Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(111 produits)
- CDK(525 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(46 produits)
- DYRK(49 produits)
- Dynamine(26 produits)
- Ferroptose(224 produits)
- HSP(180 produits)
- Intégrine(256 produits)
- Kinésine(86 produits)
- LIM Kinase(19 produits)
- Microtubules associés(284 produits)
- PKC(111 produits)
- PLK(25 produits)
- ROCK(66 produits)
- Rho(2 produits)
- Wee1(14 produits)
- c-Myc(75 produits)
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3749 produits trouvés pour "Cycle cellulaire/point de contrôle"
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MtTMPK-IN-9
MtTMPK-IN-9 moderately inhibits MtbTMPK (IC50: 48 μM), has submicromolar Mycobacterium activity, and is non-toxic, aiding tuberculosis research.Formule :C25H26N6O7Couleur et forme :SolidMasse moléculaire :522.515'-DMT-5-F-2'-dU Phosphoramidite
CAS :5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.Formule :C39H46FN4O8PCouleur et forme :SolidMasse moléculaire :748.777Antitumor agent-75
Antitumor agent-75 is a novel and potent antitumor agent.Formule :C26H23FN6Couleur et forme :SolidMasse moléculaire :438.54,5'-Dimethylangelicin-NHS
NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.Formule :C21H19NO7SCouleur et forme :SolidMasse moléculaire :429.44DYRKs-IN-1 hydrochloride
CAS :DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) & DYRK1B (8 nM IC50) with antitumor properties.Formule :C30H31Cl2N7O4Couleur et forme :SolidMasse moléculaire :624.52Chk1-IN-5
CAS :Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.Formule :C18H18FN7O2Couleur et forme :SolidMasse moléculaire :383.38GSK3335103
CAS :GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Formule :C27H36FN3O4Couleur et forme :SolidMasse moléculaire :485.59Rhodblock 1a
CAS :<p>Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.</p>Formule :C20H16N2O2Couleur et forme :SolidMasse moléculaire :316.353CDK9-IN-13
CDK9-IN-13 is a potent and selective CDK inhibitor (IC50<3 nM). CDK9-IN-13 has a very short half-life in rodents.Formule :C27H35N5O2Couleur et forme :SolidMasse moléculaire :461.6CDK2/4-IN-2
CAS :CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.Formule :C18H20F3N7O3S2Couleur et forme :SolidMasse moléculaire :503.52LNA-GTP
CAS :LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.Formule :C11H16N5O14P3Couleur et forme :SolidMasse moléculaire :535.19DNA gyrase B-IN-1
DNA gyrase B-IN-1, a potent inhibitor of P. aeruginosa DNA gyrase B, has IC50 of 2.2 μM with high affinity and stability.Formule :C23H18ClF3N6O4SCouleur et forme :SolidMasse moléculaire :566.942'-O-MOE-GMP
CAS :<p>2'-O-MOE-GMP is a nucleotide analogue that can be utilized in the synthesis of oligonucleotides.</p>Formule :C13H20N5O9PCouleur et forme :SolidMasse moléculaire :421.30WEE1/PKMYT1-IN-1
CAS :<p>WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.</p>Formule :C16H16N4O3Couleur et forme :SolidMasse moléculaire :312.323SF0166
CAS :SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Formule :C23H27F2N5O4Couleur et forme :SolidMasse moléculaire :475.49PCNA-IN-1
CAS :PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.Formule :C19H18I3NO3Couleur et forme :SolidMasse moléculaire :689.065N-Isobutyryl-2', 3'-acetyl-guanosine
CAS :N-Isobutyryl-2', 3'-acetyl-guanosine is a derivative of guanosine.Formule :C18H23N5O8Couleur et forme :SolidMasse moléculaire :437.4042-CEES
CAS :2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.Formule :C4H9ClSCouleur et forme :SolidMasse moléculaire :124.632Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formule :C29H33ClN4O3SCouleur et forme :SolidMasse moléculaire :553.12DDO-6079
CAS :DDO-6079 is an efficient CDC37 inhibitor. It suppresses the HSP90-CDC37 and CDC37-CDK4/6 chaperone complexes by binding to an allosteric site on CDC37. Additionally, DDO-6079 reduces the thermal stability of CDK6.Formule :C18H13ClN2O3Couleur et forme :SolidMasse moléculaire :340.76USP7-IN-10
CAS :USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.Formule :C26H29ClN4O3SCouleur et forme :SolidMasse moléculaire :513.05Z4P
