Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(114 produits)
- CDK(545 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(47 produits)
- Dynamine(27 produits)
- Ferroptose(226 produits)
- HSP(179 produits)
- Intégrine(249 produits)
- Kinésine(87 produits)
- LIM Kinase(20 produits)
- Microtubules associés(274 produits)
- PKC(124 produits)
- PLK(25 produits)
- ROCK(62 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3859 produits trouvés pour "Cycle cellulaire/point de contrôle"
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Uridine-5-(N-Fmoc-methylamino)-acetyl (9-fluorenylmethyl) ester
Uridine derivative with antitumor properties blocks DNA synthesis and induces apoptosis in lymphoid cancers.Formule :C41H37N3O10Couleur et forme :SolidMasse moléculaire :731.75RAD51-IN-3
CAS :RAD51-IN-3 is a Rad51 inhibitor.Formule :C31H41N5O5S2Couleur et forme :SolidMasse moléculaire :627.82GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Formule :C21H22N6O2Couleur et forme :SolidMasse moléculaire :390.44Antibacterial agent 271
Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.Couleur et forme :Odour SolidFarletuzumab
CAS :Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :145.36 kDa5'-O-DMT-ibu-dC
CAS :5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.Formule :C34H37N3O7Couleur et forme :SolidMasse moléculaire :599.67CDK9 ligand 3
CAS :CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.Formule :C18H18BrCl2N5O3Couleur et forme :SolidMasse moléculaire :503.177JAMM protein inhibitor 2
CAS :JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formule :C21H26N2O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :338.44CDK1-IN-2
CAS :CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM.Formule :C17H11ClN2ODegré de pureté :98.53%Couleur et forme :SoildMasse moléculaire :294.73Ref: TM-T64373
1mg50,00€5mg107,00€10mg170,00€25mg354,00€50mg567,00€100mg810,00€500mg1.644,00€1mL*10mM (DMSO)103,00€KWR137
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.Formule :C33H31ClF3N9O4Couleur et forme :SolidMasse moléculaire :710.105PROTAC CDK9 degrader-8
PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].Formule :C44H52Cl2N10O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :903.85CTP Synthetase-IN-1 Ammonium salt
CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infectionsFormule :C20H22F3N7O3S2Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :529.56CDK7-IN-7
CAS :CDK7-IN-7: Selective CDK7 inhibitor, IC50 < 50 nM (Patent CN112661745A).Formule :C20H20BrF3N6O2Couleur et forme :SolidMasse moléculaire :513.319Cytidine 5'-diphosphate trisodium salt
CAS :CDP, a trisodium salt, helps synthesize DNA/RNA by aiding phosphoryl transfer from ATP to CMP via UMPK.Formule :C9H15N3Na3O11P2Degré de pureté :99.55%Couleur et forme :White Crystalline PowderMasse moléculaire :472.15SMS 121
CAS :SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Formule :C20H21NO5Degré de pureté :98.29%Couleur et forme :SoildMasse moléculaire :355.38DSPE-PEG2000-cRGD
DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.Couleur et forme :Odour Solid2-Amino-3',5'-di-O-acetyl-N6,N6-dimethyl-2'-O-methyladenosine
2-Amino-3’,5’-di-O-acetyl-N6,N6-dimethyl-2’-O-methyladenosine is an adenosine analog.Formule :C17H24N6O6Couleur et forme :SolidMasse moléculaire :408.41PLK1-IN-2
CAS :PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.Formule :C24H27FN8OSCouleur et forme :SolidMasse moléculaire :494.592'-β-C-Methyl-3-deazauri dine
