Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(95 produits)
- CDK(502 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(226 produits)
- Kinésine(68 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(69 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(68 produits)
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3493 produits trouvés pour "Cycle cellulaire/point de contrôle"
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DYRKs-IN-1 hydrochloride
CAS :DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) & DYRK1B (8 nM IC50) with antitumor properties.Formule :C30H31Cl2N7O4Couleur et forme :SolidMasse moléculaire :624.52CLK1/4-IN-1
<p>CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.</p>Formule :C18H14ClNO4SCouleur et forme :SolidMasse moléculaire :375.83MtTMPK-IN-5
<p>MtTMPK-IN-5 inhibits Mtb TMPK with IC50 of 34 μM and fights tuberculosis with MIC of 12.5 μM, aiding TB research.</p>Formule :C21H23N5O2Couleur et forme :SolidMasse moléculaire :377.44PPA-037
CAS :<p>PPA-037 is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). It induces the degradation of Cyclin K, thereby enhancing antiproliferative effects on tumor cells. PPA-037 holds potential for use in cancer research.</p>Formule :C25H27N7Couleur et forme :SolidMasse moléculaire :425.53RAD51-IN-5
CAS :<p>RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)</p>Formule :C26H38N4O5S2Couleur et forme :SolidMasse moléculaire :550.73DNA Gyrase-IN-16
CAS :<p>DNA Gyrase-IN-16 (Compound 9) is an inhibitor of DNA gyrase, with an IC50 of 1.609 μM. It exhibits antibacterial properties, effectively inhibiting S. aureus and MRSA, with a MIC of 3.125 μM for both.</p>Formule :C17H15N3O3Couleur et forme :SolidMasse moléculaire :309.319MtTMPK-IN-1
<p>MtTMPK-IN-1 inhibits MtTMPK with 2.5 μM IC50, shows moderate anti-tuberculosis activity, and is low in cytotoxicity.</p>Formule :C22H24N4O3Couleur et forme :SolidMasse moléculaire :392.45Zorubicin
CAS :<p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>Formule :C34H35N3O10Couleur et forme :SolidMasse moléculaire :645.66WEE1 degrader 1
<p>WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.</p>Formule :C30H31N5O3Couleur et forme :SolidMasse moléculaire :509.6TMX-3013
CAS :<p>TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.</p>Formule :C17H14BrFN6O3SCouleur et forme :SolidMasse moléculaire :481.3BRD4 Inhibitor-40
CAS :<p>BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.</p>Formule :C27H32N8OCouleur et forme :SolidMasse moléculaire :484.596CHK1 inhibitor
CAS :CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Formule :C17H21BrN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.28Valopicitabine dihydrochloride
CAS :<p>Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Formule :C15H25ClN4O6Couleur et forme :SolidMasse moléculaire :392.842′-OMe-ADP
CAS :<p>2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.</p>Formule :C11H17N5O10P2Couleur et forme :SolidMasse moléculaire :441.23N-Nitrosonornicotine
CAS :<p>N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.</p>Formule :C9H11N3OCouleur et forme :SolidMasse moléculaire :177.22,5-Di-tert-butyl-1,4-benzoquinone
CAS :<p>2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.</p>Formule :C14H20O2Couleur et forme :SolidMasse moléculaire :220.31OSI-7904L free acid
CAS :<p>OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties.</p>Formule :C27H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :500.5CDK1-IN-6
<p>CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.</p>Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.43GHP-88309
CAS :<p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>Formule :C16H11FN2OCouleur et forme :SolidMasse moléculaire :266.27BET/Aurora kinase-IN-1
CAS :<p>BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.</p>Formule :C25H30FN7OCouleur et forme :SolidMasse moléculaire :463.55