CAS :Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB), inhibited glioblastoma growth and recurrence in combination with Temozolomide.Formule :C19H24N2O2Degré de pureté :98.99%Couleur et forme :SolidMasse moléculaire :312.41WEE1-IN-10
CAS :WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.Formule :C28H30Cl2N8ODegré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :565.5IIP0943
CAS :IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.Formule :C26H28N6O3SCouleur et forme :SolidMasse moléculaire :504.604NusB-IN-1
NusB-IN-1 (22r) is an oral bacterial rRNA inhibitor, effective against MRSA and VRSA.Formule :C21H16N2O3Couleur et forme :SolidMasse moléculaire :344.363-deoxy-3-fluoro-β-D-Ribofuranose 25
CAS :Compound 25, β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate), exhibits strong activity in inhibiting the growth of tumor cells [1].Formule :C17H19FO7Masse moléculaire :354.33Antitumor agent-74
Antitumor agent-74, a quinazoline derivative, inhibits DNA, arrests cell cycle, and induces apoptosis with agent-75.Formule :C26H23FN6Couleur et forme :SolidMasse moléculaire :438.5Aurora A inhibitor 4
CAS :Aurora A inhibitor4 (compound C9) is a potent inhibitor of Aurora A, with GI50 values of 4.26 μM in DU 145 cells and 7.08 μM in HT-29 cells.Formule :C22H23N5O3Masse moléculaire :405.45CLK1/4-IN-1
CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.Formule :C18H14ClNO4SCouleur et forme :SolidMasse moléculaire :375.83RNAP-σ interaction inhibitor-2
CAS :RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor targeting the interaction between RNA polymerase and the sigma factor. It demonstrates inhibitory activity against S. aureus with a minimum inhibitory concentration (MIC) of 2 µg/mL.Formule :C27H19Cl3N2O6S2Couleur et forme :SolidMasse moléculaire :637.939PD-1/PD-L1-IN-53
CAS :<p>PD-1/PD-L1-IN-53 (compound B3) serves as an inhibitor targeting both the PD-1/PD-L1 and VISTA signaling pathways. It is utilized in cancer research.</p>Formule :C31H37N3O4Couleur et forme :SolidMasse moléculaire :515.64(R)-Atuveciclib
CAS :Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].Formule :C18H18FN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.43MtTMPK-IN-1
MtTMPK-IN-1 inhibits MtTMPK with 2.5 μM IC50, shows moderate anti-tuberculosis activity, and is low in cytotoxicity.Formule :C22H24N4O3Couleur et forme :SolidMasse moléculaire :392.45Protein kinase inhibitor 14
CAS :Protein kinase inhibitor 14 (Compound 13) exhibits inhibitory effects on various serine/threonine kinases and receptor/non-receptor tyrosine kinases.Formule :C22H22F2N6OMasse moléculaire :424.447CDK2-IN-30
CAS :CDK2-IN-30 (Formula (I)) is a CDK2 inhibitor with an IC50 of ≤20 nM, utilized primarily in tumor research.Formule :C18H25N7O3SCouleur et forme :SolidMasse moléculaire :419.50Tetrahydrouridine dihydrate
THU dihydrate, a potent CDA inhibitor, outperforms cytidine by blocking the enzyme's active site.Formule :C9H20N2O8Couleur et forme :SolidMasse moléculaire :284.26Anti-neuroinflammation agent 3
CAS :Compound A.10.3 (Anti-neuroinflammation agent 3) exhibits inhibitory activity against various Ser/Thr kinases or receptor/non-receptor tyrosine kinases.Formule :C22H23FN6O2Masse moléculaire :422.455RMS-07
CAS :RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.Formule :C35H40N8O2Couleur et forme :SolidMasse moléculaire :604.74PKMYT1-IN-7
CAS :PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM for PKMYT1 and 0.06 μM for pCDK1. It inhibits the phosphorylation of CDK1 at T14 and Y15 sites and exhibits anticancer activity both in vitro and in vivo.Formule :C17H18FN5O3Couleur et forme :SolidMasse moléculaire :359.355MtTMPK-IN-2
CAS :MtTMPK-IN-2 inhibits M. tuberculosis TMPK (IC50: 1.1 μM), Mtb H37Rv (MIC: 12.5 μM), and is cytotoxic in MRC-5 cells (EC50: 6.1 μM).Formule :C23H24ClN3O3Couleur et forme :SolidMasse moléculaire :425.91ART615
ART615 is a related isomer of ART558. ART615 inhibits Polθ by <10% at 12 μM and is able to act as a control for ART558 (IC50:7.9 nM).Formule :C21H21F3N4O2Couleur et forme :SolidMasse moléculaire :418.412'-(2-Nitrobenzyl)-ATP
CAS :2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.Formule :C17H21N6O15P3Couleur et forme :SolidMasse moléculaire :642.305-Iminodaunorubicin hydrochloride
