Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
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3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
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N4-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine
<p>N4-Benzoyl-3'-O-DMT cytidine analog inhibits DNA methyltransferases like Zebularine.</p>Formule :C41H43N3O9Couleur et forme :SolidMasse moléculaire :721.79HSDVHK-NH2 TFA
<p>HSDVHK-NH2 TFA acts as an antagonist to the αvβ3-vitronectin integrin interaction, displaying an inhibitory concentration (IC 50) of 1.74 pg/mL (2.414 pM) [1] [</p>Formule :C32H49F3N12O11Couleur et forme :SolidMasse moléculaire :834.85-O-TBDMS-N4-Benzoyl-2-deoxycytidine
CAS :<p>5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.</p>Formule :C22H31N3O5SiCouleur et forme :SolidMasse moléculaire :445.58Erythromycin thiocyanate
CAS :<p>Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.</p>Formule :C38H68N2O13SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :793.02Integrin Binding Peptide
CAS :<p>Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels.</p>Formule :C42H63N15O16SCouleur et forme :SolidMasse moléculaire :1066.12m7GpppUmpG
CAS :<p>m7GpppUmpG, a trinucleotide cap analogue, enables RNA synthesis with cap 0 or 1 structures.</p>Formule :C31H42N12O26P4Couleur et forme :SolidMasse moléculaire :1122.632'-Deoxy-2'-fluoroguanosine 5'-monophosphate triethyl ammonium
<p>2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits broad antitumor activity specifically targeting indolent</p>Formule :C22H43FN7O7PCouleur et forme :SolidMasse moléculaire :567.59LEB-03-146
CAS :<p>LEB-03-146: WEE1 DUBTAC linking AZD1775 to OTUB1 via PEG2; stabilizes WEE1 in HEP3B cells.</p>Formule :C46H57N11O8Couleur et forme :SolidMasse moléculaire :892.01O-Glycoprotease
<p>O-Glycoprotease is a specific endoprotease for O-glycoproteins, capable of catalyzing the hydrolysis of peptide bonds directly adjacent to O-glycan structures in natural mucin-type O-glycosylated proteins. The sequence of O-Glycoprotease is derived from Akkermansia muciniphila, and it is recombinantly expressed in E. coli with a C-terminal 6×His tag. This enzyme maintains high activity within a pH range of 5.5 to 7.5, is resistant to 1 M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn2+.</p>Couleur et forme :Odour Solid5'-O-DMT-N2-DMF-dG
CAS :<p>5'-O-DMT-2'-O-TBDMS-rI, a modified nucleoside, finds application in deoxyribonucleic acid (DNA) or nucleic acid synthesis.</p>Formule :C34H36N6O6Couleur et forme :SolidMasse moléculaire :624.69813-TP
<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>Formule :C12H19F2N6O12P3Couleur et forme :SolidMasse moléculaire :570.23Nocarnickelamides B
<p>Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.</p>Formule :C29H42N6O9Couleur et forme :Odour SolidMasse moléculaire :618.68Xylocytidine
CAS :<p>Xylocytidine is a biochemical.</p>Formule :C9H13N3O5Couleur et forme :SolidMasse moléculaire :243.22GSK270822A
CAS :<p>GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.</p>Formule :C24H20N4O2Degré de pureté :98.64% - 99.78%Couleur et forme :SolidMasse moléculaire :396.44Endo-1,4-β-xylanase
CAS :<p>Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.</p>Couleur et forme :SolidCDK12-IN-6
CAS :<p>CDK12-IN-6, a pyrazolotriazine, strongly inhibits CDK12 (IC50 1.19 μM at 2 mM ATP), but not CDK2/Cyclin E or CDK9/Cyclin T1 (both IC50 >20 μM).</p>Formule :C20H21F2N9Couleur et forme :SolidMasse moléculaire :425.448GSK299423
CAS :<p>GSK299423: Antibiotic possibly effective against bacteria with New Delhi metal-β-lactamase, targeting topoisomerases.</p>Formule :C25H27N5O2SDegré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :461.58Biotin-PEG7-C2-S-Vidarabine
<p>Biotin-PEG7-C2-S-Vidarabine: PEG linker with antiviral adenosine analog effective against herpes and zoster.</p>Formule :C36H60N8O12S2Couleur et forme :SolidMasse moléculaire :861.04CDK4/6-IN-23
<p>CDK4/6-IN-23 (Compound 42) is a potent and selective inhibitor of CDK4/6, displaying an IC50 of 11 nM for CDK6. This compound significantly activates immune cells and enhances IL-3 production. In mice undergoing 5-FU chemotherapy, CDK4/6-IN-23 demonstrates dual bone marrow protection and immunomodulatory effects.</p>Formule :C32H34FN7O4Couleur et forme :SolidMasse moléculaire :599.655PP-C8
<p>PP-C8: PROTAC CDK12-Cyclin K degrader with DC50s 416/412 nM; synergizes with PARP inhibitor against TNBC.</p>Formule :C43H51FN12O7Couleur et forme :SolidMasse moléculaire :866.94Guanosine triphosphate
CAS :<p>Guanosine triphosphate (GTP), a native nucleotide, and its derivatives may serve as specific inhibitors against COVID-19 [1].</p>Formule :C10H16N5O14P3Couleur et forme :SolidMasse moléculaire :523.18Ceftriaxone
