Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
Affichez 10 plus de sous-catégories
3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Uridine triphosphate 13C9,15N2 sodium
CAS :<p>Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.</p>Formule :C9H1415N2NaO15P3Couleur et forme :SolidMasse moléculaire :517.04EC0489
CAS :<p>EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (</p>Formule :C111H156N22O43S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2550.7PLK1-IN-2
CAS :<p>PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.</p>Formule :C24H27FN8OSCouleur et forme :SolidMasse moléculaire :494.59Cytidine 5'-diphosphate trisodium salt
CAS :<p>CDP, a trisodium salt, helps synthesize DNA/RNA by aiding phosphoryl transfer from ATP to CMP via UMPK.</p>Formule :C9H15N3Na3O11P2Degré de pureté :99.55%Couleur et forme :White Crystalline PowderMasse moléculaire :472.15Nocarnickelamides B
<p>Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.</p>Formule :C29H42N6O9Couleur et forme :Odour SolidMasse moléculaire :618.68Etrolizumab
CAS :<p>MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.</p>Degré de pureté :98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Couleur et forme :LiquidDHODH-IN-16
CAS :<p>DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).</p>Formule :C24H25FN4O3Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :436.48CDK8-IN-12
CAS :<p>CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.</p>Formule :C21H20ClN3O2Degré de pureté :99.46% - 99.83%Couleur et forme :SoildMasse moléculaire :381.86PD-1/PD-L1-IN-50
<p>Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.</p>Couleur et forme :Odour SolidN3-[(Pyrid-4-yl)methyl]uridine
<p>N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, may have antiepileptic properties and aid in researching anticonvulsants and anxiolytics.</p>Formule :C15H17N3O6Couleur et forme :SolidMasse moléculaire :335.31AB-3PRGD2
CAS :<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formule :C137H215IN30O45SCouleur et forme :SolidMasse moléculaire :3161.32Pyrindamycin A
CAS :<p>Pyrindamycin A is an antibiotic that inhibits DNA synthesis,and shows antitumor activities against murine leukemia.</p>Formule :C26H26ClN3O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.95Apcin A HCL
CAS :<p>Apcin A HCL is an Apcin-derived APC inhibitor that binds Cdc20 and hinders ubiquitination, useful for synthesizing PROTAC CP5V.</p>Formule :C10H15Cl4N5O2Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :379.073'-Deoxyuridine-5'-triphosphate trisodium
<p>3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).</p>Formule :C9H12N2Na3O14P3Couleur et forme :SoildMasse moléculaire :534.08CCT241533 dihydrochloride
CAS :<p>Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.</p>Formule :C23H29Cl2FN4O4Couleur et forme :SolidMasse moléculaire :515.41TLR7 agonist 12
CAS :<p>TLR7 agonist 12, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.</p>Formule :C14H19N5O8Couleur et forme :SolidMasse moléculaire :385.33N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS :<p>N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].</p>Formule :C21H35N12O17P3Couleur et forme :SolidMasse moléculaire :820.49Antibacterial agent 144
<p>Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin.</p>Formule :C26H23N7O3Couleur et forme :SolidMasse moléculaire :481.512'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
CAS :<p>dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.</p>Formule :C10H14N5Na2O8PCouleur et forme :SolidMasse moléculaire :409.202dUTP trisodium
CAS :<p>dUTP trisodium (Deoxyuridine triphosphate) is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.</p>Formule :C9H12N2Na3O14P3Degré de pureté :100.00%Couleur et forme :SolidMasse moléculaire :534.09CDK7-IN-5
CAS :<p>CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).</p>Formule :C34H45N9O2Couleur et forme :SolidMasse moléculaire :611.795PROTAC CDK9 degrader-2
CAS :<p>PROTAC CDK9 degrader-2, potent, selective, IC50 17 μM in MCF-7, wogonin-derived, targets CRBN.</p>Formule :C39H36N6O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :748.745'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
<p>5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.</p>Formule :C44H49F2N4O7PCouleur et forme :SolidMasse moléculaire :814.85CPS2