CAS :5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.Formule :C27H31ClN2O9Couleur et forme :SolidMasse moléculaire :563.00Ladirubicin
CAS :Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.Formule :C29H31NO11SCouleur et forme :SolidMasse moléculaire :601.62BAY-364
CAS :BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+Formule :C23H19N3O4Couleur et forme :SolidMasse moléculaire :401.41CDK6-IN-1
CAS :CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.Formule :C30H23N5Couleur et forme :SolidMasse moléculaire :453.54CDK7-IN-31
CAS :CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.Formule :C27H32F5N6O2PCouleur et forme :SolidMasse moléculaire :598.55Ascofuranone
CAS :Ascofuranone is an inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO), as well as an inhibitor of HsDHODHFormule :C23H29ClO5Couleur et forme :SolidMasse moléculaire :420.93RAD51-IN-7
CAS :RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)Formule :C25H31N5O4S2Couleur et forme :SolidMasse moléculaire :529.67CDK9-IN-11
CAS :CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].Formule :C20H25N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :371.43β-catenin-IN-8
CAS :β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.Formule :C15H12ClN3O2SCouleur et forme :SolidMasse moléculaire :333.79Plevitrexed
CAS :Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor & reduced folate carrier, treats gastric cancer.Formule :C26H25FN8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :532.53UM-C162
CAS :UM-C162, a benzimidazole derivative, offers protection to nematodes from Staphylococcus aureus infections. It inhibits biofilm formation without impairing bacterial viability. Additionally, UM-C162 disrupts the production of Staphylococcus aureus hemolysins, proteases, and coagulases. This compound holds potential as an antivirulence agent for managing Staphylococcus aureus infections.Formule :C30H25N3O4Masse moléculaire :491.54Cdc7-IN-11
CAS :Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.Formule :C20H22F2N4O2SCouleur et forme :SolidMasse moléculaire :420.48CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.432′-OMe-UMP
CAS :2′-OMe-UMP is a nucleotide analog used in the synthesis of oligonucleotides.Formule :C10H15N2O9PMasse moléculaire :338.21TMX-3013
CAS :TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.Formule :C17H14BrFN6O3SCouleur et forme :SolidMasse moléculaire :481.3WEE1 degrader 1
WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.Formule :C30H31N5O3Couleur et forme :SolidMasse moléculaire :509.62′-F-UDP
CAS :2′-F-UDP is a nucleotide analogue used in the synthesis of oligonucleotides.Formule :C9H13FN2O11P2Couleur et forme :SolidMasse moléculaire :406.15RAD51-IN-8
RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.Formule :C16H14Cl2FN3O2Couleur et forme :SolidMasse moléculaire :370.21T-2513 hydrochloride
CAS :T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.Formule :C25H28ClN3O5Couleur et forme :SolidMasse moléculaire :485.96LIMK1 inhibitor 2
CAS :LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.Formule :C10H11N3OSCouleur et forme :SolidMasse moléculaire :221.279Antibacterial agent 110
Compound 4e, an antibacterial against P. aeruginosa, disrupts cell membranes (MIC: 1 μg/ml).Formule :C22H21N5O4SCouleur et forme :SolidMasse moléculaire :451.5Dyrk1A-IN-2
Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.Formule :C27H32N6O4Couleur et forme :SolidMasse moléculaire :504.58L-Tyrosyl-L-glutamic acid
CAS :L-Tyrosyl-L-glutamic acid acts as an inhibitor of the amino acid permease GAP1.Formule :C14H18N2O6Couleur et forme :SolidMasse moléculaire :310.3ROCK/HDAC-IN-1
ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.Formule :C19H22N4O3SCouleur et forme :SolidMasse moléculaire :386.47D-G23
CAS :<p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>Formule :C19H22N4O3Couleur et forme :SolidMasse moléculaire :354.403Tizolemide
CAS :Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.Formule :C11H14ClN3O3S2Couleur et forme :SolidMasse moléculaire :335.83Xanthosine-5'-Triphosphate trisodium
