Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(112 produits)
- CDK(527 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(46 produits)
- DYRK(49 produits)
- Dynamine(26 produits)
- Ferroptose(226 produits)
- HSP(179 produits)
- Intégrine(259 produits)
- Kinésine(87 produits)
- LIM Kinase(19 produits)
- Microtubules associés(284 produits)
- PKC(111 produits)
- PLK(25 produits)
- ROCK(66 produits)
- Rho(2 produits)
- Wee1(14 produits)
- c-Myc(77 produits)
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3764 produits trouvés pour "Cycle cellulaire/point de contrôle"
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Cdc7-IN-11
CAS :Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.Formule :C20H22F2N4O2SCouleur et forme :SolidMasse moléculaire :420.48TH9619
CAS :TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). Anticancer.Formule :C17H18FN7O7Degré de pureté :98.07%Masse moléculaire :451.37PKMYT1-IN-2
CAS :PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].Formule :C22H19N5O2Couleur et forme :SolidMasse moléculaire :385.42Dyrk1A-IN-1
Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.Formule :C23H20N4O3SCouleur et forme :SolidMasse moléculaire :432.49DB18
CAS :DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].Formule :C24H18ClN7O3Couleur et forme :SolidMasse moléculaire :487.9MTH1 activator-1
CAS :MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.Formule :C29H23F3N4O2Couleur et forme :SolidMasse moléculaire :516.514WRN inhibitor 7
CAS :<p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>Formule :C27H23N3O6Couleur et forme :SolidMasse moléculaire :485.49PAIR2
CAS :PAIR2 is a selective IRE1α RNase partial antagonist, blocking its ATP site and preventing KIRA from hindering XBP1 splicing.Formule :C27H26F4N6O3SCouleur et forme :SolidMasse moléculaire :590.59CTX-712
CAS :CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.Formule :C19H17FN8O2Couleur et forme :SolidMasse moléculaire :408.39CDK4/6-IN-13
CAS :Compounds 10B and 10C: potent cdk4/6 inhibitors with low nM activity, great antiproliferative effects, excellent metabolism, and good pharmacokinetics.Formule :C25H29N7OCouleur et forme :SolidMasse moléculaire :443.54Aurora/LIM kinase-IN-1
Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.Formule :C16H20N6OCouleur et forme :SolidMasse moléculaire :312.37Des-ethyl-carafiban
CAS :Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.Formule :C22H23N5O5Couleur et forme :SolidMasse moléculaire :437.448ATIC-IN-2
CAS :<p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>Formule :C4H4N4O3SCouleur et forme :SolidMasse moléculaire :188.165CDK2 degrader 6
CAS :CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.Formule :C23H22F5N5O3Couleur et forme :SolidMasse moléculaire :511.44DNA Gyrase-IN-1
DNA Gyrase-IN-1: potent, selective promoter inhibitor. IC50: 2.6 μM, inhibits Mtb, MIC: 0.49 μM. Useful for tuberculosis research.Formule :C24H24FN7O6Couleur et forme :SolidMasse moléculaire :525.49OPN expression inhibitor 1
CAS :OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.Formule :C25H33N3O5Degré de pureté :99.78%Couleur et forme :SolidMasse moléculaire :455.55Anticancer agent 30
<p>Anticancer agent 30 (6f-Z), a 3-arylidene-2-oxindole, selectively inhibits CDK2, showing potent anticancer potential.</p>Formule :C22H15ClFNOCouleur et forme :SolidMasse moléculaire :363.81L-Tyrosyl-L-glutamic acid
CAS :L-Tyrosyl-L-glutamic acid acts as an inhibitor of the amino acid permease GAP1.Formule :C14H18N2O6Couleur et forme :SolidMasse moléculaire :310.3CDK7-IN-18
CAS :CDK7-IN-18: potent, pyrimidine-based CDK7 inhibitor with cancer research potential.Formule :C22H24F3N7OSDegré de pureté :99.28%Couleur et forme :SolidMasse moléculaire :491.53PNR-3-80
CAS :PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 μM, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.Formule :C24H14ClN3O3SCouleur et forme :SolidMasse moléculaire :459.90Fradafiban
CAS :Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.Formule :C20H21N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.40LNA-CTP
CAS :<p>LNA-CTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>Formule :C10H16N3O14P3Couleur et forme :SolidMasse moléculaire :495.17PKMYT1-IN-7
CAS :PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM for PKMYT1 and 0.06 μM for pCDK1. It inhibits the phosphorylation of CDK1 at T14 and Y15 sites and exhibits anticancer activity both in vitro and in vivo.Formule :C17H18FN5O3Couleur et forme :SolidMasse moléculaire :359.355FR-145715
CAS :FR-145715 is a histamine H2 receptor antagonist characterized by its specific anti-Helicobacter pylori activity. This compound is utilized in the study of gastric lesions.Formule :C16H21N5O2SCouleur et forme :SolidMasse moléculaire :347.44INX-315
CAS :INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.Formule :C19H21N7O3SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :427.48Cdc7-IN-8
CAS :Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)Formule :C19H21N5O2Couleur et forme :SolidMasse moléculaire :351.40Antimalarial agent 44
Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.Formule :C37H37N5O7Couleur et forme :SolidMasse moléculaire :663.722'-F-CDP
CAS :2'-F-CDP is a nucleotide analog that can be utilized in the synthesis of oligonucleotides.Formule :C9H14FN3O10P2Couleur et forme :SolidMasse moléculaire :405.17EFdA-TP tetrasodium
CAS :EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.Formule :C12H11FN5Na4O12P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :621.12CDK7-IN-26
