Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(115 produits)
- CDK(547 produits)
- Arrêt du cycle cellulaire(5 produits)
- Chk(48 produits)
- DYRK(46 produits)
- Dynamine(27 produits)
- Ferroptose(227 produits)
- HSP(180 produits)
- Intégrine(269 produits)
- Kinésine(87 produits)
- LIM Kinase(21 produits)
- Microtubules associés(273 produits)
- PKC(127 produits)
- PLK(25 produits)
- ROCK(61 produits)
- Rho(6 produits)
- Wee1(14 produits)
- c-Myc(76 produits)
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3912 produits trouvés pour "Cycle cellulaire/point de contrôle"
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PLK1-IN-14
PLK1-IN-14 (Compound Hit-4) is a selective PLK1 inhibitor with an IC50 of 22.61 pM for PLK1, and an IC50 of 0.09 nM for inhibiting the proliferation of DU-145 prostate cancer cells. It is applicable in prostate cancer research.Couleur et forme :Odour Solidm7GpppApG
CAS :M7GpppApG is a trinucleotide mRNA 5' cap analog utilized for in vitro RNA synthesis [1].Formule :C31H41N15O24P4Couleur et forme :SolidMasse moléculaire :1131.64TAS-119
CAS :TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formule :C23H22Cl2FN5O3Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :506.36Ref: TM-T34787
1mg97,00€5mg235,00€1mL*10mM (DMSO)261,00€10mg378,00€25mg748,00€50mg1.169,00€100mg1.644,00€Mps1-IN-6
Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].Formule :C35H39N9O3Couleur et forme :SolidMasse moléculaire :633.74DNA Gyrase-IN-12
DNA Gyrase-IN-12 (Compound 6d) is an inhibitor of DNA gyrase. It exhibits antibacterial activity with MIC values ranging from 0.031 to 0.0625 μg/mL against Vancomycin-Intermediate Staphylococcus aureus (VISA) and Enterococcus faecium.Couleur et forme :Odour SolidXanthosine-5'-Triphosphate
CAS :Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.Formule :C10H15N4O15P3Couleur et forme :SolidMasse moléculaire :524.164NUAK1-IN-2
NUAK1-IN-2 (Compound 24) is an inhibitor of NUAK1 with an IC50 of 3.162 nM, as well as an inhibitor of CDK2/4/6. It is applicable in research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formule :C24H30N6OCouleur et forme :SolidMasse moléculaire :418.5355'-O-Benzoyl-3'-O-(4-methoxybenzyl)-2'-O,4'-C-methyleneuridine
5’-O-Benzoyl-3’-O-(4-methoxybenzyl)-2’-O,4’-C-methyleneuridine is a purine nucleoside analog with broad antitumor activity, primarily targeting indolentFormule :C25H24N2O8Couleur et forme :SolidMasse moléculaire :480.47TLR7 agonist 12
CAS :TLR7 agonist 12, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.Formule :C14H19N5O8Couleur et forme :SolidMasse moléculaire :385.33AB-3PRGD2
CAS :AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.
Formule :C137H215IN30O45SCouleur et forme :SolidMasse moléculaire :3161.32PDI-IN-4
PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.Formule :C17H12F3NO2Couleur et forme :SolidMasse moléculaire :319.278Endo-1,4-β-xylanase
CAS :Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.Couleur et forme :SolidGS-443902 trisodium
CAS :GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.Formule :C12H16N5O13P3·xNaCouleur et forme :Solid2-Diethoxymethyl adenosine
2-Diethoxymethyl adenosine, an adenosine analog, dilates smooth muscle, inhibits cancer, and leads to drugs like Acadesine.Formule :C23H31N5O10Couleur et forme :SolidMasse moléculaire :537.52Clofarabine-5'-diphosphate
CAS :Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formule :C10H13ClFN5O9P2Couleur et forme :SolidMasse moléculaire :463.645'-O-DMT-rI
CAS :5’-O-DMT-Ri can be used in the synthesis of oligoribonucleotides[1].Formule :C31H30N4O7Couleur et forme :SolidMasse moléculaire :570.59m7GpppGpG
CAS :m7GpppGpG, a trinucleotide cap, protects mRNA from 5′ exonucleases & aids splicing and translation.Formule :C31H41N15O25P4Couleur et forme :SolidMasse moléculaire :1147.642'-O-Methyladenosine 5'-monophosphate triethyl ammonium
2’-O-Methyladenosine 5’-monophosphate triethyl ammonium is an adenosine analog.Formule :C11H14N5O7P2Couleur et forme :SolidMasse moléculaire :359.23ONX 0801 trisodium
CAS :ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Formule :C32H30N5Na3O10Couleur et forme :SolidMasse moléculaire :713.58AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Formule :C28H32FN9O2Couleur et forme :SolidMasse moléculaire :545.61