CAS :2’-β-C-Methyl-3-deazauridine, a purine nucleoside analogue, exhibits wide antitumor activity specifically against indolent lymphoid malignancies.Formule :C11H15NO6Couleur et forme :SolidMasse moléculaire :257.24ChlaDUB1-IN-2
ChlaDUB1-IN-2 (Compound 27a) serves as an inhibitor of the deubiquitinating enzyme ChlaDUB1 from Chlamydia trachomatis, with an IC50 of 0.97 μM. It also inhibits the formation of Chlamydia trachomatis inclusions, exhibiting an IIC50 of 25.6 μg/mL.Formule :C22H16N6O2Couleur et forme :SolidMasse moléculaire :396.4Retreversine
CAS :Retreversine serves as an inactive control counterpart to Reversine, a pioneering class of ATP-competitive Aurora kinase inhibitor.Formule :C21H27N7OCouleur et forme :SolidMasse moléculaire :393.49Orbofiban acetate
CAS :Orbofiban Acetate is a compound that serves as an antagonist to the platelet GPIIb/IIIa receptor, effectively inhibiting platelet aggregation when administeredFormule :C19H27N5O6Couleur et forme :SolidMasse moléculaire :421.45AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.61MYC-IN-2
CAS :MYC-IN-2 is a protein-protein inhibitor targeting the MYC protein, designed for use in cancer research.Formule :C25H17N3O2SCouleur et forme :SolidMasse moléculaire :423.49DNA Gyrase-IN-12
DNA Gyrase-IN-12 (Compound 6d) is an inhibitor of DNA gyrase. It exhibits antibacterial activity with MIC values ranging from 0.031 to 0.0625 μg/mL against Vancomycin-Intermediate Staphylococcus aureus (VISA) and Enterococcus faecium.Couleur et forme :Odour Solid2-Diethoxymethyl adenosine
2-Diethoxymethyl adenosine, an adenosine analog, dilates smooth muscle, inhibits cancer, and leads to drugs like Acadesine.Formule :C23H31N5O10Couleur et forme :SolidMasse moléculaire :537.52RNA splicing modulator 2
CAS :RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .Formule :C20H21N5OSCouleur et forme :SolidMasse moléculaire :379.48m7GpppGpG
CAS :m7GpppGpG, a trinucleotide cap, protects mRNA from 5′ exonucleases & aids splicing and translation.Formule :C31H41N15O25P4Couleur et forme :SolidMasse moléculaire :1147.641-(β-D-Xylofuranosyl)-N6-(m-trifluoromethylbenzyl)adenine
1-(β-D-Xylofuranosyl)-N6-(m-trifluoromethylbenzyl)adenine is an adenosine analog.Formule :C18H18F3N5O4Couleur et forme :SolidMasse moléculaire :425.36GRGDSP
CAS :Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide.Formule :C22H37N9O10Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :587.58Echistatin
CAS :Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Formule :C217H341N71O74S9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5417.1N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS :N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].
Formule :C21H35N12O17P3Couleur et forme :SolidMasse moléculaire :820.49GS-443902 trisodium
CAS :GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.Formule :C12H16N5O13P3·xNaCouleur et forme :SolidN4-Benzoyl-2'-deoxy-2'-fluoro-β-D-arabinocytidine
N4-Benzoyl-2’-deoxy-2’-fluoro-β-D-arabinocytidine, a purine nucleoside analog, exhibits widespread antitumor activity, particularly against indolent lymphoidFormule :C16H16FN3O5Couleur et forme :SolidMasse moléculaire :349.31BSJ-03-204
CAS :BSJ-03-204 is a selective Cdk4/6 degrader.Formule :C43H48N10O8Couleur et forme :SolidMasse moléculaire :832.9N1-Methyl-2'-O-(2-methoxyethyl) guanosine
N1-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Formule :C14H21N5O6Couleur et forme :SolidMasse moléculaire :355.35PLK1-IN-12