CAS :<p>Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.</p>Formule :C18H18N8O7S3Degré de pureté :96.08%Couleur et forme :SolidMasse moléculaire :554.58Methylcarbamyl PAF C-8
<p>Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.</p>Couleur et forme :Odour Solid3'-Deoxy-GTP trisodium
<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.</p>Couleur et forme :Odour SolidCDK9 inhibitor HH1
CAS :<p>CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.</p>Formule :C13H15N3OSDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :261.34Ficellomycin
CAS :<p>Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.</p>Formule :C13H24N6O3Couleur et forme :SolidMasse moléculaire :312.37HSDVHK-NH2
CAS :<p>Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.</p>Formule :C30H48N12O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :720.785'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
<p>5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.</p>Formule :C44H49F2N4O7PCouleur et forme :SolidMasse moléculaire :814.85PDI-IN-4
<p>PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.</p>Formule :C17H12F3NO2Couleur et forme :SolidMasse moléculaire :319.278Brr2-IN-2
<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>Formule :C21H25FN4O2Couleur et forme :SolidMasse moléculaire :384.45α2β1 Integrin Ligand Peptide
CAS :<p>The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular</p>Formule :C14H22N4O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :390.355'-O-DMT-N4-Bz-2'-F-dC
CAS :<p>5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.</p>Formule :C37H34FN3O7Couleur et forme :SolidMasse moléculaire :651.68RA-V
<p>RA-V is a natural product that can be used as a reference standard.</p>Formule :C160H202N24O41Couleur et forme :SolidMasse moléculaire :3117.5N3-[(Pyrid-4-yl)methyl]uridine
<p>N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, may have antiepileptic properties and aid in researching anticonvulsants and anxiolytics.</p>Formule :C15H17N3O6Couleur et forme :SolidMasse moléculaire :335.31GK13S
<p>G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.</p>Formule :C21H22N6O2Couleur et forme :SolidMasse moléculaire :390.44UnyLinker 12 TEA
<p>UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.</p>Formule :C39H35NO10C6H15NCouleur et forme :SolidMasse moléculaire :778.34655Censavudine
CAS :<p>Censavudine (OBP-601) is an HIV-1/2 treatment and prevention drug, a reverse transcriptase inhibitor with EC50 of 30-890 nM.</p>Formule :C12H12N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.23CDK7-IN-5
CAS :<p>CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).</p>Formule :C34H45N9O2Couleur et forme :SolidMasse moléculaire :611.795PD-1/PD-L1-IN-52
<p>PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.</p>Couleur et forme :Odour SolidCDK6/9-IN-1
CAS :<p>CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).</p>Formule :C22H25ClN8OCouleur et forme :SolidMasse moléculaire :452.95N7-Methyl-2'-O-(2-methoxyethyl) guanosine
<p>N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formule :C14H21N5O6Couleur et forme :SolidMasse moléculaire :355.35Ac-dA Phosphoramidite
CAS :<p>Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>Formule :C42H50N7O7PCouleur et forme :SolidMasse moléculaire :795.878Fuzapladib
CAS :<p>Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.</p>Formule :C15H20F3N3O3SDegré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :379.4Filanesib TFA
CAS :<p>Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.</p>Formule :C22H23F5N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.5Dihydro-5-azacytidine
CAS :<p>Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.</p>Formule :C8H14N4O5Degré de pureté :>99.99%Couleur et forme :SolidMasse moléculaire :246.22Garenoxacin
CAS :<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Formule :C23H20F2N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :426.415'-O-DMT-ibu-dC
CAS :<p>5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.</p>Formule :C34H37N3O7Couleur et forme :SolidMasse moléculaire :599.67Carboxy-pyridostatin
CAS :<p>Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.</p>Formule :C35H34N10O7Couleur et forme :SolidMasse moléculaire :706.71CDK12-IN-2
CAS :<p>CDK12-IN-2 selectively inhibits CDK12 (IC50: 52 nM) with minimal effect on CDK2, CDK7, and CDK9, useful for CDK12 research.</p>Formule :C32H32N6O2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :532.64Py-MAA-Val-Cit-PAB-DX8951
CAS :<p>Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].</p>Formule :C57H66FN11O13SCouleur et forme :SolidMasse moléculaire :1164.26