CAS :<p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>Formule :C10H12N4Na3O15P3Couleur et forme :SolidMasse moléculaire :590.111LNA-GMP
CAS :LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.Formule :C11H14N5O8PCouleur et forme :SolidMasse moléculaire :375.23GSK_WRN4
CAS :<p>GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research</p>Formule :C16H20N2O4SDegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :336.41Cimpuciclib tosylate
CAS :Cimpuciclib tosylate, a selective CDK4 inhibitor (IC50: 0.49 nM), exhibits anti-tumor activity.Formule :C37H43FN8O4SCouleur et forme :SolidMasse moléculaire :714.85CDK12/13 ligand 1
CAS :ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.Formule :C26H26BrN5OCouleur et forme :SolidMasse moléculaire :504.42Polθ-IN-6
CAS :Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.Formule :C25H23N3O3SCouleur et forme :SolidMasse moléculaire :445.536-B345TTQ
CAS :6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.Formule :C22H20BrNO4Couleur et forme :SolidMasse moléculaire :442.303WRN inhibitor 12
CAS :WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Formule :C33H33ClF3N9O5Couleur et forme :SolidMasse moléculaire :728.12Lobucavir
CAS :<p>Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).</p>Formule :C11H15N5O3Couleur et forme :SolidMasse moléculaire :265.27DNA Gyrase-IN-13
CAS :<p>DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.</p>Formule :C15H21N3O3SCouleur et forme :SolidMasse moléculaire :323.41WRN inhibitor 11
CAS :WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.Formule :C34H35ClF3N9O5Couleur et forme :SolidMasse moléculaire :742.15Cdc7-IN-10
CAS :Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.Formule :C20H22F2N4O2SCouleur et forme :SolidMasse moléculaire :420.48CDK4-IN-1
CAS :CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50Formule :C22H29ClN8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.97WEE1-IN-11
CAS :WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.Formule :C26H29FN8OS2Couleur et forme :SolidMasse moléculaire :552.69CDK2-IN-31
CAS :CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.Formule :C37H52N6O5Couleur et forme :SolidMasse moléculaire :660.85BWC0977
CAS :BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.Formule :C22H21FN6O5Couleur et forme :SolidMasse moléculaire :468.44SGC-CLK-1
CAS :SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.Formule :C19H15F3N6O2Couleur et forme :SolidMasse moléculaire :416.36Galidesivir
CAS :Galidesivir (BCX4430) is an antiviral compound that inhibits viral RNA-dependent RNA polymerase (RdRp) activity and reduces lung infections in infected animals.Formule :C11H15N5O3Degré de pureté :96.73% - 99.13%Couleur et forme :SolidMasse moléculaire :265.27Polθ-IN-5
CAS :Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.Formule :C23H18ClF2N7O3SCouleur et forme :SolidMasse moléculaire :545.95TASIN-30
CAS :<p>TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.</p>Formule :C18H30N2O3SCouleur et forme :SolidMasse moléculaire :354.51Werner syndrome RecQ helicase-IN-2
CAS :Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Formule :C32H34F3N9O5Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :681.67DYRK1-IN-1
CAS :DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.Formule :C12H12N6Couleur et forme :SolidMasse moléculaire :240.2612(S)-HETE
CAS :<p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>Formule :C20H32O3Couleur et forme :SolidMasse moléculaire :320.47Glycyl H-1152 hydrochloride
CAS :Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.Formule :C18H26Cl2N4O3SCouleur et forme :SolidMasse moléculaire :449.39Haspin-IN-2
CAS :Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).Formule :C12H8N4O3Couleur et forme :SolidMasse moléculaire :256.22APE1-IN-3
CAS :<p>APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.</p>Formule :C17H16O4Couleur et forme :SolidMasse moléculaire :284.3114α-Demethylase/DNA Gyrase-IN-1
14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.Formule :C26H22N4O4Couleur et forme :SolidMasse moléculaire :454.48TY-011
CAS :<p>TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.</p>Formule :C18H16ClN5Couleur et forme :SolidMasse moléculaire :337.81Pseudouridine 5'-OTBDPS