PLK1-IN-12 is a highly selective, orally active PLK1 inhibitor with an IC50 of 20 nM. It demonstrates greater selectivity for PLK1 over PLK2 (IC50: >10000 nM) and PLK3 (IC50: 3953 nM). PLK1-IN-12 exhibits anticancer efficacy across a wide range of cell lines and is applicable to anti-leukemia research.Couleur et forme :Odour Solid2-(3-Methyln-propylidene hydrazino) adenosine
2-(3-Methyln-propylidene hydrazino) adenosine: a purine analog with antitumor properties, inhibits DNA synthesis, induces apoptosis.Formule :C15H23N7O4Couleur et forme :SolidMasse moléculaire :365.39UnyLinker 12 TEA
UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.Formule :C39H35NO10C6H15NCouleur et forme :SolidMasse moléculaire :778.34655TFMU-ADPr triethylamine
TFMU-ADPr triethylamine is a substrate for PARG activity measurement, releasing a fluorophore to indicate PAR hydrolase activity.Formule :C25H26F3N5O16P2·5C6H15NCouleur et forme :SolidMasse moléculaire :1024.42YKL-5-124 TFA
CAS :YKL-5-124 TFA is a potent CDK7 inhibitor (IC50: 53.5 nM), more than 100x selective over CDK9/2, not active on CDK12/13, and disrupts the cell cycle.Formule :C30H34F3N7O5Couleur et forme :SolidMasse moléculaire :629.63Viquidacin
CAS :NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.Formule :C25H29FN2O4S2Couleur et forme :SolidMasse moléculaire :504.64IRE1-IN-2
IRE1-IN-2 (compound G15) functions as a potent inhibitor of IRE1. It effectively suppresses lipid accumulation induced by FFA, exhibiting an IC50 value of 2.06 μM.Formule :C16H20O6Couleur et forme :SolidMasse moléculaire :308.12599DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Couleur et forme :Odour Solidm7Gpppm6AmpG
CAS :m7Gpppm6AmpG, a trinucleotide mRNA 5’ cap analog, facilitates RNA synthesis in vitro [1].Formule :C33H45N15O24P4Couleur et forme :SolidMasse moléculaire :1159.692-(P-Cyanophenyl methylidene hydrazino) adenosine
2-(P-Cyanophenyl methylidene hydrazino) adenosine: a purine analog with antitumor effects via DNA synthesis inhibition and apoptosis.Formule :C18H18N8O4Couleur et forme :SolidMasse moléculaire :410.39PKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Formule :C24H26FN5O2Couleur et forme :SolidMasse moléculaire :435.49PDI-IN-4
PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.Formule :C17H12F3NO2Couleur et forme :SolidMasse moléculaire :319.27816,16-dimethyl Prostaglandin A1
CAS :16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.Formule :C22H36O4Couleur et forme :SolidMasse moléculaire :364.526TC113
TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.Formule :C37H50F2N12O13Couleur et forme :SolidMasse moléculaire :908.86DSPE-PEG3000-iRGD
DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.Couleur et forme :Odour SolidAntibacterial agent 144
Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin.Formule :C26H23N7O3Couleur et forme :SolidMasse moléculaire :481.51(+)-Glaucarubinone
(+)-Glaucarubinone is a natural product that can be used as a reference standard.Formule :C25H34O10Couleur et forme :SolidMasse moléculaire :494.537DMT-5Me-dC(Bz)-CE Phosphoramidite
CAS :DMT-5Me-dC(Bz)-CE Phosphoramidite aids in crafting LNAs for better fluorescent probes.Formule :C47H54N5O8PCouleur et forme :SolidMasse moléculaire :847.935'-O-DMT-Bz-rC
CAS :5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.Formule :C37H35N3O8Couleur et forme :SolidMasse moléculaire :649.69α-Methyl-DL-aspartic acid
CAS :α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.Formule :C5H9NO4Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :147.13NUAK1-IN-1
NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formule :C25H30N6OCouleur et forme :SolidMasse moléculaire :430.545α2β1 Integrin Ligand Peptide TFA
α2β1 Integrin Ligand Peptide TFA interacts with the integrin receptor on the cell membrane and enters the cell to mediate extracellular signaling.It is aFormule :C16H23F3N4O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :504.37N6-Methyl-2'-β-C-ethynyl adenosine
N6-Methyl-2’-beta-C-ethynyl adenosine is a purine nucleoside analog.Formule :C13H15N5O4Couleur et forme :SolidMasse moléculaire :305.29PROTAC CDK9 degrader-11
CAS :PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Formule :C39H48Cl2N10O5Couleur et forme :SolidMasse moléculaire :807.768[pThr3]-CDK5 Substrate
CAS :[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate.[pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM[1].Formule :C53H100N15O15PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1218.43Nuclease S1
CAS :Nuclease S1 breaks down ssDNA and RNA, trims protruding ends of dsDNA.Couleur et forme :Solid5'-O-DMT-rU
CAS :5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.Formule :C30H30N2O8Couleur et forme :SolidMasse moléculaire :546.57Isocytosine
CAS :Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C4H5N3OCouleur et forme :White To Off-White SolidMasse moléculaire :111.1Clofarabine-5'-diphosphate trisodium
Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formule :C10H10ClFN5Na3O9P2Couleur et forme :SolidMasse moléculaire :529.58Cyclothialidine
CAS :Cyclothialidine is an inhibitor of DNA gyrase.Formule :C26H35N5O12SCouleur et forme :SolidMasse moléculaire :641.655'-DMTr-3'dA(Bz)-methylphosphonami dite
5’-DMTr-3’dA(Bz)-methylphosphonamidite, a purine nucleoside analog, exhibits wide-ranging antitumor activity, specifically targeting indolent lymphoidFormule :C45H51N6O6PCouleur et forme :SolidMasse moléculaire :802.9NUAK1-IN-2
NUAK1-IN-2 (Compound 24) is an inhibitor of NUAK1 with an IC50 of 3.162 nM, as well as an inhibitor of CDK2/4/6. It is applicable in research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formule :C24H30N6OCouleur et forme :SolidMasse moléculaire :418.535N4-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine
N4-Benzoyl-3'-O-DMT cytidine analog inhibits DNA methyltransferases like Zebularine.Formule :C41H43N3O9Couleur et forme :SolidMasse moléculaire :721.79Pseudouridimycin
CAS :Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.Formule :C17H26N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.44Erythromycin thiocyanate
CAS :Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.Formule :C38H68N2O13SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :793.026-Methoxypurine-9-β-D-5'(R)-C-methylriboside
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside, an analog of hypoxanthine—a purine base predominantly found in muscle tissue and a metabolite generated whenFormule :C12H16N4O5Couleur et forme :SolidMasse moléculaire :296.28MS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Couleur et forme :Odour Solid3'-β-C-Ethynyl-4-deoxyuridine
3’-Beta-C-Ethynyl-4-deoxyuridine is a purine nucleoside analog.Formule :C11H12N2O5Couleur et forme :SolidMasse moléculaire :252.225'-O-DMT-N4-Bz-2'-F-dC
CAS :5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.Formule :C37H34FN3O7Couleur et forme :SolidMasse moléculaire :651.68CDK2/PIM1-IN-1
CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.
