerase inhibitor with antibacterial activity. Its effectiveness depends on the β' subunit and the 622nd residue of the RNAP ω subunit. MRL-436 can inhibit Rifampicin-resistant RNA polymerase derivatives and shows antibacterial activity against Rifampicin-resistant strains.Formule :C24H22N4OCouleur et forme :SolidMasse moléculaire :382.46DNA Gyrase-IN-1
DNA Gyrase-IN-1: potent, selective promoter inhibitor. IC50: 2.6 μM, inhibits Mtb, MIC: 0.49 μM. Useful for tuberculosis research.Formule :C24H24FN7O6Couleur et forme :SolidMasse moléculaire :525.49CBP/p300-IN-2
CAS :CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc).Formule :C27H29F2N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.56Cimpuciclib tosylate
CAS :Cimpuciclib tosylate, a selective CDK4 inhibitor (IC50: 0.49 nM), exhibits anti-tumor activity.Formule :C37H43FN8O4SCouleur et forme :SolidMasse moléculaire :714.85