CAS :<p>CPS2: potent, selective PROTAC CDK2 degrader. IC50=24nM, targets acute myeloid leukemia research.</p>Formule :C38H42N12O10S2Couleur et forme :SolidMasse moléculaire :890.94N6-Methyl-2'-O-(2-methoxyethyl) adenosine
<p>N6-Methyl-2’-O-(2-methoxyethyl) adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formule :C14H21N5O5Couleur et forme :SolidMasse moléculaire :339.35CD532 hydrochloride
<p>CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.</p>Couleur et forme :SolidLorutengitide
CAS :<p>Lorutengitide is a transcription-regulating peptide with antiproliferative activity.</p>Formule :C30H50N8O12Couleur et forme :SolidMasse moléculaire :714.764ROCK-IN-32
CAS :<p>ROCK-IN-32 is an effective Rho-kinase inhibitor.</p>Formule :C20H17Cl2N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.27Anti-EMMPRIN/CD147 Antibody
<p>Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.</p>Couleur et forme :Odour Liquidwrwycr-NH2 TFA
<p>wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.</p>Couleur et forme :Odour Solid5'-O-DMT-PAC-dA
CAS :<p>5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].</p>Formule :C39H37N5O7Couleur et forme :SolidMasse moléculaire :687.74LDV FITC
CAS :<p>fluorescent ligand that binds to the α4β1 integrin (VLA-4)</p>Formule :C69H81N11O17SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1368.53Erythromycin A dihydrate
CAS :<p>Erythromycin dihydrate, a macrolide antibiotic from Streptomyces erythreus, targets 50S ribosomal subunits, blocking protein synthesis.</p>Formule :C37H69NO14Couleur et forme :SolidMasse moléculaire :751.94AV-153
CAS :<p>AV-153, a 1,4-dihydropyridine, reduces DNA damage, stimulates repair, and has anti-cancer properties.</p>Formule :C14H19NNaO6Couleur et forme :SolidMasse moléculaire :320.2978-NH2-ATP
CAS :<p>8-NH2-ATP is an inactive derivative of adenosine triphosphate (ATP), synthesized from 8-NH2-Ado.</p>Formule :C10H17N6O13P3Couleur et forme :SolidMasse moléculaire :522.205-Caroxy uracil-1-yl acetic acid benzyl ester
<p>5-Caroxy uracil-1-yl acetic acid benzyl ester, a purine analog, inhibits DNA synthesis and induces apoptosis to combat lymphoid cancers.</p>Formule :C14H12N2O6Couleur et forme :SolidMasse moléculaire :304.25Isocytosine
CAS :<p>Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formule :C4H5N3OCouleur et forme :White To Off-White SolidMasse moléculaire :111.1IV-361
CAS :<p>IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1</p>Formule :C23H32FN5O2SiCouleur et forme :SolidMasse moléculaire :457.625Rev 2'-O-MOE-C(Bz)-5'-amidite
<p>'Rev 2’-O-MOE-C(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.</p>Formule :C49H58N5O10PCouleur et forme :SolidMasse moléculaire :907.99Dafsolimab
CAS :<p>Dafsolimab (SPV-T3a), an IgG2a murine monoclonal antibody (anti-CD3), induces cell death by modulating and activating the CD3/T cell receptor complex and is</p>Couleur et forme :LiquidSR15006
CAS :<p>SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).</p>Formule :C16H20ClN3O4SDegré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :385.87Nogalamycin
CAS :<p>Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.</p>Formule :C39H49NO16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :787.812Chrexanthomycin C
<p>Chrexanthomycin C, orally active, binds DNA (G4C2)4 G4, Kd 2.8 mM, potential in ALS research.</p>Formule :C31H24O15Couleur et forme :SolidMasse moléculaire :636.51Ac-MRGDH-NH2
<p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>Formule :C25H41N11O8SCouleur et forme :SolidMasse moléculaire :655.727DHFR-IN-8
<p>DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth.</p>Formule :C18H14N6SCouleur et forme :SolidMasse moléculaire :346.41N1-Methylpseudouridine-5′-triphosphate tetralithium
<p>N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.</p>Formule :C10H13Li4N2O15P3Couleur et forme :SolidMasse moléculaire :521.9GRGDSP
CAS :<p>Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide.</p>Formule :C22H37N9O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :587.583'-β-C-Methyl-N6-isopentenyl adenosine
<p>3’-Beta-C-Methyl-N6-isopentenyl adenosine is an adenosine analog.</p>Formule :C16H23N5O4Couleur et forme :SolidMasse moléculaire :349.38Brr2-IN-2
<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>Formule :C21H25FN4O2Couleur et forme :SolidMasse moléculaire :384.453'-Deoxy-GTP trisodium
<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.</p>Couleur et forme :Odour Solid