CAS :<p>Pseudouridine5'-OTBDPS [5-(5-O-TBDPS-β-D-ribofuranosyl)uracil] is an intermediate of Pseudouridine.</p>Formule :C25H30N2O6SiCouleur et forme :SolidMasse moléculaire :482.60Valopicitabine
CAS :<p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>Formule :C15H24N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :356.37GHP-88309
CAS :<p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>Formule :C16H11FN2OCouleur et forme :SolidMasse moléculaire :266.27DS96432529
DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.Formule :C18H26N4O3SCouleur et forme :SoildMasse moléculaire :378.49Kolavenic acid analog
CAS :KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.Formule :C25H38O4Couleur et forme :SolidMasse moléculaire :402.57CHK1-IN-4
CAS :<p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>Formule :C18H18BrN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.29CDK7/12-IN-1
CAS :CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.Formule :C25H34N8OCouleur et forme :SolidMasse moléculaire :462.59GTSE1-IN-1
CAS :GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.Formule :C21H24FN7Couleur et forme :SolidMasse moléculaire :393.46PD-L1-IN-7
CAS :PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.Formule :C46H50N6O7Couleur et forme :SolidMasse moléculaire :798.93CDK7-IN-17
CAS :CDK7-IN-17, a pyrimidine-based CDK7 inhibitor, shows promise for various cancers, especially with abnormal transcription.Formule :C24H26F3N6OPDegré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :502.47Aurora/LIM kinase-IN-1
Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.Formule :C16H20N6OCouleur et forme :SolidMasse moléculaire :312.37PolQi1
CAS :<p>PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.</p>Formule :C18H14ClF5N4O2Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :448.77PLK1-IN-11
CAS :PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.Formule :C12H11N5OCouleur et forme :SolidMasse moléculaire :241.249Epolactaene
CAS :Epolactaene: neuritogenic, inhibits mammalian DNA polymerases & human DNA topoisomerase II.Formule :C21H27NO6Couleur et forme :SolidMasse moléculaire :389.44LIMK-IN-2
CAS :<p>LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].</p>Formule :C28H27N5O2Couleur et forme :SolidMasse moléculaire :465.55Mps1-IN-8
CAS :Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].Formule :C35H47N8O6PCouleur et forme :SolidMasse moléculaire :706.77iPAF1C
CAS :<p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>Formule :C27H26BrFN4OCouleur et forme :SolidMasse moléculaire :521.42CD 10899
CAS :CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].Formule :C34H50N8O4Couleur et forme :SolidMasse moléculaire :634.81FT3967385
FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.Formule :C21H19N5O2Couleur et forme :SolidMasse moléculaire :373.41LY 254155
CAS :LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.Formule :C19H23N5O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :449.48CHK1-IN-11
CAS :CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.Formule :C20H22N8O2Couleur et forme :SolidMasse moléculaire :406.44Dyrk1A-IN-8
CAS :Dyrk1A-IN-8 is an active molecule that can be used in life science related research. The CAS number of Dyrk1A-IN-8 is 101578-13-6.Formule :C17H21N3OCouleur et forme :SolidMasse moléculaire :283.37PLK1-IN-5
CAS :PLK1-IN-5, a potent PLK1 inhibitor, has an IC50 of less than 500 nM and demonstrates anticancer effects (WO2008113711A1; compound I-4) [1].Formule :C28H39N7O3Couleur et forme :SolidMasse moléculaire :521.65YKL-1-116
CAS :YKL-1-116 is an effective, selective, and covalent CDK7 inhibitor.Formule :C34H38N8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :606.72Haspin-IN-1
Haspin-IN-1 blocks haspin (IC50: 119 nM) and inhibits CLK1, DYRK1A, CDK9 with potential as an anticancer drug.Formule :C12H8N4O2SCouleur et forme :SolidMasse moléculaire :272.28HRO761
CAS :HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Formule :C31H31ClF3N9O5Degré de pureté :98.74% - 99.62%Couleur et forme :SolidMasse moléculaire :702.08CTPS1-IN-1
