Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase(94 produits)
- CDK(500 produits)
- Arrêt du cycle cellulaire(4 produits)
- Chk(42 produits)
- DYRK(48 produits)
- Dynamine(23 produits)
- Ferroptose(215 produits)
- HSP(169 produits)
- Intégrine(224 produits)
- Kinésine(66 produits)
- LIM Kinase(19 produits)
- Microtubules associés(261 produits)
- PKC(102 produits)
- PLK(28 produits)
- ROCK(70 produits)
- Rho(2 produits)
- Wee1(15 produits)
- c-Myc(69 produits)
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3477 produits trouvés pour "Cycle cellulaire/point de contrôle"
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Gly-Arg-Gly-Asp-Ser
CAS :<p>Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.</p>Formule :C17H30N8O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :490.47PROTAC CDK9 degrader-7
CAS :<p>PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (</p>Formule :C43H50Cl2N8O9Couleur et forme :SoildMasse moléculaire :893.81CW-2
<p>CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).</p>Formule :C43H42Cl2FN11O10PtCouleur et forme :SolidMasse moléculaire :1156.21251DSPE-PEG2000-iRGD
<p>DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.</p>Couleur et forme :Odour SolidXylocytidine
CAS :<p>Xylocytidine is a biochemical.</p>Formule :C9H13N3O5Couleur et forme :SolidMasse moléculaire :243.22N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS :<p>N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].</p>Formule :C21H35N12O17P3Couleur et forme :SolidMasse moléculaire :820.49STX-100
<p>PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.</p>Degré de pureté :97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Couleur et forme :Odour LiquidChk1-IN-6
CAS :<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Formule :C16H18F3N7Couleur et forme :SolidMasse moléculaire :365.364BAY-728
<p>BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].</p>Formule :C24H28F3N5O2SCouleur et forme :SolidMasse moléculaire :507.57Forimtamig
<p>Forimtamig (RG-6324) is a bispecific antibody that targets GPRC5D and CD3 T cells. It features a 2 + 1 structure, comprising two high-affinity GPRC5D binding segments and one CD3-binding module. Forimtamig is engineered with a P329G LALA mutation in its Fc domain to prevent Fcγ receptor and C1q binding, while maintaining Fc receptor interaction. Its isotype control corresponds to human IgG1 kappa.</p>Couleur et forme :Odour LiquiddUTP trisodium
CAS :<p>dUTP trisodium (Deoxyuridine triphosphate) is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.</p>Formule :C9H12N2Na3O14P3Degré de pureté :100.00%Couleur et forme :SolidMasse moléculaire :534.09HSDVHK-NH2 TFA
<p>HSDVHK-NH2 TFA acts as an antagonist to the αvβ3-vitronectin integrin interaction, displaying an inhibitory concentration (IC 50) of 1.74 pg/mL (2.414 pM) [1] [</p>Formule :C32H49F3N12O11Couleur et forme :SolidMasse moléculaire :834.8A20FMDV2
CAS :<p>A20FMDV2 is a highly selective αvβ6 integrin inhibitor with an IC 50 of 3 nM, demonstrating 1,000-fold greater selectivity for αvβ6 compared to other RGD-directed integrins like αvβ3, αvβ5, and α5β1. This compound can be derived from the foot-and-mouth disease virus and is suitable for radiolabeling, enabling PET imaging of αvβ6 integrin-positive tumors.</p>Formule :C93H163N31O28Couleur et forme :SolidMasse moléculaire :2163.48BRP
<p>BRP, a peptide related to BRINP2, exhibits anti-obesity activity through the activation of FOS. It triggers FOS activation in the central nervous system, and its effect is independent of leptin, GLP-1 receptor, and melanocortin 4 receptor.</p>Couleur et forme :Odour SolidPyrindamycin A
CAS :<p>Pyrindamycin A is an antibiotic that inhibits DNA synthesis,and shows antitumor activities against murine leukemia.</p>Formule :C26H26ClN3O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :543.95Men 10376
CAS :<p>Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.</p>Formule :C57H68N12O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1081.22Censavudine
CAS :<p>Censavudine (OBP-601) is an HIV-1/2 treatment and prevention drug, a reverse transcriptase inhibitor with EC50 of 30-890 nM.</p>Formule :C12H12N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :248.23O-Glycoprotease
<p>O-Glycoprotease is a specific endoprotease for O-glycoproteins, capable of catalyzing the hydrolysis of peptide bonds directly adjacent to O-glycan structures in natural mucin-type O-glycosylated proteins. The sequence of O-Glycoprotease is derived from Akkermansia muciniphila, and it is recombinantly expressed in E. coli with a C-terminal 6×His tag. This enzyme maintains high activity within a pH range of 5.5 to 7.5, is resistant to 1 M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn2+.</p>Couleur et forme :Odour SolidBarasertib
CAS :<p>AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.</p>Formule :C26H31FN7O6PDegré de pureté :99.63% - 99.92%Couleur et forme :SolidMasse moléculaire :587.54Biotin-PEG7-C2-S-Vidarabine
<p>Biotin-PEG7-C2-S-Vidarabine: PEG linker with antiviral adenosine analog effective against herpes and zoster.</p>Formule :C36H60N8O12S2Couleur et forme :SolidMasse moléculaire :861.04[pSer2, pSer5, pSer7]-CTD TFA
<p>Substrate '[pSer2, pSer5, pSer7]-CTD (TFA)' for CDK7 phosphorylates RNA Pol II CTD at ser2, 5, 7.</p>Formule :C98H138F3N21O39Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2291.25NUAK1-IN-1
