
Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(111 produits)
- CDK(526 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(46 produits)
- DYRK(49 produits)
- Dynamine(26 produits)
- Ferroptose(225 produits)
- HSP(179 produits)
- Intégrine(256 produits)
- Kinésine(87 produits)
- LIM Kinase(19 produits)
- Microtubules associés(283 produits)
- PKC(111 produits)
- PLK(25 produits)
- ROCK(66 produits)
- Rho(2 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3756 produits trouvés pour "Cycle cellulaire/point de contrôle"
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2-Amino-2'-fluoro-2'-deoxyadenosine
CAS :<p>2-Amino-2'-fluoro-2'-deoxyadenosine is a component of nucleic acids.</p>Formule :C10H13FN6O3Couleur et forme :SolidMasse moléculaire :284.25ROCK/HDAC-IN-1
ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.Formule :C19H22N4O3SCouleur et forme :SolidMasse moléculaire :386.47Tizolemide
CAS :Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.Formule :C11H14ClN3O3S2Couleur et forme :SolidMasse moléculaire :335.832'-F-AMP
CAS :2'-F-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.Formule :C10H13FN5O6PMasse moléculaire :349.21Terpendole E
CAS :Terpendole E is an atypical L5 site inhibitor.Formule :C28H39NO3Couleur et forme :SolidMasse moléculaire :437.61Methyl 3-oxodecanoate
CAS :<p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>Formule :C11H20O3Couleur et forme :SolidMasse moléculaire :200.2753-deoxy-3-fluoro-β-D-Ribofuranose 25
CAS :Compound 25, β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate), exhibits strong activity in inhibiting the growth of tumor cells [1].Formule :C17H19FO7Masse moléculaire :354.33RECTAS-2.0
CAS :<p>RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G>A mutation, intended for research in Fabry disease.</p>Formule :C18H17ClN4O4Couleur et forme :SolidMasse moléculaire :388.8053-IN-PP1
CAS :3-IN-PP1: PKD inhibitor (IC50: 94-108 nM for PKD1/2/3), broad anticancer agent for research.Formule :C17H18N6Couleur et forme :SolidMasse moléculaire :306.36WEE1-IN-10
CAS :WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.Formule :C28H30Cl2N8ODegré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :565.5Z4P
CAS :Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB), inhibited glioblastoma growth and recurrence in combination with Temozolomide.Formule :C19H24N2O2Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :312.412′-F-UDP
CAS :2′-F-UDP is a nucleotide analogue used in the synthesis of oligonucleotides.Formule :C9H13FN2O11P2Couleur et forme :SolidMasse moléculaire :406.15Bersiporocin
CAS :<p>Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.</p>Formule :C15H19Cl2N3ODegré de pureté :98.88% - 99.79%Couleur et forme :SolidMasse moléculaire :328.24DDO-6079
CAS :DDO-6079 is an efficient CDC37 inhibitor. It suppresses the HSP90-CDC37 and CDC37-CDK4/6 chaperone complexes by binding to an allosteric site on CDC37. Additionally, DDO-6079 reduces the thermal stability of CDK6.Formule :C18H13ClN2O3Couleur et forme :SolidMasse moléculaire :340.76CYP2C19-IN-1
CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.Formule :C26H26N2O6SCouleur et forme :SolidMasse moléculaire :494.562-CEES
CAS :2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.Formule :C4H9ClSCouleur et forme :SolidMasse moléculaire :124.632SR121566A
CAS :SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).Formule :C20H25N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.51Antiangiogenic agent 2
<p>Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.</p>Formule :C26H26FN3O4Couleur et forme :SolidMasse moléculaire :463.5Aurora B inhibitor 1
CAS :Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.Formule :C25H26ClF2N7O2Degré de pureté :98.37%Couleur et forme :SolidMasse moléculaire :529.97CDK12/13 ligand 1
CAS :ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.Formule :C26H26BrN5OCouleur et forme :SolidMasse moléculaire :504.42Polθ-IN-6
CAS :Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.Formule :C25H23N3O3SCouleur et forme :SolidMasse moléculaire :445.53WRN inhibitor 12
CAS :WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Formule :C33H33ClF3N9O5Couleur et forme :SolidMasse moléculaire :728.12Lobucavir
CAS :<p>Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).</p>Formule :C11H15N5O3Couleur et forme :SolidMasse moléculaire :265.27DNA Gyrase-IN-13
CAS :<p>DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.</p>Formule :C15H21N3O3SCouleur et forme :SolidMasse moléculaire :323.41PCNA-IN-1
CAS :PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.Formule :C19H18I3NO3Couleur et forme :SolidMasse moléculaire :689.0652′-O-MOE-AMP
CAS :2′-O-MOE-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.Formule :C13H20N5O8PCouleur et forme :SolidMasse moléculaire :405.30CDK2-IN-8
CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.Formule :C22H25N5O3Couleur et forme :SolidMasse moléculaire :407.47WRN inhibitor 11
CAS :WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.Formule :C34H35ClF3N9O5Couleur et forme :SolidMasse moléculaire :742.15GFB-12811
CAS :GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.Formule :C22H23F4N5ODegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :449.44CTPS1-IN-1
CAS :CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Formule :C21H22N6O4S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :486.57VCPIP1-IN-1
CAS :VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Formule :C13H15ClN2O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :266.72Elacytarabine
CAS :Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.Formule :C27H45N3O6Degré de pureté :97.69%Couleur et forme :SolidMasse moléculaire :507.66HRO761
CAS :HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Formule :C31H31ClF3N9O5Degré de pureté :98.74% - 99.62%Couleur et forme :SolidMasse moléculaire :702.08LY3143921 hydrate
CAS :LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Formule :C16H14FN5O2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :327.31SR 11302
CAS :SR 11302 is an inhibitor of activator protein-1 (AP-1).Formule :C26H32O2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :376.53INCB086550
CAS :INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Formule :C41H39N7O4Degré de pureté :98.49%Couleur et forme :SolidMasse moléculaire :693.79Troxacitabine
CAS :Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.Formule :C8H11N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :213.19Bicyclomycin benzoate
CAS :Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.Formule :C19H22N2O8Couleur et forme :SolidMasse moléculaire :406.392'-Deoxy-2'-fluoro-5-iodouridine
CAS :2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.Formule :C9H10FIN2O5Couleur et forme :SolidMasse moléculaire :372.09Tanuxiciclib
CAS :Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.Formule :C15H13FN6OCouleur et forme :SolidMasse moléculaire :312.308Ethynylcytidine
CAS :Ethynylcytidine is a nucleoside antimetabolite.Formule :C11H13N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.24GSK-3/CDK5/CDK2-IN-1
CAS :GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].Formule :C21H22N4O2Couleur et forme :SolidMasse moléculaire :362.4333BrB-PP1
CAS :3BrB-PP1 is an ATP-competitive analog that exhibits specific inhibitory activity towards protein kinase, particularly effective against protein kinases with mutations in the ATP-binding pocket, such as the Thr97 mutation within Sty1's ATP-binding pocket.Formule :C16H18BrN5Couleur et forme :SolidMasse moléculaire :360.259N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS :N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.Formule :C38H35N5O6Couleur et forme :SolidMasse moléculaire :657.727Formycin A
CAS :Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.Formule :C10H13N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.245'-DMT-3'-TBDMS-ibu-rG
CAS :5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.Formule :C41H51N5O8SiCouleur et forme :SolidMasse moléculaire :769.965'-O-DMT-N6-ibu-dA
CAS :5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Formule :C35H37N5O6Couleur et forme :SolidMasse moléculaire :623.71PLK1-IN-6
<p>PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.</p>Formule :C28H37N9O3Couleur et forme :SolidMasse moléculaire :547.65NSC639828
CAS :NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Formule :C18H13BrClN5O3Couleur et forme :SolidMasse moléculaire :462.69PF-03814735
CAS :PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Formule :C23H25F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.48MitoE10
CAS :MitoE10 is an effective mitochondrial targeting antioxidant.Formule :C42H55O5PSCouleur et forme :SolidMasse moléculaire :702.926-Amino-5-nitropyridin-2-one
CAS :6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.Formule :C5H5N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :155.11Ribocil-C
CAS :Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.Formule :C21H21N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.5Tibremciclib
CAS :<p>Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].</p>Formule :C28H32F2N8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.6PHI-101
CAS :<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Formule :C19H19FN4O2SDegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :386.44YK-2168
CAS :<p>YK-2168 is a differentiated selective inhibitor of CDK9.</p>Formule :C16H18ClN5Couleur et forme :SolidMasse moléculaire :315.80