CAS :CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Formule :C21H22N6O4S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :486.57Elacytarabine
CAS :Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.Formule :C27H45N3O6Degré de pureté :97.69%Couleur et forme :SolidMasse moléculaire :507.66GFB-12811
CAS :GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.Formule :C22H23F4N5ODegré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :449.44VCPIP1-IN-1
CAS :VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Formule :C13H15ClN2O2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :266.72SR 11302
CAS :SR 11302 is an inhibitor of activator protein-1 (AP-1).Formule :C26H32O2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :376.53LY3143921 hydrate
CAS :LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Formule :C16H14FN5O2Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :327.31INCB086550
CAS :INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Formule :C41H39N7O4Degré de pureté :98.49%Couleur et forme :SolidMasse moléculaire :693.79Bicyclomycin benzoate
CAS :Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.Formule :C19H22N2O8Couleur et forme :SolidMasse moléculaire :406.39Troxacitabine
CAS :Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.Formule :C8H11N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :213.192'-Deoxy-2'-fluoro-5-iodouridine
CAS :2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.Formule :C9H10FIN2O5Couleur et forme :SolidMasse moléculaire :372.095'-O-DMT-N6-ibu-dA
CAS :5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Formule :C35H37N5O6Couleur et forme :SolidMasse moléculaire :623.71Formycin A
CAS :Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.Formule :C10H13N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.24Tanuxiciclib
CAS :Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.Formule :C15H13FN6OCouleur et forme :SolidMasse moléculaire :312.308PLK1-IN-6
<p>PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.</p>Formule :C28H37N9O3Couleur et forme :SolidMasse moléculaire :547.65Ethynylcytidine
CAS :Ethynylcytidine is a nucleoside antimetabolite.Formule :C11H13N3O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :267.245'-DMT-3'-TBDMS-ibu-rG
CAS :5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.Formule :C41H51N5O8SiCouleur et forme :SolidMasse moléculaire :769.96N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS :N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.Formule :C38H35N5O6Couleur et forme :SolidMasse moléculaire :657.727NSC639828
CAS :NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Formule :C18H13BrClN5O3Couleur et forme :SolidMasse moléculaire :462.693BrB-PP1
CAS :3BrB-PP1 is an ATP-competitive analog that exhibits specific inhibitory activity towards protein kinase, particularly effective against protein kinases with mutations in the ATP-binding pocket, such as the Thr97 mutation within Sty1's ATP-binding pocket.Formule :C16H18BrN5Couleur et forme :SolidMasse moléculaire :360.259GSK-3/CDK5/CDK2-IN-1
CAS :GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].Formule :C21H22N4O2Couleur et forme :SolidMasse moléculaire :362.433PF-03814735
CAS :PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Formule :C23H25F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.48MitoE10
CAS :MitoE10 is an effective mitochondrial targeting antioxidant.Formule :C42H55O5PSCouleur et forme :SolidMasse moléculaire :702.92Ribocil-C
CAS :Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.Formule :C21H21N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :419.56-Amino-5-nitropyridin-2-one
CAS :6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.Formule :C5H5N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :155.11Tibremciclib
CAS :<p>Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].</p>Formule :C28H32F2N8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :518.6PHI-101
CAS :<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Formule :C19H19FN4O2SDegré de pureté :99.4%Couleur et forme :SolidMasse moléculaire :386.44YK-2168
CAS :<p>YK-2168 is a differentiated selective inhibitor of CDK9.</p>Formule :C16H18ClN5Couleur et forme :SolidMasse moléculaire :315.80