<p>NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.</p>Formule :C25H30N6OCouleur et forme :SolidMasse moléculaire :430.545Mps1-IN-6
<p>Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].</p>Formule :C35H39N9O3Couleur et forme :SolidMasse moléculaire :633.74CDK12/13-IN-2
<p>CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.</p>Formule :C24H22FN7O2Couleur et forme :SolidMasse moléculaire :459.48Cytidine 5'-diphosphate trisodium salt
CAS :<p>CDP, a trisodium salt, helps synthesize DNA/RNA by aiding phosphoryl transfer from ATP to CMP via UMPK.</p>Formule :C9H15N3Na3O11P2Degré de pureté :99.55%Couleur et forme :White Crystalline PowderMasse moléculaire :472.15LEB-03-146
CAS :<p>LEB-03-146: WEE1 DUBTAC linking AZD1775 to OTUB1 via PEG2; stabilizes WEE1 in HEP3B cells.</p>Formule :C46H57N11O8Couleur et forme :SolidMasse moléculaire :892.01Carboxy pyridostatin trifluoroacetate salt
<p>Carboxy pyridostatin trifluoroacetate salt exhibits higher molecular specificity for RNA over DNA G4s.</p>Formule :C37H35F3N10O9Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :820.73Ribonuclease T1
CAS :<p>Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.</p>Couleur et forme :Solidm7GpppCpG
CAS :<p>m7GpppCpG, a trinucleotide cap analogue, is used for synthesizing RNA with cap 0 or cap 1 structures.</p>Formule :C30H41N13O25P4Couleur et forme :SolidMasse moléculaire :1107.61Py-MAA-Val-Cit-PAB-DX8951
CAS :<p>Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].</p>Formule :C57H66FN11O13SCouleur et forme :SolidMasse moléculaire :1164.26Emofolin sodium
CAS :<p>Emofolin sodium, a synthetic folate analogue, inhibits DNA/RNA/protein synthesis by blocking dihydrofolate reductase.</p>Formule :C21H25N7Na2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.45DSPE-PEG2000-cRGD
<p>DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.</p>Couleur et forme :Odour Solid5'(R)-C-Methyl-5-fluorouridine
<p>5’(R)-C-Methyl-5-fluorouridine, a uridine analogue, possesses potential antiepileptic properties.</p>Formule :C10H13FN2O6Couleur et forme :SolidMasse moléculaire :276.22Nusinersen
CAS :<p>Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.</p>Degré de pureté :98.62%Couleur et forme :Solid(S)-DI-87
CAS :<p>(S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor，reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.</p>Formule :C23H30N6O3S2Degré de pureté :99.42%Couleur et forme :SoildMasse moléculaire :502.65CDK2/PIM1-IN-1
<p>CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.</p>Couleur et forme :Odour SolidhuATN-658
<p>huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.</p>Couleur et forme :Odour Liquidc-Myc inhibitor 13
<p>c-Myc inhibitor13 (compound A6) is an inhibitor of c-MYC transcription. It selectively stabilizes c-MYCG4 and inhibits G4-related c-MYC transcription.</p>Formule :C30H39N9OMasse moléculaire :541.32776DSPE-PEG1000-iRGD
<p>DSPE-PEG1000-iRGD is a PEG compound made from DSPE and the αv-integrin-targeting peptide (iRGD). The iRGD peptide initially binds to αv-integrins and undergoes proteolytic cleavage within tumors to produce CRGDK/R, which interacts with neuropilin-1, thereby facilitating tumor targeting and penetration. DSPE-PEG1000-iRGD is useful for drug delivery applications.</p>Couleur et forme :Odour SolidCDK2-IN-43
<p>CDK2-IN-43 (Compound 3a) is a CDK2-cyclin E2 inhibitor with an IC50 value of 6.0 nM. It is applicable to cancer research.</p>Formule :C19H27N7OCouleur et forme :SolidMasse moléculaire :369.464dAURK-4
CAS :<p>dAURK-4, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].</p>Formule :C52H52ClFN8O12Couleur et forme :SolidMasse moléculaire :1035.47Xanthosine-5'-Triphosphate
CAS :<p>Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.</p>Formule :C10H15N4O15P3Couleur et forme :SolidMasse moléculaire :524.164c-Myc inhibitor 10
CAS :<p>c-Myc inhibitor 10 enhances cell potency with improved permeability from methylated morpholine nitrogen.</p>Formule :C28H38N6O3Couleur et forme :SolidMasse moléculaire :506.64Mulnitorsen
CAS :<p>Mulnitorsen acts as an inhibitor of antisense non-coding mitochondrial RNA (ASncmtRNA) synthesis and serves as an antitumor agent [1].</p>Formule :C172H217N74O82P17S17Couleur et forme :SolidMasse moléculaire :5704.66Cytarabine triphosphate
CAS :<p>Ara-CTP, active Cytarabine metabolite, inhibits DNA synthesis, predicts leukemic chemosensitivity.</p>Formule :C9H16N3O14P3Couleur et forme :SolidMasse moléculaire :483.16Ceftriaxone
CAS :<p>Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.</p>Formule :C18H18N8O7S3Degré de pureté :96.08%Couleur et forme :SolidMasse moléculaire :554.58Methylcarbamyl PAF C-8
<p>Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.</p>Couleur et forme :Odour SolidCDK9 inhibitor HH1
CAS :<p>CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.</p>Formule :C13H15N3OSDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :261.34Endo-1,4-β-xylanase
CAS :<p>Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.</p>Couleur et forme :SolidCentaureidin
CAS :<p>Centaureidin is a useful organic compound for research related to life sciences. The catalog number is T125588 and the CAS number is 17313-52-9.</p>Formule :C18H16O8Couleur et forme :SolidMasse moléculaire :360.318