CAS :CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.Formule :C22H22FN6OPSMasse moléculaire :468.49Dmf-dg
CAS :Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a nucleoside of deoxyguanosine (dG) with a dimethylaminomethylene (DMF) base protection, employed in the synthesis of oligonucleotides.Formule :C13H18N6O4Couleur et forme :SolidMasse moléculaire :322.32MtTMPK-IN-5
MtTMPK-IN-5 inhibits Mtb TMPK with IC50 of 34 μM and fights tuberculosis with MIC of 12.5 μM, aiding TB research.Formule :C21H23N5O2Couleur et forme :SolidMasse moléculaire :377.44Dyrk1A-IN-4
CAS :Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.Formule :C14H13F3N6Couleur et forme :SolidMasse moléculaire :322.29YKL-1-116
CAS :YKL-1-116 is an effective, selective, and covalent CDK7 inhibitor.Formule :C34H38N8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :606.72RAD51-IN-5
CAS :RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)Formule :C26H38N4O5S2Couleur et forme :SolidMasse moléculaire :550.73ROCK/HDAC-IN-1
ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.Formule :C19H22N4O3SCouleur et forme :SolidMasse moléculaire :386.47CTPS1-IN-1
CAS :CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Formule :C21H22N6O4S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :486.57Elacytarabine
CAS :Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.Formule :C27H45N3O6Degré de pureté :97.69%Couleur et forme :SolidMasse moléculaire :507.66GFB-12811
CAS :GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.Formule :C22H23F4N5ODegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :449.44HRO761
CAS :HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Formule :C31H31ClF3N9O5Degré de pureté :98.74% - 99.62%Couleur et forme :SolidMasse moléculaire :702.08VCPIP1-IN-1
CAS :VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Formule :C13H15ClN2O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :266.72LY3143921 hydrate
CAS :LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Formule :C16H14FN5O2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :327.31SR 11302
CAS :SR 11302 is an inhibitor of activator protein-1 (AP-1).Formule :C26H32O2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :376.53INCB086550
CAS :INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Formule :C41H39N7O4Degré de pureté :98.49%Couleur et forme :SolidMasse moléculaire :693.79Bicyclomycin benzoate
CAS :Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.Formule :C19H22N2O8Couleur et forme :SolidMasse moléculaire :406.39Troxacitabine
CAS :Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.Formule :C8H11N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :213.19GSK-3/CDK5/CDK2-IN-1
CAS :GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].Formule :C21H22N4O2Couleur et forme :SolidMasse moléculaire :362.4332'-Deoxy-2'-fluoro-5-iodouridine
CAS :2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.Formule :C9H10FIN2O5Couleur et forme :SolidMasse moléculaire :372.095'-O-DMT-N6-ibu-dA
CAS :5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Formule :C35H37N5O6Couleur et forme :SolidMasse moléculaire :623.713BrB-PP1
CAS :3BrB-PP1 is an ATP-competitive analog that exhibits specific inhibitory activity towards protein kinase, particularly effective against protein kinases with mutations in the ATP-binding pocket, such as the Thr97 mutation within Sty1's ATP-binding pocket.Formule :C16H18BrN5Couleur et forme :SolidMasse moléculaire :360.259NSC639828
CAS :NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Formule :C18H13BrClN5O3Couleur et forme :SolidMasse moléculaire :462.69Ethynylcytidine
CAS :Ethynylcytidine is a nucleoside antimetabolite.Formule :C11H13N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.24Formycin A
CAS :Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.Formule :C10H13N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.24Tanuxiciclib
CAS :Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.Formule :C15H13FN6OCouleur et forme :SolidMasse moléculaire :312.308N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS :N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.Formule :C38H35N5O6Couleur et forme :SolidMasse moléculaire :657.727PLK1-IN-6
<p>PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.</p>Formule :C28H37N9O3Couleur et forme :SolidMasse moléculaire :547.655'-DMT-3'-TBDMS-ibu-rG
CAS :5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.Formule :C41H51N5O8SiCouleur et forme :SolidMasse moléculaire :769.96PF-03814735
CAS :PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Formule :C23H25F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.486-Amino-5-nitropyridin-2-one
CAS :6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.Formule :C5H5N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :155.11MitoE10
CAS :MitoE10 is an effective mitochondrial targeting antioxidant.Formule :C42H55O5PSCouleur et forme :SolidMasse moléculaire :702.92Ribocil-C
CAS :Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.Formule :C21H21N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.5Tibremciclib
CAS :<p>Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].</p>Formule :C28H32F2N8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.6PHI-101
CAS :<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Formule :C19H19FN4O2SDegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :386.44YK-2168
CAS :<p>YK-2168 is a differentiated selective inhibitor of CDK9.</p>Formule :C16H18ClN5Couleur et forme :SolidMasse moléculaire :315.80