Couleur et forme :Odour SolidRA-V
RA-V is a natural product that can be used as a reference standard.Formule :C160H202N24O41Couleur et forme :SolidMasse moléculaire :3117.5LSN3106729 hydrochloride
CAS :LSN3106729 hydrochloride, an Abemaciclib metabolite, is a CDK-inhibiting antitumor PROTAC CDK4/6 degrader.Formule :C25H29ClF2N8OCouleur et forme :SoildMasse moléculaire :531.00N3-[(Pyrid-4-yl)methyl]uridine
N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, may have antiepileptic properties and aid in researching anticonvulsants and anxiolytics.Formule :C15H17N3O6Couleur et forme :SolidMasse moléculaire :335.31wrwyar-NH2 TFA
wrwyar-NH2 (TFA) serves as the control peptide for wrwycr-NH2.Couleur et forme :Odour SolidN4-(n-Palmitoyl)-4'-azido-2'-deoxy-2'-fluoro-arabinocytidine
N4-(n-Palmitoyl)-4’-azido-2’-deoxy-2’-fluoro-arabinocytidine is a cytidine nucleoside analog.Formule :C25H41FN6O5Couleur et forme :SolidMasse moléculaire :524.63WAY-322243
CAS :WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.Formule :C18H18N2O2SDegré de pureté :99.88%Couleur et forme :SoildMasse moléculaire :326.41HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt
CAS :HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt inhibits pre-miR-21 RNA, potential for cancer research.Formule :C57H62N8O10SCouleur et forme :SolidMasse moléculaire :1051.21PROTAC MTP3 degrade-1
PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.Formule :C44H38N6O8Couleur et forme :SolidMasse moléculaire :778.275115'-O-DMT-2'-O-TBDMS-Bz-rC
CAS :5'-O-DMT-2'-O-TBDMS-Bz-rC, a modified nucleoside, is utilized in the synthesis of DNA or RNA.Formule :C43H49N3O8SiCouleur et forme :SolidMasse moléculaire :763.9523-Oxa-OSW-1
CAS :23-Oxa-OSW-1 (SBF-1), a derivative of OSW-1, serves as a potent inhibitor of the osterol-binding protein (OSBP) with demonstrated antitumor activity [1] [2].Formule :C54H82O16Couleur et forme :SolidMasse moléculaire :987.22Guanosine triphosphate
CAS :Guanosine triphosphate (GTP), a native nucleotide, and its derivatives may serve as specific inhibitors against COVID-19 [1].Formule :C10H16N5O14P3Couleur et forme :SolidMasse moléculaire :523.18DHFR-IN-9
DHFR-IN-9 (compound 8A), a dihydrofolate reductase (DHFR) inhibitor, impedes purine and thymidylate biosynthesis, pivotal in cell proliferation and growth.Formule :C19H16N6SCouleur et forme :SolidMasse moléculaire :360.44Evybactin
Evybactin: a selective DNA gyrase inhibitor for Mycobacterium tuberculosis (MIC 0.25 µg/mL), first of its kind.Formule :C64H89N21O21Couleur et forme :SolidMasse moléculaire :1488.52S3 Fragment
S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinaseFormule :C73H120N18O24S2Couleur et forme :SolidMasse moléculaire :1697.97WRN inhibitor 17
CAS :WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.Formule :C33H34F4N4O6SCouleur et forme :SolidMasse moléculaire :690.71Carboxy pyridostatin trifluoroacetate salt
Carboxy pyridostatin trifluoroacetate salt exhibits higher molecular specificity for RNA over DNA G4s.Formule :C37H35F3N10O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :820.73Haspin-IN-4
Haspin-IN-4 (Compound 60) is a selective Haspin inhibitor with an IC50 of 0.01 nM and exhibits anticancer activity, making it suitable for cancer research.Couleur et forme :Odour SolidN2-Acetylguanine
CAS :Compound 19962-37-9, with CAS No. 19962-37-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 19962-37-9 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formule :C7H7N5O2Degré de pureté :99.90%Couleur et forme :White SolidMasse moléculaire :193.166CW-2
CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).Formule :C43H42Cl2FN11O10PtCouleur et forme :SolidMasse moléculaire :1156.21251CDK2/4-IN-1
CDK2/4-IN-1 (compound B-4a) serves as both a CDK2/4 inhibitor and a microtubule polymerization inhibitor, making it useful in cancer research.Couleur et forme :Odour SolidClofarabine-5'-triphosphate
CAS :Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.Formule :C10H14ClFN5O12P3Couleur et forme :SolidMasse moléculaire :543.62PROTAC CDK9 degrader-2
CAS :PROTAC CDK9 degrader-2, potent, selective, IC50 17 μM in MCF-7, wogonin-derived, targets CRBN.Formule :C39H36N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :748.74Filanesib TFA
CAS :Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.
Formule :C22H23F5N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.5Censavudine
CAS :Censavudine (OBP-601) is an HIV-1/2 treatment and prevention drug, a reverse transcriptase inhibitor with EC50 of 30-890 nM.Formule :C12H12N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.23
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